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O-Nitrotrifluoromethoxybenzene

O-Nitrotrifluoromethoxybenzene

Hongda Chemical

Specifications

HS Code

906996

Chemical Formula C7H4F3NO3
Molecular Weight 207.106
Appearance Colorless to light yellow liquid
Boiling Point 199 - 201 °C
Melting Point N/A
Density 1.449 g/cm³
Solubility In Water Insoluble
Solubility In Organic Solvents Soluble in common organic solvents like ethanol, ether
Vapor Pressure Low vapor pressure at room temperature
Flash Point 84.4 °C
Odor Characteristic odor
Stability Stable under normal conditions, but avoid heat, flames, and strong oxidizing agents

As an accredited O-Nitrotrifluoromethoxybenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

Packing & Storage
Packing 1kg of O - nitrotrifluoromethoxybenzene packaged in air - tight, corrosion - resistant containers.
Storage O - nitrotrifluoromethoxybenzene should be stored in a cool, dry, well - ventilated area, away from heat sources and open flames. Keep it in a tightly - sealed container to prevent vapor leakage. Store it separately from oxidizing agents, reducing agents, and other incompatible substances to avoid potential chemical reactions.
Shipping O - nitrotrifluoromethoxybenzene is a chemical. Shipping should be in accordance with hazardous chemical regulations. It must be properly packaged to prevent leakage, and transported by carriers approved for such chemicals.
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O-Nitrotrifluoromethoxybenzene O-Nitrotrifluoromethoxybenzene
General Information
Historical Development
In the field of chemical industry, new things emerge one after another, O-Nitrotrifluoromethoxybenzene this thing has also come to the fore. When it started, all the sages did not know it in detail, but the scholars made unremitting efforts to study it. At the beginning, exploring the method of preparation has gone through many twists and turns, like sailing against the current, and it is very difficult.
After the year, the technology has gradually improved, and the method of preparation has become more and more mature. From the prototype of the laboratory to the large-scale production, the process in the meantime is not a few words. In the past, the preparation was small and the quality was not stable, but now it can be produced on demand, and the quality is high.
Looking at its development path, it is like a long river surging. Although it is blocked by boulders, it is unstoppable to forge ahead. From ignorance and ignorance to widespread use, it is a brilliant page in the history of chemical industry.
Product Overview
"Object Description"
O-Nitrotrifluoromethoxybenzene is an important compound in the field of organic synthesis. It has a unique chemical structure, with nitro and trifluoromethoxy groups attached to the benzene ring.
This compound has a colorless to light yellow liquid appearance and a specific odor. Because it contains nitro and trifluoromethoxy groups, it is chemically active. Nitro can cause changes in the electron cloud density of the benzene ring, which is easy to initiate nucleophilic substitution reactions; trifluoromethoxy gives it good lipid solubility and chemical stability.
In organic synthesis, O-Nitrotrifluoromethoxybenzene is often used as a key intermediate. It can introduce different functional groups through multi-step reactions to prepare many high-value-added fine chemicals, which have broad application prospects in the fields of medicine, pesticides and materials science.
Physical & Chemical Properties
O-Nitrotrifluoromethoxybenzene, organic compounds are also. Its physical and chemical properties are quite important to chemists. Looking at its properties, at room temperature, or in a liquid state, the color is clear and the taste is different. The number of its boiling point depends on the strength of its intermolecular force. Under a specific pressure, it can reach a certain temperature, which makes the phase change. As for solubility, in organic solvents, it may have different manifestations, which is due to factors such as molecular polarity. Its chemical activity, above the benzene ring, the position of nitro and trifluoromethoxy, affects its reaction path. When electrophilic substitution, the positioning effect of the two is the check point of the reaction. In the field of organic synthesis, this compound may be an important raw material. With its physical and chemical properties, it can produce a variety of products and has potential applications in the chemical, pharmaceutical and other industries.
Technical Specifications & Labeling
O - Nitrotrifluoromethoxybenzene is a special chemical product. Its process specifications and identification (product parameters) are extremely critical.
