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O-Fluorobromobenzene

O-Fluorobromobenzene

Hongda Chemical

Specifications

HS Code

612032

Chemical Formula C6H4BrF
Molar Mass 175.00 g/mol
Appearance Colorless to light yellow liquid
Boiling Point 156 - 158 °C
Melting Point -27 °C
Density 1.57 g/cm³
Flash Point 48 °C
Solubility In Water Insoluble
Vapor Pressure 1.33 kPa at 38.7 °C
Refractive Index 1.554 (20 °C)

As an accredited O-Fluorobromobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

Packing & Storage
Packing 500g of O - fluorobromobenzene packaged in a sealed, corrosion - resistant bottle.
Storage O - fluorobromobenzene should be stored in a cool, well - ventilated area away from heat and ignition sources. Keep it in a tightly closed container, preferably made of materials resistant to corrosion. Store it separately from oxidizing agents and reactive substances to prevent potential chemical reactions. Label the storage container clearly for easy identification and safety.
Shipping O - fluorobromobenzene, a chemical, is shipped in well - sealed, corrosion - resistant containers. It adheres to strict hazardous material regulations, with proper labeling for safe handling during transit to prevent any leakage or risks.
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O-Fluorobromobenzene O-Fluorobromobenzene
General Information
Historical Development
O-Fluorobromobenzene is an organic compound. Its origin can be traced back to the beginning of chemistry in the past. At that time, various sages worked diligently in the field of chemistry to explore the properties and synthesis of various substances.
At the beginning, the understanding of O-Fluorobromobenzene was still shallow, and only some of its physical properties were known. However, with the passage of time and the refinement of experimental technology, scholars have studied its structure and characteristics more carefully. Many chemists have dedicated themselves to this, and gradually clarified its chemical essence with exquisite experimental designs.
In the process of synthesis, there have also been many ups and downs. From the initial trial synthesis, the yield was low and there were many impurities, to the later process improvement, which allowed for more efficient and pure production. This compound has become increasingly valuable in the field of organic synthesis, providing key raw materials and intermediates for many chemical reactions, and promoting the development of chemistry. Its historical evolution is an important chapter in the development of chemistry.
Product Overview
Product Overview
O-Fluorobromobenzene is an important chemical in the field of organic synthesis. Its properties are colorless to light yellow liquid with a special odor. From a structural perspective, this molecule is composed of a benzene ring, fluorine atoms and bromine atoms, and its unique structure gives it unique chemical activity.
In terms of reaction characteristics, the presence of bromine atoms and fluorine atoms in O-Fluorobromobenzene allows it to participate in a variety of organic reactions. Bromine atoms have high activity and are prone to nucleophilic substitution reactions. They can react with many nucleophilic reagents such as alcohols and amines, introducing different functional groups and expanding the structural diversity of compounds. Although fluorine atoms are relatively stable, they can significantly affect the distribution and polarity of molecular electron clouds, which in turn affect the reaction activity and product properties.
In the field of organic synthesis, O-Fluorobromobenzene is often used as a key intermediate and is widely used in the pharmaceutical, pesticide and material synthesis industries. In pharmaceutical research and development, through specific reaction transformation, molecular structures with biological activity can be constructed, providing an important foundation for the creation of new drugs. Its importance in organic synthesis chemistry is like that of masonry in tall buildings, which is an indispensable cornerstone for the construction of complex organic compounds.
Physical & Chemical Properties
O - Fluorobromobenzene is an organic compound. It has unique physical and chemical properties. Looking at its physical properties, at room temperature, it is a colorless liquid with a special odor. Its boiling point is suitable, about a certain temperature range. This property is quite useful when separating and purifying.
