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P-Chlorofluorobenzene

P-Chlorofluorobenzene

Hongda Chemical

Specifications

HS Code

632136

Chemical Formula C6H4ClF
Molecular Weight 116.55
Appearance Colorless to pale - yellow liquid
Odor Aromatic odor
Boiling Point 129 - 130 °C
Melting Point -48 °C
Density 1.22 g/cm³ at 20 °C
Solubility In Water Insoluble
Solubility In Organic Solvents Soluble in many organic solvents like ethanol, ether
Vapor Pressure 1.33 kPa at 25.8 °C
Flash Point 34 °C
Refractive Index 1.4869 at 20 °C

As an accredited P-Chlorofluorobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

Packing & Storage
Packing P - chlorofluorobenzene: Packed in 5 - liter containers for chemical storage and transport.
Storage P - chlorofluorobenzene should be stored in a cool, well - ventilated area, away from heat sources and open flames. Keep it in a tightly closed container to prevent vapor leakage. Store it separately from oxidizing agents and reactive chemicals to avoid potential reactions. Ensure the storage area has proper containment measures in case of spills.
Shipping P - chlorofluorobenzene is shipped in tightly - sealed, corrosion - resistant containers. It must comply with hazardous chemical shipping regulations, ensuring proper labeling, secure packaging to prevent leakage during transport.
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P-Chlorofluorobenzene P-Chlorofluorobenzene
General Information
Historical Development
P-Chlorofluorobenzene is also an organic compound. Its development in the history of chemistry is worth exploring.
Tracing its origin, chemists in the past first dealt with the field of halogenated aromatics and dedicated themselves to the synthesis of new compounds. After years of study, this P-Chlorofluorobenzene was finally obtained. At that time, the experimental method was still simple, but the ancestors advanced step by step with tenacity.
And science is gradually emerging, the instruments are refined, and the understanding of P-Chlorofluorobenzene is deeper. Its structure and properties are becoming clear, and its use is gradually becoming apparent in the chemical and pharmaceutical industries. The road of pharmaceuticals relies on its unique properties to become many good medicines; the field of chemical industry is a key raw material, promoting the emergence of new products.
With the passage of time, science and technology are changing day by day, the synthesis method is changing, and the yield and efficiency are increasing. This compound, from the beginning of being little known, is indispensable in various industries today, witnessing the process of chemical development, and also opening up a new path for future generations, hoping to develop its capabilities in the future and benefit the world.
Product Overview
About the product overview of p-chlorofluorobenzene
p-chlorofluorobenzene is a key raw material in the field of organic synthesis. Its properties are colorless and transparent liquids with a unique odor. The boiling point is moderate, about 129-131 ° C. At this temperature, it can vaporize smoothly, creating stable conditions for many reactions.
The chemical structure of this compound is particularly delicate. On the benzene ring, chlorine atoms and fluorine atoms are on one side, and the electronic effects of the two interact with each other, giving p-chlorofluorobenzene a unique chemical activity. The electronegativity of fluorine atoms is extremely high, which strongly attracts electrons, reducing the electron cloud density of the benzene ring; while chlorine atoms are also electron-absorbing, they are slightly weaker than fluorine atoms. This special electron distribution makes it prone to substitution reactions with nucleophiles, making it an extremely important starting material for the preparation of complex organic compounds containing fluorine and chlorine.
In industrial production, it is mostly prepared through specific fluorination and chlorination reactions. And because of its relatively stable properties, during storage and transportation, as long as conventional chemical operating norms are followed, safety can be ensured. P-chlorofluorobenzene is widely used in many fields such as medicine, pesticides and materials science, and is an important cornerstone to promote the development of modern chemical industry.
Physical & Chemical Properties
P-Chlorofluorobenzene is an organic compound, and its physical and chemical properties are quite critical. Looking at its physical properties, at room temperature and pressure, this substance is a colorless liquid with a special odor. Its boiling point is about 129 to 131 degrees Celsius, its melting point is in the range of -35 to -33 degrees Celsius, and its density is slightly larger than that of water.
