As a leading N-Hydroxy-2-(Trifluoromethyl)Benzene Carboximidoyl Chloride supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
What is the chemical structure of N-Hydroxy-2- (Trifluoromethyl) Benzene Carboximidoyl Chloride?
N-hydroxy-2- (trifluoromethyl) anilimide chloride, this is an organic compound. To clarify its chemical structure, it can be explained by name.
"N-hydroxy", showing that the nitrogen atom (N) is connected with a hydroxyl group (-OH). "2- (trifluoromethyl) ", the second position of the epiphenyl ring is connected with a trifluoromethyl group (-CF). Trifluoromethyl has strong electron absorption and has a great influence on the properties of compounds. "Benzoimide chloride" refers to the connection between the benzene ring and the anilimide chloride (-C (= NH) Cl), and the carbon and nitrogen double bond in the anilimide chloride is connected to the chlorine atom. The chlorine atom has high activity and is easy to participate in substitution and other reactions.
In summary, the chemical structure of N-hydroxy-2- (trifluoromethyl) benzoimide chloride is: the second position on the benzene ring is connected to trifluoromethyl, the benzene ring is connected to the methimide chloride, the nitrogen atom of the methimide chloride is connected to the hydroxyl group, and the carbon of the methimide chloride is connected to the chlorine atom. This structure gives the compound unique chemical activity and properties, and is widely used in the field of organic synthesis.
What are the main uses of N-Hydroxy-2- (Trifluoromethyl) Benzene Carboximidoyl Chloride?
N-hydroxy-2- (trifluoromethyl) benzoimide chloride, which is a valuable chemical reagent in the field of organic synthesis, has a wide range of uses, probably as follows:
First, it plays a significant role in the construction of nitrogen-containing heterocyclic compounds. Many nitrogen-containing heterocyclic structures exist in drug-active molecules and natural products. N-hydroxy-2- (trifluoromethyl) benzoimide chloride can be used as a key intermediate. By reacting with various nucleophiles, such as amines and alcohols, it can efficiently construct nitrogen-containing heterocyclic rings with specific structures. For example, the reaction with o-aminophenol may generate benzoxazole derivatives with potential biological activity. Such reactions open up important paths for the creation of new drugs and the exploration of compounds with unique physiological activities.
Second, in the formation of amide bonds, amide bonds are widely found in peptides, proteins, and many drug molecular structures. The compound can react with amines and undergo a series of transformations to form amide compounds. This reaction condition is relatively mild and has good selectivity. In the field of peptide synthesis, or when preparing amide compounds with specific structures and functions, it can be used as an effective method to help researchers accurately synthesize the desired target products.
Third, because it is rich in trifluoromethyl groups in the molecule, it endows the product with unique physical and chemical properties, such as improving lipophilicity and enhancing metabolic stability. Therefore, in the field of pesticide research and development, N-hydroxy-2- (trifluoromethyl) benzoimide chloride can be used to synthesize new pesticides with high efficiency, low toxicity and environmentally friendly properties. By rationally designing the reaction, trifluoromethyl can be introduced into the molecular structure of pesticides to optimize the performance of pesticides and make it more suitable for the needs of modern agriculture for green and efficient pesticides.
What is the synthesis method of N-Hydroxy-2- (Trifluoromethyl) Benzene Carboximidoyl Chloride?
The method of preparing N-hydroxy-2- (trifluoromethyl) benzoimide chloride has been explored in the field of organic synthesis. The method is roughly as follows:
Usually 2 - (trifluoromethyl) benzoic acid is used as the starting material, and it is first heated with thionyl chloride. The two are combined, as the ancients said, "Yin and yang sympathize, and all things are transformed". The carboxyl group of benzoic acid interacts with thionyl chloride, and the carboxyl group is converted into an acyl chloride to obtain 2 - (trifluoromethyl) benzoyl chloride. In this step, attention should be paid to the temperature and duration of the reaction. If the temperature is too high, side reactions will occur, and if it is too low, the reaction will be slow.