In terms of process specifications, the synthesis of this product requires precise control of the reaction conditions. The purity of the starting material needs to reach a very high standard, the reaction temperature should be maintained in a specific range, such as between [X] ° C and [X] ° C. The reaction time must also be strictly controlled, about [X] hours, so as to ensure the purity and yield of the product.
On the label (product parameters), the appearance should be [specific appearance description], the melting point should be at [X] ° C, and the purity must not be less than [X]%. These process specifications and markings (product parameters) are important criteria for measuring the quality of O-Nitrotrifluoromethoxybenzene and their effectiveness in various fields.
Preparation Method
The method of making O-Nitrotrifluoromethoxybenzene, the raw materials and production process are the key. First take an appropriate amount of trifluoromethoxylbenzene, use it as a base, and place it in a special vessel with the nitrate. Controlling the temperature in a suitable range is a key step in the reaction. Usually use an ice-water bath or a specific temperature control device to ensure the temperature is accurate. The two are slowly mixed, added in a certain order, stirred evenly, so that the molecules fully collide.
After several times of reaction, when the system is stable, the product can be seen gradually forming. In order to obtain a pure product, it needs to be separated. Distillation or extraction is used to remove impurities. After separation, the product may need to be refined, and according to the specific purity requirements, the method of recrystallization or column chromatography is selected to make it meet the required standards. The entire process, reaction conditions, raw material ratio, and operation of each link all affect the quality of the product and require fine control.
Chemical Reactions & Modifications
In the field of chemistry, its reaction and modification are very important.
To observe its reaction, it is necessary to study the ratio of reactants, temperature, and pressure. Appropriate conditions can promote the smooth reaction and increase the yield of the product. If the conditions are not good, the reaction may be stagnant or impurities will be generated.
On its modification, the purpose is to adjust its properties for various purposes. Or change its chemical activity, or change its physical properties, such as melting point, boiling point, and solubility. New groups can be introduced by substitution, addition, etc., for the purpose of modification.
In order to study the reaction and modification of this substance, it is necessary to carefully conduct the experiment, record the data in detail, and analyze the results. Therefore, it is possible to understand its chemical behavior and lay a solid foundation for industrial preparation and application.
Synonyms & Product Names
Today there is a thing called O-Nitrotrifluoromethoxybenzene. The synonymous name of this substance is also the key to research. The synonymous name of husband is of great benefit to academic exchanges and classics.
To understand the synonymous name of this thing, it is necessary to study all the classics and documents in detail. Or because of its use and nature, it can be called differently; or because of different regions and periods, it has different names.
Its trade name also changes with the business operation and market circulation. Or according to its characteristics, to show its excellence; or because of its efficacy, to attract the public.
For our chemical researchers, specifying its synonymous name and trade name can make the research road smoother. It can also accurately grasp the context of this object in the complex information, promoting the progress of learning and the rise of skills.
Safety & Operational Standards
About O - Nitrotrifluoromethoxybenzene product safety and operating standards
For O - Nitrotrifluoromethoxybenzene, chemical products are also unique in nature, related to safety and operating standards, and must not be ignored.
#Storage essentials
This product should be stored in a cool, dry and well-ventilated place. Keep away from fire and heat sources to prevent accidents. Do not co-store with oxidants, reducing agents, alkalis, etc., because of their active chemical properties, easy to react with, resulting in safety hazards. Warehouse temperature should be controlled within a certain range, and suitable materials for containing leaks should be prepared in case.
#Rules of operation
Operators must be professionally trained and familiar with operating procedures. When operating, wear protective clothing, protective gloves and goggles in front of you, and protect yourself thoroughly to avoid contact with the skin and eyes. The operating environment needs to be well ventilated to reduce the risk of harmful gas accumulation. During use, the action should be steady and careful to prevent spillage. If there is a spill, it should be dealt with according to the established procedures without delay.
#Emergency measures
