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What is the chemical structure of (+/-) -N-Methyl-Gamma- (4- (Trifluoromethyl) Phenoxy) Benzenepropanamine?
(±) -N-methyl - γ -( 4- (trifluoromethyl) phenoxy) amphetamine, which is an organic compound. To clarify its chemical structure, it is necessary to analyze it from the nomenclature.
"N-methyl", which means that the nitrogen atom is connected with a methyl group. "Gamma - (4- (trifluoromethyl) phenoxy) ", which indicates that at the gamma position of the main chain, there is a phenoxy-based group, and the 4 position of the phenyl ring is replaced by trifluoromethyl. "Amphetamine", indicating that the main chain structure is based on amphetamine as the parent nucleus.
The structure of amphetamine is that the phenyl ring is connected by an ethylamine group. In this compound, a 4- (trifluoromethyl) phenoxy group is attached to the γ position of the parent nucleus of amphetamine (that is, the third carbon atom connected to the benzene ring), and there is a methyl substitution on the nitrogen atom.
Specifically, the first look at the amphetamine part has an benzene ring, and the side chain of the benzene ring is an ethylamine structure in which two carbon atoms are connected to the nitrogen atom. The carbon atom at the γ position is connected to an oxygen atom, which is in turn connected to a benzene ring, and there is a trifluoromethyl group at the 4 position of the benzene ring. The nitrogen atom is connected to the methyl group. In this way, the chemical structure of (±) -N -methyl - γ -( 4- (trifluoromethyl) phenoxy) amphetamine is constructed. The complexity of its structure stems from the existence of multiple substituents, the interaction of each group, and the unique physical and chemical properties of the compound.
What are the physical properties of (+/-) -N-Methyl-Gamma- (4- (Trifluoromethyl) Phenoxy) Benzenepropanamine?
(±) -N-methyl - γ -( 4- (trifluoromethyl) phenoxy) amphetamine, this compound has the following physical properties:
Its appearance is often white to white crystalline powder, with fine texture. Under normal temperature and pressure, the properties are stable, and it is difficult to change qualitatively without external specific conditions.
The melting point is usually in a specific range, but due to subtle differences in measurement conditions, the specific value may fluctuate, and the approximate range is [X] ℃ - [X] ℃. The melting point is important because it is one of the characteristics of material purity and characteristics, so that its quality can be identified. In terms of solubility, in organic solvents such as ethanol and chloroform, it exhibits good solubility and can be miscible with them to form a uniform and stable solution. This property makes it easy to use these organic solvents as a medium to carry out related operations in many fields such as organic synthesis and drug preparation. However, in water, the solubility is poor and only slightly soluble. This difference is due to its molecular structure characteristics, and the hydrophilic and hydrophobic properties of the groups contained in the molecule.
Density is also an important physical property, about [X] g/cm ³. Density reflects the quality of a substance per unit volume. It is a key consideration in practical applications such as formulation development and process design. It is related to product quality, stability and performance.
In addition, the compound may be volatile to a certain extent, but the degree of volatilization is weak. Although it evaporates slowly under normal conditions, the volatilization rate may increase slightly in specific environments such as high temperature and ventilation. This characteristic should be paid attention to during storage and use to prevent changes in content due to volatilization and affect the subsequent use effect.
What are the main uses of (+/-) -N-Methyl-Gamma- (4- (Trifluoromethyl) Phenoxy) Benzenepropanamine?
(±) -N-methyl - γ -( 4- (trifluoromethyl) phenoxy) amphetamine, the use of this substance is quite specific. In ancient times, although there was no such accurate cognition as modern times, it may be involved in the field of medical exploration and chemical synthesis.
Looking at the way of medicine, doctors in the past searched for new prescriptions, or hoped that it could adjust the virtual reality of the human body and treat various diseases. If it has unique pharmacological activity, it may act on the neurotransmitter system, such as regulating the transmission of dopamine and serotonin, to treat mental diseases, such as depression and anxiety. In the process of chemical synthesis, or as a key intermediate, it is used to build more complex and delicate organic molecular structures, such as creating new materials, so that the materials have special electrical, optical or mechanical properties, and are used in equipment manufacturing, electronic equipment and other industries.
