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What is the chemical structure of -4-Fluorobenzenesulfonamide N- (4-Chloro-5-Formyl-3-Phenyl-1, 3-Thiazol-2 (3H) -Ylidene)?
This compound is called N- (4-chloro-5-formyl-3-phenyl-1,3-thiazole-2 (3H) -subunit) -4-fluorobenzenesulfonamide. Looking at its name, it can be known that its structure contains several key parts.
The thiazole ring is one of its cores and is in the form of a subunit at the 2nd position. This structure may have an important impact on the properties of the compound. The third position of the thiazole ring is connected with a phenyl group. The existence of the benzene ring or the hydrophobicity and steric hindrance of the molecule.
The thiazole ring has a chlorine atom at the 4th position and a formyl group at the 5th position. Different substituents endow molecules with diverse chemical activities. Chlorine atoms have electron-withdrawing properties, which can affect the distribution of surrounding electron clouds; the carbonyl group of formyl groups is polar, or involves a variety of chemical reactions.
Another key part is the 4-fluorobenzenesulfonamide group. The fluorine atom at the 4th position of the benzene ring also has an electron-withdrawing effect. Sulfonamide groups are important active groups, which can participate in the formation of hydrogen bonds and other functions, and are essential for the biological activity of compounds.
In summary, this compound has a unique structure, and its various parts interact, or give it unique physical and chemical properties and biological
What are the main physical properties of N- (4-Chloro-5-Formyl-3-Phenyl-1, 3-Thiazol-2 (3H) -Ylidene) -4-Fluorobenzenesulfonamide
This is a chemical substance named N- (4-chloro-5-formyl-3-phenyl-1,3-thiazole-2 (3H) -subunit) -4-fluorobenzenesulfonamide. Its main physical properties are as follows:
From a solid point of view, this substance is mostly in the form of powder. Because its molecular structure contains many aromatic rings and polar groups, the intermolecular force is strong, causing it to exist in a solid state at room temperature and pressure.
It is related to the melting point. Although the exact value needs to be determined experimentally, it can be inferred that its melting point is quite high based on its structural characteristics. Due to the existence of a conjugate system in the molecule, the stability of the molecule is enhanced, and more energy is required to destroy the lattice.
In terms of solubility, due to the polar sulfonamide group and formyl group, it may have certain solubility in polar organic solvents such as dimethyl sulfoxide, N, N-dimethylformamide; but because it contains more non-polar phenyl groups and thiazole rings, its solubility in water is poor.
In addition, the substance contains conjugated systems and electron-absorbing groups, or has specific optical properties, such as under specific wavelength light irradiation, or can exhibit fluorescence phenomenon, but the specific optical properties also need to be tested in detail. Its density, boiling point and other physical properties are also restricted by molecular structure and intermolecular forces, but the exact value needs to be accurately determined by professional experiments.
In which fields is N- (4-Chloro-5-Formyl-3-Phenyl-1, 3-Thiazol-2 (3H) -Ylidene) -4-Fluorobenzenesulfonamide used?
N- (4-chloro-5-formyl-3-phenyl-1,3-thiazole-2 (3H) -subunit) -4-fluorobenzenesulfonamide, this compound may have extraordinary uses in the fields of medicine and materials science.
In the field of medicine, its unique structure may be in close contact with specific biological targets. It may act on some key enzymes, regulating the activity of enzymes by specifically binding to enzyme activity check points, thereby affecting the process of intracellular biochemical reactions. For example, in tumor-related studies, if the compound can inhibit tumor cell proliferation-related enzymes, it may become a potential anticancer drug. Or in inflammatory diseases, if it can regulate the activity of inflammation-related enzymes, it may be beneficial for inflammation treatment.
In the field of materials science, due to its special chemical structure, it may endow materials with novel properties. Or it can be incorporated into polymer materials as functional additives to improve the optical and electrical properties of materials. For example, adding to specific optical materials can optimize their light absorption and emission characteristics for the manufacture of advanced optical devices. Or in electronic materials, enhance the conductivity or stability of materials and help improve the performance of electronic devices.
