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O-Nitrofluorobenzene

O-Nitrofluorobenzene

Hongda Chemical

Specifications

HS Code

948817

Chemical Formula C6H4FNO2
Molar Mass 141.10 g/mol
Appearance Yellow liquid
Boiling Point 205 - 206 °C
Melting Point 3 - 4 °C
Density 1.309 g/cm³
Solubility In Water Insoluble
Solubility In Organic Solvents Soluble in many organic solvents
Odor Pungent
Flash Point 88 °C
Vapor Pressure Low at room temperature
Refractive Index 1.533

As an accredited O-Nitrofluorobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

Packing & Storage
Packing 1 kg of O - nitrofluorobenzene packaged in a sealed, corrosion - resistant container.
Storage O - nitrofluorobenzene should be stored in a cool, well - ventilated warehouse. Keep it away from heat, sparks, and open flames. Store it separately from oxidizing agents, reducing agents, and bases to prevent reactions. The storage area should be equipped with leak - handling and fire - fighting equipment. Ensure containers are tightly sealed to avoid leakage.
Shipping O - nitrofluorobenzene is shipped in tightly - sealed containers. It must be transported in accordance with regulations for hazardous chemicals, ensuring proper handling to prevent spills, with appropriate safety measures during transit.
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O-Nitrofluorobenzene O-Nitrofluorobenzene
General Information
Historical Development
The chemical industry is changing with each passing day, and the research of substances is related to people's livelihood. O-Nitrofluorobenzene is also important in the field of chemistry.
Its initial discovery originated from the research of various sages. In the past, many scholars studied the physical properties and went through countless experiments to obtain this compound. At the beginning, the preparation was difficult, and the output was very small. It was only a treasure in the laboratory.
However, the years pass by, and science and technology advance day by day. The method of preparation has gradually become more delicate, from simple methods to efficient processes, and the output has also increased significantly. What used to exist only in research dishes can now be produced in large quantities and used in various industries. It is either the foundation of pharmaceutical synthesis or the source of material preparation, and has made great contributions to the rise of industry. Its development process is like the stars shining brightly and gradually shining in the sky of chemical industry, paving the way for future generations to develop scientific research and industry.
Product Overview
"Description"
O-Nitrofluorobenzene is an organic compound. It is a colorless to light yellow liquid with a special odor.
This substance has a wide range of uses in the chemical industry. It can be used as an important intermediate in the synthesis of medicines, pesticides, dyes, etc. Due to its chemical properties, it can participate in many reactions. By the activity of nitro and fluorine atoms, groups are introduced into the molecular structure to form a variety of products.
The method of preparation is often obtained by specific fluorination and nitrification reactions. However, when preparing, the reaction conditions, such as temperature, pressure, and ratio of reactants, need to be carefully controlled to ensure the purity and yield of the product. When using
, it is also necessary to pay attention to safety. Because it is toxic and irritating, or endangers human health, it is necessary to follow safety procedures and take protective measures during operation to avoid risks.
Physical & Chemical Properties
O-Nitrofluorobenzene, organic compounds are also. Its physical and chemical properties are particularly important. Looking at its physical properties, it is a colorless to light yellow liquid at room temperature, and the taste is slightly irritating. Its boiling point is about 153-155 ° C, which makes the substance undergo phase transformation under specific conditions. The melting point is about -29 ° C, and it can be solid at low temperatures.
In terms of its chemical properties, the nitro group and fluorine atoms above the benzene ring give their unique reactivity. Nitro has strong electron absorption, which reduces the electron cloud density of the benzene ring, and it is difficult to cause electrophilic substitution reactions, but the nucleophilic substitution reaction activity is enhanced. Although fluorine atoms have high electronegativity, due to their small atomic radius, the C-F bond energy formed with the benzene ring is large, which also affects their chemical reaction paths. These physical and chemical properties provide a basis for the preparation of related compounds in the fields of organic synthesis, assisting chemists in understanding their reaction mechanisms, and then controlling the reaction direction and products.
Technical Specifications & Labeling
