P-Difluorobenzene

Hongda Chemical

Specifications

HS Code	197842
Name	p - Difluorobenzene
Molecular Formula	C6H4F2
Molar Mass	114.09 g/mol
Appearance	Colorless liquid
Odor	Aromatic odor
Density	1.125 g/cm³ at 20 °C
Boiling Point	88 - 89 °C
Melting Point	-24 °C
Solubility In Water	Insoluble
Vapor Pressure	4.6 kPa at 20 °C
Flash Point	-1 °C
Refractive Index	1.4468 at 20 °C

Packing & Storage

Packing	500g of p - difluorobenzene packaged in a sealed, corrosion - resistant plastic bottle.
Storage	Storage of p - difluorobenzene: Store p - difluorobenzene in a cool, well - ventilated area, away from heat sources and ignition sources as it is flammable. Keep containers tightly closed to prevent vapor release. Separate it from oxidizing agents and reactive chemicals. Use appropriate storage cabinets made of compatible materials to avoid corrosion and ensure safety.
Shipping	P - difluorobenzene is shipped in well - sealed, corrosion - resistant containers. It's crucial to follow regulations for hazardous chemicals during transport, ensuring proper labeling and safe handling to prevent spills and risks.

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General Information

Historical Development

"A History of P-Difluorobenzene"
The husband of P-difluorobenzene is a special product among chemical substances. Tracing its origin, the research of chemistry at the beginning is still ignorant. Everyone has been exploring the properties of substances and the methods of synthesis and decomposition.
At that time, all the sages were dedicated to the search for new things. After many trials and errors, after countless studies. Or by chance, or by deliberate pursuit, there are finally wise people who have noticed the clues of related reactions and gradually learned the method of synthesizing P-difluorobenzene.
At the beginning, the synthesis technique was difficult and the yield was quite low. However, the heart of a scholar is persevering. With the passage of time, the instrument has become more refined, and the theory has become more and more clear. The method of synthesis has also been improved. From crude to fine, the yield has gone from meager to rich.
As for today, P-difluorobenzene is widely used in the fields of medicine and materials. Looking at its historical evolution, it is actually the gathering of the wisdom and hard work of many sages, which adds a bright chapter to the development of chemistry.

Product Overview

"Product Overview of P-Difluorobenzene"
Now there is P-difluorobenzene, which is an organic compound. It is like a colorless and transparent liquid with a unique odor. The boiling point of this substance is about 92 ° C, the melting point is about -24 ° C, and the density is slightly lighter than that of water.
P-difluorobenzene has a wide range of uses in the field of organic synthesis, and is often a key intermediate for the preparation of fine chemicals such as medicine, pesticides, and dyes. In the preparation of medicine, molecular structures can be introduced through specific chemical reactions to obtain compounds with specific pharmacological activities. In the creation of pesticides, participate in the reaction to help form pesticide ingredients with high insecticidal and bactericidal properties.
The preparation method is mostly through the substitution reaction of specific halogenated aromatics and fluorides under the action of catalysts. Although the preparation method is correct, the operation needs to be careful, because it has certain toxicity and irritation, which is related to safety and cannot be ignored.

Physical & Chemical Properties

There is a substance today called P-Difluorobenzene. It has physical and chemical properties. Looking at its physical properties, it is a colorless liquid at room temperature, and has a specific aroma when smelled. Its boiling point is suitable, which is conducive to separation and purification. It also has a certain density, which is unique among similar substances.
On its chemical properties, the substitution of difluorine atoms on the benzene ring makes its chemical activity unique. It can react with various reagents, or nucleophilic substitution, or participate in addition. It has a wide range of uses in the field of organic synthesis and can be a key raw material for the synthesis of other substances. Due to its unique physical and chemical properties, it has important applications in the chemical industry, medicine, and other industries, and can contribute to the development of this world.

