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P-Difluoromethoxybromobenzene

P-Difluoromethoxybromobenzene

Hongda Chemical

Specifications

HS Code

184204

Chemical Formula C7H6BrFO2
Molecular Weight 221.024 g/mol
Appearance Typically a colorless to light - colored liquid
Boiling Point Around 210 - 220 °C (estimated, actual may vary based on purity)
Density Approx. 1.6 - 1.7 g/cm³ (estimated)
Solubility In Water Poorly soluble
Solubility In Organic Solvents Soluble in common organic solvents like dichloromethane, chloroform, ethyl acetate
Vapor Pressure Low vapor pressure at room temperature
Flash Point Should be handled with care due to potential flammability, flash point likely above 100 °C (estimated)

As an accredited P-Difluoromethoxybromobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

Packing & Storage
Packing 100g of p - difluoromethoxybromobenzene packaged in a sealed, chemical - resistant bottle.
Storage P - difluoromethoxybromobenzene should be stored in a cool, dry, well - ventilated area, away from heat sources and ignition points. Keep it in a tightly - sealed container to prevent vapor leakage. Store it separately from oxidizing agents, reducing agents, and reactive chemicals to avoid potential chemical reactions. Regularly check storage conditions to ensure product integrity.
Shipping P - difluoromethoxybromobenzene is shipped in specialized, leak - proof containers. Adequate cushioning is used to prevent breakage. Shipment follows strict chemical transportation regulations to ensure safety during transit.
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P-Difluoromethoxybromobenzene P-Difluoromethoxybromobenzene
General Information
Historical Development
P - Difluoromethoxybromobenzene, organic compounds are also. Its research and development process is an important matter in the field of chemistry. In the past, chemists studied the way of organic synthesis and dedicated themselves to exploring new substances. At first, the understanding of this compound was still shallow and only existed in theoretical concepts.
With the passage of time, the experimental technology has become more and more mature, and many scientists have devoted themselves to the research of this compound. After repeated attempts and improvements in the synthesis method, its properties and structure have been gradually clarified.
The early synthesis was difficult and the yield was low. However, the researchers persevered and continued to explore the reaction conditions and raw material selection. After countless failures, there was finally a breakthrough. From the initial crude attempt to the current mature preparation process, the development of P-Difluoromethoxybromobenzene has witnessed the progress of chemical research and laid the foundation for many fields of application.
Product Overview
There is a compound called P-difluoromethoxy bromobenzene. The structure of this compound is based on a benzene ring, with a bromine atom and a P-difluoromethoxy group attached to it respectively. Its appearance is often colorless to light yellow liquid, with specific physical and chemical properties.
From the perspective of physical properties, its boiling point and melting point are fixed, and under specific temperature conditions, it is either a liquid state or a solid state. Its density is also an important physical constant, which is related to its distribution in various media.
Discusses chemical properties. The presence of bromine atoms and difluoromethoxy groups in its structure gives it unique reactivity. It can participate in nucleophilic substitution reactions, and bromine atoms are easily replaced by nucleophilic reagents; the characteristics of difluoromethoxy also make the compound exhibit different chemical behaviors under specific reaction conditions. This compound is widely used in the field of organic synthesis and is often a key intermediate in the preparation of complex organic compounds, assisting chemists to achieve many delicate synthesis routes.
Physical & Chemical Properties
P-Difluoromethoxybromobenzene, organic compounds also. It has unique physical and chemical properties. Looking at its physical properties, under room temperature, or liquid, the color is clear and transparent, and it has a slightly specific smell. Its boiling point and melting point are fixed, with several boiling points and geometric melting points, which is related to the strength of the intermolecular force. When it comes to chemical properties, its fluorine and bromine atoms are active. Under suitable reaction conditions, substitution reactions can occur, and fluorine and bromine atoms are easily replaced by other groups. Its methoxy group also has certain chemical activity and can participate in a variety of organic reactions, such as nucleophilic substitution. From this perspective, P-Difluoromethoxybromobenzene in the field of organic synthesis, it has great potential and can be an important raw material for the preparation of other complex organic compounds. With its special physical and chemical properties, it can help chemists create more novel and practical substances.
Technical Specifications & Labeling
Nowadays, there is P-difluoromethoxy bromobenzene. In the field of chemical industry, its technical specifications and identification (product parameters) are crucial.
To make this product, it is necessary to clarify its technical specifications. The choice of materials must be pure and accurate, and the amount of various reagents must be in line with the regulations. In the reaction environment, the temperature and pressure are fixed, and there should be no slight difference. When heating up and cooling down, the rate should also be controlled appropriately. When reacting, the speed of stirring is also related to the quality of the product. If it is fast, it will be uniform, and if it is slow, it will be uneven.