The process specifications and identification (product parameters) of this product of O-Nitrofluorobenzene are the key. Its process specifications, raw materials must be carefully selected, and the ratio must be accurate. During the reaction, temperature, pressure and other conditions should be strictly controlled, and a slight difference will affect the quality of the product.
In terms of identification (product parameters), the purity must reach a very high standard, and the impurity content should be minimal. The appearance color is also determined, which should be [specific appearance description]. And its physical and chemical indicators, such as melting point, boiling point, etc., should conform to the established values. In this way, high-quality O-Nitrofluorobenzene products can be obtained to meet the needs of all parties and play their role in various fields of industry.
Preparation Method
The raw materials and production process are the key to the preparation of O-Nitrofluorobenzene. First take an appropriate amount of fluorobenzene as the raw material, which is the foundation. With mixed acid as the reaction medium, concentrated nitric acid and concentrated sulfuric acid are matched in delicate proportions, and the two are coordinated to initiate the reaction.
The reaction steps are rigorous and orderly. Fluorobenzene is slowly injected into the mixed acid, and the temperature is controlled to a suitable range, about 30 to 40 degrees Celsius, to prevent overstimulation. Stir well to promote full contact and smooth progress of the reaction.
The catalytic mechanism cannot be ignored. In this reaction, mixed acid is not only a reactant, but also has catalytic power, which accelerates the reaction rate and increases the yield. After this operation, O-Nitrofluorobenzene can be obtained, which is subsequently purified and refined, and the impurity is removed and pure, and the final product is obtained with high purity.
Chemical Reactions & Modifications
O-Nitrofluorobenzene is an organic compound. Its chemical reaction and modification are important for our research.
The way of its reaction, or nucleophilic substitution, the fluorine atom is easily replaced by other groups. Due to the absorption of nitro groups on the benzene ring, the activity of ortho-fluorine is increased. If it encounters nucleophilic reagents, fluorine leaves and new bonds are formed.
As for modification, its properties can be adjusted by chemical means. For example, modifying the benzene ring, adding different groups can change its solubility, anti-activity, etc. Or borrowing light, heat and other external fields to induce changes in its structure and obtain new properties.
To explore the reaction and modification of this compound is of great benefit in the fields of organic synthesis and drug development, and can open up new paths to create more useful things.
Synonyms & Product Names
"On the Synonyms and Trade Names of O-Nitrofluorobenzene"
Today there is the chemical substance O-Nitrofluorobenzene, and the discussion of its synonyms and trade names is quite important. This substance may have another name to meet the needs of different scenarios. In the academic world, there may be customary synonyms to facilitate academic communication and accurate expression. In the business domain, merchants will also give it a unique trade name for the convenience of marketing.
The synonyms of O-Nitrofluorobenzene should be an alternative name recognized by the academic community to accurately convey its chemical characteristics. The trade name may be determined according to market positioning and product characteristics to attract customers' attention. If you want to fully understand this chemical and clarify its synonyms and trade names, it is a crucial step to help with research, application, trading, and other matters, so as not to be mistaken due to confusion.
Safety & Operational Standards
Code for the safe production and operation of O-Nitrofluorobenzene
For O-Nitrofluorobenzene, chemical substances are also used in chemical industries, and are widely used. However, its nature is dangerous, which is related to safety and operation standards, and must not be ignored.
First, safety, this material is toxic and flammable. In the storage place, it must be cool, dry and well ventilated. Keep away from fire and heat sources, and do not store it with oxidants, alkalis, etc., to prevent it from reacting chemically and causing disasters. Where it is stored, it is necessary to prepare fire extinguishing devices and set up obvious warning signs to make people aware of its danger and be cautious.
When it comes to operation, the operator must be specially trained to know the characteristics of this object and emergency methods before acting. During operation, wear protective gloves and goggles in front of protective clothing to prevent it from touching the skin and eyes. Operate in a well-ventilated environment. If it is a closed room, a ventilation device must be set up to prevent the accumulation of harmful gases.
Furthermore, when using this object, the amount must be accurate, and no excessive fees should be charged. During operation, the action should be stable and slow, and do not splash. If there is a splash, quickly absorb it with inert substances such as sand and vermiculite, put it in a special container, and dispose of it according to regulations. Do not discard it at will.
