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Methyl 4-Amino-3-Fluorobenzenecarboxylate

Methyl 4-Amino-3-Fluorobenzenecarboxylate

Hongda Chemical

    Specifications

    HS Code

    417483

    Chemical Formula C8H8FNO2
    Molecular Weight 169.153 g/mol
    Appearance Typically a solid (state can vary based on conditions)
    Melting Point Data may vary, specific value needs further research
    Boiling Point Data may vary, specific value needs further research
    Solubility In Water Limited solubility, being an organic compound
    Solubility In Organic Solvents Soluble in common organic solvents like ethanol, dichloromethane
    Density Data may vary, specific value needs further research
    Pka Data may vary, specific value needs further research
    Flash Point Data may vary, specific value needs further research

    As an accredited Methyl 4-Amino-3-Fluorobenzenecarboxylate factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing 100g of Methyl 4 - amino - 3 - fluorobenzenecarboxylate packaged in a sealed plastic bag.
    Storage Methyl 4 - amino - 3 - fluorobenzenecarboxylate should be stored in a cool, dry, and well - ventilated area. Keep it away from heat sources, open flames, and oxidizing agents. Store in a tightly sealed container to prevent moisture absorption and potential reaction with air components. Label the storage container clearly to avoid confusion.
    Shipping Methyl 4 - amino - 3 - fluorobenzenecarboxylate is shipped in accordance with chemical transport regulations. It's carefully packaged to prevent leakage, typically in sealed containers, and transported by approved carriers to ensure safety during transit.
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    Methyl 4-Amino-3-Fluorobenzenecarboxylate Methyl 4-Amino-3-Fluorobenzenecarboxylate
    General Information
    Historical Development
    The industry of chemical industry is changing with each passing day. There is a name Methyl 4 - Amino - 3 - Fluorobenzenecarboxylate. Its birth is also gathered by the efforts of all researchers. At the beginning, the road of exploration was full of thorns, and everyone cut through thorns in the path of chemistry. After countless trials, or due to the poor preparation of raw materials, or the inappropriate conditions of the reaction, the results were not obvious. However, the public was not discouraged, and they devoted themselves to studying, analyzing the past mistakes, and adjusting the strategy. Gradually, the mechanism of the reaction became clearer, and the method of craftsmanship became better. Therefore, this compound has been prepared on a large scale since the very beginning, and its process is similar to the fragrance of cold plum through frost and snow, witnessing the progress of the chemical industry, and also leaving valuable lessons for subsequent researchers. I hope future generations will continue to build on the past and write new books at the peak of chemistry.
    Product Overview
    A new organic chemical substance, called Methyl 4 - Amino - 3 - Fluorobenzenecarboxylate. The structure of this substance, above the benzene ring, fluorine atoms are cleverly related to amino groups and methyl formate groups. Its properties, at room temperature, or as white crystal powder, have certain stability.
    The preparation method may be obtained by multi-step reaction. Using benzene derivatives as starting materials, after many steps such as halogenation, amination, esterification, etc., step by step, the product can be obtained. During the reaction, the conditions of each step need to be precisely controlled, and temperature and reagent dosage are the keys.
    This product has great potential in the field of organic synthesis. It can be used as a key intermediate for the preparation of various fluoride-containing medicines, pesticides and functional materials. Because of its unique structure, it may endow new products with excellent biological activities and physical properties. It may have broad prospects in scientific research and industrial applications. We need to delve deeper into it to uncover more mysteries.
    Physical & Chemical Properties
    There is a substance called Methyl 4 - Amino - 3 - Fluorobenzenecarboxylate. Its physical and chemical properties are worth studying.
    The color of this substance, or a colorless to slightly yellow state, looks like glass, clear and bright. Its shape is often crystalline at room temperature, fine and regular.
    As for its chemical properties, it has specific reactivity. Amino and carboxyl groups give it the ability to participate in many reactions. Under suitable conditions, amino groups can combine with acids, and carboxyl groups can also be esterified with alcohols. The existence of fluorine atoms adds unique features to its chemical properties, affecting the rate and path of its reaction.
    Its melting point is also a fixed number. The temperature of the melting point is a specific value, which is related to the change of its physical state. When the boiling point is, it turns into a gaseous state, and this physical transformation follows the laws of physical chemistry. Its solubility, soluble or insoluble in a specific solvent, is also an important property characterization.
    Looking at this Methyl 4 - Amino - 3 - Fluorobenzenecarboxylate, the physical and chemical properties complement each other, forming a unique chemical entity, waiting for us to explore in depth to understand its more mysteries.
