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Trifluoromethoxybenzene

Trifluoromethoxybenzene

Hongda Chemical

Specifications

HS Code

127377

Chemical Formula C7H5F3O
Molecular Weight 162.11
Appearance Colorless liquid
Odor Characteristic
Boiling Point 148 - 150 °C
Density 1.24 g/cm³
Solubility In Water Insoluble
Solubility In Organic Solvents Soluble in common organic solvents
Flash Point 42 °C
Refractive Index 1.437

As an accredited Trifluoromethoxybenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

Packing & Storage
Packing 100 mL of trifluoromethoxybenzene in a sealed, chemical - resistant glass bottle.
Storage Trifluoromethoxybenzene should be stored in a cool, well - ventilated area away from heat, sparks, and open flames as it is flammable. Keep it in a tightly closed container, preferably made of materials resistant to its corrosive nature. Store it separately from oxidizing agents and incompatible substances to prevent potential chemical reactions.
Shipping Trifluoromethoxybenzene is shipped in accordance with strict chemical transportation regulations. It's packaged in specialized containers to prevent leakage. Shipment is handled by carriers trained in transporting hazardous chemicals, ensuring safety.
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Trifluoromethoxybenzene Trifluoromethoxybenzene
General Information
Historical Development
trifluoromethoxybenzene, organic compounds are also. Its origin can be traced back to the time when chemistry was booming in the past. At that time, all the sages were dedicated to the way of organic synthesis, and they tried their best to explore the unknown.
At the beginning, there were only hazy thoughts about its preparation, and there were many attempts, but many setbacks. However, the ambition of scholars is as solid as a rock, and they are unyielding. After years, the research has become more and more profound. New synthesis methods have gradually emerged, making the preparation of trifluoromethoxybenzene easier and the yield has gradually increased.
Since it first appeared in the academic world, it has been widely used in various fields today, such as medicine and materials. The development process of this compound is just like the rise of the stars, blooming a unique glow in the chemical firmament, paving the way for future research and opening up endless possibilities.
Product Overview
"The Book of Chemicals"
There is a substance today called trifluoromethoxylbenzene (Trifluoromethoxybenzene). It is an organic compound with unique properties. Looking at its shape, it is a colorless liquid under normal conditions, clear and clear, and has a specific fragrance.
This substance is widely used in the field of chemical industry. It can be used as an essential material for organic synthesis to make various fine chemicals. Because it contains trifluoromethoxy, it has strong electronegativity and special spatial conformation, giving the product different properties.
In the reaction, trifluoromethoxylbenzene is active and flexible, and can combine with many reagents to derive a variety of products. Either participating in nucleophilic substitution or participating in addition reactions can follow a specific mechanism to achieve new compounds. It also has extraordinary power in the creation of medicines and pesticides, providing a key foundation for the development of novel drugs and efficient pesticides.
Physical & Chemical Properties
"On the Physical and Chemical Properties of Trifluoromethoxylbenzene"
Trifluoromethoxylbenzene is also an organic compound. Its shape is a colorless liquid with a special odor. The boiling point is about a specific range. Due to the presence of trifluoromethoxy in the molecular structure, its physical properties are unique.
From the perspective of chemical properties, the electron-absorbing properties of trifluoromethoxy groups change the electron cloud density of the benzene ring. It exhibits unique activity in electrophilic substitution reactions. It can react with many reagents. In case of halogenated reagents, halogen atoms can be introduced at specific positions in the benzene ring.
And because of its fluorine-containing atoms, it endows compounds with certain stability and special chemical behaviors. Due to its physicochemical properties, it has great application potential in the fields of organic synthesis, medicinal chemistry, and is an important raw material for chemical research and industrial production.
Technical Specifications & Labeling
"On the Technical Specifications and Labeling (Product Parameters) of Trifluoromethoxylbenzene"
Trifluoromethoxylbenzene is an important product in the field of chemistry. Its technical specifications are related to many subtleties. From the perspective of its chemical structure, the structure of the benzene ring containing trifluoromethoxy determines its unique physical and chemical properties. The preparation method requires precise control of the reaction conditions. If the reaction temperature is appropriate, it should be within a certain range. Too high or too low will affect the purity and yield of the product.
