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P-Chlorotrifluoromethylbenzene

P-Chlorotrifluoromethylbenzene

Hongda Chemical

Specifications

HS Code

602279

Chemical Formula C7H4ClF3
Molecular Weight 180.55
Appearance Colorless to light yellow liquid
Boiling Point 139 - 141 °C
Melting Point -48 °C
Density 1.32 g/cm³
Vapor Pressure 1.33 kPa (25.5 °C)
Flash Point 38 °C
Solubility In Water Insoluble
Solubility In Organic Solvents Soluble in many organic solvents
Odor Characteristic odor
Stability Stable under normal conditions

As an accredited P-Chlorotrifluoromethylbenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

Packing & Storage
Packing 500g of p - chlorotrifluoromethylbenzene packaged in a sealed, corrosion - resistant bottle.
Storage P - chlorotrifluoromethylbenzene should be stored in a cool, well - ventilated area, away from direct sunlight and heat sources. Keep it in a tightly sealed container to prevent vapor leakage. Store it separately from oxidizing agents, reducing agents, and reactive substances to avoid potential chemical reactions. Ensure proper labeling for easy identification and handling.
Shipping P - chlorotrifluoromethylbenzene is shipped in tightly - sealed, corrosion - resistant containers. Shipment follows strict chemical transport regulations to prevent leakage, ensuring safety during transit. Special handling due to its chemical nature.
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P-Chlorotrifluoromethylbenzene P-Chlorotrifluoromethylbenzene
General Information
Historical Development
P-Chlorotrifluoromethylbenzene, organic compounds are also. It began in the process of chemical research. In the past, chemists devoted themselves to exploring the properties and synthesis of various substances. At the beginning, the exploration of aromatic compounds containing fluorine and chlorine gradually flourished.
In the laboratory, Zhu Xian tried repeatedly with scientific methods. After countless adjustments to the reaction conditions and the selection of raw materials, this P-Chlorotrifluoromethylbenzene was finally achieved. When it was first obtained, it was only a small amount, but its unique structure and properties attracted the attention of researchers.
In the following years, the technology was gradual, the synthesis method was optimized, and the yield was gradually increased. The scope of application has also expanded from the laboratory to the industrial field, emerging in materials science, medical chemistry, and many other aspects, making it an indispensable compound in today's chemical research and industrial production. Its historical evolution is an example of the development of chemistry.
Product Overview
P-Chlorotrifluoromethylbenzene, organic compounds are also. Its color is clear and light, and it is a liquid at room temperature and pressure. In the molecular structure, the chlorine atom on the benzene ring is opposite to the trifluoromethyl group, and the layout is orderly.
The preparation method is often obtained by a specific chemical reaction. Or the raw materials containing chlorine and trifluoromethyl are used to finely adjust the reaction conditions, such as temperature, pressure, and the type and dosage of catalysts, so that the molecules are cleverly combined to polymerize into this compound.
has a wide range of uses. In the field of pharmaceutical chemistry, it can be used as a key intermediate to help synthesize a variety of drugs. Due to its specific structure, it can endow drugs with unique activity and efficacy. In the field of materials science, it is also indispensable. It can participate in the preparation of high-performance materials and improve the stability and corrosion resistance of materials. It is actually a valuable compound in the chemical industry.
Physical & Chemical Properties
P-Chlorotrifluoromethylbenzene is an organic compound with unique physical and chemical properties. Looking at its physical properties, under normal conditions, this substance is a colorless liquid with a special odor. The boiling point is about 139-141 ° C, the melting point is about -34 ° C, and the density is about 1.48 g/cm ³. It is difficult to dissolve in water, but it is easily soluble in common organic solvents such as ethanol and ether.
Talking about chemical properties, because its benzene ring is connected with chlorine atoms and trifluoromethyl, and its properties are active. The chlorine atom changes the electron cloud density of the benzene ring, causing it to undergo nucleophilic substitution reactions. Trifluoromethyl has strong electron absorption, which affects the activity and selectivity of benzene ring reactions. This compound can participate in many organic synthesis reactions, such as reacting with nucleophiles to generate new organic compounds, and is widely used in the fields of medicine, pesticides and materials science.