In the event of a leak, quickly keep unrelated people away and prohibit its ignition. Emergency responders must wear protective equipment and clean up according to established laws. Small leaks, adsorbed as above; if there are large leaks, block the embankment and move it to a special container with an explosion-proof pump.
In short, the safety production and operation specifications of O-Nitrofluorobenzene are for the safety of people and the environment. Practitioners must abide by the rules and not slack a little, so as to avoid disasters and make the chemical industry go smoothly.
Application Area
O-Nitrofluorobenzene, chemical substances are also worth exploring in their application field. In the field of medicine, this compound is often a key raw material for the preparation of special drugs. Its unique structure can be combined with many bioactive molecules to help develop new drugs and contribute to the treatment of various diseases.
In materials science, it also has its place. It can participate in the synthesis of high-performance materials to improve the stability and functionality of materials, such as special coatings to enhance their protective properties.
In the dye industry, O-Nitrofluorobenzene can be used as an important intermediate to help produce bright and long-lasting dyes, making fabric printing and dyeing more attractive. All these application fields demonstrate the important value of this compound, which is indispensable in the process of modern industry and scientific research.
Research & Development
I am committed to the study of O-Nitrofluorobenzene. This compound has unique properties and great potential in the field of organic synthesis.
At the beginning, the method of its preparation was explored, and after many attempts, a suitable path was found. The choice of raw materials and the control of reaction conditions are all key. Temperature, pressure, and catalyst dosage are slightly poor, and the product is impure.
Then study its properties to gain insight into its chemical activity and stability. It was found that it can exhibit extraordinary properties in specific reactions, providing an opportunity for the development of new synthesis methods.
Today, the application of O-Nitrofluorobenzene is gradually expanding, and it has emerged in medicine, materials, and other fields. However, we still need to make unremitting efforts to explore its potential in order to promote the further development of this compound and bring more innovations to various fields.
Toxicity Research
Taste and smell chemical substances, and the observation of their nature is related to the lives of all people. In today's discussion O-Nitrofluorobenzene this product, the investigation of toxicity is actually a priority.
O-Nitrofluorobenzene, the color is special, but its toxicity is hidden inside. Touch it or smell it, it can endanger physical health. Into the skin, poison gradually invades, can cause poor qi and blood, skin redness, swelling and ulceration; if it enters the lungs through nasal breath, the lung collaterals are damaged, and the symptoms of pneumonia and asthma occur.
And it is in the environment, and it is also a bane. Scattered in water and soil, it makes plants and trees unglorious, and insects and fish suffer. Looking at the structure of its molecules, nitro is connected to fluorobenzene, which makes it highly toxic. Although the chemical industry has its uses, it is necessary to prevent toxicity. Therefore, by exploring its toxicity and understanding its harm, we can avoid disasters and protect the safety of all things.
Future Prospects
O-Nitrofluorobenzene is a chemical substance. Looking at its future prospects, it has great potential. In the field of organic synthesis, it can be a key raw material, can help to form a variety of exquisite compounds, introduce new ones, and make the road of organic synthesis broader.
And it may make a name for itself in the way of pharmaceutical research and development. It can be used as a precursor to pave the foundation for the creation of new drugs, which is expected to cure many difficult diseases and benefit living beings.
Furthermore, in the field of materials science, there is also potential. Or it can participate in the creation of new functional materials, endowing materials with specific properties, such as excellent electrical conductivity and optical properties, and open up new frontiers for the field of materials. In time, O-Nitrofluorobenzene will be able to shine in various fields and become an important corner of future development.
Where to Buy O-Nitrofluorobenzene in China?
As a trusted O-Nitrofluorobenzene manufacturer, we deliver: Factory-Direct Value: Competitive pricing with no middleman markups, tailored for bulk orders and project-scale requirements. Technical Excellence: Precision-engineered solutions backed by R&D expertise, from formulation to end-to-end delivery. Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
Frequently Asked Questions

