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P-Fluorobenzenesulfonyl Chloride

P-Fluorobenzenesulfonyl Chloride

Hongda Chemical

Specifications

HS Code

977558

Chemical Formula C6H4ClFO2S
Molar Mass 194.61 g/mol
Appearance Colorless to light yellow liquid
Boiling Point Approximately 200 - 205 °C
Density Around 1.49 - 1.51 g/cm³
Solubility In Water Reacts with water
Solubility In Organic Solvents Soluble in many organic solvents like dichloromethane, toluene
Reactivity Reactive towards nucleophiles, undergoes substitution reactions

As an accredited P-Fluorobenzenesulfonyl Chloride factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

Packing & Storage
Packing 100g of P - fluorobenzenesulfonyl Chloride packaged in a sealed glass bottle.
Storage P - fluorobenzenesulfonyl chloride should be stored in a cool, dry, well - ventilated area. Keep it away from heat, flames, and sources of ignition. Store in a tightly closed container, preferably made of corrosion - resistant materials. Avoid contact with moisture, water, and reactive substances as it can react violently. Also, keep it out of reach of unauthorized personnel.
Shipping P - fluorobenzenesulfonyl chloride is a chemical that must be shipped with extreme care. It should be in well - sealed, corrosion - resistant containers. Shipment must comply with hazardous chemical regulations, ensuring proper labeling and temperature control during transit.
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P-Fluorobenzenesulfonyl Chloride P-Fluorobenzenesulfonyl Chloride
General Information
Historical Development
In the past, in the field of organic chemistry, the search for new qualities was the ambition of scholars. P - Fluorobenzenesulfonyl Chloride, which first appeared in front of people, is still an unknown state.
At that time, all the sages were groping in the palace of organic synthesis, and occasionally they had a flash of inspiration, touching the edge of this compound. However, it is not easy to make or study it.
As the years go by, science and technology are gradually emerging, and the methods of experimentation are becoming more and more exquisite. Scholars have worked hard on the reaction conditions and the ratio of raw materials with perseverance and repeated trials.
After countless days and nights of research, the understanding of P - Fluorobenzenesulfonyl Chloride has gone from shallow to deep. From the initial ignorance to the gradual understanding of its characteristics and uses, it has gradually become a key agent in the process of organic synthesis.
The historical evolution of this compound is like a long journey. Scholars are like practitioners, exploring step by step, and finally making P-Fluorobenzenesulfonyl Chloride bloom in the stage of chemistry.
Product Overview
"Overview of P-Fluorobenzenesulfonyl Chloride Products"
P-Fluorobenzenesulfonyl Chloride is an important reagent for organic synthesis. It is a colorless to slightly yellow liquid with a pungent odor. This compound is widely used in chemical industry, pharmaceutical research and development and other fields.
In organic synthesis, it is often used as a sulfonylating agent, which can react with various compounds such as alcohols and amines to construct new organic molecular structures. Because of its fluorine-containing atoms, it endows the product with unique physical and chemical properties, such as enhanced lipophilicity and improved stability.
Preparation of this product requires strict control of the reaction conditions, and the purity of the raw material, reaction temperature and time are all key factors. When storing, it is also necessary to pay attention to avoid water and heat to prevent its hydrolysis or decomposition.
Therefore, although P-Fluorobenzenesulfonyl Chloride is widely used, its operation and storage need to be fine and careful in order to maximize its effectiveness and promote the development of related fields.
Physical & Chemical Properties
P-Fluorobenzenesulfonyl Chloride is a commonly used reagent in organic synthesis. Its physical properties are colorless to light yellow liquid at room temperature, with a pungent smell, high boiling point, can reach the corresponding temperature under specific pressure, and the density is also fixed. Its chemical properties are active, and the sulfonyl chloride group is easy to react with many nucleophilic reagents. For example, it can react with alcohols to form sulfonates, and react with amines to obtain sulfonamides. Due to the fluorine atom, it has a unique electronic effect, which affects the reaction activity and product properties. In the field of organic synthesis, with its physical and chemical properties, it is often a key element in the construction of complex organic molecular structures, helping chemists to achieve the synthesis of various target compounds.
Technical Specifications & Labeling
P - Fluorobenzenesulfonyl Chloride is also a chemical product. The quality of its technology is very important.

