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What are the main application fields of N-Hydroxy-2- (Trifluoromethoxy) Benzene Carboximidoyl Chloride
N-hydroxy-2- (trifluoromethoxy) benzoimide chloride, this compound is widely used in the field of organic synthesis.
First, it is often a key raw material in the synthesis of heterocyclic compounds. Taking pyridine heterocycles as an example, through a specific reaction path, N-hydroxy-2- (trifluoromethoxy) benzoimide chloride can interact with suitable reagents and undergo a series of reactions such as cyclization to construct a pyridine ring system. Due to its structure containing trifluoromethoxy and imide chloride groups, the products are endowed with unique electronic and spatial effects, which makes the synthesized heterocyclic compounds have potential biological activities in the field of medicinal chemistry, or can exhibit many pharmacological activities such as antibacterial, antiviral, and antitumor.
Second, it also plays an important role in the preparation of amide compounds. Under appropriate reaction conditions, imide chloride groups can undergo nucleophilic substitution reactions with amine compounds to form amide bonds efficiently. The obtained amide products can be used as polymer monomers with special properties in the field of materials science. Due to the existence of trifluoromethoxy groups, they may endow materials with excellent properties such as chemical resistance and low surface energy.
Third, in the field of pesticide chemistry, derivatives synthesized from this compound as a starting material through multi-step reactions may have biological activities such as insecticidal and herbicide. Due to its special fluorine-containing structure, it can enhance the interaction between the compound and the relevant receptors in the target organism, improve the efficacy and selectivity of pesticides, and provide an important structural basis for the creation of new pesticides.
In summary, N-hydroxy-2- (trifluoromethoxy) benzoimide chloride has an indispensable location and broad application prospects in many key fields of organic synthesis, such as drugs, materials, pesticides, etc.
What is the synthesis method of N-Hydroxy-2- (Trifluoromethoxy) Benzene Carboximidoyl Chloride
The method of synthesizing N-hydroxy-2- (trifluoromethoxy) benzoimide chloride is quite delicate. The first step is to choose a suitable starting material, usually 2 - (trifluoromethoxy) benzoic acid. This acid is first co-placed with chlorinated reagents such as sulfinyl chloride, and reacted at a suitable temperature to obtain 2 - (trifluoromethoxy) benzoyl chloride. The key to this step is to control the reaction temperature and time. If the temperature is high, the side reaction will be raw, and if the temperature is low, the reaction will be slow.
After 2 - (trifluoromethoxy) benzoyl chloride is obtained, it is combined with hydroxylamine hydrochloride and acid binding agents, such as pyridine, into a suitable solvent, such as dichloromethane. In this system, the reaction conditions are carefully regulated to acylate the acid chloride and hydroxylamine hydrochloride, and then N-hydroxy-2 - (trifluoromethoxy) benzoamide is formed. The amount of acid binding agent is also critical. Most of them are expensive and may affect the product, and at least the reaction environment is not good.
After that, N-hydroxy-2- (trifluoromethoxy) benzamide is reacted with chlorinated reagents such as phosphorus pentachloride or oxalyl chloride. This step needs to be carried out in a low temperature and anhydrous environment to prevent the product from hydrolyzing. After this reaction, the carbonyl oxygen of the amide is replaced by chlorine to obtain N-hydroxy-2- (trifluoromethoxy) benzoimide chloride. After each step of the reaction, the product needs to be purified by extraction, column chromatography, etc. to maintain purity, so that the synthesis path can be smooth and the target product can be obtained.
What are the physicochemical properties of N-Hydroxy-2- (Trifluoromethoxy) Benzene Carboximidoyl Chloride
N-hydroxy-2 - (trifluoromethoxy) benzoimide chloride, this is an organic compound. Looking at its physical and chemical properties, it is worth studying carefully.