    Technical Specifications & Labeling
    Today, there is a product called Methyl 4 - Amino - 3 - Fluorobenzenecarboxylate, which is also a chemical product. Its technical specifications and identification (commodity parameters) are the key. The technical specifications of this product need to specify the production method, from the selection of raw materials, the precision of the ratio, to the reaction conditions, all of which should be accurate. And the identification (commodity parameters) should clearly present its properties, purity, ingredients and other information. In this way, this product can be clearly known to users in the field of chemical industry. When it is produced and applied, it can be used to the fullest extent according to the specifications and labels, so as to meet the rigorous way of chemical industry.
    Preparation Method
    To prepare Methyl 4 - Amino - 3 - Fluorobenzenecarboxylate, prepare the raw materials first. Take 4 - nitro - 3 - fluorobenzoate methyl ester as the starting material, use iron powder and hydrochloric acid as the reducing agent, through the reduction reaction, the nitro group is turned into an amino group, this is the key step. During the reaction, control the temperature at an appropriate value, do not overheat or overcool, to avoid side effects. After the reaction is completed, extract with an appropriate solvent, remove impurities and refine.
    As for the catalytic mechanism, iron powder interacts with hydrochloric acid, and iron gradually dissolves to produce ferrous ions, which are reductive and promote nitro conversion. In this process, hydrochloric acid provides a proton environment, which facilitates the reaction. After separation and purification, a pure product is obtained. The operation must be rigorous and follow the process in order to produce good products.
    Chemical Reactions & Modifications
    Today there is a thing called Methyl 4 - Amino - 3 - Fluorobenzenecarboxylate. In the field of chemistry, it is crucial to explore its reaction and modification.
    Looking at the reaction of this compound, many paths can be found. Or with a certain reagent, the substitution changes, so that its structure is changed, and then its performance is also different. In this substitution, the replacement of functional groups and the choice of check points have profound implications, which are related to the characteristics of the product.
    As for modification, we can use physical methods and chemical methods. Physical methods, such as temperature control and pressure regulation, make the crystal form shift and affect its aggregation state. In chemistry, by introducing new radicals, the distribution of electron clouds is changed, causing its activity, stability and other properties to change. All these are to make the compound more suitable for the needs of materials, medicine and other fields.
    Synonyms & Product Names
    Today there is a thing called Methyl 4 - Amino - 3 - Fluorobenzenecarboxylate. Its synonymous name is also of concern to everyone. It covers the field of chemical industry and has a wide range of uses, so the synonymous name and the trade name have important meanings.
    This compound may have another name to meet the needs of different situations. In various classics and industries, the synonymous name is easier from time to time, which is designed to express the meaning accurately and is also convenient for all parties to apply. The trade name is related to the circulation and identification of the market, and is clearly marked in commercial activities.
    Those who study this product need to carefully investigate its synonymous name and trade name, and clarify its origin, similarities and differences, so that they can proceed smoothly in the research and application without any mistakes, and give full play to its due ability in the chemical industry to achieve the best.
    Safety & Operational Standards
    The name of the chemical product today is Methyl 4 - Amino - 3 - Fluorobenzenecarboxylate. In our research, its safety and operation standards are of paramount importance.
    All operations involving this product must be strictly followed. At the beginning of the experiment, be sure to check the equipment used to ensure cleanliness and non-damage, to prevent impurities from mixing in and affecting the quality of the product, and to ensure the safety of the experiment.
    Operators should wear special protective clothing, such as chemical-resistant laboratory clothes, and protective gloves. The material must be able to effectively resist the possible erosion of the product. Face protection is also indispensable. The goggles should be clear, transparent and flawless to protect the eyes from splashing liquids or volatile aerosols.
    In the operating space, the ventilation conditions must be good. This product may be volatile. If the ventilation is not smooth, the accumulation of harmful gases may endanger the health of the operator. Strong ventilation equipment should be set up to discharge the volatile gas in time to maintain fresh air.
    When taking the product, the action should be steady and accurate. Use an accurate measuring tool to measure the required amount to avoid waste and prevent excessive use from causing danger. During the transfer process, beware of product dripping. If there is dripping, clean it immediately and properly handle it with a special cleaning agent to eliminate latent risk.