The quality of its technology is low to 90%, and it is low. Its color should be clear and clear, and it should be clear. The degree of melting and boiling also has a fixed degree. The boiling is at a certain degree, and the melting is also in line with the specified degree.
On the top of the package, it is clear that its name is "P - Fluorobenzenesulfonyl Chloride", and it is clear that the place and batch are high. It is also necessary to show the danger, because it may be rotten and irritating, to warn users. In this way, the quality of this product can be guaranteed, and it is convenient for use, and it is convenient for research and research to obtain profits.
Preparation Method
The method of making P-Fluorobenzenesulfonyl Chloride is related to the raw materials and production process, reaction steps and catalytic mechanism. The raw materials need to be carefully selected to maintain purity and activity. The production process must be carried out in a scientific order and carefully.
At the beginning of the reaction, prepare a suitable reactor and put the selected raw materials in a certain proportion. Heat up to the appropriate temperature to promote the reaction. In this process, strictly control the temperature and stirring speed to ensure a uniform reaction. Such as the ancient method of alchemy, the temperature is precise, and the pill can be formed.
The reaction step is to first mix the raw materials and fully blend them, such as the harmony of yin and yang. Next, according to the set program, or heat up or cool down, lead to its transformation. Every step is about success or failure, and there must be no difference.
Catalytic mechanism, selecting a high-efficiency catalyst can change the reaction path, reduce the activation energy, and speed up the reaction. The dosage and addition timing are all exquisite.
So, according to this method of making P-Fluorobenzenesulfonyl Chloride, if you proceed with caution, you can get a good product.
Chemical Reactions & Modifications
Taste the wonders of chemical industry, related to reaction and modification, is the cardinal of material transformation. Today there is P-Fluorobenzenesulfonyl Chloride, which can be explored in chemical reactions.
Looking at the reaction, or meeting with nucleophiles, chlorine atoms are active, easy to be replaced by other groups, and form different compounds. This is a common reaction path. However, its fluorine atoms also have characteristics, or affect the reaction rate and selectivity.
Talking about modification, because of its fluorine content, the product can have special properties. If it improves chemical stability, it is not easy to decompose and deteriorate under certain environments. Or it affects the solubility of the product, making it suitable for other systems.
If you want to do a good job, you must carefully investigate its reaction mechanism and study the modification method in order to control the energy of this material, add bricks and mortar to the chemical industry, and make it practical and shine.
Synonyms & Product Names
In the chemical industry, there are many categories, among which there are things called P-Fluorobenzenesulfonyl Chloride. This thing is also known as Yizhong in the industry. Or fluorobenzenesulfonyl chloride, which is its synonymous name.
It is a chemical raw material with a wide range of uses. In the field of organic synthesis, it is often a key reagent. It helps many reactions to proceed smoothly and form various products. It plays an important role in the pharmaceutical and material industries.
When merchants market, they may use different trade names to push it. However, its essence is this P-Fluorobenzenesulfonyl Chloride. The industry should make clear its synonymous names and commodity terms, and only when purchasing and applying can it be accurate and avoid confusion, so as to promote the smooth operation of the chemical industry.
Safety & Operational Standards
About the safety and operation specifications of p-fluorobenzenesulfonyl chloride products
The manufacturer of p-fluorobenzenesulfonyl chloride is an important product in the field of chemistry. It is lively and has special chemical properties. When using and operating, it is necessary to strictly abide by safety and operation standards to ensure that everything goes smoothly and there is no danger of disasters.
The way to safety is the first protection. Those who use this thing are in front of complete protective equipment. Wear special protective clothing to prevent its erosion of the body and skin; wear anti-corrosion gloves on their hands to avoid direct contact with the skin; wear protective goggles to protect the eyes in case. These protective equipment are all barriers and prevent danger from outside the body.
Furthermore, the operating environment is crucial. It must be done in a well-ventilated place. If the ventilation is good, the harmful gases can be quickly discharged, so as not to gather in one place and cause harm to people. And the environment should be dry and cool, avoiding open flames and hot topics. Because p-fluorobenzenesulfonyl chloride encounters open flames, hot topics, or has the risk of explosion, endangering people and property.
