As a leading N-[4-[[3-Chloro-4-[(3-Fluorophenyl)Methoxy]Phenyl]Amino]-6-Quinazolinyl]-2-Propenamide 4-Methylbenzenesulfonate supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
What is the chemical structure of N- [4- [[3-chloro-4- [ (3-fluorophenyl) methoxy] phenyl] amino] -6-quinazolinyl] -2-acrylamide 4-methylbenzenesulfonate
This is a problem of structural analysis of organic compounds. The chemical structure of Ximing "N- [4- [3-cyano-4- [ (3-methoxybenzyl) methoxy] benzyl] amino-6-pyridyl] -2-proparynylbenzoxazole-4-methylbenzylsulfonolactone" needs to be analyzed according to the following steps.
Looking at the main structure, this compound has benzoxazole as the core part. There are 2-proparynyl groups in the 2 positions of benzoxazole, indicating that the proparynyl group is connected to the proparynyl group at the 2 position of the benzoxazole ring through a chemical bond. The proparynyl group contains a carbon-carbon triple bond, which gives the compound a certain reactivity.
Looking at the 4-position again, the 4-methylbenzyl sulfonolactone fragment is connected. In this structure, benzyl is connected to the 4-position of benzoxazole ring, and the counter-position of benzyl has methyl substitution. At the same time, benzyl forms a specific structure with sulfonolactone, which affects the physical and chemical properties of the compound.
Next, the side chain attached to the N atom is complicated. The N atom is connected to the 4- [3-cyano- 4- [ (3-methoxybenzyl) methoxy] benzyl] amino-6-pyridyl fragment. Wherein, the pyridyl group is connected to the above-mentioned amino-containing structure at the 6th position, and the amino group is connected to the benzyl group. The third position of the benzyl group has a cyano group, and the fourth position is modified by [ (3-methoxybenzyl) methoxy]. 3-methoxybenzyl is connected to the fourth position of the benzyl group through an oxygen atom, and the 3-methoxybenzyl group itself has a methoxy group at the third position of the benzyl group.
In summary, the structure of this compound is complex, and each group affects each other to determine its unique physical and chemical properties and reactivity. The synergistic structure of each part makes the compound have specific biological activities, chemical stability and other characteristics, and may have important value in organic synthesis, medicinal chemistry and
What is the main use of N- [4- [[3-chloro-4- [ (3-fluorophenyl) methoxy] phenyl] amino] -6-quinazolinyl] -2-acrylamide 4-methylbenzene sulfonate
N- [4- [[3-cyano-4- [ (3-ethoxy) acetyl] phenyl] amino] -6-pyridyl] -2-methylbenzothiazole-4-acetic acid is an organic compound, which has many important uses in the field of modern medicinal chemistry.
In the process of drug development, one of its important functions is as a key intermediate for active pharmaceutical ingredients (APIs). By specific modification and modification of its chemical structure, new drugs with different pharmacological activities can be created. For example, in the development of anti-tumor drugs, by delicately adjusting the structure of the compound, new agents that exhibit highly selective inhibitory activity on specific tumor cells may be derived, because it can precisely act on some key targets in tumor cells, block tumor cell growth and proliferation signaling pathways, and then curb the rampant growth of tumor cells.
In the field of anti-inflammatory drug development, the compound may play a significant anti-inflammatory effect by modulating the body's inflammatory response-related signaling pathways. For example, inhibiting the excessive release of inflammatory mediators and regulating the activity of immune cells, so as to relieve inflammatory symptoms and provide new opportunities and approaches for the treatment of inflammatory diseases.
In addition, in the process of medicinal chemistry research, this compound acts as an important model molecule, which helps researchers to deeply explore the mechanism of drug-biological target interaction and clarify the structure-activity relationship. By systematically transforming and optimizing its structure, the effects of different substituents and spatial configurations on drug activity, selectivity, and pharmacokinetic properties can be understood, laying a solid theoretical foundation for rational drug design and the creation of new high-efficiency and low-toxicity drugs.
What is the safety of N- [4- [[3-chloro-4- [ (3-fluorophenyl) methoxy] phenyl] amino] -6-quinazolinyl] -2-acrylamide 4-methylbenzene sulfonate
This compound is named N- [4- [3-cyanopropyl) methoxy] phenyl] amino-6-pyridyl] -2-methylfurano [3,4-b] thiophene-4-ylacetic acid, which is a complex organic compound. In terms of its safety, it needs to be carefully analyzed from many aspects.
First, from the perspective of chemical structure, this group contains cyanide groups, which are potentially toxic. Cyanyl groups can release cyanide ions under specific conditions, which can bind to iron ions in cytochrome oxidase, block the respiratory chain of cells, cause hypoxia in cells, cause serious toxicity to organisms, or endanger life.
Secondly, the compound contains many heterocyclic structures, such as furan, thiophene and pyridine rings. Although heterocyclic structures are widely found in various bioactive molecules, some heterocyclic rings may generate toxic or carcinogenic intermediates during metabolism. For example, furan rings are metabolically activated in vivo, or electrophilic intermediates are generated, which covalently bind to biological macromolecules such as DNA and proteins, causing cell damage and mutation.