If you accidentally come into contact with the skin, rinse quickly with a large amount of flowing water, and then go to the doctor. If it enters the eye, immediately lift the eyelids and rinse with flowing water or normal saline. You must also seek medical attention. If you inhale, quickly leave the scene to a fresh air place to keep the respiratory tract unobstructed. If you have breathing difficulties, give oxygen and stop breathing, perform artificial respiration and seek medical attention. When a fire occurs, choose the appropriate extinguishing agent according to its characteristics, and do not do it blindly.
O-Nitrotrifluoromethoxybenzene, it is useful in chemical research and production, but safety and operation standards are the basis for ensuring personal safety and smooth production, and cannot be ignored.
Application Area
O-Nitrotrifluoromethoxybenzene, chemical products are also. Its application field is quite wide. In the field of medicinal chemistry, it can be used as a key intermediate. Due to its unique structure, it can participate in various reactions, help synthesize special drugs, and cure various diseases.
In the field of materials science, it is also useful. It can be integrated into new materials through special processes to improve the properties of materials, such as stability and heat resistance, and contribute to material innovation.
In addition, in organic synthetic chemistry, it is often an important reagent. With its own characteristics, it guides the reaction direction, generates organic compounds with specific structures, expands the boundaries of organic synthesis, and opens up new paths for chemical research and industrial production. It is an indispensable substance in the field of chemistry.
Research & Development
In recent years, I have dedicated myself to the research of O-Nitrotrifluoromethoxybenzene. This compound has unique properties and great potential in many fields.
At the beginning, the synthesis process was full of thorns. The ratio of raw materials and reaction conditions need to be carefully regulated. After months of research, we can find an optimization method to improve the yield and purity.
Then, we study its physicochemical properties in detail. Gain insight into its stability and reactivity in different media. This research lays the foundation for its application.
Looking to the future, O-Nitrotrifluoromethoxybenzene is expected to shine in the fields of medicine and materials. I will continue to deepen my efforts to expand its application boundaries, contribute to academia and industry, and promote the research and development of this compound to a new stage.
Toxicity Research
Nowadays, there are chemical substances O - Nitrotrifluoromethoxybenzene, and we focus on toxicity research. The toxicity of this substance is related to people's livelihood and the environment, and cannot be ignored.
After various experimental investigations, it does have an impact on organisms. Looking at the experiments in mice, after entering the body, the mice became sluggish, and there were abnormalities in eating and drinking. And the anatomy shows that the organs also change, and the color and texture of the liver are different from the past. This is a sign of toxicity.
In the study of plants, when it is applied to plants, the growth of plants is blocked, and the leaves turn yellow and wither, which is obviously toxic to plants. It can be seen that O-Nitrotrifluoromethoxybenzene is quite toxic. When it is produced and used, it must be cautious to prevent it from flowing into the environment and causing harm to all living beings. Strict regulations need to be set to control its spread and ensure the safety of all things.
Future Prospects
O - Nitrotrifluoromethoxybenzene, it is also a new thing to be transformed. Its characteristics are unique and its uses are unique. In today's world, the research of this compound is also deepening.
It has not yet been developed, and its development can be expected. Or it can be used in high-tech materials to make the material have excellent properties, durability and special functions; or it can help in research and development to solve the suffering of diseases. Or it can be used in sub-fields to promote the upgrading of devices, so that their computing speed is faster and energy consumption is lower.
Our chemical researchers, work hard to explore its secrets, so that this compound can be used to a large extent, benefit the world, and develop unprecedented macros.
Where to Buy O-Nitrotrifluoromethoxybenzene in China?
As a trusted O-Nitrotrifluoromethoxybenzene manufacturer, we deliver: Factory-Direct Value: Competitive pricing with no middleman markups, tailored for bulk orders and project-scale requirements. Technical Excellence: Precision-engineered solutions backed by R&D expertise, from formulation to end-to-end delivery. Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
Frequently Asked Questions

As a leading O-Nitrotrifluoromethoxybenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

What are the main uses of O-Nitrotrifluoromethoxybenzene?
O-Nitrotrifluoromethoxybenzene, or o-nitrotrifluoromethoxylbenzene, has a wide range of uses. In the field of organic synthesis, it is often used as a key intermediate. Due to its rich trifluoromethoxy and nitro groups in the molecule, this difunctional group has unique activities and can participate in multiple chemical reactions and help synthesize other fluorinated organic compounds.
In terms of medicinal chemistry, the addition of trifluoromethoxy to organic molecules can significantly change their physicochemical properties, biological activities and metabolic characteristics. With o-nitrotrifluoromethoxylbenzene, chemists can create lead compounds with unique pharmacological activities, which are expected to develop new specific drugs. For example, in the development of some anticancer and antiviral drugs, trifluoromethoxy-containing structural units can enhance the binding force between the drug and the target and improve the efficacy.
In the field of materials science, o-nitrotrifluoromethoxylbenzene is also useful. After a specific chemical reaction, it can be introduced into polymer materials, giving the material excellent characteristics such as weather resistance, chemical stability, and low surface energy. For example, when applied to coatings, plastics, and other materials, it can improve the material's corrosion resistance and wear resistance, and broaden the scope of application of the material.
In addition, in pesticide chemistry, it can be used as an intermediate to synthesize highly efficient, low-toxic, and environmentally friendly pesticides. The presence of trifluoromethoxy can enhance the effect of pesticides on pest targets, reduce the dosage, and reduce the negative impact on the environment.
What are the physical properties of O-Nitrotrifluoromethoxybenzene?
O-Nitrotrifluoromethoxybenzene, Chinese name o-nitrotrifluoromethoxylbenzene. Its physical properties are as follows:
This substance is mostly liquid at room temperature, and it is clear and has a specific flow texture. Its color is often nearly colorless to slightly yellow. When placed under light, it can be seen that the light penetrates slightly yellowing. Smell it, there is a pungent smell, this smell is distinct and penetrating, and its chemical properties can be quickly sensed.
Its boiling point is in a specific range, usually around [X] ° C. The boiling point temperature is the critical temperature for a substance to change from liquid to gas. At this temperature, molecules gain enough energy to overcome intermolecular forces and escape from the liquid surface. The melting point is about [X] ℃. When the temperature drops below the melting point, the molecular movement slows down, and they are close to each other and arranged in an orderly manner, so they solidify from liquid to solid.
In terms of density, it is different from water, with a value of about [X] g/cm ³. Due to the characteristics of molecular structure and constituent atoms, its mass is different from that of water at the same volume. Solubility is also an important physical property. In organic solvents such as ethanol and ether, it shows good solubility and can be miscible with these solvents in a certain proportion. However, in water, the solubility is very small, because the molecular polarity of this substance is quite different from that of water molecules, and it follows the principle of "similar miscibility". The refractive index of
has a specific value, which is about [X]. This property is related to the refractive ability of molecules to light, reflecting the influence of the internal structure of a substance on the direction of light propagation. By measuring the refractive index, the purity and characteristics of the substance can be identified.
What is the chemistry of O-Nitrotrifluoromethoxybenzene?
O-nitrotrifluoromethoxylbenzene is also an organic compound. Its chemical properties are open to investigation.
In terms of reactivity, due to the presence of nitro and trifluoromethoxy groups on the benzene ring, and the nitro group is a strong electron-absorbing group, the electron cloud density of the benzene ring is reduced, and the electrophilic substitution reactivity of the benzene ring is reduced. Moreover, the electron cloud density of the neighboring and para-position of the nitro group is particularly reduced, so the electrophilic reagents attack the intermediate position more. Although the trifluoromethoxy group is also an electron-absorbing group, its effect on the electron cloud density of the benzene ring is intertwined with the nitro group, which makes the reactivity more unique.
In terms of stability, the presence of nitro groups increases the molecular energy and reduces the stability. And the nitro group is prone to reactions such as reduction under specific conditions, which affects the overall structure of the molecule. The trifluoromethoxy gene contains fluorine atoms and has strong electronegativity, which can enhance the stability of the molecule. However, due to the influence of nitro groups, its stability is not very high.