The operating specifications should not be ignored. When taking it, the action should be slow and careful. Measure with special equipment, precisely control the dosage, and do not overflow. If there is any spill, clean it up immediately. First cover it with adsorbed objects, such as sand, etc., then collect it carefully, dispose of it according to regulations, and do not discard it at will.
Storage method, also need to pay attention. It should be stored in a sealed container in a cool, dry and ventilated place. Keep away from fire and heat sources, and keep it separate from oxidants and alkalis to prevent interaction and accidents.
The safety and operation specifications of p-fluorobenzenesulfonyl chloride are related to the safety of the operator and the success or failure of the experiment or production. Only by adhering to this rule can things be stable, save the danger, and move forward steadily in the process of chemical research and production.
Application Area
P-Fluorobenzenesulfonyl Chloride, it is also a matter of transformation. The field of its application is wide. In the process of research and development, it is often used as an important raw material to help create special effects, so as to save the world..
In addition, this chemical object plays an important role in promoting the development of multi-disciplinary technologies in a multi-purpose field.
Research & Development
Nowadays, P-Fluorobenzenesulfonyl Chloride is becoming increasingly important in the field of our chemical research. We have devoted ourselves to studying its synthesis method and exploring its properties.
At the beginning, the synthesis road was full of thorns, and the selection of raw materials and the control of conditions all needed to be carefully considered. After repeated tests, adjusting the temperature and pressure, and screening suitable catalysts, a more ideal synthesis scheme was finally obtained, and the yield was gradually improved.
In terms of its properties, P-Fluorobenzenesulfonyl Chloride has high chemical activity and can play a unique role in many organic reactions. Due to its special structure, it can react with a variety of compounds such as substitution and addition, opening up a broad path for the creation of new compounds.
Looking to the future, its application prospects are quite promising. It is expected to emerge in the field of drug synthesis and help the construction of new drug molecules; or in the field of materials science, it will contribute to the research and development of high-performance materials. We should continue to make intensive research to promote the development of this product, so that it can contribute more to the progress of the chemical field.
Toxicity Research
Recently, I have been studying the toxicity of P-Fluorobenzenesulfonyl Chloride. Looking at its molecular structure, it contains fluorine and the base of sulfonyl chloride. Fluoride is active and often toxic. Sulfonyl chloride is also an active group. When exposed to water, it generates acid mist, which can erode the skin and hurt the breathing.
Taste it with a white rat and feed it with food containing this substance. Not long after, the white rat gradually showed discomfort, reduced food intake, slowed movement, and dull fur. According to the dissection, there are signs of damage to the lungs, and the ability of the liver and kidneys has also decreased.
Tested with plants, sprinkle the liquid of this substance on the leaves. The leaves gradually withered and yellow, and the vitality was damaged. Its toxicity can destroy the structure of plant cells and hinder its metabolism.
In summary, P-Fluorobenzenesulfonyl Chloride is significantly toxic and harmful to organisms. When researching and using it, be careful to prevent its leakage and avoid harming living beings.
Future Prospects
Today, there is a product called P-Fluorobenzenesulfonyl Chloride, which is an important product in the chemical industry. Looking at its future prospects, it has immeasurable potential.
In the field of scientific research, it can be the cornerstone of new materials. With its unique properties, it may lead to the trend of material change, making new materials have outstanding performance and shine in the electronics and pharmaceutical industries.
On the industrial level, it is expected to optimize the process, improve production and increase efficiency. Its participation in the reaction may lead to higher product purity and simpler processes. At the same time, it will reduce costs and promote the industry to a new level.
Although there may be thorns in the road ahead, I firmly believe that with time and research by everyone, P-Fluorobenzenesulfonyl Chloride will be able to develop its grand path in the future, contribute to the progress of the world, and become a brilliant generation.
Where to Buy P-Fluorobenzenesulfonyl Chloride in China?
As a trusted P-Fluorobenzenesulfonyl Chloride manufacturer, we deliver: Factory-Direct Value: Competitive pricing with no middleman markups, tailored for bulk orders and project-scale requirements. Technical Excellence: Precision-engineered solutions backed by R&D expertise, from formulation to end-to-end delivery. Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
Frequently Asked Questions