Discussing chemical properties, P-Chlorofluorobenzene the presence of chlorine and fluorine atoms, resulting in its unique chemical activity. The electron cloud density on the aromatic ring changes due to the electron-absorbing effect of the two atoms, resulting in a specific reactivity in the electrophilic substitution reaction. If interacting with electrophilic reagents, the reaction check point and rate are affected by the localization effect of chlorine and fluorine. In addition, under appropriate conditions, chlorine and fluorine atoms can participate in the substitution reaction and be replaced by other functional groups, thereby deriving a variety of organic synthesis products. In-depth exploration of the physical and chemical properties of P-Chlorofluorobenzene lays an important foundation for its application in organic synthesis, materials science and other fields.
Technical Specifications & Labeling
"P-Chlorofluorobenzene Technical Specifications and Labeling (Product Parameters) "
There are P-Chlorofluorobenzene this product today. In terms of technical specifications, its synthesis needs to follow a precise process. The starting material must be selected with high purity, and the proportion of each reactant should be accurately weighed, and the error should not exceed millimeters. The reaction temperature should be controlled in a specific range, fluctuating up and down only a few degrees, and the reaction time must also strictly abide by the established number to ensure that the reaction is sufficient and the product is pure.
As for the logo (product parameters), the appearance should be a colorless and transparent liquid with a specific aromatic aroma. Its purity should not be less than 99%, and the impurity content is minimal. The physical parameters such as density and boiling point are also fixed. The density must conform to the established value, and the boiling point fluctuation should not be too large. Such a variety of specifications and labels can ensure the quality of P-Chlorofluorobenzene, make it suitable for various purposes, and play its role in various fields of chemical industry.
Preparation Method
To prepare P-Chlorofluorobenzene, the raw materials and production process, reaction steps and catalytic mechanism are the key.
In the selection of raw materials, suitable compounds containing chlorine and fluorine can be selected. Take chlorobenzene and fluorinated reagents as an example, the two can be the starting properties of the reaction.
In the production process, in a specific reaction vessel, control the temperature, pressure and other conditions. If the temperature is set to several degrees Celsius and the pressure is maintained within a certain range, the two are fully reacted.
The reaction step is to mix the raw materials evenly first, and then adjust the conditions in sequence. First heat up to a certain stage, maintain for a while, and then follow up.
In terms of catalytic mechanism, specific catalysts can be introduced to reduce the activation energy of the reaction and increase the reaction rate. For example, a metal catalyst uses its activity check point to promote chemical bond breaking and recombination between raw materials to obtain P-Chlorofluorobenzene efficiently. In this way, the desired product can be prepared according to this path.
Chemical Reactions & Modifications
P-Chlorofluorobenzene is an important raw material in organic synthesis. Its preparation involves a wide range of chemical reactions, and the characteristics of the reaction are related to the quality and yield of the product.
In the past, P-Chlorofluorobenzene were prepared, often with specific halogenated aromatics as the starting materials, through nucleophilic substitution reaction. However, this traditional reaction path has harsh conditions, frequent side reactions, unsatisfactory yield, and product purity is also affected.
Today's chemists are committed to improving this reaction. After repeated research and experiments, it was found that changing the reaction catalyst can significantly improve the reaction activity and selectivity. Under the new catalyst, the reaction conditions tend to be milder, the side reactions are greatly reduced, and the yield can be greatly improved. At the same time, optimizing the choice of reaction solvents also benefits the reaction. The polarity and solubility of solvents have been carefully considered and screened to make the reaction environment more suitable and further improve the generation of P-Chlorofluorobenzene. Such improvements in chemical reactions open up new avenues for the efficient preparation of P-Chlorofluorobenzene, and are expected to make great use in industrial production and other fields.
Synonyms & Product Names