Although it is difficult to find its detailed information in ancient books, according to today's scientific perspective, it may have played a hidden and key role in the development of pharmaceutical and chemical industry, like clues hidden in the fog of history, waiting for future discoveries and clarification.
What are the synthesis methods of (+/-) -N-Methyl-Gamma- (4- (Trifluoromethyl) Phenoxy) Benzenepropanamine?
The synthesis method of (±) -N-methyl-gamma- (4- (trifluoromethyl) phenoxy) amphetamine is a crucial exploration in the field of organic synthesis. Its synthesis path is like the ancients exploring the passage in a maze, which requires exquisite conception and exquisite skills.
One method can start from the starting material 4- (trifluoromethyl) phenol, and first make it undergo nucleophilic substitution reaction with suitable halogenated hydrocarbons to generate corresponding ether compounds. This step is similar to the fit of mortise and tenon. It is necessary to accurately grasp the reaction conditions, such as temperature, solvent, alkali type, etc., to ensure the smooth formation of ether bonds.
Then, the obtained ether intermediates can be condensed with amphetamine compounds. This condensation step, like two delicate damask sutures, also requires careful regulation of the reaction parameters to promote the formation of the target product. During the reaction process, the choice of catalyst is crucial, and a suitable catalyst is like a good general, which can speed up the reaction process and improve the yield.
Furthermore, there are other methods. Amphetamine can be properly functionalized first, and then reacted with reagents containing trifluoromethylphenoxy. This path requires careful consideration of the reaction sequence and reaction conditions of each step to avoid unnecessary side reactions. It is like marching into an array, and every step needs to be cautious.
In the synthesis process, separation and purification are also key links. Like panning gold in sand, it is necessary to use methods such as column chromatography and recrystallization to precisely extract the target product from the reaction mixture to obtain high-purity (±) -N-methyl-gamma - (4- (trifluoromethyl) phenoxy) amphetamine, which can meet the needs of subsequent research and application.
(+/-) -N-Methyl-Gamma- (4- (Trifluoromethyl) Phenoxy) Benzenepropanamine What are the precautions during use?
(±) -N-methyl - γ -( 4- (trifluoromethyl) phenoxy) amphetamine, there are many things to pay attention to when using it.
First of all, it should be understood that it is a compound with specific structures and properties, which contains trifluoromethyl and phenoxy groups, etc. These groups may cause the compound to have special chemical and biological activities. Therefore, when operating, it is necessary to strictly abide by safety procedures, because of its chemical activity or dangerous reactions, such as improper contact with certain substances, or violent chemical reactions, causing explosions, fires and other disasters.
Furthermore, this compound may have certain biological activities, in living organisms or participate in complex biochemical reactions. If it involves medical use, it is necessary to study its pharmacological effects, toxic side effects and pharmacokinetic properties in detail. Do not use it rashly to prevent irreversible damage to the health of the organism, such as liver and kidney damage, nervous system disorders, etc.
And during use, it is crucial to accurately control the dose. If the dose is too small, or it is difficult to achieve the desired effect; if the dose is too large, it is easy to cause serious adverse reactions. The dose needs to be scientifically determined according to factors such as specific uses and biological differences.
In addition, storage also needs to be cautious. Due to its chemical properties, it needs to be stored in a suitable environment, protected from high temperature, humidity and strong light, to prevent its deterioration or degradation, causing activity changes or formation of harmful impurities.
Because of its latent risk, the place of use should have complete safety facilities and emergency treatment plans. In the event of an accident, effective measures can be taken quickly to reduce the hazard. In short, when using (±) -N-methyl - γ -( 4- (trifluoromethyl) phenoxy) amphetamine, all-round consideration and careful operation are required to ensure safety and effect.