Technical Specifications & Labeling
P-Chlorotrifluoromethylbenzene is an organic compound, which is widely used in the chemical industry. Its preparation process requires specific technical specifications and standards.
Preparation of this compound, usually with specific raw materials, according to the established process. The reaction process requires strict control of temperature, pressure and other parameters. For example, in a certain reaction stage, the temperature should be maintained at XX degrees Celsius, and the pressure should be stable at XX kPa to ensure a smooth reaction and improve the purity and yield of the product.
There are also clear indicators for quality testing. The appearance should be colorless and transparent liquid, the purity should be more than XX%, and the impurity content should be strictly controlled within the specified range. Through advanced testing methods, such as gas chromatography and mass spectrometry, the parameters of the product can be accurately determined to ensure compliance with commercial specifications and standards. In this way, the quality of P-Chlorotrifluoromethylbenzene can be guaranteed to meet different industrial needs.
Preparation Method
To make P-Chlorotrifluoromethylbenzene, it is necessary to clarify its raw materials and production process, reaction steps and catalytic mechanism.
To make this product, an aromatic hydrocarbon is often used as the initial raw material. After halogenation, chlorine atoms are introduced, and the reaction conditions, such as temperature, pressure and catalyst type and dosage, are precisely controlled, so that the reaction can be carried out efficiently in the direction of the target product. After halogenation, trifluoromethyl is added. This step is related to the success or failure of the overall synthesis. It is necessary to select the appropriate trifluoromethylation reagent, like some fluorine-containing active compounds, with the help of a specific catalytic system to promote the effective connection of groups.
The reaction steps are advanced in sequence, and each step is closely connected. After each step is completed, fine separation and purification are required to remove impurities As for the catalytic mechanism, the selected catalyst can reduce the activation energy of the reaction, accelerate the reaction rate, and make the reaction occur smoothly under milder conditions. At different reaction stages, according to the reaction characteristics, either a homogeneous catalyst or a heterogeneous catalyst is selected to achieve the best catalytic effect and efficiently prepare P-Chlorotrifluoromethylbenzene.
Chemical Reactions & Modifications
The formation of P-Chlorotrifluoromethylbenzene, the process of chemical reaction, is quite interesting. The initial reaction may be caused by the interaction of specific raw materials and chemical forces. However, the initial reaction is often not good, the yield is not ideal, and the purity of the product can also be improved.
Therefore, in order to improve its chemical properties, it is necessary to optimize the reaction. Or find new catalysts to promote the speed of the reaction and increase the amount of product. Or adjust the conditions of the reaction, such as temperature and pressure, to make the reaction perfect. When with a prudent heart, study the laws of its chemistry, observe the subtle changes, hope in the reaction, get a better method, so that the output of P-Chlorotrifluoromethylbenzene, more sophisticated, more outstanding, in order to meet many needs, in the field of chemistry, bloom brilliance.
Synonyms & Product Names
P-Chlorotrifluoromethylbenzene, organic compounds are also. Its synonymous name is also known as p-chlorotrifluorotoluene in the academic community. This substance is widely used in the chemical industry.
In the process of industrial preparation, it is often obtained through specific chemical reactions. Its properties are colorless liquid at room temperature and have a special smell. Due to the presence of fluorine, chlorine and other elements, the chemical properties have their own unique characteristics.
On the market, its trade names also vary with different manufacturers. However, its essence is P-Chlorotrifluoromethylbenzene. It is often used as an important intermediate in organic synthesis and can derive many downstream products, contributing a lot to the development of the chemical industry.
Safety & Operational Standards