In terms of identification, the product parameters must be clearly marked. Its appearance may be a colorless and transparent liquid, and the smell has a special aromatic aroma. Purity, when expressed in accurate values, such as a few percent, is the key to measuring quality. Density, boiling point, and other parameters should not be ignored. They should all be labeled in detail so that users can use them in various chemical processes according to their characteristics.
Preparation Method
The method of making this Trifluoromethoxybenzene is essential for raw materials and processes. The raw materials are often taken from several organic compounds and carefully proportioned. The preparation process requires specific reaction conditions, such as temperature and pressure, which are related to the reaction rate and product purity. The reaction steps are rigorous. First, the raw materials are mixed in the reactor, and specific chemical reactions occur in sequence. The catalytic mechanism is also critical. A suitable catalyst can promote the reaction to proceed efficiently, reduce the activation energy of the reaction, and improve the rate of product formation. If a catalyst is involved, the temperature is controlled in a suitable range, and the raw materials are converted in a series, and the final product is Trifluoromethoxybenzene. In this way, through fine control of raw materials, processes, reaction steps and catalytic mechanisms, high-quality Trifluoromethoxybenzene products can be obtained.
Chemical Reactions & Modifications
To taste the wonders of chemical industry, it is related to the change of substances. In Trifluoromethoxybenzene this product, its chemical reaction and modification are valued by the academic community.
To make this product, the common reaction is nucleophilic substitution. Halogenated aromatics and trifluoromethoxy reagents are combined under appropriate conditions. However, this reaction is often limited by the activity of the substrate, the choice of reagents, and the reaction conditions are harsh, and it cannot be improved without careful regulation.
In order to modify, scholars are mostly committed to the optimization of the catalytic system. Introduce new catalysts, or modify the reaction solvent, in order to increase its yield and improve its selectivity. Or on top of the molecular structure, add other groups to make it have different properties, such as changing its solubility and stability, to suit different needs.
The chemical reaction and modification of these substances, although the road resistance and long, but the academic community has been studying unremitting, expecting to obtain exquisite methods in the future, expand its application field, and contribute to the rise of chemical industry.
Synonyms & Product Names
Today there is a thing called Trifluoromethoxybenzene. The synonyms and trade names of this thing are also what we should investigate. Its synonyms may be called by chemical structure or by its characteristics. As for the trade name, the merchant is to recognize the difference of its thing, or to take a unique name.
The name of a chemical thing depends on its composition and properties. Trifluoromethoxybenzene, containing trifluoromethoxy and benzene ring, this is the main structure. According to this, synonyms may refer to its structural description. And trade names are related to the needs of the market and the use of promotion. Merchants hope to use a good name to attract the public and increase their market share.
We are the researchers of chemistry, and we should carefully observe its synonyms and trade names. Knowing the change of its name is also clear about the nature of its things. In this way, it is helpful for the research of chemistry and the prosperity of the industry. Although it is only two hundred words, it may be helpful to Trifluoromethoxybenzene the study of synonyms and trade names.
Safety & Operational Standards
Specifications for the safe production and operation of trifluoromethoxylbenzene
Trifluoromethoxylbenzene is an important raw material in the chemical industry. It is unique and widely used in many fields. However, due to its characteristics, safe production and standardized operation are the top priority.
#1. Storage rules
Trifluoromethoxylbenzene should be stored in a cool, dry and well-ventilated place. Keep away from fire and heat sources, and the storage temperature should not exceed 30 ° C. It should be stored separately from oxidants, acids, alkalis, etc., and should not be mixed. The warehouse must be equipped with suitable materials to contain leaks, just in case. The storage container used must be firmly sealed to prevent volatilization and leakage.
#2. The essentials of operation
When operating, it is necessary to ensure good ventilation. Operators should be specially trained and strictly abide by the operating procedures. It is recommended that operators wear self-priming filter gas masks (half masks), chemical safety protective glasses, anti-poison infiltration work clothes, and rubber oil-resistant gloves. Avoid contact with oxidants, acids, and alkalis. When handling, it should be handled lightly to prevent damage to packaging and containers.
#3. Emergency response