As for the identification (product parameters), its physical and chemical properties, such as color, taste, and state, must be detailed. The melting point, density and geometry are all important numbers. Purity is a key, it must meet high standards, and the amount of impurities must be minimal. This is the key to the technical specifications and identification (product parameters) of P-difluoromethoxy bromobenzene, which is related to the quality of the product.
Preparation Method
If you want to make P-Difluoromethoxybromobenzene this substance, you should study the method of making it in detail. First of all, the raw materials need to prepare specific reactants, and choose them carefully according to their properties and reaction reasons.
The process of making, the first step is to set up the reaction. In a suitable device, control the temperature, pressure and reaction time. First, let the raw materials enter in sequence, so that they can fully touch each other. In the meantime, a catalyst may be needed to promote the reaction speed, choose the appropriate one, and adjust the dosage.
The reaction step is the first step, the raw materials are initially mixed, and the reaction gradually begins. Then, depending on the reaction situation, either heat or add an agent, make sure the reaction goes forward. Finally, the reaction is completed, and the product is obtained.
The mechanism of refining is also required. By the method of separation and purification, the impurities are removed and the essence is stored. For example, by distillation and extraction, the product can be purified and meet the required standards to obtain good P-Difluoromethoxybromobenzene.
Chemical Reactions & Modifications
I am dedicated to the chemical research of P - Difluoromethoxybromobenzene, its chemical reaction and modification, and I am very diligent. The chemical change is like the change of the universe, which is wonderful.
The reaction of P - Difluoromethoxybromobenzene often depends on various conditions, such as temperature and catalyst. The rise and fall of temperature, like the cold and summer of the day, can ease the speed of the reaction and the amount of products. Catalysts, like guides on the road, can change the way of chemical reactions, reduce the required energy, and make the reaction smooth.
As for modification, you want to give this thing a new quality. Or add functional groups, or change the structure of its molecules, hoping that its performance is unique and its use is extensive. This is not only about the ingenuity of chemistry, but also the need for industrial practicality. I have been studying day and night, hoping to make breakthroughs in the precision of chemical reactions and the refinement of modification, adding luster to one of the fields of chemistry. I also hope that this research can benefit the industry and be used by the world.
Synonyms & Product Names
"On the same name and trade name of P-difluoromethoxy bromobenzene"
Today there is a chemical thing called P-difluoromethoxy bromobenzene. Its name may have similarities and differences between academia and the city. The same person refers to the chemical name of its essence, which is recognized by scholars to clarify its structure and composition. It is accurately identified, such as the name "P-difluoromethoxy bromobenzene". It is established according to the rules of chemical naming and is commonly used in academic exchanges.
In the commercial market, merchants establish separate product names for the convenience of marketing, or because of the unique process or the desire to recognize its characteristics. Although this trade name is different from the scientific name, it refers to P-difluoromethoxybromobenzene. Because merchants want to highlight their products in the public, in order to attract the eyes of the patron.
Although the names are similar and different, they all refer to this thing. We who study chemistry should understand the same and know the difference, and clearly distinguish between academic and commercial use, so as not to confuse them. In this way, we can sell chemistry in research and commerce without hindrance.
Safety & Operational Standards
Regarding the safety and operation specifications of P-difluoromethoxy bromobenzene products
For P-difluoromethoxy bromobenzene, the preparation and use of chemical products are also related to safety and standards, and cannot be ignored.
At the beginning of preparation, the selection and weighing of raw materials must be accurate. All reagents must be properly stored and used according to their characteristics. Such as difluoromethanol, which is volatile and irritating, should be operated in a well-ventilated place, and the operator should wear protective equipment, such as gas masks, acid and alkali-resistant gloves, to avoid its harm.
When reacting, temperature, pressure, time and other factors are all critical. Temperature control needs to be precise, so as not to overreact and cause danger. Set up a heating method, when using a suitable heating appliance, and pay close attention to temperature changes. If the temperature is too high, it may cause explosion. At the same time, the stirring rate should not be ignored. If it is uniform, the reaction will be good, if it is uneven, it will cause local overheating.
When the product is separated and purified, the methods used, such as distillation, extraction, etc., must also be carried out in accordance with specifications. During distillation, the installation of the device must be stable and sealed to prevent the product from escaping, polluting the environment, and endangering people. The solvents used in extraction are mostly toxic and flammable. When kept away from fire sources, operate with caution.