"Safety and operation of P-Chlorotrifluoromethylbenzene products"
P-Chlorotrifluoromethylbenzene, the important things in chemical products are also important. Its nature is special, and it is widely used in the field of work, but it is also accompanied by safety. Therefore, it is clear that its safe operation is essential.
First talk about safety. This thing has a certain toxicity. If you accidentally pick up the skin, wash it with a lot of water at high speed, and it will be treated immediately. If it enters the eyes, you should immediately wash it with physiological water or clean water. Do not delay, and ask for it immediately. Inhale its steaming speed until it is good, and keep breathing. If the symptoms are not clear, you must be sent to hospital urgently. And because of its flammability, if it is not stored, it is advisable to store the fire source and oil source in a dry and good place, and store the oxidized and raw materials separately to prevent accidental reaction.
Until the operation is completed. During the operation, the operator must use protective clothing, wear protective gloves and gas masks, and keep it safe and cannot be ignored. The operation is well-connected to reduce the steaming degree. After use, the utensils must be properly cleaned to avoid leaving them behind. In addition, during the operation or raw process, it is advisable to operate according to the established procedures and shall not change the steps without authorization. And the operator must be familiar with this material property, hazard and emergency treatment method before he can do anything.
In this case, P-Chlorotrifluoromethylbenzene of useful chemical products, but their safe operation cannot be slack. Only by observing this can we ensure the safety of operations and make life, research and other activities profitable.
Application Area
P-Chlorotrifluoromethylbenzene is an organic compound with a wide range of application fields. In the field of pharmaceutical synthesis, it is often used as a key intermediate to help create many specific drugs. For example, through specific chemical reactions, it can be cleverly combined with other compounds to generate pharmaceutical ingredients that have good therapeutic effects on specific diseases, making great contributions to human health.
In the field of materials science, this compound also plays an important role. It can be used to prepare polymer materials with special properties, such as some new materials with excellent corrosion resistance and heat resistance. By polymerizing with other monomers, the material is endowed with unique physical and chemical properties, broadening the application scenarios of materials, and showing unique advantages in high-end fields such as aerospace and electronics.
In terms of pesticide research and development, P-Chlorotrifluoromethylbenzene can be used as raw materials to synthesize high-efficiency and low-toxicity pesticides. With its chemical structure characteristics, the prepared pesticides have strong pertinence and lethality to pests, and have little impact on the environment. It is in line with the current green development concept and provides strong support for the sustainable development of agriculture.
Research & Development
I am committed to the study of P-Chlorotrifluoromethylbenzene. This material is special and widely used in various fields of chemical industry.
At the beginning, I explored the method of its synthesis, and tried various paths over many years. Or according to the classical method, adjust the temperature, pressure and amount of reagents of the reaction, but the yield obtained is not as expected. Later, I thought of innovative methods to observe the ingenuity of the synthesis of similar substances, and got an inspiration. After repeated experiments, the conditions of the reaction were optimized, and the yield gradually increased.
And study its properties, analyze the relationship between its structure and characteristics. With modern instruments, explore its molecular state, clarify its physicochemical properties, and lay the foundation for its application.
As for its development, this substance has broad prospects in the fields of materials and medicine. However, in order to be widely used, many problems need to be solved, such as reducing costs and increasing its purity. I will make unremitting efforts to promote its better development and use it for the world.
Toxicity Research
"Study on the toxicity of p-chlorotrifluorotoluene"
Taste of chemical substances, its characteristics are special, and those who have p-chlorotrifluorotoluene need to study its toxicity in detail.
The current study aims to investigate its impact on living beings. If this substance is not carefully entered into the body, or through breathing, or through skin contact, it can cause harm. Looking at various experiments, the animals under test, after exposure to this substance, sometimes look sluggish, and their physiological functions may also appear to be disordered. In the respiratory tract, it can cause irritation and make the breath not smooth; in the viscera, it may also damage its function, causing health problems.
However, the study of toxicity is not achieved overnight. It is necessary to collect a wide range of data and investigate the rationale in order to clarify the depth and scope of its harm, so as to be a guide for protection and application, and to protect all living beings from its poison.
Future Prospects
Today there is a thing, the name P-Chlorotrifluoromethylbenzene. In the hearts of our researchers, the future of this thing is really promising. Its nature is unique, or it can be used in various wonderful ways. In the field of chemical industry, it can be used as a delicate raw material to make novel products to meet the needs of the world. In the field of medicine, it may also have extraordinary uses, assisting in the research of ingenious medicines and solving the diseases of everyone. And its synthesis method, if it is refined, will be able to reduce its cost and expand its output. We should study it diligently and explore its endless possibilities. In time, this thing will surely shine in the future world, benefit everyone, flourish all things, develop infinite brilliant prospects, and help the world prosper.
Where to Buy P-Chlorotrifluoromethylbenzene in China?
As a trusted P-Chlorotrifluoromethylbenzene manufacturer, we deliver: Factory-Direct Value: Competitive pricing with no middleman markups, tailored for bulk orders and project-scale requirements. Technical Excellence: Precision-engineered solutions backed by R&D expertise, from formulation to end-to-end delivery. Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
Frequently Asked Questions

As a leading P-Chlorotrifluoromethylbenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

What are the main uses of P-Chlorotrifluoromethylbenzene?
P-chlorotrifluoromethylbenzene is a crucial raw material in the field of organic synthesis and plays an important role in the preparation of many chemical products.
First, this substance is widely used in the field of pesticide synthesis. Due to its unique chemical properties endowed by its structure, it can be used as a key intermediate to participate in the creation of many high-efficiency pesticides. Taking fluorinated pesticides as an example, P-chlorotrifluoromethylbenzene can be converted into compounds with excellent insecticidal, bactericidal or herbicidal activities through a series of chemical reactions. Such fluorinated pesticides have significant toxic effects on pests and bacteria, and have good environmental compatibility. They can effectively reduce the adverse effects on the ecological environment, so they play an important role in modern agricultural production.
Second, in the field of pharmaceutical synthesis, P-chlorotrifluoromethylbenzene also plays an indispensable role. In the construction process of many drug molecules with special pharmacological activities, trifluoromethyl and chlorine atoms need to be introduced to optimize the physicochemical properties and biological activities of the drug. For example, in the development of some anti-cancer drugs and cardiovascular drugs, with the help of P-chlorotrifluoromethylbenzene as a starting material, through ingenious chemical synthesis paths, innovative drugs with definite efficacy and small side effects can be prepared, making outstanding contributions to human health.
Third, in the field of materials science, P-chlorotrifluoromethylbenzene can be used to prepare high-performance polymer materials. After polymerization, its structural units are introduced into the polymer chain, which can endow the material with excellent thermal stability, chemical stability and low surface energy. Such high-performance materials are widely used in high-end fields such as aerospace, electronics and electrical appliances, such as parts of aerospace vehicles, packaging materials for electronic chips, etc., which are of great significance for promoting technological progress in related fields.
In summary, the unique structure and chemical properties of P-chlorotrifluoromethylbenzene have shown great application value in many fields such as pesticides, medicine, materials science, etc., providing a solid material foundation for the development of various fields.
What are the physical properties of P-Chlorotrifluoromethylbenzene?
P-Chlorotrifluoromethylbenzene, or p-chlorotrifluoromethylbenzene, is an important compound in organic chemistry. Its physical properties are quite unique and widely used in many fields.
First of all, on its appearance, p-chlorotrifluoromethylbenzene is usually a colorless and transparent liquid, clear and pure, without obvious impurities, which gives people a sense of purity. Its smell also has characteristics, with a specific aromatic smell, although not pungent, it is unique and easy to identify, which can help chemists to identify by smell.
In terms of boiling point, the boiling point of p-chlorotrifluoromethylbenzene is about 138-140 ° C. This boiling point value enables it to achieve gas-liquid transformation under certain temperature conditions. In chemical production and experimental operations, the substance can be separated and purified by controlling the temperature. For example, during distillation operations, the temperature is precisely controlled, so that p-chlorotrifluoromethylbenzene is separated in a gaseous form, and then cooled and liquefied to obtain a pure product.
The melting point is also a key physical property, and its melting point is about -34 ° C. This low-temperature melting point indicates that p-chlorotrifluoromethylbenzene is a liquid at room temperature, and when the temperature drops below -34 ° C, it condenses into a solid state. This property requires special attention during storage and transportation to avoid solidification due to low temperature, which affects the use.