If a leak occurs accidentally, personnel in the leakage contaminated area should be quickly evacuated to the safe area, and quarantined to strictly restrict access. Cut off the source of fire. It is recommended that emergency personnel wear self-contained positive pressure breathing apparatus and anti-gas clothing. Cut off the source of leakage as much as possible. Prevent flow into restricted spaces such as sewers and flood drains. Small leaks: adsorbed or absorbed with sand or other non-combustible materials. It can also be scrubbed with an emulsion made of non-combustible dispersant, and the lotion is diluted and placed into the wastewater system. Large leaks: build a dike or dig a pit for containment. Cover with foam to reduce vapor disasters. Transfer to a tanker or a special collector with an explosion-proof pump for recycling or transportation to a waste treatment site for disposal.
If there is personal contact, skin contact, should immediately take off the contaminated clothes, rinse with a large amount of flowing water for at least 15 minutes, and seek medical treatment; eye contact, lift the eyelids, rinse with flowing water or normal saline, and seek medical treatment; inhalers, quickly leave the scene to fresh air, keep the respiratory tract unobstructed, such as breathing difficulties, give oxygen, if breathing stops, immediately perform artificial respiration, medical treatment.
Safe production is related to human life and the rise and fall of the industry. Strictly abide by the safety and operating standards of trifluoromethoxylbenzene, in order to promote the chemical industry to move forward steadily, to ensure the safety of personnel and the environment.
Application Area
trifluoromethoxybenzene, it can be used to make things. In the field of production, it can be used as raw materials to help cause good health and human diseases. In the field of production, it can be used to avoid damage. And in the field of materials, there are also some benefits. It can be synthesized into special materials to increase their properties, such as their resistance and resistance. Therefore, trifluoromethoxybenzene in the field of multiple uses, it has important effects, which can promote the steps of all walks of life and be used by the world, for the benefit of life, and those who cannot be ignored in the chemical industry.
Research & Development
Today there are Trifluoromethoxybenzene names, I am a chemical researcher, studying its research and development in detail. This material is unique, has a wide range of uses, and has potential in the fields of chemical industry and medicine.
At the beginning, we explored the synthesis method, and after repeated experiments, we found an effective path. Optimize conditions to improve yield and purity. The process was difficult, but we worked tirelessly and finally achieved success.
During the research and development process, problems frequently appeared. Raw materials are scarce, costly, and the reaction is complex, which is not easy to control. So we found alternative raw materials and improved processes to solve the dilemma.
Today, this product is gradually maturing. However, we still need to improve, expand the scope of application, and improve quality. I will continue to study it, hoping it will shine in various fields, contribute to development, and drive the industry forward.
Toxicity Research
Yu Taste is committed to the study of poisons, and recently focused on Trifluoromethoxybenzene this substance. The poison of its sex is related to the public. Although it has not been seen in ancient books, it cannot be ignored with today's scientific experience.
Trifluoromethoxybenzene poison, or involving the viscera. After research, it enters the body, or messes with the biochemistry in the body, damaging the ability of the liver and kidney. And this substance evaporates in the air, and people inhale it, for fear of causing airway discomfort, and even hurting the brain.
Although the research is still shallow, I already feel that its poison is not light. In the future, we should explore its nature in detail, investigate the source of its harm, and find ways to solve it, so as to protect everyone's well-being, and prevent the disease of poisons before they are conceived.
Future Prospects
Looking at the research of our generation in Trifluoromethoxybenzene this thing, the prospect is bright, and the future development is quite high hope.
Trifluoromethoxybenzene, their unique nature, can be used in various fields. It is expected that in the future, in the field of medicine, it may be the basis for creating new agents, helping to treat diseases, and relieving the suffering of many diseases. In the field of materials, it may be able to become novel materials, increasing the ability of equipment, and expanding the way of practicality.
We should be diligent, study its theory, and explore its undiscovered secrets. With time, we will be able to make the Trifluoromethoxybenzene can be fully developed, used by the world, benefit the common people, and paint a splendid scene in the future, which will live up to our research and pursuit.
Where to Buy Trifluoromethoxybenzene in China?
As a trusted Trifluoromethoxybenzene manufacturer, we deliver: Factory-Direct Value: Competitive pricing with no middleman markups, tailored for bulk orders and project-scale requirements. Technical Excellence: Precision-engineered solutions backed by R&D expertise, from formulation to end-to-end delivery. Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
Frequently Asked Questions