As a leading O-Nitrofluorobenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

What are the main uses of O-Nitrofluorobenzene?
O-nitrofluorobenzene is an important agent in organic synthesis. It has a wide range of uses and has important applications in the fields of medicine, pesticides, and dyes.
In the field of medicine, O-nitrofluorobenzene is often the key intermediate. With it, a variety of specific drugs can be prepared, such as anti-hypertension, antibacterial and other drugs. Because of its fluoride atom, it can change the biological activity, fat solubility and metabolic stability of the compound, making the drug more effective and less side effects.
In the field of pesticides, it is also indispensable. From it, it can synthesize high-efficiency and low-toxicity pesticides, which can effectively control pests and diseases and ensure crop harvest. Its structural characteristics help to improve the selectivity and effectiveness of pesticides and reduce the impact on the environment.
In the dye industry, O-nitrofluorobenzene is an important raw material for the preparation of new dyes. After chemical reaction, dyes with bright color and excellent fastness can be prepared to meet the needs of textile, printing and dyeing industries.
In addition, in fine chemicals, it is also used as a starting material for the synthesis of specialty chemicals. It can react with different reagents to build complex organic molecular structures to meet the specific needs of many high-end industries. In short, O-nitrofluorobenzene's unique chemical structure and reactivity play a key role in many industrial fields, promoting the development and progress of various industries.
What are the physical properties of O-Nitrofluorobenzene?
O-nitrofluorobenzene is an organic compound. It has specific physical properties and is hereby referred to as Jun Chen.
Looking at its color state, at room temperature, O-nitrofluorobenzene is a colorless to light yellow liquid with a clear appearance. It is different from ordinary colorless and transparent liquids. It has a slight color, which is the characteristic of its appearance.
When it comes to odor, it has a pungent smell and a pungent smell. This smell is due to its molecular structure, and this pungent smell also warns everyone to treat it with caution.
As for the melting point, the melting point is about -6.3 ° C, and the boiling point is 205.7 ° C. The melting point is low, so it is a liquid at room temperature; the boiling point is relatively high, and a higher temperature is required to gasify it. This characteristic is quite critical in chemical operations such as separation and purification.
In terms of density, it is about 1.479 g/cm ³, which is heavier than water. If mixed with water, it will sink underwater. This density difference can be used in operations such as liquid-liquid separation.
In terms of solubility, O-nitrofluorobenzene is slightly soluble in water, but soluble in organic solvents such as ethanol and ether. This difference in solubility is due to the difference between its molecular polarity and that of water molecules, and the adaptation of the intermolecular forces of organic solvents, so it presents such solubility characteristics. In the field of organic synthesis, this property is related to the choice of reaction medium.
In addition, O-nitrofluorobenzene has a low vapor pressure and relatively weak volatility. However, due to its irritation and toxicity, it is still necessary to pay attention to ventilation during operation to ensure safety. Its refractive index also has specific values, which can be used as one of the identification bases in optical correlation detection and analysis. These are all important physical properties of O-nitrofluorobenzene.
What is the chemistry of O-Nitrofluorobenzene?
O-nitrofluorobenzene is also an organic compound. It has active chemical properties, because of its nitro and fluorine atoms in the molecule.
Nitro is a strong electron-absorbing group, which can reduce the electron cloud density of the benzene ring, making the benzene ring more vulnerable to attack by nucleophiles. Although fluorine atoms are highly electronegative, their atomic radius is small, and when connected to the benzene ring, the C-F bond energy is larger. But under appropriate conditions, this bond can also react.