The density is about 1.37 g/mL. This density causes it to be stratified due to density differences when mixed with other liquids such as water. In some chemical processes involving liquid-liquid separation, p-chlorotrifluoromethylbenzene can be easily separated from other liquids with different densities according to this characteristic, and effective purification can be achieved.
In terms of solubility, p-chlorotrifluoromethylbenzene is insoluble in water. This is because in its molecular structure, trifluoromethyl is connected to the benzene ring, so the polarity of the molecule is relatively weak, while water is a polar solvent. According to the principle of "similar miscibility", the two are difficult to dissolve. However, p-chlorotrifluoromethylbenzene is soluble in common organic solvents such as ethanol, ether, acetone, etc. This solubility characteristic facilitates its use as a solvent in organic synthesis reactions, which can dissolve various organic reactants and promote the smooth progress of the reaction.
The physical properties of p-chlorotrifluoromethylbenzene determine its important position in the chemical industry, medicine, materials and other fields. In the chemical industry, it is often used as an intermediate and participates in the synthesis of complex organic compounds; in the pharmaceutical field, it can be used to develop specific drugs due to its unique physical and chemical properties; in the material field, it helps to prepare materials with special properties.
What is the chemistry of P-Chlorotrifluoromethylbenzene?
P-Chlorotrifluoromethylbenzene, known as p-chlorotrifluoromethylbenzene, has a unique chemical property that is quite striking. This compound contains a chlorine atom and trifluoromethyl, which give it a different chemical activity.
In terms of reactivity, due to the strong electron absorption of trifluoromethyl, the electron cloud density of the benzene ring decreases, which increases the difficulty of electrophilic substitution reactions. However, this property also makes the substance more sensitive to nucleophiles, which can initiate unique nucleophilic substitution reactions. For example, under appropriate conditions, chlorine atoms can be replaced by nucleophiles to form new derivatives.
In terms of stability, the chemical stability of the compound has been improved due to the presence of trifluoromethyl. Trifluoromethyl has high carbon-fluorine bond energy, and its strong electron-absorbing effect can disperse the charge of benzene ring, reducing the overall energy of the molecule, so it is more difficult to undergo thermal decomposition or other degradation reactions.
Its physical properties are also related to chemical properties. Trifluoromethyl changes the polarity of the molecule, affecting its solubility in different solvents. Generally speaking, it has good solubility in organic solvents, but it is difficult to dissolve in water. This property is crucial in the separation and purification process.
In the field of organic synthesis, P-Chlorotrifluoromethylbenzene is an important intermediate. With its unique chemical properties, it can be used to construct various aromatic compounds containing trifluoromethyl, which are widely used in medicine, pesticides and materials science. For example, some drugs containing trifluoromethyl have better biological activity and metabolic stability due to the introduction of this group.
In short, P-Chlorotrifluoromethylbenzene plays an important role in many fields of organic chemistry due to the synergistic effect of chlorine atoms and trifluoromethyl. The study of its properties is of great significance for expanding organic synthesis methods and developing new functional materials.
What is P-Chlorotrifluoromethylbenzene production method?
There are two common methods for preparing p-chlorotrifluoromethylbenzene. One is to take p-chlorotoluene as the starting material and react with chlorination and fluorination in two steps.