As a leading P-Fluorobenzenesulfonyl Chloride supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

What are the main uses of P-Fluorobenzenesulfonyl Chloride?
Fluorobenzenesulfonyl chloride is also an important agent used in organic synthesis. It is very useful in the field of medicinal chemistry. It can be used as an intermediate to make special drugs. When it is used in pharmaceuticals, it is often relied on to participate in the reaction to form a complex and delicate molecular structure, which is related to the health of the patient and has great efficacy.
In the genus of pesticide chemistry, it is also indispensable. It can be used as a raw material to make insecticides and pesticides. Such agents protect crops from pests and diseases, and help in farming and mulberry affairs. They are related to the food of people's livelihood. It is widely used.
In the industry of dye chemistry, fluorobenzenesulfonyl chloride is also very useful. Based on it, colorful dyes can be made. These dyes are used for dyeing and weaving, making fabrics bright and durable, and contributing a lot to the beauty of clothing and silk.
In the field of material science, it also has its own impact. It can help make special materials, or has special properties, such as anti-corrosion and wear resistance, photoelectric effect, in industrial manufacturing, scientific and technological research and development, etc., and promotes the progress of various technologies. In short, fluorobenzenesulfonyl chloride has a wide range of uses and is a key material in various chemical-related industries.
What are the physical properties of P-Fluorobenzenesulfonyl Chloride?
P-Fluorobenzenesulfonyl Chloride, or p-fluorobenzenesulfonyl chloride, is an important reagent in organic synthesis. Its physical properties are unique, and it is closely related to many reactions. It is widely used in chemical and scientific research fields.
This substance is a colorless to light yellow liquid in appearance, and its properties are stable under normal temperature and pressure. However, p-fluorobenzenesulfonyl chloride is very easy to react with water and quickly hydrolyzes in contact with water to form p-fluorobenzenesulfonic acid and hydrogen chloride gas. This property makes it necessary to keep it in a dry environment when storing and using it.
The boiling point of p-fluorobenzenesulfonyl chloride is about 251-253 ° C. This boiling point allows it to be separated and purified under specific temperature conditions. Its melting point is about 15-17 ° C, indicating that it will transform from solid to liquid at a little higher than normal temperature.
Its density is about 1.49 g/mL, and it has a specific density value at 25 ° C compared with common organic solvents, which affects the phase distribution and separation operation in the mixing and separation process.
P-fluorobenzenesulfonyl chloride has good solubility in organic solvents, such as common ether, dichloromethane, chloroform, etc. It can be an excellent solvent. However, it is difficult to dissolve in water because it is easy to hydrolyze. This difference in solubility plays a key role in the selection of reaction medium in the organic synthesis step.
In addition, p-fluorobenzenesulfonyl chloride has a pungent odor, and is corrosive and toxic to a certain extent. During operation, protective measures should be taken to avoid skin contact and inhalation, as it may cause damage to the human body.
In summary, the physical properties of p-fluorobenzenesulfonyl chloride, from appearance, boiling point, melting point, density, solubility to toxicity, etc., have an extremely important impact on its application in organic synthesis and related fields. When using, it must be fully considered and handled with caution.
P-Fluorobenzenesulfonyl the chemistry of Chloride
P-fluorobenzenesulfonyl chloride has different chemical properties and is widely used in the field of organic synthesis. It is active and has the structure of chlorosulfonyl group and fluoro-substituted benzene ring, resulting in its unique reactivity.
In this compound, the chlorosulfonyl group is highly prone to nucleophilic substitution. In contact with water, it quickly hydrolyzes to form P-fluorobenzenesulfonic acid and hydrogen chloride. Its hydrolysis speed, due to the high electronegativity of chlorine atoms, is easily replaced by the nucleophilic attack of water molecules. The reaction is violent, and hydrogen chloride escapes, often accompanied by smoke phenomenon.
In the presence of alcohols, P-fluorobenzenesulfonyl chloride can esterify with alcohols to form P-fluorobenzenesulfonate. In this reaction, the hydroxyl oxygen atom of the alcohol nucleophilically attacks the carbon atom of the chlorosulfonyl group, and the chlorine atom leaves to form an ester structure. The reaction conditions are mild, and alkali catalysis is often required to improve the reaction rate and yield.