Let's talk about the physical properties first. It is usually a solid state, but the specific melting point and boiling point vary depending on the preparation and purity. Generally speaking, its melting point or in a specific temperature range, the temperature is high or low, the strength of the intermolecular force. In its molecular structure, the existence of trifluoromethoxy group greatly affects its physical properties. This group has strong electronegativity, which changes the polarity of the molecule, which in turn affects the melting point and boiling point.
As for solubility, in organic solvents, such as common tetrahydrofuran, dichloromethane, etc., there may be a certain solubility. Due to the principle of similar miscibility, the structure of the compound is compatible with the molecular structure of organic solvents, so it can be miscible. However, in water, because its polarity does not exactly match the water molecule, the solubility may be quite limited.
In terms of its chemical properties, the chlorine atom in this compound is very active. As a part of the acid chloride group, it is prone to nucleophilic substitution reactions. Hydroxyl groups coexist in one molecule, which also affects the reaction activity. In case of nucleophilic reagents, chlorine atoms are easily replaced to form various derivatives. For example, when reacted with alcohols, esters can be formed; when reacted with amines, amides are formed. And the electron-absorbing effect of trifluoromethoxy will reduce the electron cloud density of the benzene ring and weaken the electrophilic substitution reaction activity on the benzene ring. The presence of hydroxyl groups may participate in the hydrogen bonding between molecules or molecules, affecting its chemical stability and reaction path. The various physicochemical properties of this compound are important considerations in the field of organic synthesis, and are relevant to the design and implementation of many reactions.
What should be paid attention to when storing and transporting N-Hydroxy-2- (Trifluoromethoxy) Benzene Carboximidoyl Chloride
N-Hydroxy-2 - (trifluoromethoxy) benzoimide chloride is one of the chemical substances. When storing and transporting, be careful.
First, the storage place must be dry and cool. This substance is afraid of moisture, and moisture can easily cause it to deteriorate. Therefore, the humidity of the warehouse should be controlled at a low level, and the temperature should not be too high to prevent it from decomposing due to heat. If placed in a high temperature place, it may cause chemical reactions, cause changes in its chemical properties, and even risk safety.
Second, when transporting, the packaging must be tight. Use a suitable container to ensure no leakage. Due to its certain corrosive and chemical activity, if it leaks, it will not only damage the transportation tool, but also endanger the surrounding environment and personnel safety. The packaging materials used should be resistant to the erosion of this substance, and should be handled with care during handling to avoid collisions and bumps to prevent package damage.
Third, whether it is stored or transported, it should be kept away from fire sources and oxidants. This substance is very easy to burn or even explode when exposed to open flames or oxidants. Therefore, fireworks are strictly prohibited near warehouses and transportation vehicles, and they should not be stored and transported with oxidants to prevent accidents. At the same time, when the storage and transportation places are equipped with complete fire and emergency treatment equipment, they can respond quickly in case of emergencies. This way, the safety of the storage and transportation of this substance can be guaranteed.
What is the market price of N-Hydroxy-2- (Trifluoromethoxy) Benzene Carboximidoyl Chloride?
I look at your question, but I am inquiring about the market price of N - Hydroxy - 2 - (Trifluoromethoxy) Benzene Carboximidoyl Chloride. However, the price of this product cannot be hidden in a word.
The price of the product often changes due to various factors. The first one to bear the brunt is the difficulty of production. If its preparation requires exquisite craftsmanship and rare raw materials, the price must be high. In addition, the state of market supply and demand is also the key. If there are many people who want it, and there are few products, the price will rise; conversely, if the supply exceeds the demand, the price will fall.
Furthermore, the difference between merchants also affects the price. Different companies have different prices due to their cost accounting and profit making. There are those who have high prices for heavy quality, and those who seek small profits and low prices.
According to the market in the past, the price of such chemicals varies greatly from year to year and region. If you want to know the exact price at the moment, you need to consult the platform for trading chemical raw materials in detail, or consult a merchant specializing in such chemicals. It must offer accurate prices according to the current situation.