Furthermore, in the field of organic synthesis, its structure can be used as a key intermediate to build more complex organic molecular structures, open up new paths for organic synthesis chemistry, and promote the development of organic compound diversity.
What is the preparation method of N- (4-Chloro-5-Formyl-3-Phenyl-1, 3-Thiazol-2 (3H) -Ylidene) -4-Fluorobenzenesulfonamide
To prepare N- (4-chloro-5-formyl-3-phenyl-1,3-thiazole-2 (3H) -subunit) -4 -fluorobenzenesulfonamide, the method is as follows:
First, all raw materials, such as 4-chloro-5-formyl-3-phenyl-1,3-thiazole-2 (3H) -thione and 4-fluorobenzenesulfonyl chloride, must be pure and good to ensure a smooth reaction.
Before the reaction kettle at a suitable temperature, add an appropriate amount of organic solvent, such as dichloromethane or N, N-dimethylformamide, as the reaction medium. Then add 4-chloro-5-formyl-3-phenyl-1,3-thiazole-2 (3H) -thione into the kettle and stir well.
Slowly drop 4-fluorobenzenesulfonyl chloride in the kettle, and control the temperature at the same time to prevent excessive reaction. When the drop is completed, the temperature is raised to an appropriate value, and the stirring number is continued, the progress of the reaction must be constantly monitored, which can be measured by thin layer chromatography or high performance liquid chromatography.
When the reaction is close to completion, pour the reaction solution into an appropriate amount of ice water to allow the product to separate. Extract it with a suitable organic solvent, combine the organic phases, dry it with anhydrous sodium sulfate, and remove the water.
After distillation under reduced pressure, in addition to the solvent, the crude product is obtained. Then, by column chromatography or recrystallization, select the eluent or solvent, such as petroleum ether and ethyl acetate mixture, to obtain high purity N- (4-chloro-5-formyl-3-phenyl-1,3-thiazole-2 (3H) -subunit) -4 -fluorobenzenesulfonamide. Throughout the process, it is necessary to abide by the rules of operation and strictly protect the experimental environment in order to achieve optimum results.
What are the safety and toxicity of N- (4-Chloro-5-Formyl-3-Phenyl-1, 3-Thiazol-2 (3H) -Ylidene) -4-Fluorobenzenesulfonamide?
I look at this "N- (4-chloro-5-formyl-3-phenyl-1,3-thiazole-2 (3H) -subunit) -4-fluorobenzenesulfonamide", the study of its safety and toxicity is quite complicated.
First of all, safety, this compound shows different performance under different environments and conditions. If placed in a suitable storage environment, protected from high temperature, open flame and oxidant, and packaged intact, its stability is acceptable, it is not prone to qualitative change in a short time, and has no significant adverse effects on the surrounding environment. However, if it is not stored properly, causing it to leak out, come into contact with air, water or other substances, or cause a chemical reaction to produce an unknown product, the safety of this unknown product is unpredictable.
As for toxicity, its molecular structure contains elements such as chlorine and fluorine, and compounds of such elements are often toxic. From the perspective of animal experiments, if it is directly exposed to or ingested, it may affect the physiological functions of animals. Or cause digestive system disorders, such as vomiting, diarrhea, etc.; or disturb the nervous system, causing convulsions and abnormal behavior. At the cellular level, or destroy the integrity of cell membranes, interfere with normal cell metabolism, and affect cell growth and division. However, the toxicity is also closely related to the dose. At low doses, the organism may be able to decompose and expel it by virtue of its own metabolic system, and the toxicity is slight; at high doses, it may cause irreversible damage to the organism, or even endanger life.
In short, the safety and toxicity of this compound require comprehensive and careful consideration of various factors, and experimental research is also indispensable in order to clarify its characteristics and effectively avoid risks.