Furthermore, methoxy, propyl and other substituents in the compound may affect its physical and chemical properties and biological activities. Methoxy can increase the fat solubility of the compound, affecting its absorption, distribution and excretion in the body. If the metabolic pathway is not smooth, or the compound accumulates in the body, it increases the latent risk.
In addition, toxicological experimental data are indispensable for the safety assessment of the compound. Acute toxicity experiments can measure the lethal dose and toxicity symptoms of the organism after a large amount of exposure in a short period of time; subacute and chronic toxicity experiments can explore the effects of long-term low-dose exposure on the organism, including functional damage to the liver, kidneys, nervous system and other important organs, as well as potential carcinogenicity, teratogenicity and mutagenicity.
In short, it is difficult to fully and accurately determine the safety of this compound based on its structure alone, and it is necessary to combine detailed toxicological studies with practical application scenarios. In practical application, it is necessary to strictly follow safety operating procedures and relevant regulatory standards to ensure safety.
What is the market prospect of N- [4- [[3-chloro-4- [ (3-fluorophenyl) methoxy] phenyl] amino] -6-quinazolinyl] -2-acrylamide 4-methylbenzene sulfonate?
Today there is a product named N- [4- [[3-cyanogen-4- [ (3-ethoxyphenyl) ethoxy] phenyl] amino] -6-pyridyl] -2-methylbenzothiazole-4-acetic acid, which is the name of the chemical substance. Let me elaborate on its market prospects.
This product has extraordinary potential in the field of pharmaceutical research and development. At present, the pharmaceutical industry is constantly exploring new compounds in search of effective remedies for diseases. The unique structure of this compound may give it a specific biological activity, which can play a role in targeting certain disease targets. If it can be confirmed by in-depth research and tests that its efficacy is accurate and its safety is good, it will definitely gain a place in the pharmaceutical market.
In the scientific research community, the research on this type of complex structure compound has also attracted much attention. The optimization of its synthesis method and the exploration of the reaction mechanism are all directions for researchers to study. If there can be breakthroughs in synthesis technology, increase yield and reduce costs, it will definitely promote the large-scale preparation and application of this compound and its derivatives, and then expand its market space.
However, its market prospects also pose challenges. The road to drug development is arduous and long, and it requires multiple rounds of rigorous trials and approvals. From laboratory research to clinical application requires a lot of manpower, material resources and time. And the pharmaceutical market is fiercely competitive, with similar or alternative products emerging in an endless stream. If you can't highlight your advantages in efficacy, price, safety, etc., it may be difficult to stand out.
To sum up, N- [4 - [3 - cyano- 4 - [ (3 - ethoxyphenyl) ethoxy] phenyl] amino] - 6 - pyridyl] - 2 - methylbenzothiazole - 4 - acetic acid The market prospect, opportunities and challenges coexist. Only with continuous scientific research innovation and rigorous clinical trials can we open up a broad market.
What are the synthesis methods of N- [4- [[3-chloro-4- [ (3-fluorophenyl) methoxy] phenyl] amino] -6-quinazolinyl] -2-acrylamide 4-methylbenzene sulfonate
To prepare N - [4- [3-cyano-4- [ (3-methoxyphenyl) methoxy] phenyl] amino-6-pyridyl] -2-methylquinoxaline-4-formate ethyl ester, there are many methods, and the following are common synthesis paths:
First, pyridine, quinoxaline and benzene derivatives containing specific substituents are used as starting materials. The specific substituent is introduced before the 6-position of pyridine, which can be achieved by nucleophilic substitution or electrophilic substitution reaction. For example, a suitable halogenated pyridine is reacted with a nucleophilic reagent containing the target substituent in a suitable base and solvent environment, such as potassium carbonate as a base, acetonitrile as a solvent, and heated to reflux, so that the nucleophilic reagent can successfully replace the halogen atom.
The construction of the quinoxaline part is often formed by condensation of o-diamines and dicarbonyl compounds. Such as phthalamine and methyl glyoxal, under acidic catalysis, react in ethanol solvent to form a quinoxaline parent nucleus. Subsequently, by esterification reaction, ethyl ester is introduced at the quinoxaline-4-position, and ethanol and suitable acylating reagents, such as acid chloride or acid anhydride, are esterified under base catalysis.
As for the installation of complex substituents on the benzene ring, a palladium-catalyzed coupling reaction can be used. For example, 4-halo-3-cyanobenzene derivatives and 3-methoxybenzyl alcohol derivatives are reacted in a suitable solvent (such as N, N-dimethylformamide) under the action of palladium catalysts (such as tetra (triphenylphosphine) palladium) and bases (such as cesium carbonate) to achieve the connection of 3-cyano-4- [ (3-methoxyphenyl) methoxy] phenyl substituents. Finally, by condensation reaction, pyridine, quinoxaline and benzene three parts are connected to obtain the target product.
In addition, it can also be synthesized from other key intermediates according to different reaction sequences and conditions. However, regardless of the method, it is necessary to pay attention to the precise control of the reaction conditions, such as temperature, pH, reaction time, etc., in order to increase the reaction yield and selectivity, while taking into account the difficulty of obtaining raw materials and the cost, choose the most suitable method.