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What is the chemical structure of (α S )-α-[[( 1R) -1- [3,5-bis (trifluoromethyl) phenyl] ethoxy] methyl] -α-vinylaniline maleate?
The structure of this organic compound needs to be studied carefully.
The structure of (α S ) - α - [[( 1R) -1 - [3,5 -bis (triethylamino) benzyl] ethoxy] ethyl ] - α - ethyl-butyrolactone. Among them, (α S) and (1R) exhibit specific three-dimensional configurations, which are related to the spatial arrangement of atoms in the molecule and have a great impact on their physical and chemical properties.
α-ethyl indicates that ethyl is attached to the carbon at the α position. The structure of this part of [[ (1R) -1- [3,5-bis (triethylamino) benzyl] ethoxy] ethyl] is complex. [3,5-bis (triethylamino) benzyl], "benzyl" is benzyl, and there are bis (triethylamino) attached to the 3 and 5 positions. "Triethylamino" is composed of three ethyl groups connected to the nitrogen atom. Ethoxy is an ethyl group connected to the oxygen atom to form a -O-CH -2-CH 🥰 structure, and this ethoxy group is connected to the 1-position carbon of the (1R) configuration. This overall structure is in turn connected to the α-ethyl and butyrolactone parts.
Butyrolactone is a five-membered ring structure containing an oxygen atom, with lactone characteristics, and the carbon atoms on the ring are connected to other groups.
In this compound structure, the interaction of various groups, the combination of stereo configuration and functional groups, endows it with unique chemical activities and physical properties, which may be of great significance in organic synthesis, medicinal chemistry and other fields.
What are the pharmacological effects of (α S )-α-[[( 1R) -1- [3,5-bis (trifluoromethyl) phenyl] ethoxy] methyl] -α-vinylaniline maleate?
(α S ) -α - [( 1R) -1 - [3,5 -Bis (tert-butyl) phenyl] ethoxy] methyl-α-ethyl-pyridylphenyl butyrate naphthyl ester This drug has the following pharmacological effects:
First, it can regulate lipid metabolism. It can affect the lipid distribution and metabolic process of the body. Through specific molecular mechanisms, it acts on the relevant links of lipid synthesis, transport and decomposition, helping to maintain various lipid components in the blood, such as cholesterol, triglycerides, at a reasonable level, and then play a certain protective effect on the cardiovascular system, which can reduce the risk of cardiovascular diseases caused by lipid metabolism disorders to a certain extent.
Second, it has anti-inflammatory properties. In the cascade process of inflammatory response, this drug can act on multiple targets, inhibit the release of inflammatory mediators and the activation of related inflammatory signaling pathways, thereby reducing the damage caused by inflammatory response to tissues and organs. It has potential therapeutic significance for some diseases accompanied by inflammatory pathological changes, such as some chronic inflammatory diseases.
Third, it has an effect on cell signaling. It can bind to specific receptors on the cell surface or signaling molecules in cells to regulate important life activities such as cell proliferation, differentiation and apoptosis, and play a role in cell growth regulation. This may have certain value for the research and treatment of diseases related to abnormal cell proliferation such as tumors, and may provide direction for the development of new therapeutic strategies.
Fourth, it affects the function of the nervous system. By acting on the release of neurotransmitters and the activity of nerve receptors, it regulates the balance of excitability and inhibition in the nervous system. It may have potential therapeutic effects on some neurological diseases, such as neuralgia and neurodegenerative diseases, and is expected to improve the symptoms and quality of life of patients.
What are the clinical applications of (α S )-α-[[( 1R) -1- [3,5-bis (trifluoromethyl) phenyl] ethoxy] methyl] -α-vinylaniline maleate?
(α S ) -α - [[( 1R) -1 - [3,5 -bis (trifluoromethyl) phenyl] ethoxy] methyl] phenyl-α-ethylfuranylbenzothiophene maleic anhydride is widely used in clinical applications. It can be used as a key active ingredient in the development of new drugs in the field of pharmaceutical research and development. Some studies have shown that the drugs developed on this basis have significant therapeutic effects on specific diseases and may bring good news to many patients.
In medicinal chemistry experiments, this compound is an important research object. Scientists explore its chemical properties, reactivity and interactions with other substances through various experimental means, hoping to gain a deeper understanding of its pharmacological mechanism and optimize drug formulations.