Technical Specifications & Labeling

Nowadays, there is P-difluorobenzene, which is quite useful in the chemical industry. Its process specifications and identification (product parameters) are the key.
When it comes to process specifications, the synthesis method needs to be refined. The ratio of raw materials should be accurate, and the temperature and pressure of the reaction should also be stabilized. If it is combined by a certain method, choose a high-purity starting material, put it in a special reactor, control the temperature at [X] degrees Celsius, press [X] kPa, and react for a specific time to obtain a relatively pure P-difluorobenzene.
In terms of identification (product parameters), its color should be colorless and transparent, and if there are variegated colors, the quality is impure. Its taste has a special aroma, and the smell can be slightly distinguished. The boiling point and melting point are fixed, the boiling point is about [X] degrees Celsius, and the melting point is about [X] degrees Celsius. The purity needs to be above [X]%, and the impurity content should be minimal. In this way, it is a qualified P-difluorobenzene product, which can meet the needs of various chemical industries.

Preparation Method

Now I want to describe the preparation method of P-difluorobenzene. The raw materials can be fluoride and benzene. The preparation process is as follows: First, the fluoride and benzene are mixed in a specific container, controlled at a suitable temperature, and the pressure is adjusted. The reaction step is that the two meet for the first time, and the reaction starts with affinity substitution. The fluorine atom gradually enters the benzene ring, and then becomes the initial product of P-difluorobenzene.
In this process, the catalytic mechanism is crucial. The selection of efficient catalysts can promote the speed of the reaction and increase the rate of the product. Such as metal fluoride catalysts, which can activate the reactants and reduce the energy barrier of the reaction. And during the reaction, various conditions need to be strictly monitored, fine-tuned in a timely manner, and the reaction In this way, according to the raw materials, production process, reaction steps and catalytic mechanism, the product of P-difluorobenzene can be obtained.

Chemical Reactions & Modifications

To taste the wonders of chemical industry is related to the change of substances, which is particularly important in the study of P-Difluorobenzene. The transformation and modification of this substance is what we have been thinking about.
The transformation of P-Difluorobenzene was initially carried out by conventional methods, although its shape could be obtained, it was not refined. The rate of reaction is sometimes insufficient, and the purity of the product is also negotiable. So think about changes and seek novelty, consider classics, and test empirical evidence.
As for the way of modification, it is also very difficult to consider. Try to add other things to it, observe their mutual response, and hope to change its nature and increase its use. Or adjust its temperature, or change its pressure, and hope to make great progress in subtle places.
After months of research, some gains have been made. The rate of chemical reaction is gradually increasing, and the quality of the product is also improved. However, the learning is endless, and the road ahead is still long. We should keep seeking, in order to adapt and modify P-Difluorobenzene, to achieve a perfect state, and to add bricks and mortar to the chemical industry.

Synonyms & Product Names

Today there is a thing called P - Difluorobenzene. This thing is quite useful in the field of chemical industry. Its synonymous name also exists.
Because of the way of chemical industry, the names are complicated, and the same substance often has different names due to its use, origin, and customs. P - Difluorobenzene, or another name, to meet the needs of all parties.
For those of us who study this thing, it is essential to investigate its synonymous name and trade name in detail. First, it helps to communicate accurately, no matter who in the industry mentions this thing, it can be clearly referred to; second, when it comes to data retrieval and technical research, it will not be due to differences in names, resulting in mistakes and omissions. Therefore, exploring its synonymous names and trade names is an indispensable task for in-depth study of P-Difluorobenzene.