    Storage should be placed in a cool, dry and ventilated place, away from fire and heat sources. Separate from other chemicals to avoid mutual reaction. The container must be well sealed to prevent moisture, volatilization or reaction with air components.
    After the operation, clean, disinfect and store the utensils used in time. The remaining products should be properly disposed of according to regulations and should not be discarded at will to prevent pollution to the environment.
    Strictly abide by safety and operating standards in order to ensure the safety of personnel in the study of Methyl 4-Amino-3-Fluorobenzenecarboxylate, promote the smooth experiment and achieve the expected results.
    Application Area
    Today there is a product called Methyl 4 - Amino - 3 - Fluorobenzenecarboxylate. The application field of this product is quite wide. In the field of pharmaceutical research and development, it may be a key intermediate, helping to create new drugs to cure various diseases and eliminate diseases for all living beings. In the field of material science, it may endow materials with unique properties, such as improving the stability and optical properties of materials, making materials suitable for a variety of scenarios. Or in the field of fine chemicals, with its special structure, participate in the synthesis of various fine chemicals to improve the quality and efficiency of products. This is a summary of Methyl 4 - Amino - 3 - Fluorobenzenecarboxylate application field, and its role in many fields cannot be underestimated.
    Research & Development
    Recently, in the field of organic synthesis, Wu specialized in Methyl 4 - Amino - 3 - Fluorobenzenecarboxylate. This compound has a unique structure and contains fluorine and amino functional groups. It has great application prospects in the fields of medicine and materials.
    Wu began to explore the classic organic synthesis method to optimize the reaction conditions, such as temperature, catalyst, reactant ratio, etc. After repeated trial and error, an efficient synthesis path was gradually obtained. The yield was only 20-30% at the beginning, but after improvement, it could reach 60-70%.
    At the same time as synthesis, the properties of this substance were investigated in detail. Measure its physical properties, such as melting point, boiling point, solubility, etc.; analyze its chemical activity, and know that under specific conditions, it can react with a variety of reagents to derive new compounds.
    Looking forward to the future, it will expand its application research. Hope to work with colleagues in the medical industry to explore its potential in drug research and development, or become a key ingredient in anti-cancer and antibacterial new drugs. We also want to study its application in the field of materials, hoping to contribute to the creation of advanced materials. With this material, we hope to promote the development of the chemical field and benefit the world.
    Toxicity Research
    Since modern times, the study of chemical substances has deepened. Today there is Methyl 4 - Amino - 3 - Fluorobenzenecarboxylate this agent, and the study of its toxicity is quite important.
    We use scientific methods to investigate this agent in detail. Take various experimental methods to observe how it interacts with other things and how it changes in the body of the living thing. Observe the path of its entry into the body, either by mouth, or through the skin, or inhaled between breaths.
    After many experiments, we know the trend of its toxicity. If the amount exceeds the normal limit, it can cause the biological body to violate. Light ones feel uncomfortable, heavy ones may endanger life. It is harmful to the structure of cells and physiological functions. Therefore, when using this agent, it is necessary to be cautious and clear about its nature, so that the security is safe and will not cause all kinds of disasters, so as to ensure the safety of all living beings.
    Future Prospects
    Although Guanfu methyl 4-amino-3-fluorobenzoate is present in our case, its future prospects are really imaginative.
    As chemical researchers, we are well aware of the potential of this compound. In the field of organic synthesis, it may serve as a key intermediate to assist in the construction of many delicate structures. In the future, it may be able to use this material to develop new drugs with excellent pharmacological effects to relieve the suffering of patients all over the world.
    Or in the field of materials science, it has been ingeniously modified to have specific optoelectronic properties, which will contribute to the creation of new materials. Although the road ahead is uncertain, we will be able to explore more possibilities with the heart of exploration. With time, this "methyl 4-amino-3-fluorobenzoate" will surely bloom, pave the way to science, and bring endless benefits to future generations, so as to achieve our ambitions for the future.
    Where to Buy Methyl 4-Amino-3-Fluorobenzenecarboxylate in China?
    As a trusted Methyl 4-Amino-3-Fluorobenzenecarboxylate manufacturer, we deliver: Factory-Direct Value: Competitive pricing with no middleman markups, tailored for bulk orders and project-scale requirements. Technical Excellence: Precision-engineered solutions backed by R&D expertise, from formulation to end-to-end delivery. Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
    Frequently Asked Questions