As a leading Trifluoromethoxybenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

What are the main uses of Trifluoromethoxybenzene?
Trifluoromethoxybenzene is also an organic compound. It has a wide range of uses and is used in various fields.
In the field of medicinal chemistry, it is often a key intermediate for the synthesis of drugs. Due to its unique structure, it can endow drugs with specific activities and properties. By introducing trifluoromethoxy groups, the lipophilicity, metabolic stability and bioavailability of drugs can be improved. For example, in the synthesis of some anti-depressant and anti-tumor drugs, trifluoromethoxybenzene plays an important role in helping drugs act more effectively on targets and improve efficacy.
It is also indispensable in materials science. It can be used to prepare high-performance polymer materials. Polymers containing trifluoromethoxylbenzene structure often have excellent thermal stability, chemical stability and electrical properties. Such polymers are widely used in electronic devices, such as liquid crystal displays, organic Light Emitting Diodes, etc. Because it can optimize the performance of materials, the display effect of devices is better, and the service life is longer.
In the field of pesticide chemistry, trifluoromethoxylbenzene also has a place. Pesticides synthesized from it are often highly efficient, low toxic, and broad-spectrum. It can effectively resist a variety of pests and diseases, and ensure the growth and yield of crops. Its unique chemical structure can enhance the interaction between pesticides and target organisms, and improve the activity and selectivity of pesticides.
In addition, in the field of fine chemicals, trifluoromethoxybenzene can be used as a raw material for the synthesis of special fragrances, dyes and surfactants. Through ingenious chemical reactions, products can be endowed with unique properties and qualities to meet the specific needs of different industries.
In summary, trifluoromethoxybenzene, with its unique chemical structure, plays a crucial role in many fields such as medicine, materials, pesticides and fine chemicals, promoting the development and progress of various industries.
What are the physical properties of Trifluoromethoxybenzene?