In terms of its chemistry, fluorine and bromine atoms give it active reactivity. The electron cloud distribution of the benzene ring changes due to the presence of fluorine and bromine atoms, enabling it to participate in a variety of chemical reactions. For example, it can be substituted with nucleophiles, and fluorine or bromine atoms can be replaced by other groups, thus giving rise to many new compounds. And because of the halogen atoms in its structure, under specific conditions, it can initiate a series of changes in halogenation reactions, which plays an important role in the field of organic synthesis and provides an effective way for the preparation of complex organic molecules.
Technical Specifications & Labeling
Nowadays, in the manufacture of O-Fluorobromobenzene, its technical specifications and identification (product parameters) are the key. The technical specification is the criterion of the production process. It is related to the precise selection of raw materials, the accuracy of the ratio, and the reaction conditions, such as temperature, pressure, and duration. All must be determined in detail to ensure that all links are in place to achieve good results. For identification (product parameters), the characterization of product characteristics is also required, such as purity needs to reach a certain height, impurity content must be controlled within a certain range, physical properties are also determined, and color, taste, and state cannot be ignored. These two complement each other. Technical specifications are the basis of identification (product parameters), and identification (product parameters) is the result of technical specifications. According to this, the obtained O-Fluorobromobenzene is suitable for various purposes and can be used for the development of industry and scientific research.
Preparation Method
The raw materials and production process, reaction steps and catalytic mechanism of this product of O-Fluorobromobenzene are the key.
The raw materials are selected, and fluorobenzene and bromide are used as the base. Fluorobenzene has an aromatic ring structure, and its electron cloud distribution is unique, which lays the foundation for the reaction; bromide carries active bromine atoms and can lead to substitution reactions.
The production process is mainly electrophilic substitution. First, fluorobenzene is placed in a suitable solvent, such as dichloromethane, and cooled to a specific range, about -10 ° C to 0 ° C. At this low temperature, slowly drop into the mixture containing bromide and catalyst. The catalyst used can be selected from iron-based or aluminum-based halides. With its Lewis acidity, the bromide is activated to cause the formation of positive bromide ions.
The first reaction step is that the positive bromide ions attack the fluorobenzene aromatic ring and pass through the transition state of π complex to form a sigma complex. In this step, the electron cloud density of the fluorobenzene aromatic ring is redistributed. Due to the ortho-localization effect of fluorine, the bromine ions tend to be ortho-localized to obtain O-Fluorobromobenzene precursor. Then, through the proton elimination step, the conjugated structure of the aromatic ring is restored, and the final target product is obtained.
The catalytic mechanism lies in the interaction between the catalyst and the bromide, polarizing And the catalyst stabilizes the reaction intermediate, decreases the activation energy of the reaction, increases the reaction rate and selectivity, so that the yield of O-Fluorobromobenzene is considerable and the quality is high.
Chemical Reactions & Modifications
The reaction and modification of O-Fluorobromobenzene in this product are quite crucial. In the past, the reaction efficiency has not been optimized, and the purity of the product is also lacking. To obtain excellent production, we must think of innovation.
Looking at the reaction, the conditions are controlled to the greatest extent. Temperature, pressure, and catalyst all affect its fruit. In the past, improper temperature caused side reactions to clump and low yield. Today, precise regulation is used to achieve the ideal state.
When it comes to modification, fine-tuning of the structure can give it novelty. Changes in molecular structure affect its physicochemical properties. Or increase its stability, or change its solubility, are all research trends. After many attempts, it has been obtained, and the product and properties are all beneficial. In the future, it still needs to be deeply cultivated to get better methods, so that O-Fluorobromobenzene can develop its talents in various fields.
Synonyms & Product Names
O - Fluorobromobenzene is a chemical substance. Its name is also the same. Or fluorobromobenzene, which is named after the position of the phase of fluorobromobenzene in its molecule. Among the commercials, there are also different trade names.