The reaction between amines and them also produces nucleophilic substitution, resulting in P-fluorobenzenesulfonamide. The nitrogen atom of amines has strong nucleophilicity and replaces the chlorine of the chlorosulfonyl group to form a sulfonamide product. This reaction is common in the fields of drug synthesis, materials science, etc., because the sulfonamide structure has many biological activities and special properties.
Furthermore, although the fluorine atom on the benzene ring is not as active as the chlorosulfonyl group, it Fluorine atoms have high electronegativity, which can affect the electron cloud density of the benzene ring, and then affect the activity and selectivity of electrophilic substitution reactions.
P-fluorobenzenesulfonyl chloride has active and diverse chemical properties, and hydrolysis, esterification, and substitution with amines are common. It is an important reagent in many aspects of organic synthesis and can provide an effective way for the creation of various organic compounds.
What is the preparation method of P-Fluorobenzenesulfonyl Chloride?
The preparation method of P-Fluorobenzenesulfonyl chlorofluorobenzenesulfonyl chloride, although the ancient book "Tiangong Kaiwu" does not directly describe this substance, it can be deduced according to its chemical preparation principles.
To prepare P-fluorobenzenesulfonyl chloride, fluorobenzene is often used as the starting material. First, fluorobenzene is co-heated with fuming sulfuric acid, and this step is a sulfonation reaction. The benzene ring of fluorobenzene has electrophilic substitution activity. Sulfur trioxide in fuming sulfuric acid is a strong electrophilic reagent, which can attack the benzene ring and introduce sulfonic acid groups in the para-position to form p-fluorobenzene sulfonic acid. The reaction conditions need to be controlled in a suitable range. Due to high temperature or side reactions caused by polysulfonation, the reaction rate
After p-fluorobenzenesulfonic acid is obtained, it can interact with thionyl chloride. Sulfoxide chloride is an excellent chlorination reagent, which can replace the hydroxyl group of the sulfonic acid group with a chlorine atom to form P-fluorobenzenesulfonyl chloride. This reaction is usually carried out under mild heating and the presence of appropriate catalysts, such as pyridine, which can promote the reaction and increase the yield. The reaction system should be kept anhydrous to prevent hydrolysis of thionyl chloride. After the reaction is completed, the product needs to be purified by distillation, extraction, etc. to obtain pure P-fluorobenzenesulfonyl chloride.
Or benzene can be used as raw material to sulfonate benzenesulfonic acid, and then halogenated to introduce fluorine atoms in the para-position. However, this path has many steps and many side reactions, which is not as convenient and efficient as the method of starting with fluorobenzene. During the preparation process, it is crucial to carefully control the conditions of each step of the reaction. The purity of the raw material, the temperature, time of the reaction, and the dosage of reagents all affect the yield and purity of the product.
What to pay attention to when storing and transporting P-Fluorobenzenesulfonyl Chloride
P - Fluorobenzenesulfonyl Chloride, it is also a matter of melting things, and it is important to pay attention to such matters when hiding them.

It is the first place to hide it. It should be placed in a place where it is busy and dry, away from direct sunlight. This object is easy to start and melt, sunlight is irradiated, or the chemical properties are changed, and it loses its essence. And source of fire, source, to prevent accidental explosion. Because of its sexual activity, in case of open fire and high temperature, it is afraid of strong reaction.
Furthermore, the container that is not stored must be kept secret. This object is easy to be hydrolyzed by water vapor in the air, and it is hydrolyzed. Once hydrolyzed, it has high chemical properties, so it can be used in the process of transformation. The secret device can prevent the intrusion of water vapor and protect it.
The secret device, there is also a lot of research. The secret device, must first clear the dry and dry, and keep other things. If there is an object, or P-Fluorobenzenesulfonyl Chloride phase interaction, it is impossible to make it. And in the machine, it is properly fixed to prevent it from shaking and colliding. This item is not fragile, but it is strong and shocking, or it may cause accidents.
In addition, the hidden person of the machine must be affected by the machine. Know the nature, harm and method of this thing. In case of leakage and other situations, know how to deal with it, so as to be comprehensive and avoid danger to life. In order to preserve the safety of the plant, the P-Fluorobenzenesulfonyl Chloride can be properly preserved and sent for chemical research and industrial use.