In biomedical research, (α S ) -α - [[( 1R) -1 - [3,5 - bis (trifluoromethyl) phenyl] ethoxy] methyl] phenyl - α - ethylfuranylbenzothiophene maleic anhydride also plays an important role. With the help of its research, researchers can further clarify the pathogenesis of related diseases and provide a strong basis for the formulation of disease diagnosis and treatment strategies. Many cutting-edge studies have been carried out around it, striving to open up new fields of medicine and improve human health.
What are the adverse reactions of (α S )-α-[[( 1R) -1- [3,5-bis (trifluoromethyl) phenyl] ethoxy] methyl] -α-vinylaniline maleate?
The formula you are talking about is quite complicated. The expression of many chemical groups is involved. To understand what cannot react with a certain group, it is necessary to analyze the properties of each group in detail.
(α S ) -α -[( 1R) -1 - [3,5 -Bis (tri-tert-butyl) benzyl] ethoxy] ethyl-α-isobutyryl benzyl tropin acid ester, this compound has a complex structure, and each group has its own unique properties.
tri-tert-butyl benzyl, its steric resistance is large, which will affect the reactivity of the connected part. Ethoxyethyl, with certain nucleophilic and electrophilic properties. And the isobutyryl benzyl tropinate part, its ester group and benzyl structure also have a specific tendency to react.
However, only according to this formula, it is difficult to directly determine what kind of unreachable reaction. The occurrence of the cover chemical reaction is not only related to the group itself, but also closely related to the reaction conditions, such as temperature, solvent, catalyst, etc.
If only in terms of group stability, the third tert-butyl benzyl group with a large steric resistance may be difficult to participate in some reactions with high space requirements. And the ester group is easy to hydrolyze under alkaline conditions, so it is not absolutely non-reactive. Other reactions can still occur only under suitable conditions.
Furthermore, different reaction types, such as nucleophilic substitution, electrophilic substitution, redox, etc., the reactivity of each group varies. Therefore, it is difficult to determine exactly what kind of unreachable reaction is based on this structure alone. It needs to be determined according to the specific reaction type and conditions.
What is the preparation method of (α S )-α-[[( 1R) -1- [3,5-bis (trifluoromethyl) phenyl] ethoxy] methyl] -α-vinylaniline maleate?
To prepare (α S ) - α - [[( 1R) -1 - [3,5 - bis (tri-tert-butyl) benzyl] ethoxy] methyl] benzyl - α - acetoxyphenylacetate methyl ester, the method is as follows:
First take an appropriate amount of raw materials, in which the proportion of related reactants needs to be precisely prepared. React (1R) -1 - [3,5 - bis (tri-tert-butyl) benzyl] ethanol with suitable reagents to form (1R) -1 - [3,5 - bis (tri-tert-butyl) benzyl] ethoxy related intermediates. This step requires attention to the reaction conditions, such as temperature, reaction duration, and catalyst dosage. The temperature should be controlled within a certain range, and the duration should be just right. Too much or too little catalyst may affect the reaction process and product purity.
At the same time, the benzyl compound is properly treated to make it have the activity of combining with the above intermediates. Then, the two are mixed and reacted to form a benzyl structure product containing ethoxy methyl groups. In this process, factors such as the pH of the reaction environment are also crucial and must be carefully regulated.
Next, the resulting product is further modified to introduce acetoxy groups. This step requires the selection of suitable acetylation reagents and the reaction under suitable conditions to ensure that the acetoxy group is accurately connected to the target position.
Furthermore, the construction of methyl phenylacetate structure is carried out. Through specific reaction steps, the modified benzyl product is combined with phenylacetic acid-related raw materials and converted into methyl ester form. This process requires attention to the influence of various reaction conditions on the stereochemical structure of the product, and strives to obtain a high-purity (α S) configuration product.
After each step of the reaction, suitable separation and purification methods, such as column chromatography and recrystallization, are required to remove impurities and improve product purity. Thus, the target product (α S ) - α - [[( 1 R) - 1 - [3,5 - bis (tri-tert-butyl) benzyl] ethoxy] methyl] benzyl - α - acetoxy methyl phenylacetate can be obtained by careful operation and treatment in multiple steps.