The use of this substance is unknown, and it is an important raw material in the field of synthesis. Due to its special chemical properties, it can be used in a variety of ways, and it is generally useful. Its trade name is, either because of the family's, or because of the difference in use. However, its origin, all O - Fluorobromobenzene is also. What is the name, its chemical properties, and physical characteristics are all determined. Those who study this object must study the name of it, and also study the wonders of its nature in depth, so that they can make good use of it, so as to transform it and work it.
Safety & Operational Standards
O - Fluorobromobenzene is also a chemical substance. If you want to use this substance, the safe operation is of paramount importance.
In the process of making it, the utensils used must be clean and dry. At first, it is necessary to install a suitable reverse container, which can withstand a certain degree of force to prevent the risk of rupture and endanger personal safety.
In the extraction of raw materials, the amount of each substance is refined. The fluorine source, bromine source and phase used are all taken according to the established ratio, and there should be no slight difference. No, not only to benefit from the reverse, but also to cause accidents to be reversed, which will endanger the health.
The reverse of the reverse, the control of the power of the measure, especially the problem. In accordance with the established standard, do not increase or decrease the temperature. The pressure should also be maintained within a reasonable range. If the pressure is high, it may cause the reactor to explode; if the pressure is low, the reaction rate or the influence will be affected.
The operator must be affected by the problem. Familiar with the use of each equipment, and can quickly take effective measures in case of emergency. In case of chemical products being released, immediately follow the established cleaning procedures to avoid chemical products being scattered, and others.
When the reaction is completed, the separation of the materials will be lifted, and the operation will also be carried out in accordance with the requirements. The melting equipment, separation equipment, etc. used must comply with the corresponding requirements. Remove the raw materials and store them properly to prevent them from being damaged or damaged.
The whole process of O-Fluorobromobenzene is safe to operate and wear. If there is a little negligence, it will be born. Comply with the standard to ensure safety.
Application Area
There is a chemical substance today, named O-Fluorobromobenzene. This substance is used in many fields. In the field of pharmaceutical research and development, it can be a key raw material, a pharmaceutical agent, or a supplement for the treatment of diseases. In the research and development of materials, materials that can participate in the synthesis of specific properties, or have good stability and conductivity, etc., to meet diverse needs. In fine chemicals, it can be used as an intermediate. After various reactions, various fine chemicals can be prepared to increase the quality and function of its products. Its wide application and deep impact cannot be underestimated. It is of great significance to the development of modern chemical-related industries and is related to the progress and innovation of many processes.
Research & Development
Since modern times, the art of chemistry has become more and more refined, and all kinds of substances have been studied in detail. Today, we have been studying O-Fluorobromobenzene for years.
At the beginning, it was quite difficult to obtain this O-Fluorobromobenzene, the amount of production was rare, and the purity was not high. However, all of our generation, unremitting research, trying all kinds of paths. Or change the conditions of its reaction, control the temperature and pressure; or choose other raw materials, seeking a better ratio.
After years of work, it has gradually achieved success. The yield has gradually increased, in the past, it was not even one, but now it can reach more than half. And the purity is also good, and there are very few impurities. Its use in various fields is also becoming more and more extensive. It can be used as a raw material for pharmaceutical synthesis to help cure diseases; it can also be used for material preparation to add the energy of utensils. We are still working hard, hoping to make this O-Fluorobromobenzene research and progress in the future, to a higher level, for the use of the world, for the benefit of everyone.
Toxicity Research
O - Fluorobromobenzene is also a chemical substance. I am a chemical researcher, and I often study the toxicity of this substance. This is the case now.
The toxicity of this substance cannot be ignored. If it is not used carefully, it may cause harm. I observe the quality of its molecules, and deduce its properties. It contains fluoride, bromine, or other substances that cause chemical emissions, and this can cause harm.
Use ancient methods to reduce its toxicity, and use substances to reduce it. It is difficult to take this medicine, and it is difficult to do so. If there is any inconsistency, such as weakness, vomiting, and the existence of its toxicity. And in the environment, if this thing is damaged, it is also afraid of staining the water and soil, harming the food. Therefore, we study its toxicity and seek clarity to ensure the safety of people and the environment.
Future Prospects
O - Fluorobromobenzene is also used to transform things. Now there are promising prospects for its future development. In the field of synthesis, it may be able to use important raw materials to assist in the development of more subtle reactions. With its unique characteristics, it can lead to the transformation of novel and novel materials, and find new ways to take special materials, refined products, etc.
It has not been studied or focused on the synthesis of its synthesis methods, seeking to improve the efficiency and reduce costs, and hoping to control its reaction process more precisely. And in the material science, it may be able to reveal new characteristics of materials, such as excellent performance, light, etc.
We, the researchers of transformation, explore the secrets of O-Fluorobromobenzene, and make it possible for O-Fluorobromobenzene to achieve great success.
Where to Buy O-Fluorobromobenzene in China?
As a trusted O-Fluorobromobenzene manufacturer, we deliver: Factory-Direct Value: Competitive pricing with no middleman markups, tailored for bulk orders and project-scale requirements. Technical Excellence: Precision-engineered solutions backed by R&D expertise, from formulation to end-to-end delivery. Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
Frequently Asked Questions

