Supplements

1 - Fluoro - 4 - Iodobenzene Synthesis Method
The synthesis of 1 - Fluoro - 4 - Iodobenzene requires a delicate method. Benzene derivatives are often used as starting materials and can be achieved through several steps of reaction. One method is to introduce a fluorine group into the benzene ring first, which can be used by nucleophilic substitution reaction, and use a suitable fluorine-containing reagent to successfully bond the fluorine atom to the benzene ring under specific reaction conditions. Subsequently, through a halogenation reaction, an iodine group is introduced. Selecting the appropriate iodizing reagent, at the appropriate temperature and in the presence of a catalyst, the iodine atom is precisely attached to the para-position of the benzene cyclofluoryl group, and the final product is 1-Fluoro-4-Iodobenzene. In this process, the control of reaction conditions is the key, and the slight difference in temperature, reaction time, and reagent dosage can affect the yield and purity of the product.

Analysis of Properties
1-Fluoro-4-Iodobenzene has unique properties. In terms of physical properties, it is a liquid at room temperature, with a specific density and boiling point. Due to the existence of fluorine and iodine atoms in the molecule, its polarity is different from that of ordinary benzene derivatives, and its solubility is also affected. In organic solvents, such as dichloromethane, ether, etc., it shows good solubility. Chemically, fluorine and iodine atoms on the benzene ring have certain reactivity. Fluorine atoms have strong electronegativity, which changes the electron cloud density distribution of the benzene ring, affecting the activity and selectivity of the electrophilic substitution reaction of the benzene ring. Iodine atoms can be used as leaving groups in many reactions, participating in nucleophilic substitution, coupling and other reactions, laying the foundation for the application of this compound in organic synthesis.

Application
1 - Fluoro - 4 - Iodobenzene has important applications in many fields. In the field of drug synthesis, due to its structural modifiability, it is often used as a key intermediate. By further reacting with the substituents on its benzene ring, compounds with specific pharmacological activities can be constructed, providing important raw materials for the development of new drugs. In the field of materials science, it can be introduced into the skeleton of polymer materials through specific chemical reactions to improve the properties of materials, such as thermal stability, optical properties, etc. In organic synthetic chemistry, as an important building block, it participates in the construction of complex organic molecules. Through various coupling reactions, it is connected with different organic fragments to expand the structural diversity of molecules and contribute to the development of organic synthetic chemistry.