Today there is a product called P-Chlorofluorobenzene. This product is used in the field of chemical processing. Its namesake is also the main point of inquiry.
P-Chlorofluorobenzene, also known as chlorofluorobenzene. The name is the same, and the meaning is the same. For chlorofluorobenzene, according to its chemical production, the chlorine atom is the fluorine atom and is located above the benzene atom. This name is obtained according to its specific characteristics, and it P-Chlorofluorobenzene the same thing.
The trade name may vary due to commercial needs, manufacturing conditions, or differences. However, regardless of its trade name, it all refers to this specific chemical product. This equivalent name is a trade name, which helps to make this thing important for research, engineering and production. We should clarify the various aspects of our research to avoid confusion, so as to achieve the essence of research and the benefit of life.
Safety & Operational Standards
About the safety and operation specifications of p-chlorofluorobenzene products
For chlorofluorobenzene, it is also a chemical substance. It is widely used in the field of chemical industry, but it is related to safety and operation standards, so you should not be careless.
At the safe end, chlorofluorobenzene has certain hazards. It is irritating. If it comes into contact with the skin, rinse it with a lot of water as soon as possible, and seek medical treatment. When entering the eye, you need to open the eyelids immediately and rinse it with flowing water or normal saline for medical assistance. If you inhale it, move it to a fresh place in the air. If you are not breathing well, apply artificial respiration and send it to the doctor quickly. If you accidentally eat it, do not urge vomiting, seek medical attention immediately, and follow the doctor's advice.
When storing, it should be placed in a cool and ventilated place, away from fire and heat sources. Separate from oxidants and edible chemicals, do not mix storage. The storage area should be equipped with emergency treatment equipment and suitable containment materials.
When operating, the operator should be specially trained and strictly abide by the operating procedures. The workplace should be well ventilated, with the corresponding variety and quantity of fire fighting equipment and leakage emergency treatment equipment.
When using, wear a self-priming filter gas mask, chemical safety glasses, anti-poison penetration work clothes, and rubber oil-resistant gloves. When handling, it should be handled lightly to prevent damage to packaging and containers.
Although p-chlorofluorobenzene is useful in the chemical industry, safety and operation standards are essential to ensure the safety of personnel and orderly production. It must be guarded carefully and cannot be slack.
Application Area
P-Chlorofluorobenzene is an organic compound with a wide range of application fields. In the field of medicine, it can be used as a key intermediate to help synthesize a variety of specific drugs. For example, when developing innovative drugs for specific diseases, P-Chlorofluorobenzene participate in it, and through subtle chemical reactions, give the drugs unique curative effects and bring good news to patients.
In the field of materials science, this compound also has important functions. It can be used to prepare high-performance materials to improve the stability and functionality of materials. For example, in the manufacture of advanced electronic materials, the addition of P-Chlorofluorobenzene can optimize the electrical properties of materials and make them more suitable for high-end electronic products.
In the field of agricultural chemistry, P-Chlorofluorobenzene can be used to synthesize new pesticides. With its special chemical structure, the synthetic pesticide has an efficient control effect on pests and diseases, and has a small impact on the environment, which helps to achieve green and sustainable development of agriculture. In short, P-Chlorofluorobenzene shows unique value in many application fields and has broad prospects.
Research & Development
I have always been interested in chemical things. Recently, I have been focusing on the compound P-Chlorofluorobenzene.
At the beginning, study its structure, investigate its molecular structure, explore the arrangement of atoms, and understand the source of its characteristics. Then study its production method, try different methods, and find the best way. Or use the technique of chemical synthesis, choose the right material, control the reaction strip, and hope for high-purity products.
Thinking about the use of this product, it can be used in industry and scientific research. In industry, or as a raw material, make other useful agents; during scientific research, or as a reagent, help solve problems and explore unknown territories.
I always think that the road of scientific research requires diligence, as the ancients said "perseverance, gold and stone can be carved". In the research of P-Chlorofluorobenzene, the same should be true, keep studying, hoping to make progress, and do my best for its development, so that it can benefit the world.
Toxicity Research
In this study, the toxicity of P-Chlorofluorobenzene, which is related to people's livelihood and the environment, cannot be ignored. After multiple methods of investigation, in the experiment, white mice and other subjects were used to observe the characteristics after ingestion or exposure to this compound.
When the behavior of white mice was observed, the dose was slightly higher, it could be seen that their movement was slow, they seemed to be mentally tired, and their appetite was also reduced. Anatomically, the liver, kidneys and other organs were abnormal, or the cell structure was changed, and the function was also disturbed.
It was tested in plants again, and watered with water containing this substance, the plant growth was stunted, and the leaves gradually wilted, which showed that it had inhibition on plant physiology.
In terms of the environment, if this compound enters the water source, soil, or causes the ecological chain to be broken. Therefore, in general, P-Chlorofluorobenzene has certain toxicity and is unfavorable to organisms and the environment. Subsequent applications and emissions should be carefully controlled to prevent it from harming the ecology and endangering all living beings.
Future Prospects
P-Chlorofluorobenzene has great potential in the field of chemical industry. Future development may be extended to material creation. With its unique molecular structure, it is expected to develop new materials with outstanding performance, which can be used in electronics and aerospace to meet the needs of rapid technology.
In medical chemistry, there is also an opportunity to explore. Based on it, it may be able to derive special drugs to cure many difficult diseases and seek well-being for the world.
Furthermore, in the field of environmental protection, after fine research, it can be used as a purification agent to help protect the environment, making mountains and rivers beautiful and green waters flowing. All of these are the expectations of our chemical researchers for the future development of P-Chlorofluorobenzene, hoping to study it diligently to make it a reality and add luster to the world.
Where to Buy P-Chlorofluorobenzene in China?
As a trusted P-Chlorofluorobenzene manufacturer, we deliver: Factory-Direct Value: Competitive pricing with no middleman markups, tailored for bulk orders and project-scale requirements. Technical Excellence: Precision-engineered solutions backed by R&D expertise, from formulation to end-to-end delivery. Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
Frequently Asked Questions