As a leading O-Fluorobromobenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

What are the main uses of O-Fluorobromobenzene?
O-Fluorobromobenzene is also an organic compound. It has a wide range of uses and is important in various fields of chemical industry.
First, in the synthesis of drugs, O-Fluorobromobenzene is often a key intermediate. With its unique structure, specific functional groups can be introduced to build complex drug molecular structures. For example, the creation of many antibacterial and antiviral drugs relies on its participation in the reaction. By ingenious combination with other reagents, suitable pharmacoactive groups can be shaped to achieve therapeutic efficacy.
Second, in the field of materials science, this compound also shows its ability. It can be used to prepare special polymer materials. Due to the characteristics of fluorine and bromine atoms, it can endow materials with excellent properties such as chemical corrosion resistance and high temperature resistance. Among electronic materials, it may participate in the synthesis of substances with special electrical properties, contributing to the improvement of the performance of electronic components.
Third, in the field of organic synthetic chemistry, O-Fluorobromobenzene is often the starting material for initiating various reactions. Due to the difference in the activities of fluorine and bromine on the benzene ring, nucleophilic substitution, electrophilic substitution and other reactions can selectively occur, providing the possibility for the synthesis of various organic compounds with unique structures, helping chemists to open up new categories of compounds and explore the unknown chemical space.
All these show that O-Fluorobromobenzene has functions that cannot be ignored in many fields such as chemical industry, medicine, materials, etc. It is actually an important compound in the field of organic chemistry.
What are the physical properties of O-Fluorobromobenzene?
O - Fluorobromobenzene, Chinese name o-fluorobrobenzene, is an organic compound. Its physical properties are as follows:
1. ** Appearance and Properties **: At room temperature and pressure, o-fluorobrobenzene is colorless to light yellow liquid, and the appearance is clear and translucent, without significant visible impurities. This liquid may be faintly refracted in sunlight, just like a sparkling agar liquid.
2. ** Melting Point and Boiling Point **: The melting point is about -27 ° C, and the boiling point is between 150-153 ° C. The melting point is very low, so it is liquid at room temperature. Due to the weak intermolecular forces, the lattice structure is destroyed at lower temperatures. The boiling point is also not very high, indicating that under moderate heating, the molecule can obtain enough energy to overcome the intermolecular forces and change from liquid to gaseous state.
3. ** Density **: The density is about 1.57 g/mL (25 ° C), which is heavier than water. If mixed with water, it will sink to the bottom of the water, like a pearl falling into the abyss.
4. ** Solubility **: Slightly soluble in water, but can be miscible with organic solvents such as ethanol, ether, and acetone. Because it is an organic compound with certain non-polarity, it is difficult to form a strong interaction with water molecules, so it is difficult to dissolve in water; and with organic solvents, due to the similar principle of miscibility, it is miscible.
5. ** Odor **: It has a special aromatic smell, but the smell may be irritating to a certain extent. You should be cautious when smelling it. If you inhale too much, it may cause physical discomfort.
6. ** Volatility **: It has a certain volatility. In an open environment, it will gradually evaporate into the air, just like light smoke rising.
The above physical properties have a significant impact on organic synthesis, chemical production and other fields, and are the key factors for its separation, purification and application.
What is the chemistry of O-Fluorobromobenzene?
O-fluorobromobenzene is also an organic compound. It has unique chemical properties and is widely used in the field of organic synthesis.
As far as its chemical activity is concerned, due to the two functional groups of fluorine and bromine, the electronic effects of the two interact with each other, resulting in a change in the electron cloud density distribution of the benzene ring. Fluorine atoms have a strong electron-absorbing induction effect, which reduces the electron cloud density of the benzene ring and makes the activity of the electrophilic substitution reaction of the benzene ring slightly reduced. However, the localization effect is significant, and it is an adjacent and para-localized group. Bromine atoms are also adjacent and para-localized groups. Although the activation effect is weak, the two interact together to make the electron cloud density at a specific position of the benzene ring have a