In nucleophilic substitution reactions, O-nitrofluorobenzene is quite typical. Nucleophiles can attack carbon atoms connected to fluorine atoms on the benzene ring, and fluorine atoms leave to form new compounds. Due to the electron-absorbing conjugation effect of nitro groups, the electron cloud density of the check point on the benzene ring is lower, and the nucleophilic reagents are easier to interact with.
And its chemical activity varies with the reaction conditions. Increasing temperature and choosing suitable solvents and catalysts can affect the reaction rate and product selectivity. For example, in polar aprotic solvents, the rate of nucleophilic substitution can often be accelerated.
And because of its structural properties, O-nitrofluorobenzene also participates in many organic synthesis reactions. It is an important intermediate for the preparation of various nitrogenous and fluorine-containing organic compounds, and is widely used in medicine, pesticides, materials and other fields. Due to its lively chemical properties, it offers many possibilities for organic synthetic chemistry, allowing chemists to cleverly design reactions to achieve the construction of specific structural organic compounds.
What is the preparation method of O-Nitrofluorobenzene?
To make O-nitrofluorobenzene, take fluorobenzene as the starting material. In a suitable device, put an appropriate amount of fluorobenzene, cool it, and control the temperature within a specific range. Gradually add nitric acid, which is prepared by the appropriate ratio of nitric acid and sulfuric acid. Add time slowly and evenly, and stir at the same time to make it sufficient. Nitric acid, with the help of sulfuric acid, produces nitroyl positive ions, which are electrophilic reagents, which attack the benzene ring of fluorobenzene. The fluoro group is an ortho-site group, but due to the steric barrier, the ortho-product is the main product, that is, O-nitrofluorobenzene.
During the reaction, the temperature control is very important. If the temperature is high, the side should rise, the yield decreases and the amount of impurities increases; if the temperature is low, it should be slow and time-consuming. After the application is completed, the reactant is poured into ice water, and there is sedimentation, which is the crude product of O-nitrofluorobenzene. After filtration, washing, drying, distillation, impurity removal and purification, pure O-nitrofluorobenzene is obtained. The whole process, all operations need to be careful, in accordance with regulations, to ensure good yield and purity.
O-Nitrofluorobenzene what are the precautions during use
O-nitrofluorobenzene is also an important substance to be used, so be careful when making it.
The first priority is safety. This substance is poisonous and rotten, touching it, damaging the skin and mucous membranes, absorbing it, harming the respiratory tract and viscera. Therefore, when operating, it is necessary to wear protective gear, such as gloves, masks, protective clothing, etc., to avoid direct contact with it. And it is suitable to operate in the common place, and set up waste systems to prevent it from fouling.
Second words reaction control. Its activity is special, and when it involves reverse, it is necessary to be warm, thick, and agent-to-agent. If the temperature is high, it may be dangerous; if the temperature is low, it will slow down or stop. Therefore, it is necessary to precisely control the temperature, according to the reaction and process, choose the method of heating, and monitor it with a thermometer. The agent ratio is also tight, which is related to the yield and purity, and must be prepared according to the prescription.
Furthermore, caution should be used in storage and transportation. Store in cool, dry, and pass places, protected from light and heat, to prevent package damage and leakage. During transportation, according to dangerous regulations, choose adapters and methods, and ensure stable transportation. Shock-free, collision-induced leakage.
In addition, inspection and division should be accurate. Reverse, analyze production by spectral and color methods, measure purity and heterogeneity, and ensure quality. If the quality is not good, review the reverse process, find the cause and adjust the parameter, so as to improve it.
In short, with O-nitrofluorobenzene, safety is the first, the control is accurate, the storage and transportation compliance, and the inspection is correct, so as to avoid risks and increase efficiency and achieve the desired results.