As for storage, P-difluoromethoxy bromobenzene should be placed in a cool, dry and ventilated place away from direct sunlight. It must be placed separately from oxidizing agents, acids, alkalis and other substances to prevent chemical reactions and safety accidents.
When using, operators need to be professionally trained to be familiar with its properties and hazards. The experimental table should be kept clean, and the equipment used should be cleared immediately after use. In the operation room, fire equipment should be complete for emergencies.
In general, the safety and operation specifications of P-difluoromethoxy bromobenzene run through the preparation, storage and use of all links. Only by treating with caution and following regulations can we ensure the safety of personnel, promote smooth production, and avoid accidents.
Application Area
Taste the wonders of chemical industry, the wonders of creation, there is a thing called P-Difluoromethoxybromobenzene. This thing has a wide range of uses, and can be used as a raw material for synthesizing good medicines in the field of medicine. With its unique structure, it can participate in many delicate reactions, help drugs to form, and heal pains. In the material industry, it also shows extraordinary power. It can optimize the material properties, make the material more tough and durable, and is suitable for all kinds of equipment and appliances. And in scientific research and exploration, it provides key support for many experiments, helping scholars to gain insight into microscopic mysteries and open up unknown fields. Although it is not widely known, its potential in various application fields cannot be underestimated, just like a pearl lurking, shining brightly when the time comes.
Research & Development
In recent years, Yu devoted himself to the study of P-Difluoromethoxybromobenzene. This material is unique and has great potential in various fields. At first, analyze its structure, identify the wonder of its atomic connection, and clarify its basic characteristics.
Then, explore the method of synthesis. Through various attempts, try different reagents and conditions, hoping to achieve high efficiency. The process is difficult, there are many setbacks, the reaction yield is not up to expectations, and impurities are difficult to remove.
However, it is not discouraged, repeated research and adjustment of strategies. After long-term efforts, progress is gradually made. Optimize the synthesis steps, control temperature, adjust time, and select the best reagents, the yield increases gradually, and the purity also increases.
Looking forward to the future, I hope this achievement can be widely used. In medicine, it may become a key intermediate to assist in the development of new drugs; in materials, it may endow materials with novelty and expand their uses. I will make unremitting efforts to see this substance bloom and contribute to research and development.
Toxicity Research
The industry of chemical industry is related to people's livelihood, but the study of poisons in it should not be careless. Today there is P-Difluoromethoxybromobenzene this substance, and our generation should study its toxicity in detail.
Looking at this substance, its molecular structure is unique, including fluorine and bromine elements. Fluoride is active and often toxic; bromine is also irritating. The two are connected to the benzene ring, or cause P-Difluoromethoxybromobenzene to be quite toxic.
In order to study its toxicity, we should try it with all kinds of creatures according to ancient methods. Observe its impact on insects and livestock, and observe the changes in their eating, action, and growth. If insects touch it, they may become stiff or die; if livestock eat it, they may vomit or become sick. It can be seen from this that its toxicity is strong. And if this substance is scattered in water and soil, it will be afraid of sewage sources, bad soil, and harm the surrounding creatures. Therefore, studying its toxicity, in order to prevent its harm, ensure the well-being of all beings, and protect the tranquility of nature, is really the heavy responsibility of our chemical researchers.
Future Prospects
P - Difluoromethoxybromobenzene, the things that are transformed are also. In this world, the first step of transformation is the new moon every day. The use of this compound is unknown, or it involves the research of, or the research of materials.
Looking at the future, it can be developed. In the field of, it may be able to assist in the research of new technologies, so as to save people from diseases and save the world. In terms of materials, it may be possible to explore new ways, make materials special, and use them in new technologies.
I am a researcher of, study things carefully, and be diligent. Expect to use the wisdom of intensive research to explore its secrets and explore its capabilities. Make P - Difluoromethoxybromobenzene in the future, and use it for the benefit of the people, so as to become the macro of our researchers.
Where to Buy P-Difluoromethoxybromobenzene in China?
As a trusted P-Difluoromethoxybromobenzene manufacturer, we deliver: Factory-Direct Value: Competitive pricing with no middleman markups, tailored for bulk orders and project-scale requirements. Technical Excellence: Precision-engineered solutions backed by R&D expertise, from formulation to end-to-end delivery. Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
Frequently Asked Questions