First of all, its appearance, under normal conditions, trifluoromethoxylbenzene is a colorless and transparent liquid, and it looks clear and pure, like jade dew. Its smell, slightly aromatic, but not very strong, placed under the nose to smell, you can get a wisp of fragrance.
As for the boiling point, it is about 105-106 ° C. This boiling point value allows trifluoromethoxylbenzene to be converted into a gaseous state when properly heated. Its melting point is relatively low, about -45 ° C. Such a low melting point makes it stable in a liquid state at room temperature.
Furthermore, the density of trifluoromethoxylbenzene is about 1.26 g/mL. This density is slightly higher than that of water, so if it is placed in one place with water, trifluoromethoxylbenzene will sink to the bottom of the water. Its solubility also has characteristics. In organic solvents, such as ethanol and ether, it is quite miscible and very popular. However, in water, its solubility is not good. The two seem to be distinct and difficult to blend.
In terms of its volatility, trifluoromethoxylbenzene has a certain degree of volatility. In an open environment, it can slowly evaporate into the air. Its vapor pressure also has a specific value at a certain temperature, which is related to the rate and degree of its volatilization.
In addition, the refractive index of trifluoromethoxylbenzene is also one of its important physical properties, about 1.417 - 1.419. This refractive index allows light to pass through the substance to produce a specific refractive phenomenon, which may be relevant in the optical field.
In summary, the physical properties of trifluoromethoxylbenzene are unique, and they have specific applications in many fields of organic synthesis and chemical industry due to their properties.
What is the chemistry of Trifluoromethoxybenzene?
Trifluoromethoxy benzene is also an organic compound. Its chemical properties are unique and worth exploring.
In terms of its stability, due to the inclusion of trifluoromethoxy, the group has strong electronegativity, which makes the molecular structure stable and can resist the action of many chemical reagents. In common oxidation environments, trifluoromethoxy benzene is not easy to be oxidized, due to the high carbon-fluorine bond energy, it is difficult to break, and it is difficult for oxidants to attack its structure.
Its solubility also has characteristics. In organic solvents, such as dichloromethane, chloroform, etc., it exhibits good solubility. Due to the principle of similar miscibility, the non-polar structure of trifluoromethoxy benzene is compatible with the non-polar structure of organic solvents. However, in water, due to its weak molecular polarity, the solubility is poor.
Then talk about the reactivity. After the introduction of trifluoromethoxy group on the benzene ring, the electron cloud density of the benzene ring is changed. The trifluoromethoxy group is an electron-absorbing group, which reduces the electron cloud density of the benzene ring and weakens the activity of electrophilic substitution. For example, in the halogenation reaction, trifluoromethoxy benzene requires more violent reaction conditions than benzene to introduce halogen atoms. However, in the case of nucleophilic substitution reaction, due to the decrease in the electron cloud density of the benzene ring, it is more susceptible to attack by nucleophilic reagents, making nucleophilic substitution more likely to occur.
In a high temperature environment, trifluoromethoxylbenzene may decompose, and carbon-fluorine bonds, carbon-oxygen bonds, etc. may break due to high temperature energy, resulting in small molecule products such as hydrogen fluoride and carbon dioxide.
In summary, trifluoromethoxylbenzene exhibits chemical properties such as stability, solubility and unique reactivity due to its special chemical structure, which is of great significance and application in many fields such as organic synthesis.
What is Trifluoromethoxybenzene production method?
There are two common methods for making trifluoromethoxylbenzene. One is the route using phenols as the starting material. First, take the phenol and make it react with the base to form a phenol salt. Take phenol as an example, react with sodium hydroxide to obtain sodium phenol. Then, let the phenate react with the trifluoromethylation reagent. The commonly used trifluoromethylation reagent is a trifluoromethyl halide, such as trifluoromethyl bromide (CF 🥰 Br). Under appropriate reaction conditions, the oxygen anion of the phenate will attack the carbon atom of the trifluoromethyl halide, and the halogen ion will leave, thus forming trifluoromethoxylbenzene. This reaction needs to be carried out under anhydrous and suitable temperature and catalyst conditions. In general, in organic solvents, such as N, N-dimethylformamide (DMF), in the presence of a base, the reaction can occur smoothly.
The second is to use halogenated benzene as the starting material. Taking bromobenzene as an example, the bromobenzene is first reacted with metal magnesium to form a Grignard reagent, namely phenylmagnesium bromide (C-H-MgBr). After that, the Grignard reagent is reacted with a trifluoromethylating reagent, such as trifluoromethylsulfonate (CF-SO-R). The carbon-magnesium bond in the Grignard reagent is strongly nucleophilic, which will attack the carbon atom of the trifluoromethylsulfonate, and the sulfonate group will leave, which will then form trifluorometh This process also needs to be carried out in an anhydrous and oxygen-free environment in a suitable organic solvent, such as ether or tetrahydrofuran, and the reaction temperature and time should be controlled to achieve a higher yield. In short, these two methods have their own advantages and disadvantages, and the appropriate production method should be selected according to the actual situation, such as the availability of raw materials, cost and product purity requirements.
Trifluoromethoxybenzene to pay attention to when storing and transporting
trifluoromethoxybenzene, it is an organic compound. During storage and transportation, many matters cannot be ignored.
The first to bear the brunt, the storage place must be cool and dry. This is because of its susceptibility to temperature and humidity, high temperature and humidity, or the risk of deterioration. Therefore, it should be placed in a well-ventilated place, away from fire and heat sources, to prevent accidental explosion.
In addition, the substance has a certain volatility, and the storage container must be tightly sealed to avoid escape. And it is necessary to keep away from oxidants, strong acids and alkalis, etc., because it may react violently with them, endangering safety.
As for transportation, also be cautious. The means of transport used should be clean and dry, and must be stable to prevent package damage due to bumps and collisions. During transportation, the escort must pay close attention to changes in temperature and humidity and adjust at any time.
Packaging should not be ignored. It must be made of packaging materials that meet safety standards, and clear warning labels should be marked on the outside to indicate its characteristics and hazards, so that everyone can be alerted.
In short, when storing and transporting trifluoromethoxybenzene, everything must follow safety procedures and must not be slack at all, so as to keep safe.