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The method of synthesizing related substances with 1-bromo-3-fluoro-4-iodobenzene as the core
Now we want to take 1-bromo-3-fluoro-4-iodobenzene as the core and 1bromo3fluoro4iodobenzene as the direction of synthesis exploration.

1-bromo-3-fluoro-4-iodobenzene has a unique structure, with bromine, fluorine and iodine trihalogen atoms coexisting on the benzene ring. Based on this, the reaction can be carried out by taking advantage of the activity difference of halogen atoms.

If you want to go in the 1bromo3fluoro4iodobenzene direction, you can consider the cross-coupling reaction catalyzed by palladium. With 1-bromo-3-fluoro-4-iodobenzene and specific organometallic reagents, in the presence of suitable palladium catalysts and ligands, the reaction temperature, time and solvent can be regulated, or the introduction of specific groups can be realized, so as to achieve the purpose of conversion to 1bromo3fluoro4iodobenzene direction.

Or use different halogen atoms to react with nucleophiles. Iodine atoms have higher activity, and can first react with suitable nucleophiles to introduce specific groups, and then subsequent conversion of bromine and fluorine atoms as appropriate, so as to construct a structure that meets the needs of 1bromo3fluoro4iodobenzene direction.

For another example, by functionalizing the benzene ring, starting with 1-bromo-3-fluoro-4-iodobenzene, through a series of electrophilic substitution, nucleophilic substitution and other reactions, the framework of the target structure can be gradually constructed, and then the synthesis process can be advanced in the 1bromo3fluoro4iodobenzene direction.