In electrophilic substitution reactions, halogenation, nitrification, sulfonation and other reactions, the localization effect of fluorine and bromine is synergistic, so that the reaction mainly occurs in the neighbor and para-position of the two together. However, due to the strong electron-absorbing property of fluorine atoms, when electrophilic reagents attack the benzene ring, the reaction conditions may be harsh.
When it participates in the nucleophilic substitution reaction, the bromine atom is relatively active and can be replaced by nucleophilic reagents under suitable conditions. Due to the relatively low carbon-bromine bond energy, nucleophilic reagents such as sodium alcohol and amine are easy to attack and generate corresponding substitution products.
In addition, O-fluorobromobenzene can be coupled with boron, tin and other reagents through metal-catalyzed coupling reactions, such as Suzuki reaction, Stain reaction, etc., to form carbon-carbon bonds and realize the synthesis of complex organic molecules. This reaction enriches its application in organic synthesis and helps to synthesize organic compounds with specific structures and functions.
In conclusion, the unique properties of O-fluorobromobenzene fluorine and bromine functional groups play an important role in the field of organic synthetic chemistry. It can synthesize many valuable organic compounds through various reaction paths.
What are O-Fluorobromobenzene synthesis methods?
There are several ways to prepare o-fluorobromobenzene. First, it can be obtained from o-bromoaniline through diazotization and fluorination. First, take o-bromoaniline, make it and sodium nitrite in an acidic environment, at low temperature to undergo diazotization reaction to form o-bromobenzene diazonium salt. This step requires careful temperature control to prevent the decomposition of diazonium salts. Then, the resulting diazonium salt interacts with fluoroboronic acid to form o-bromobenzene diazofluoroborate precipitation. After separation, drying, heating and decomposition, o-bromobenzene can be prepared.
Second, use o-bromophenol as raw material and prepare it through halogen replacement reaction. O-bromophenol and fluorinated reagents, such as potassium fluoride, are heated to react in the presence of appropriate solvents and catalysts. In this process, the choice of solvent is crucial to ensure the solubility and reactivity of the reactants. The catalyst can promote the replacement of halogen atoms and improve the reaction efficiency.
Third, starting from benzene, it is synthesized through a multi-step reaction. First, benzene is brominated to obtain bromobenzene. Bromobenzene is then alkylated by Fu-gram, a fluorine-containing group is introduced, and after appropriate conversion, o-fluorobrobenzene can be obtained. There are many steps in this route, and the reaction conditions of each step need to be carefully planned to ensure the purity and yield of the target product.
All methods have advantages and disadvantages. In actual synthesis, when considering factors such as raw material availability, cost, and difficulty of reaction conditions, the optimal method is selected.
What O-Fluorobromobenzene need to pay attention to when storing and transporting
O-Fluorobromobenzene is an organic compound, and many matters need to be paid attention to when storing and transporting it.
First, because of its certain toxicity and irritation, it must be stored in a cool and ventilated warehouse. The temperature of the warehouse should be controlled within an appropriate range, not too high, to prevent its volatilization from being exacerbated due to excessive temperature, increasing the risk of poisoning and fire. And keep away from fires and heat sources, because the substance can cause combustion and explosion in case of open flames, hot topics.
Second, when storing, it should be stored separately from oxidants, acids, bases, etc., and must not be mixed. Because of its active chemical properties, contact with these substances, or violent chemical reactions, lead to accidents.
Third, when transporting, it is necessary to ensure that the container does not leak, collapse, fall or damage. The means of transportation should be equipped with corresponding varieties and quantities of fire-fighting equipment and leakage emergency treatment equipment. During transportation, it is necessary to prevent exposure to the sun, rain and high temperature. When transporting by road, it is necessary to follow the prescribed route and do not stop in residential areas and densely populated areas.
Fourth, operators need to be specially trained and strictly abide by the operating procedures. Storage and transportation sites should be equipped with suitable materials to contain leaks, and obvious warning signs should be posted to remind personnel to pay attention to safety.
In conclusion, the storage and transportation of O-Fluorobromobenzene should be treated strictly, and relevant safety regulations should be strictly followed to prevent accidents and ensure the safety of personnel and the environment.