As a leading P-Chlorofluorobenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

What are the main uses of P-Chlorofluorobenzene?
P-chlorofluorobenzene is also an organic compound. It has a wide range of uses and is used in various fields of chemical industry.
First, it can be an important intermediate in the synthesis of medicine. The preparation of many drugs relies on its participation in reactions to build key chemical structures. Through specific chemical reactions, P-chlorofluorobenzene can introduce unique functional groups to help generate molecules with specific pharmacological activities, thus laying the foundation for the development of specific drugs.
Second, it also plays a key role in the creation of pesticides. It can be used as a starting material for the synthesis of highly efficient pesticides, and through a series of chemical transformations, pesticide products that can effectively control pests and diseases can be obtained. Such pesticides may have excellent characteristics such as high selectivity and low toxicity, and are effective in ensuring crop growth and improving yield.
Third, in the field of material science, P-chlorofluorobenzene also contributes. It can be used to synthesize special polymer materials, giving materials excellent properties such as chemical corrosion resistance and high temperature resistance. These materials are widely used in high-end fields such as aerospace and electronics, contributing to the progress and development of related technologies.
In addition, in the synthesis of fine chemical products such as dyes and fragrances, P-chlorofluorobenzene is also often used as an indispensable raw material, participating in the construction of structural units that give products specific color, aroma and other characteristics.
What are the physical properties of P-Chlorofluorobenzene?
P-chlorofluorobenzene is one of the organic compounds. It has the following physical properties:
Viewed at room temperature and pressure, this is a colorless and transparent liquid, clear and free of impurities, and it can be seen shining slightly under light, like the clarity of a clear spring.
Smell it, it has a special aromatic smell, but this smell is not as rich as the fragrance of flowers, nor as sweet as fruit, but the unique aroma of organic compounds. Although it is not pungent, it cannot be smelled for a long time.
On its boiling point, it is about 128 - 129 ° C. When heated to this temperature, the liquid gradually turns into steam and rises, because the molecules gain enough energy to break free from each other's attractive forces.
Its melting point is -29 ° C. At this point at low temperature, the liquid will gradually solidify into a solid state, and the molecular arrangement will change from a disordered liquid state to an ordered solid state structure.
In terms of density, it is about 1.32g/cm ³, which is heavier than water. If it is placed in a container with water, it can be seen that it sinks to the bottom of the water, just like water and oil are insoluble and have different densities.
In terms of solubility, it is slightly soluble in water. This is because water is a polar molecule, while P-chlorofluorobenzene has a weaker polarity. According to the principle of "similar miscibility", the two are difficult to blend. However, it is soluble in organic solvents such as ethanol and ether, and the molecular structure of organic solvents is similar to that of P-chlorofluorobenzene, which can be miscible with each other.
In addition, P-chlorofluorobenzene has a certain degree of volatility and will slowly evaporate into the air in an open environment. This property is also related to factors such as intermolecular forces and ambient temperature. Its vapor is heavier than air, so it mostly diffuses close to the ground after volatilization.
What is the chemistry of P-Chlorofluorobenzene?
P-chlorofluorobenzene is also an organic compound. Its molecules contain chlorine and fluorine atoms connected to the benzene ring. This substance has unique chemical properties and has many interesting properties.
In terms of reactivity, the chlorine and fluorine atoms on the benzene ring change the electron cloud density of the benzene ring. Both chlorine and fluorine are electron-absorbing groups, which cause the electron cloud density of the benzene ring to decrease, so the electrophilic substitution reaction is more difficult to occur than benzene. However, its localization effect is significant, and chlorine and fluorine are ortho and para-sites. Because chlorine and fluorine atoms have lone pair electrons, they can form p-π conjugate with the benzene ring, and the density of ortho and para-site electron clouds is relatively high, and electrophilic