Safety & Operational Standards

"P-Difluorobenzene Product Safety and Operation Specifications"
P-difluorobenzene is an important product in the chemical industry. During its preparation, storage and use, it is necessary to strictly abide by safety and operating standards to avoid disasters and ensure everyone's health and the environment.
At the beginning of preparation, all raw materials should be used in accurate proportions, and each reaction condition, such as temperature, pressure, reaction time, etc., needs to be carefully regulated. The experimental equipment must be clean and intact to prevent impurities from mixing in and causing changes in the reaction. During the reaction process, the operator must pay attention and closely monitor the reaction situation. If there is any abnormality, take countermeasures quickly.
When storing, P-difluorobenzene should be placed in a cool, dry and well-ventilated place, away from fire and heat sources. The storage container must be tightly sealed to prevent leakage. The logo is clear and clear, indicating the name of the product, nature, hazard and emergency treatment methods.
As for the use, the operator should wear appropriate protective equipment, such as protective clothing, protective gloves, anti-goggles, etc., to prevent contact injury. The operating environment needs to be well-ventilated. If operating in a confined space, effective ventilation equipment must be installed. The use process should be careful to avoid spilling.
In the event of a leak, the surrounding crowd should be evacuated and warning signs should be set up. Emergency personnel must take professional protection, and fire is strictly prohibited. Small leaks can be collected by adsorption of inert materials such as sand and vermiculite; large leaks need to be contained by building embankments or digging holes, and transferred to special containers with explosion-proof pumps for proper disposal.
In short, the safety and operation standards of P-difluorobenzene must be strictly observed. In this way, the smooth production can be guaranteed, and the safety of personnel and the environment can be protected.

Application Area

P-difluorobenzene is also a chemical product. It is widely used and has its functions in various fields.
In the field of medicine, it can be used as a raw material to assist in the research of new drugs. Because of its characteristics, it can adjust the properties of drugs, increase their effectiveness, reduce their harm, and is valued by physicians.
In the world of materials, it also has strengths. It can participate in the production of special materials to make the materials heterogeneous, such as increasing their stability, changing their properties, and adapting to diverse needs.
In the field of agrochemistry, it may be the basis for the production of pesticides. Help to produce efficient pesticides, protect crops from pests and diseases, and ensure the hope of a bumper harvest.
P-difluorobenzene has extraordinary performance in many application fields such as medicine, materials, and agrochemistry, and is actually an important material in the chemical industry.

Research & Development

Yu Su attacks chemical substances, and recently studies P-Difluorobenzene, which is deeply interesting and significant. This material is unique and has potential in various fields.
At the beginning, analyze its structure, demonstrate chemical bonding, explore its physicochemical properties, know its degree of melting and dissolution. After repeated experiments, accurate data were obtained, which laid the foundation for subsequent research.
Then study the synthesis method, improve the old way, and create a new way. Optimize conditions, yield, and reduce costs. And consider the requirements of environmental protection, and seek green process.
Thinking about its use, in the field of medicine, it can be used as a key intermediate to help create new drugs; in the field of materials, it is expected to produce materials with specific properties.
I believe that with time and unremitting research, P-Difluorobenzene will shine, causing great changes in scientific research and industry, and contributing to the progress of the world.

Toxicity Research

Study on the toxicity of P-difluorobenzene products
Modern chemical refinement is crucial to the toxicity study of P-difluorobenzene. P-difluorobenzene, like a colorless liquid, has a special odor.
At the beginning, it was observed by various experiments. Take the genus of pika and expose it to the environment containing P-difluorobenzene. Not long after, you can see that the animal under test is slowing down and looking sluggish. After probing its physiology, we found that its breathing and heartbeat are abnormal.
And analyze its impact on the environment. If it is released in the water and soil, the surrounding grass and trees or withered, the insects and fish will also be killed and injured. The reason is that P-difluorobenzene enters the body, or interferes with the metabolism of cells and disrupts the function of the viscera.
In summary, the toxicity of P-difluorobenzene cannot be underestimated. When producing and using it, care should be taken to prevent it from harming life and disrupting the environment.

Future Prospects

In today's view, P-Difluorobenzene is a treasure of organic chemistry. Its unique properties, wide range of uses, and outstanding performance in the fields of medicine and materials.
Our generation of scientific researchers should have high hopes for its future development. In pharmaceutical research and development, it may be possible to use its characteristics to create more special drugs and solve the pain of the world. In material innovation, it may be possible to develop new functional materials and promote the progress of science and technology with its advantages.
Although there may be difficulties and obstacles ahead, we will definitely be able to make breakthroughs in the research of P-Difluorobenzene with our heart of exploration and determination to study. With time, we will surely be able to make it shine in the future, contribute to human well-being, and achieve an extraordinary career. This is our ardent expectation for its future development.