    As a leading Methyl 4-Amino-3-Fluorobenzenecarboxylate supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

    What are the chemical properties of Methyl 4-Amino-3-Fluorobenzenecarboxylate?
    Methyl-4-amino-3-fluorobenzoate is a kind of organic compound. It has the following chemical properties:
    This compound contains an amino group (-NH _ 2), a fluorine atom (-F) and an ester group (-COOCH 🥰). The amino group is a nucleophilic group with certain alkalinity, which can react with acids to form corresponding salts. Because of the solitary pair of electrons on the nitrogen atom, it can provide electron pairs to bind to protons. For example, when encountering hydrochloric acid, the amino group will bind to the protons in the hydrochloric acid to form a positively charged ammonium salt.
    As a halogen atom, the fluorine atom has high electronegativity, which will affect the distribution of electron clouds in the benzene ring. The electron-absorbing effect decreases the electron cloud density of the benzene ring, which in turn affects the activity and positional selectivity of the electrophilic substitution reaction on the benzene ring. Compared with the benzene-like compounds without fluorine substitution, the electrophilic substitution reaction is more likely to occur at the position where the electron cloud density is relatively high. The presence of the
    ester group allows the compound to undergo hydrolysis. Under acidic or basic conditions, the ester group will hydrolyze. When hydrolyzed in acid, 4-amino-3-fluorobenzoic acid and methanol are formed; when hydrolyzed in alkaline, 4-amino-3-fluorobenzoic acid and methanol are formed, and the hydrolysis is more complete under alkaline conditions.
    In addition, due to the existence of a conjugated system in the molecule, that is, the π-electron conjugation of the benzene ring, the compound has a unique spectral property. In the ultraviolet-visible spectrum, a specific absorption peak will be generated due to the π - π* transition of the conjugated system, which can be used for qualitative and quantitative analysis of the compound. At the same time, the conjugated system also contributes to the molecular stability, making the compound more stable than the unconjugated structural analogues to a certain extent.
    What are the main uses of Methyl 4-Amino-3-Fluorobenzenecarboxylate?
    Methyl 4-amino-3-fluorobenzoate is an important compound in the field of organic chemistry. It has a wide range of uses and is often used as a key intermediate in the field of pharmaceutical synthesis. Medical pharmaceuticals require the synthesis of molecules with specific biological activities. Methyl 4-amino-3-fluorobenzoate can be chemically modified to add specific functional groups, so that the resulting drug molecules can precisely act on specific targets in the human body to achieve the effect of treating diseases.
    In the field of materials science, it also has important functions. When researchers make new functional materials, they can introduce them into polymer structures to give materials such as special optical and electrical properties. Due to the special structure of the compound, it can change the overall electron cloud distribution of the compound, which in turn affects the response characteristics of the material to light and electricity.
    In addition, it is also indispensable in the manufacture of fine chemical products. Such as the preparation of high-end coatings, dyes, etc. Adding this compound can optimize product properties, such as enhancing the adhesion and durability of coatings, enhancing the color brightness and light resistance of dyes. In the chemical synthesis path, it participates in various chemical reactions by virtue of its unique chemical properties, laying the foundation for the manufacture of high-quality fine chemical products. In short, methyl 4-amino-3-fluorobenzoate is of great value in many fields and plays a key role in promoting technological progress and product innovation in various fields.
    What are the synthetic methods of Methyl 4-Amino-3-Fluorobenzenecarboxylate?
    There are many ways to synthesize methyl 4-amino-3-fluorobenzoate. One can start from 4-nitro-3-fluorobenzoic acid. First, an appropriate alcohol, such as methanol, is used with 4-nitro-3-fluorobenzoic acid under the catalysis of acid. The acid used can be sulfuric acid or the like. This reaction needs to be heated to promote its formation, so that the two can be condensed to obtain methyl 4-nitro-3-fluorobenzoate. Then, with a suitable reducing agent, such as iron and hydrochloric acid, or hydrogen under the catalysis of palladium carbon, the nitro group is reduced to an amino group to obtain methyl 4-amino-3-fluorobenzoate.
    Or start with methyl 3-fluoro-4-halobenzoate. If the halogen atom is chlorine or bromine, the Ullmann reaction or the like can be used to use copper powder as a catalyst to co-heat with ammonia or other amination reagents, so that the halogen atom is replaced by an amino group, and then the target product can be obtained.