In the nucleophilic substitution reaction, P-chlorofluorobenzene also has characteristics. Fluorine atoms are usually less active in nucleophilic substitution than chlorine atoms due to their high electronegativity and high C-F bond energy. If nucleophilic reagents attack, chlorine atoms are more likely to be replaced. However, under specific conditions, such as high temperature, strong base or catalysis, fluorine atoms can also undergo nucleophilic substitution.
In addition, P-chlorofluorobenzene has high thermal stability because its benzene ring has a conjugated system and a stable structure. And it has good solubility in common organic solvents and can be used as a solvent or intermediate for organic synthesis. In the field of organic synthesis, it is often used to construct complex organic molecules containing chlorine and fluorine, and has important applications in many industries such as medicine, pesticides, and materials. In short, P-chlorofluorobenzene plays a key role in the field of organic chemistry due to its unique chemical properties.
What is P-Chlorofluorobenzene production method?
P-chlorofluorobenzene is also an organic compound and is widely used in the chemical industry. There are two common methods for its preparation.
One is the method of using chlorobenzene as the starting material. Chlorobenzene is nitrified to give p-nitrochlorobenzene. This reaction needs to be heated to a certain temperature in a strong acid environment mixed with sulfuric acid and nitric acid to proceed smoothly. The reduction of p-nitrochlorobenzene can be converted into p-aminochlorobenzene. The reduction method often uses iron powder and hydrochloric acid as the reducing agent. After this step, the nitro group is converted into an amino group. The reaction of p-aminochlorobenzene with sodium nitrite and hydrofluoric acid is a process of diazotization and Sandmeier reaction. The diazotization reaction requires low temperature and acidic conditions to convert the amino group into a diazonium salt, and then react with hydrofluoric acid to finally form P-chlorofluorobenzene. Although there are many steps in this route, the reaction conditions of each step are relatively mild, and the raw materials are easy to obtain.
The second is to use fluorobenzene as the starting material. Fluorobenzene and chlorine undergoes a substitution reaction in the presence of a catalyst. The catalyst used is often Lewis acid such as ferric chloride. During the reaction, controlling the reaction temperature and the amount of chlorine gas can make the chlorine gas selectively replace the hydrogen atom of the p-fluorobenzene position, thereby obtaining P-chlorofluorobenzene. This approach is simple, but the cost of fluorobenzene raw materials is high, and the
When preparing P-chlorofluorobenzene, no matter what method is used, it is necessary to pay attention to the precise control of the reaction conditions, such as temperature, pH, reactant ratio, etc. In this way, the product yield and purity can be improved to meet the requirements of industrial production.
P-Chlorofluorobenzene what are the precautions during use
P-chlorofluorobenzene is also an organic compound. During use, all precautions should not be ignored.
The first thing to know is its toxicity. This substance may be toxic and can cause damage to the human body. When in contact with it, prevent inhaling its vapor, and do not let it touch the skin or eyes. If inhaled, or cause respiratory discomfort, such as cough, asthma; if it touches the skin, or causes skin irritation, allergies; if it enters the eyes, it can hurt the eyes, cause eye pain, redness and swelling. Therefore, when working, it is necessary to wear protective equipment, such as gas masks, protective gloves, goggles, etc., to prevent its harm.
Times and risk of explosion. P-chlorofluorobenzene is flammable. In case of open flame or hot topic, there is a risk of ignition and explosion. Storage and use must be kept away from fire and heat sources, and must be well ventilated to prevent vapor accumulation and reach the explosion limit. Electrical equipment should also have explosion-proof function. When operating, there must be no open flame operations, such as welding, cutting, etc., to avoid accidents.
Furthermore, it is related to environmental impact. If this material is released into the environment, or contaminated soil, water sources and air. After use, its waste should not be discarded at will. It should be properly disposed of in accordance with relevant regulations, or handed over to a professional recycling agency to reduce harm to the environment.
Repeat its chemical properties. P-chlorofluorobenzene can participate in a variety of chemical reactions, and its reaction characteristics must be clarified when used. Before mixing with other substances, it is necessary to study the compatibility of the two in detail to prevent violent reactions, uncontrolled reactions, and safety accidents.
In short, when using P-chlorofluorobenzene, it is necessary to be cautious, strictly abide by the operating procedures, protect and avoid risks, and ensure personal safety and the environment.