As a leading P-Difluoromethoxybromobenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

What are the chemical properties of P-Difluoromethoxybromobenzene?
P-difluoromethoxy bromobenzene, this is an organic compound. Its chemical properties are unique, with the dual characteristics of halogenated aromatics and ether compounds.
In terms of reactivity, bromine atoms on the benzene ring can undergo many reactions. One is a nucleophilic substitution reaction, in which bromine atoms can be replaced when encountering nucleophilic reagents. If an aqueous solution of sodium hydroxide is used as a nucleophilic reagent, under suitable conditions, bromine atoms may be replaced by hydroxyl groups to form P-difluoromethoxy phenol. This reaction occurs when the nucleophilic reagent attacks the carbon attached to the bromine atom, causing the carbon-bromine bond to break. The second is a reaction involving metal-organic reagents, such as reacting with magnesium, which can form Grignard reagents The Grignard reagent is extremely reactive and can undergo addition reactions with a variety of carbonyl compounds, thereby forming new carbon-carbon bonds, which is of great significance in organic synthesis.
Furthermore, the difluoromethoxy moiety also has special properties. The fluorine atom has high electronegativity, which can enhance molecular polarity and affect the physical and chemical properties of the compound. And the oxygen atom of the difluoromethoxy group has a lone pair electron, which can participate in the formation of hydrogen bonds or complex with metal ions as a ligand.
In addition, the benzene ring of P-difluoromethoxy bromobenzene can undergo electrophilic substitution reaction. Because the benzene ring is rich in electrons, it is easy to be attacked by electrophilic reagents. For example, under the catalysis of Lewis acid, it can react with iron bromide and bromine elementals to introduce new bromine atoms at specific positions in the benzene ring. This reactivity is related to the localization effect of the original substituents on the benzene ring. The difluoromethoxy group is the ortho-and para-locator, which makes the electrophilic substitution reaction mainly occur in its ortho-and para-position.
In short, P-difluoromethoxy bromophenyl has a unique structure, presents a variety of chemical properties, and is widely used in the field of organic synthesis.
What are the main uses of P-Difluoromethoxybromobenzene?
P-difluoromethoxy bromobenzene is also an organic compound. It has a wide range of uses and is used in various fields.
First, in the field of medicinal chemistry, this compound is often a key intermediate. Through organic synthesis, chemists can use it to react with other reagents to obtain drug molecules with special pharmacological activities. Taking the development of antibacterial drugs as an example, P-difluoromethoxy bromobenzene can introduce specific functional groups through a series of chemical transformations to give the drug better antibacterial efficacy and bioavailability.
Second, in the field of materials science, it also has important functions. In the preparation of high-performance organic optoelectronic materials, P-difluoromethoxy bromobenzene can be used as a structural unit to participate in the construction of polymer materials through polymerization. The resulting materials may have unique optical and electrical properties, such as high fluorescence quantum yield and excellent carrier transport properties, etc., which are valuable in the manufacture of organic Light Emitting Diode (OLED) and organic solar cells.
Third, in the field of pesticide chemistry, P-difluoromethoxy bromobenzene can be used as a raw material for the synthesis of new pesticides. After rational molecular design and chemical synthesis, it is converted into pesticide compounds with high insecticidal, bactericidal or herbicidal activities, and such compounds may have the characteristics of low toxicity and low residue, which meets the current needs of green pesticide development.
Fourth, in organic synthetic chemistry, P-difluoromethoxy bromobenzene contains bromine atoms and difluoromethoxy groups, both of which are active functional groups and can participate in many classical organic reactions, such as nucleophilic substitution reactions, metal-catalyzed coupling reactions, etc. Chemists can use this to construct complex organic molecular structures, expand the types and functions of organic compounds, and contribute to the development of organic synthetic chemistry.
What is P-Difluoromethoxybromobenzene production method?
The method of preparing p-difluoromethoxybromobenzene often involves several steps of reaction.
The starting point is p-bromophenol. First, p-bromophenol interacts with bases such as sodium hydroxide or potassium hydroxide, and the hydrogen of the phenolic hydroxyl group is replaced by alkali metals to form phenolates. This step is due to the acidity of the phenolic hydroxyl group, which can neutralize with the base. The reaction formula is as follows:\ (C_ {6} H_ {4} BrOH + MOH\ longrightarrow C_ {6} H_ {4} BrOM + H_ {2} O\) (\ (M\) is\ (Na\) or\ (K\)).
Then, the phenolic salt is reacted with difluoromethane. This reaction is nucleophilic substitution, the oxygen anion in the phenol salt is nucleophilic, attacking the carbon linked to the bromine in the difluoromethane, the bromine ion leaves, and then the p-difluoromethoxybromobenzene is obtained. The reaction formula is:\ (C_ {6} H_ {4} BrOM + BrCHF_ {2}\ longrightarrow C_ {6} H_ {4} BrOCHF_ {2} + MBr\).