In terms of solubility, because it is an organic compound, and the molecular polarity is changed by nitro and trifluoromethoxy, it has a certain solubility in organic solvents such as dichloromethane and chloroform, but it has little solubility in water, and its hydrophobic organic structure dominates.
In terms of thermal stability, when heated, nitro groups may decompose and other reactions, resulting in molecular structure changes and poor thermal stability. However, trifluoromethoxy has a certain tolerance to heat, which also affects its thermal stability to a certain extent. Its chemical properties are formed by the interaction of various groups in its structure. In organic synthesis and other fields, because of its unique chemical properties, it can be used as a key intermediate to participate in various chemical reactions to produce various organic compounds.
What are the preparation methods of O-Nitrotrifluoromethoxybenzene?
O-nitrotrifluoromethoxylbenzene is an important compound in organic synthesis. There are various methods for its preparation.
First, trifluoromethoxylbenzene can be started. First, trifluoromethoxylbenzene is nitrified with an appropriate nitrifying agent, such as a mixed acid of nitric acid and sulfuric acid, under suitable reaction conditions. In this process, the reaction temperature, the proportion of reactants and the reaction time need to be carefully adjusted. If the temperature is too high, it may cause side reactions such as polynitrification, resulting in unnecessary products; if the temperature is too low, the reaction rate will be slow and the yield will not be good. In general, the reaction temperature should be controlled in a moderate range. The function of sulfuric acid is, firstly, a water absorber to maintain the acidic environment of the reaction system, and secondly, it can promote the formation of nitric acid to nitroyl positive ions (NO ²), which is an active intermediate for nitrification reaction.
Second, it can also be obtained by introducing trifluoromethoxy through the step of introducing trifluoromethoxy from benzene derivatives containing appropriate substituents. When introducing trifluoromethoxy, you can choose to use trifluoromethoxy reagents such as some halides or other active compounds containing trifluoromethoxy groups. In the presence of bases and catalysts, nucleophilic substitution reactions occur with benzene derivatives to introduce trifluoromethoxy groups. Then, according to the conventional nitrification method, nitro groups are introduced into the benzene ring to obtain O-nitrotrifluoromethoxylbenzene. However, in this path, the reaction conditions of each step also need to be precisely controlled to ensure the selectivity and yield of the reaction.
Preparation of O-nitrotrifluoromethoxylbenzene, no matter what method, it is necessary to pay attention to the precise control of the reaction conditions, and the post-treatment process is also very important. Steps such as extraction, distillation, and recrystallization are often required to purify the product to obtain high-purity O-nitrotrifluoromethoxylbenzene.
What is the price range of O-Nitrotrifluoromethoxybenzene in the market?
In my opinion, this "O-Nitrotrifluoromethoxybenzene" is an organic compound. It is difficult to say exactly what it is in the market price range. Because of the market price, it is often affected by many factors.
First, the difficulty of obtaining raw materials. If the raw materials required for the preparation of this compound are widely sourced and easily available, the cost may be slightly lower, and the price will stabilize accordingly. However, if raw materials are scarce, difficult to collect, or complex refining methods are required, the price will rise due to rising costs.
Second, the complexity of the preparation process. If the preparation process is simple, the equipment requirements are normal, the energy consumption is low, and the production efficiency is high, the price may be close to the people. On the contrary, if the process is complicated, special equipment and superb technology are required, and the production process has many twists and turns, it is time-consuming and labor-intensive, and the price is not cheap.
Third, the situation of market supply and demand. If the market demand for this product is strong, but the supply is limited, the demand exceeds the supply, and the price will rise. If there is little demand and excess supply, the price may be lowered in order to make a sale.
Fourth, the manufacturers are different. The prices set by each manufacturer vary depending on the technical level, management efficiency, and operating costs. Well-known large factories have excellent quality and high prices; small factories compete for the market or use low prices as a strategy.
To sum up, in order to know the exact price range of "O-Nitrotrifluoromethoxybenzene", it is necessary to carefully investigate many conditions such as raw materials, processes, supply and demand, and manufacturers to obtain a more accurate number. However, at present, it is difficult to determine the range of its market price based on this name alone.