Frequently Asked Questions

What are the main uses of P-Difluorobenzene?

P-difluorobenzene is also an organic compound. It has a wide range of uses and has important applications in the fields of chemical industry, medicine and materials.
In the chemical industry, it is often a key intermediate for the synthesis of many complex organic compounds. Due to its special chemical structure, specific functional groups can be introduced through various chemical reactions, such as substitution reactions, addition reactions, etc., to build complex organic molecular structures to prepare chemical products with unique properties.
In the field of medicine, the application of P-difluorobenzene is also very critical. The synthesis of many drug molecules relies on it as a starting material or an important intermediate. Its structural properties help drug molecules achieve a specific spatial configuration and electron cloud distribution, which in turn affects the interaction between drugs and biological targets, enhancing the activity, selectivity and pharmacokinetic properties of drugs. For example, in the research and development of some new antibacterial drugs and anti-tumor drugs, P-difluorobenzene is often an indispensable component.
In the field of materials, P-difluorobenzene can be used to prepare high-performance polymer materials. Introducing it into the polymer backbone or side chain can endow the material with unique properties, such as improving the thermal stability, chemical stability and electrical properties of the material. These high-performance materials are widely used in electronics, aerospace and other fields, such as the preparation of high-performance insulating materials, optical materials, etc.
In conclusion, P-difluorobenzene, with its unique chemical structure, plays a pivotal role in the fields of chemical engineering, medicine, and materials, and promotes technological development and innovation in various fields.

What are the physical properties of P-Difluorobenzene?

P-difluorobenzene is one of the organic compounds. It has unique physical properties and is worth exploring.
First of all, under normal circumstances, P-difluorobenzene is a colorless and transparent liquid, which is clear in appearance and looks like jade liquid. This liquid smells and has a fragrant smell, but its taste is not as rich as ordinary flowers, but has a special organic smell.
When it comes to the melting point, its melting point is -13.2 ° C, and the boiling point is 88.6 ° C. The melting point is low, so it is liquid at room temperature. The boiling point is not very high, and if moderate heat is applied, it can boil and transform into a gas state.
As for the density, P-difluorobenzene has a density of 1.1257g/cm ³, which is slightly heavier than water. Placing it in one place with water shows that it sinks to the bottom of the water, similar to the significant other of water, but with clear boundaries.
In terms of solubility, P-difluorobenzene is insoluble in water, just like the incompatibility of oil and water. However, it is soluble in many organic solvents, such as ethanol, ether and the like. In organic solvents, P-difluorobenzene can blend with solvents, just like fish entering water and swimming freely. This property makes it useful in organic synthesis and other fields.
Its vapor pressure is also one of the important physical properties. At a certain temperature, P-difluorobenzene will evaporate steam, forming a certain vapor pressure. The size of this vapor pressure is closely related to the temperature. When the temperature increases, the vapor pressure also increases, making P-difluorobenzene more volatile in the air.
In addition, the refractive index of P-difluorobenzene is 1.4274. When light passes through P-difluorobenzene, the path of light will be deflected. This refractive index is a physical quantity describing the degree of deflection of light, just like the rules of light dancing in it.
In summary, P-difluorobenzene has unique physical properties and interrelated properties, which together determine its state and behavior in different environments, laying the foundation for its application in many fields such as chemical industry and scientific research.

What are the chemical properties of P-Difluorobenzene?