When reacting, a suitable temperature and a suitable solvent are required. Too high or too low temperature can affect the reaction rate and yield. Commonly used organic solvents such as\ (N, N-\) dimethylformamide (DMF), dimethyl sulfoxide (DMSO), etc., such solvents have good solubility to the reactants and are conducive to the reaction.
In addition, the anhydrous environment of the reaction system is quite important. The presence of water or the occurrence of side reactions affects the purity and yield of the product. After the reaction, pure p-difluoromethoxy bromobenzene can be obtained by extraction, distillation, column chromatography and other separation and purification methods.
Another way to prepare this substance, such as using p-difluoromethoxy benzene as raw material, is obtained by bromination reaction. However, in comparison, the method using p-bromophenol as the starting material is more commonly used because of its easy availability of raw materials, relatively clear reaction steps, and considerable yield.
What do P-Difluoromethoxybromobenzene need to pay attention to when storing and transporting?
P-difluoromethoxy bromobenzene is also an organic compound. During storage and transportation, many matters need to be paid attention to.
The first priority is safety. This compound may have certain chemical activity and potential danger. When storing, it should be placed in a cool, dry and well-ventilated place. Keep away from fire and heat sources to prevent fire and explosion. Because it may be flammable, it is easy to cause danger in case of open flames and hot topics, so fire prevention is essential.
The second is about packaging. Packaging must be tight and reliable to avoid leakage. Choose suitable packaging materials to resist its chemical attack. For example, use special sealed containers to prevent contact with air, moisture, etc. If the package is damaged, P-difluoromethoxybromobenzene may react with external substances, causing quality changes, or endangering the environment and personal safety.
Furthermore, the storage temperature should also be precisely controlled. Improper temperature may cause changes in its physical and chemical properties. Generally speaking, it should be maintained within a specific temperature range according to its characteristics, and it must not be exposed to extreme high or low temperature environments.
When transporting, follow relevant regulations and standards. Transport personnel need to be professionally trained to be familiar with its hazardous characteristics and emergency response methods. Transport vehicles should also be equipped with necessary emergency equipment and protective supplies for emergencies.
And this compound may have an impact on the environment. During storage and transportation, it is strictly forbidden to discharge or leak at will to avoid contaminating soil, water sources, etc. Once a leak occurs, effective measures should be taken immediately and properly handled to reduce the harm.
All of these are important points that cannot be ignored when storing and transporting P-difluoromethoxybromobenzene, and need to be treated with caution to ensure safety.
What are the security risks associated with P-Difluoromethoxybromobenzene?
P-difluoromethoxy bromobenzene, one of the organic chemicals, involves its safety risks and needs to be reviewed in detail.
It is flammable. In case of open flames and hot topics, it will be like dry wood and fire, and it is very easy to burn. In high temperature environments or in contact with oxidants, it is like placing the kindle next to explosives, which may cause violent combustion and even explosion. The smoke produced by its combustion is toxic and irritating. If inhaled, it will enter the lungs like poisonous smoke, which can cause severe respiratory pain, cough, asthma, and even life-threatening.
P-difluoromethoxy bromobenzene is corrosive to the eyes, skin, and respiratory tract. If it comes into contact with strong acids, it can cause serious burns to the eye tissue and even blindness; when it comes into contact with the skin, it will cause the skin to be red, swollen, painful, and ulcerated; if it inhales its volatile gas, such as toxic mist into the throat, it can damage the mucosa of the respiratory tract, causing inflammation and edema.
If this chemical does not enter water and soil carefully, it will seep into the ground like toxic water and cause pollution to the environment. In aquatic ecosystems, it can cause poisoning, death, and damage the ecological balance of aquatic organisms; in soil, it will affect the activity of soil microorganisms and hinder plant growth.
When operating P-difluoromethoxy bromobenzene, the operator must be fully armed, wearing protective clothing, protective gloves and goggles, such as warriors, to prevent contact with the skin and eyes; work in a well-ventilated place, or with the help of ventilation equipment, to disperse the volatile gas in time, such as the breeze blowing fog; strictly prohibit fireworks, stay away from fire sources and heat sources, as if away from raging flames. In the event of a leak, the scene should be quickly isolated and the crowd evacuated, as if facing a big enemy. When a small amount of leakage, it can be adsorbed by inert materials such as sand; when a large amount of leakage, it is necessary to build embankments to contain it, and then handle it properly. Don't be sloppy, so as not to cause a big disaster.