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What is the chemical structure of N '-Hydroxy-3,5-Bis (Trifluoromethyl) Benzenecarboximidamide?
This is to explore the chemical structure of "N '-hydroxy-3,5' -bis (trifluoromethyl) benzamidine". The structure of organic chemistry is related to the arrangement and bonding of atoms, which is the cornerstone of chemical research.
This compound has "benzamidine" as its core structure. The benzene ring, a six-membered carbon ring, has a unique conjugate system and is quite stable. At the 3rd and 5th positions of the benzene ring, each is connected with "trifluoromethyl". This group is formed by connecting one carbon atom with three fluorine atoms. The fluorine atom is extremely electronegative, resulting in "trifluoromethyl" having strong electron absorption, which affects the electron cloud distribution of the benzene ring, and then changes the chemical and physical properties of the compound.
Furthermore, "N '-hydroxyl" is attached to the specific nitrogen atom of "benzamidine". The presence of hydroxyl (-OH) imparts hydrophilicity to the compound, and the oxygen atom in the hydroxyl group has a lone pair of electrons, which can participate in chemical reactions, such as the formation of hydrogen bonds, which greatly affects the reactivity and intermolecular forces of the compound.
In summary, the chemical structure of "N '-hydroxy-3,5-bis (trifluoromethyl) benzamidine" is composed of a benzene ring as the skeleton, with "trifluoromethyl" and "N' -hydroxy". The interaction of each part jointly determines the unique properties of the compound, which may have important potential applications in organic synthesis, drug development and other fields.
What are the main uses of N '-Hydroxy-3,5-Bis (Trifluoromethyl) Benzenecarboximidamide?
"N '-hydroxy-3,5-bis (trifluoromethyl) benzamidine" is a widely used substance. In the field of medicine, it is a key intermediate. It can help create a variety of specific drugs, such as antibacterial and antiviral medicines, and contribute great power to healing diseases and protecting health. Because of its unique structure, excellent chemical activity and stability, it can give new drugs excellent performance, or increase efficacy, or reduce side effects in the process of drug development.
In the field of agriculture, it also plays an important role. It can be used as a raw material for pesticide synthesis and assist in the research of high-efficiency and low-toxicity pesticides. Such pesticides can not only effectively control pests and diseases, ensure a bumper crop harvest, but also reduce environmental pollution, protect pastoral ecology, and fit the current trend of green agriculture development.
In the field of materials science, "N '-hydroxy-3,5-bis (trifluoromethyl) benzamidine" also shows potential application value. Or it can be used to prepare special polymer materials, endowing materials with unique physical and chemical properties, such as enhancing heat resistance and corrosion resistance, so as to meet the strict requirements of high-end fields such as aerospace and electronics.
It can be seen that "N '-hydroxy-3,5-bis (trifluoromethyl) benzamidine" plays an important role in many key fields due to its diverse uses, promoting the progress and development of various industries.
What are the physical properties of N '-Hydroxy-3,5-Bis (Trifluoromethyl) Benzenecarboximidamide?
N '-Hydroxy - 3,5 - Bis (Trifluoromethyl) Benzenecarboximidamide, this is an organic compound. Its physical properties are crucial, and it is related to the performance of this substance in different scenarios.
First, the appearance is usually white to off-white solid powder, which makes it easy to distinguish in experiments and production. Its color is pure and no variegation, reflecting the high purity of the substance. The texture is fine and uniform, which provides convenience for subsequent operation.
Melting point is also an important physical property. After determination, it is in a specific temperature range. This melting point characteristic is of great significance when purifying the substance. By controlling the temperature, it can be separated from other impurities according to the difference in melting point to obtain high-purity products.
In terms of solubility, it shows a certain solubility in some organic solvents. It can be moderately dissolved in common organic solvents, such as methanol and ethanol. This property is conducive to selecting a suitable solvent in the synthesis reaction and promoting the smooth progress of the reaction. Because it can be evenly dispersed in the solvent, the contact area between the reactants is increased, and the reaction rate is accelerated.