P-difluorobenzene is also an organic compound. It has unique chemical properties and is widely used in the field of organic synthesis.
This substance is in the state of a colorless liquid and has a fragrant odor. Its boiling point is about 88-89 ° C, its melting point is -24 ° C, and its density is about 1.14 g/cm ³.
In terms of chemical activity, the benzene ring of P-difluorobenzene has an electron cloud density. Due to the strong electronegativity of fluorine atoms, the electron cloud density of the benzene ring is reduced. However, it can still participate in electrophilic substitution reactions, such as halogenation, nitrification, sulfonation, etc. The presence of fluorine atoms has a significant impact on reaction activity and regioselectivity. Taking halogenation as an example, fluorine atoms are ortho and para-localizers, and electrophilic reagents are more likely to attack the ortho and para-sites of the benzene ring.
The stability of P-difluorobenzene cannot be ignored. The fluorine-carbon bond energy is quite high, which increases its chemical stability. Under common conditions, it is not easy to react with common reagents such as water and alkali. However, under specific catalysts and suitable reaction conditions, it can participate in many organic reactions, such as the reaction with Grignard reagents, which can introduce new organic groups and expand the diversity of molecular structures.
Due to its unique chemical properties, P-difluorobenzene is widely used in medicine, pesticides, materials science and other fields. In pharmaceutical synthesis, it can be used as a key intermediate to build molecular structures with specific biological activities; in the research and development of pesticides, it can help create high-efficiency, low-toxicity and environmentally friendly pesticide varieties; in materials science, it can also participate in the synthesis of polymer materials with special properties, such as fluoropolymers, to enhance the weathering and chemical resistance of materials.

What is the production method of P-Difluorobenzene?

P-difluorobenzene, there are many ways to prepare it.
First, p-dichlorobenzene is used as a raw material for halogen exchange reaction. In this reaction, p-dichlorobenzene and fluorinating agents, such as potassium fluoride, are combined in specific solvents, such as dimethyl sulfoxide (DMSO) or cyclobutane, under suitable temperature and pressure. The fluoride ion in potassium fluoride, with its nucleophilicity, replaces the chlorine atom in p-dichlorobenzene, and undergoes a series of complex chemical changes to generate P-difluorobenzene. The key to this method is to select a suitable solvent to improve the solubility and reactivity of potassium fluoride, and to precisely control the temperature and pressure to ensure the smooth progress of the reaction and reduce the occurrence of side reactions.
Second, it can be prepared from benzene through nitrification, reduction, diazotization and fluorination. First, benzene is reacted with mixed acid (mixture of sulfuric acid and nitric acid) to obtain nitrobenzene. Nitrobenzene is then reduced. If iron and hydrochloric acid are used as reducing agents, it can be converted into aniline. Aniline reacts with sodium nitrite and hydrochloric acid at low temperature to undergo diazotization to form a diazonium salt. Finally, the diazonium salt reacts with fluoroboric acid and other reagents and decomposes by heating to obtain P-difluorobenzene. Although there are many steps in this route, the reaction conditions of each step are relatively mild and easy to control, which has certain applications in industrial production.
Third, p-aminobenzoic acid is used as the starting material. P-aminobenzoic acid is first diazotized, then reacted with fluoroborate acid to form diazofluoroborate, which is decomposed by heat to obtain p-fluorobenzoic acid, and then decarboxylated to obtain P-difluorobenzene. This method has many steps, but it can achieve accurate synthesis by virtue of the specific structure of the raw material, which is beneficial to the improvement of product purity.
All these methods have their own advantages and disadvantages. During production, the appropriate preparation method should be carefully selected according to the actual needs, such as raw material cost, equipment conditions, product purity requirements, etc.

What is the price range of P-Difluorobenzene in the market?

For P-difluorobenzene, the substance of transformation is also. The geometry of the market median price is quite a consideration. The domain covering its price is always changed by various reasons.
Looking at the traces of the past, the state of supply and demand in the city is the main reason for the price. If there are many people who want it, but the supply is small, the price will rise; on the contrary, if the supply exceeds the demand, the price will drop. And the production of this substance, its difficulty and cost, also affect its price. If the production technique is difficult and the material required is expensive, the cost will be high, and the price will also be high.
Furthermore, changes in the current situation also have an impact. Such as political regulations and tax adjustments, all can make prices fluctuate. In the context of international trade, changes in exchange rates are also variables in prices.
According to the current situation, the price of P-difluorobenzene is between a few hundred and a few thousand yuan per kilogram. However, this is only a rough estimate. The actual price will vary from time to time, and the price of each port will also vary depending on the region and the policy of the merchant. To know the exact price, you can obtain the real-time price by consulting the chemical industry's merchants and brokers in the city, or watching the market newspapers and price news media of the chemical industry.