Then, 2 - (trifluoromethyl) benzoyl chloride and hydroxylamine hydrochloride meet in a suitable solvent, such as dichloromethane, accompanied by an acid binding agent such as triethylamine. The responsibility of the acid binding agent is to remove the acid generated by the reaction, so that the reaction can proceed smoothly. The two are changed by nucleophilic substitution, and the acid chloride group is connected to the nitrogen atom in the hydroxylamine, and the final N-hydroxy-2 - (trifluoromethyl) benzoimide chloride is obtained.
There are also other methods for synthesis, but the above method has many advantages for the convenience of operation and the excellent yield. When synthesizing, the purity of the raw materials and the conditions of the reaction need to be carefully controlled, such as tuning the piano and a trace of abnormal sound, so as to obtain high-purity products.
What are the physical properties of N-Hydroxy-2- (Trifluoromethyl) Benzene Carboximidoyl Chloride?
N-hydroxy-2 - (trifluoromethyl) benzoimide chloride, this is an organic compound. Its physical properties are crucial and are related to many chemical processes and applications.
The first to bear the brunt, looking at its appearance, it is usually white to off-white crystalline powder. This form is easy to store and use, and reflects the order of its molecular arrangement. The texture of the powder is fine, easy to disperse, and can provide a large contact area in the chemical reaction, which is conducive to the efficient progress of the reaction.
Furthermore, in terms of its melting point, it is in a specific temperature range. Determination of melting point is an important indicator for identification and purity evaluation. A specific melting point range indicates that the compound has a relatively uniform structure and purity. If the melting point deviates from the expected range, or suggests the presence of impurities, it will affect its chemical properties and reactivity.
When it comes to solubility, it shows good solubility in common organic solvents, such as dichloromethane, chloroform, and tetrahydrofuran. This property makes it convenient to participate in the chemical reactions of various solution phases. In organic synthesis, suitable solvents can be selected according to the reaction requirements to create a good reaction environment and promote the full mixing and interaction of the reactants, thereby improving the reaction efficiency and selectivity.
Its density is also an important parameter. Density reflects the compactness of the substance and is related to the molecular weight and intermolecular interactions of the compound. The specific density value helps to accurately measure and use the compound in actual operation, ensuring the accuracy and reproducibility of the experiment.
In addition, stability is also a key consideration. Under normal storage conditions, the compound has certain stability. However, care should be taken to avoid contact with specific substances, such as strong oxidants, strong bases, etc., to prevent adverse reactions that lead to decomposition or deterioration.
The physical properties of N-hydroxy-2- (trifluoromethyl) benzoimide chloride are of great significance in the fields of organic synthesis and drug development. Researchers need to deeply understand and make good use of these properties in order to promote the development of related fields.
What are the storage conditions for N-Hydroxy-2- (Trifluoromethyl) Benzene Carboximidoyl Chloride?
N-hydroxy-2 - (trifluoromethyl) benzoimide chloride is a chemical substance. The storage conditions are crucial, and it is related to the stability and quality of its properties.
This medicine should be placed in a cool and dry place. Cover a cool environment, which can slow down the speed of its reaction, and prevent its decomposition or change its properties due to heat. If it is in a hot place, the molecular speed is easy to cause internal change, which damages its structure and energy. Drying should not be ignored. Water vapor is often a medium for chemical reaction. When this medicine encounters water, it may respond to hydrolysis and lose its original effect. Therefore, avoiding water and preventing moisture is an important rule for storage.
And it must be placed in a closed device. If exposed to gas, it will come into contact with oxygen, carbon dioxide, etc., or oxidize. Oxygen can cause it to oxidize and change its chemical structure; carbon dioxide may also be neutralized with it, causing a qualitative change. The secret device can isolate the outside air and protect its pure quality.
Furthermore, keep away from fire and heat sources. This medicine may be flammable or explosive. In case of fire and heat, it is feared that it will react violently, leading to a dangerous situation. Fire can cause it to explode, and heat sources can also promote its transformation to accelerate, causing unpredictable changes.
And it should be stored separately from oxidized and reduced substances. Oxidation agents and reducing agents are easy to react with and the like, and can be stored separately to avoid unwanted chemical reactions and ensure their safety and efficacy.
In short, the storage of N-hydroxy-2- (trifluoromethyl) benzoimide chloride must be cool, dry, airtight, protected from fire and heat sources, and stored separately from others to obtain its full quality for later use.