In addition, the stability of the compound cannot be ignored. Under conventional environmental conditions, it can remain relatively stable. In case of extreme conditions such as high temperature, strong acid and alkali, chemical changes may occur. This stability information provides an important reference for storage and transportation. It is necessary to choose suitable environment and packaging materials to ensure that its quality is not damaged.
The physical properties of this compound, from appearance, melting point, solubility to stability, are interrelated, which are of great significance for its research, application and production.
What are the synthesis methods of N '-Hydroxy-3,5-Bis (Trifluoromethyl) Benzenecarboximidamide?
To prepare N '-hydroxy-3,5-bis (trifluoromethyl) benzamidine, the method is multi-terminal. The common method starts with 3,5-bis (trifluoromethyl) benzoic acid. First, it is heated with thionyl chloride to obtain 3,5-bis (trifluoromethyl) benzoyl chloride. This step needs to be carefully controlled at a suitable temperature and in an inert atmosphere to prevent side reactions. This acid chloride is reacted with hydroxylamine salts, such as hydroxylamine hydrochloride, in bases, such as triethylamine, in organic solvents, such as dichloromethane or tetrahydrofuran. After reaction, the target product can be obtained. However, it needs to be properly processed, such as extraction, washing, drying and column chromatography, to purify it.
Another method can be started with 3,5-bis (trifluoromethyl) benzonitrile. First, it is catalyzed with hydroxylamine in an alcohol solvent, such as ethanol, and an appropriate amount of alkali is added. The reaction is heated up. After the nucleophilic addition of the nitrile group and the hydroxylamine, N '-hydroxy-3,5-bis (trifluoromethyl) benzamidine is obtained. Then it also needs to be refined to achieve high purity.
Another group is based on 3,5-bis (trifluoromethyl) aniline. It can also be achieved by diazotizing it first, then converting it to nitrile, and then reacting the above-mentioned nitrile with hydroxylamine. However, all methods have advantages and disadvantages, depending on the ease of raw material availability, cost, difficulty in operation and product purity. At the time of preparation, it is necessary to strictly follow the procedures, pay attention to safety, and prevent harmful chemicals to form pure N '-hydroxy-3,5-bis (trifluoromethyl) benzamidine.
What are the precautions for the use of N '-Hydroxy-3,5-Bis (Trifluoromethyl) Benzenecarboximidamide?
N '-Hydroxy-3,5' -Bis (trifluoromethyl) benzamidine This substance, when used, many matters must be paid attention to.
First safety. This substance may have specific chemical activity and latent risk, and safety procedures must be followed when handling. If in contact, appropriate protection should be provided, such as gloves, goggles and protective clothing, to prevent it from coming into contact with the skin and eyes, and to prevent inhalation of its dust or vapor, causing damage to the body.
Store it in a cool, dry and well-ventilated place, away from fires, heat sources and incompatible substances. It may pose a safety hazard due to improper storage or deterioration of substances.
Further use. Accurate weighing and quantity is the key. It must be used according to the dosage required for experiment or production. Be careful to avoid waste. It is also to prevent improper dosage from causing abnormal reactions or affecting product quality.
And reaction conditions. Its participation in the reaction, temperature, pH, reaction time and other conditions, all need to be precisely controlled. A slight poor pool, or insufficient reaction, side reactions breed, affecting the purity and yield of the product.
Repeat, waste disposal. After use, the remaining substances and waste should not be discarded at will. When in accordance with relevant regulations and environmental protection requirements, it should be properly disposed of to avoid pollution to the environment.
At the end, the records are detailed. During the use process, all operations, data and phenomena should be recorded in detail for traceability and analysis, and subsequent work can learn from experience and avoid repeated mistakes. In this way, the use of N '-hydroxy-3,5-bis (trifluoromethyl) benzamidine is guaranteed to be safe and effective.