First, the p-chlorotoluene reacts with chlorine under the conditions of light or initiator. This is the free radical substitution mechanism. The chlorine atom replaces the hydrogen atom on the methyl group to form p-chlorobenzyl chloride. The reaction conditions need to be controlled at an appropriate temperature range, about 100-150 ° C, and the light needs to be stable. This step requires attention to the rate of chlorine gas entry. If the rate is too fast, the side reactions will increase and polychlorinated compounds will be formed; if the rate is too slow, the reaction time will be long and the efficiency will be low.
The reaction of p-chlorobenzyl chloride with anhydrous hydrogen fluoride in the presence of a catalyst is commonly used Lewis acids such as antimony pentachloride. This reaction is nucleophilic substitution, and fluorine ions replace chlorine atoms to generate p-chlorotrifluoromethylbenzene. This step requires high reaction equipment. Because anhydrous hydrogen fluoride is highly corrosive, a special corrosion-resistant reactor is required. And the reaction temperature also needs to be precisely controlled, about 50-80 ° C. Excessive temperature will cause product decomposition or other side reactions.
The second method uses p-chlorobenzoic acid as raw material, first converts it into p-chlorobenzoyl chloride, and commonly reacts with thionyl chloride. The reaction conditions are mild, at room temperature to about 50 ° C, and there is a little excess of thionyl chloride to ensure complete reaction. After forming p-chlorobenzoyl chloride, it reacts with fluorinated reagents such as hydrogen fluoride and antimony trifluoride, and goes through a series of complex reaction processes to generate p-chlorotrifluoromethylbenzene. In this process, the fluorination reaction is crucial, and attention should be paid to the amount of fluorinated reagent and the reaction time. If the amount of fluorinated reagent is insufficient, the fluorination is incomplete; if the reaction time is too long, it may lead to excessive fluorination or other side reactions.
Preparation of p-chlorotrifluoromethylbenzene requires fine control of the reaction conditions to improve the yield and purity of the product and reduce the occurrence of side reactions.
P-Chlorotrifluoromethylbenzene what are the precautions during use
P-chlorotrifluoromethylbenzene is also an organic compound. In the process of use, many precautions cannot be ignored.
First safety protection. This compound is toxic and irritating, and can cause skin and eye discomfort when exposed, and even harm the respiratory tract. Therefore, when using it, be sure to wear protective clothing, goggles and gloves, and operate in a well-ventilated place, such as a fume hood, to prevent its volatile gases from being inhaled into the body.
Furthermore, pay attention to its chemical properties. P-chlorotrifluoromethylbenzene is chemically active, and in case of open flames and hot topics, there is a risk of combustion and explosion. When storing, it should be placed in a cool, dry and well-ventilated place, away from fire and heat sources, and should not be mixed with oxidants, alkalis, etc., to prevent chemical reactions from occurring and causing disasters.
In addition, the operation needs to be fine during use. When measuring and transferring, use suitable equipment to try to be accurate and avoid spills. If it is accidentally spilled, immediately isolate the scene, evacuate personnel, and deal with it urgently. A small amount of spills can be absorbed by inert materials such as sand and vermiculite; if a large amount of spills is spilled, it needs to build a dike or dig a pit for containment, and transfer it to a special collector with a pump for recycling or harmless disposal.
Repeat, experimental records are crucial. The parameters of the use process, such as dosage, reaction conditions, phenomena, etc., should be recorded in detail for subsequent analysis and summary. If there are any abnormalities, there can also be evidence to check, which is conducive to solving the problem.
In short, the use of P-chlorotrifluoromethylbenzene must be based on safety, abide by the operating procedures, and make detailed records, so as to avoid disasters and achieve the purpose of experiment or production.