    Furthermore, 3-fluoro-4-methoxybenzoic acid can also be used as the starting material. The methoxy group is first removed by an appropriate method to obtain 3-fluoro-4-hydroxybenzoic acid, and then esterified to obtain methyl 3-fluoro-4-hydroxybenzoate. Subsequently, halogen atoms are introduced by diazotization and Sandmeier reaction, and then methyl 4-amino-3-fluorobenzoate can also be obtained by amination reaction. These methods have their own advantages and disadvantages, and need to be carefully selected according to the actual raw material availability, reaction conditions and product purity.
    Methyl 4-Amino-3-Fluorobenzenecarboxylate what to pay attention to when storing
    Methyl 4-amino-3-fluorobenzoate is an organic compound, and many key points need to be paid attention to when storing.
    First, it should be placed in a cool place. This compound is prone to chemical changes when heated, or causes adverse conditions such as decomposition. If the storage environment temperature is too high, it will be like frying in a hot fire, and the molecular structure may be damaged, which will affect its quality and utility. A cool place, like a quiet corner, can keep the compound safe.
    Second, it needs to be kept dry. Because of its hygroscopicity, it will deteriorate in contact with water or high humidity environment, or react with water. Just like in a humid area, items are prone to moisture and mildew, methyl 4-amino-3-fluorobenzoate will also change its characteristics due to the intrusion of water, so a dry environment is necessary for its storage.
    Third, keep away from fire sources and oxidants. This compound is flammable, and it is very likely to cause combustion or even explosion in case of open flame, hot topic or strong oxidant. Just like dry wood in case of fire, the consequences are unimaginable. Therefore, the storage place must be free of fire sources and cannot be mixed with oxidants to ensure safety.
    Fourth, it should be sealed and stored. Prevent it from evaporating and escaping, avoid excessive contact with the air, and prevent oxidation by components such as oxygen in the air, so as to maintain its chemical stability. It is like wearing a sealing armor to protect it from external interference.
    Fifth, the storage container needs to be adapted. Corrosive-resistant materials should be used to avoid reaction with the container, thereby ensuring that the purity and quality of the compound are not affected. Just like choosing a suitable residence for it to be stored safely.
    What is the market outlook for Methyl 4-Amino-3-Fluorobenzenecarboxylate?
    The market prospect of methyl 4-amino-3-fluorobenzoate in the field of chemical industry is quite promising.
    From the perspective of pharmaceutical and chemical industry, today's pharmaceutical research and development is changing with each passing day, and the creation of many new drugs requires organic compounds with special structures. The unique structure of methyl 4-amino-3-fluorobenzoate may make it a key intermediate for the synthesis of specific drugs. For example, in the synthesis path of some targeted anti-cancer drugs, the amino groups, fluorine atoms and ester groups in the structure can all construct active molecules that specifically bind to cancer cell targets through delicate organic reactions, which brings new opportunities for the research and development of anti-cancer drugs. Therefore, in the pharmaceutical research and development market, its demand is expected to rise.
    In the field of materials science, with the vigorous development of high-tech industries, the pursuit of high-performance materials is never-ending. The introduction of fluorine atoms may endow the material with unique properties, such as enhancing the corrosion resistance of the material and changing its optical properties. For example, when preparing special optical coating materials, it can participate in the polymerization reaction as a functional monomer, thereby improving the optical stability and durability of the coating. Therefore, in the field of material research and development and production, methyl methyl 4-amino-3-fluorobenzoate also has emerging opportunities, and the market prospect should not be underestimated.
    However, its market development is not smooth sailing. On the one hand, the process of synthesizing this compound may be complicated and costly, which limits its large-scale production and wide application. On the other hand, the market competition is also quite fierce, and many chemical companies are coveting this field and competing to develop related products. However, if we can refine the synthesis process, reduce production costs, and improve product quality, we will be able to occupy a place in the market and enjoy the benefits of a broad market prospect.