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Methyl 3-Fluoro-4-Nitrobenzenecarboxylate

Methyl 3-Fluoro-4-Nitrobenzenecarboxylate

Hongda Chemical

    Specifications

    HS Code

    237773

    Chemical Formula C8H6FNO4
    Molar Mass 199.14 g/mol
    Appearance Solid
    Physical State At Room Temp Solid
    Solubility In Water Insoluble
    Solubility In Organic Solvents Soluble in common organic solvents

    As an accredited Methyl 3-Fluoro-4-Nitrobenzenecarboxylate factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing 100g of Methyl 3 - fluoro - 4 - nitrobenzenecarboxylate in a sealed, labeled chemical container.
    Storage Methyl 3 - fluoro - 4 - nitrobenzenecarboxylate should be stored in a cool, dry, well - ventilated area, away from heat sources and open flames as it may be flammable. Keep it in a tightly sealed container to prevent exposure to air and moisture, which could potentially degrade the chemical. Store it separately from incompatible substances, like oxidizing agents and reducing agents, to avoid dangerous reactions.
    Shipping Methyl 3 - fluoro - 4 - nitrobenzenecarboxylate is shipped in accordance with strict chemical regulations. It's packaged securely in suitable containers to prevent leakage, and transported with care to ensure safety during transit.
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    Methyl 3-Fluoro-4-Nitrobenzenecarboxylate Methyl 3-Fluoro-4-Nitrobenzenecarboxylate
    General Information
    Historical Development
    Methyl 3 - Fluoro - 4 - Nitrobenzenecarboxylate this thing, its beginning is also, and the sages have observed its nature and studied its system between the end of the micro. In the past, the Fang skill was not refined, and the road to search was full of thorns, but those who aspire were not afraid, and they studied unremitting for many years.
    At the beginning, the production method was complicated, and the obtained was impure, and the cost was huge and the effect was minimal. Later generations of researchers have continued the past and opened up, and on top of the ancient method, the old and new. Or change its potions, or change its utensils, or change its timing. After years of work, the production method is gradually improved, the yield is increasing, and the purity is higher.
    Looking at the course of its development, it is the hard work of all researchers, but they are determined to have the excellent preparation of this thing today, which is used by future generations and has become one of the great views of chemistry.
    Product Overview
    "Description of Methyl 3-Fluoro-4-Nitrobenzoate"
    Fukmethyl 3-fluoro-4-nitrobenzoate, also an organic compound. Its shape or crystalline body, color or light state. This substance has specific physical and chemical properties, and its melting point and boiling point are inherent. In the field of chemistry, its use is quite important. It can be used as a key intermediate for the synthesis of many complex organic molecules. With the characteristics of fluorine, nitro and ester groups in its structure, it can participate in a variety of chemical reactions.
    The method of synthesis is often obtained from specific raw materials through multiple reactions. First, fluorine atoms are introduced into the benzene ring, followed by nitro groups, and finally esters are formed. Each step requires precise control of the reaction conditions, such as temperature, pressure, and catalyst dosage, to obtain high-purity products. It has potential applications in medicine, materials science, and other fields, and may provide assistance for the development of new drugs and the creation of special materials.
    Physical & Chemical Properties
    Methyl 3 - Fluoro - 4 - Nitrobenzenecarboxylate is also an organic compound. Its physical properties, at room temperature, are mostly solid, white or nearly white, if crystalline, slightly brittle. Its melting point is specific, which is a sign of identification. As for chemical properties, fluorine, nitro and carboxyl ester groups in the molecule make it have unique reactivity. Fluorine atoms are electronegative, which affects the distribution of electron clouds in molecules; nitro is a strong electron-absorbing group, which reduces the electron cloud density of benzene rings and is easy to lead to nucleophilic substitution reactions. Carboxyl ester groups can also participate in hydrolysis, alcoholysis and other reactions. In the field of organic synthesis, this compound is often a key intermediate for the construction of complex organic molecules due to its physical and chemical properties, assisting in chemical exploration and material creation.
    Technical Specifications & Labeling
    Today there is a thing called Methyl 3 - Fluoro - 4 - Nitrobenzenecarboxylate. The preparation of its technique requires fine rules. The selection of materials must be based on pure quality, and the proportion should be weighed, and it should be accurate. In the reactor, control its temperature and duration, so that all things are properly phased.
    In view of its quality, there are also guidelines. Looking at its color, it should be pure and free of impurities; measuring its degree, it should be in line with the established standard. The amount of impurities must be tiny. In this way, you can get a good product. This technical specification and identification (product parameters), related to the quality of this product, the preparation should be careful and not slack, in order to obtain a suitable Methyl 3 - Fluoro - 4 - Nitrobenzenecarboxylate.
    Preparation Method
    The method of making methyl 3-fluoro-4-nitrobenzoate is the first raw material and production process. The raw materials are selected as pure fluorobenzene, nitric acid, sulfuric acid and methanol. First, fluorobenzene and mixed acid (nitric acid and sulfuric acid in an appropriate proportion) are co-placed in a reactor, and the temperature is controlled in a specific range. This is the nitrification reaction step. After the reaction is completed, the impurities are removed by washing with water and alkali washing. Then the obtained product is reacted with methanol under the action of a catalyst at a suitable temperature and pressure to obtain the target product.
    In this preparation process, the control of the reaction conditions is the key. If the temperature is too high, it is easy to cause side reactions and the product is impure; if it is too low, the reaction is slow and takes a long time. And the proportion of each raw material also needs to be precisely prepared to make the reaction efficient. In addition, the impurity removal operation in the post-treatment stage is related to the purity of the product and cannot be ignored. In this way, following this rigorous preparation method, a relatively pure methyl 3-fluoro-4-nitrobenzoate can be obtained.
    Chemical Reactions & Modifications
    Recently, Methyl 3-Fluoro-4-nitrobenzoate (Methyl 3-Fluoro-4-Nitrobenzenecarboxylate) was studied. The way of its chemical reaction and modification is my special research.
    In the past experiments, the initial chemical reaction, the conditions are slightly harsh, and the yield is not optimal. Although the conventional method is followed, the reaction rate is slow and impurities are plentiful. In order to improve, I thought about changing its path.
    Try to make the catalyst easier to observe its effect. After various selections, a new type of catalytic product can be obtained, which can greatly increase the chemical reaction rate and the yield is also significantly increased. It also adjusts the temperature and pressure of the reaction to optimize the ratio of the material.
    On top of the modification, focus on the fine-tuning of its structure. Introduce specific groups to improve its physical and chemical properties. After this research, methyl 3-fluoro-4-nitrobenzoate has achieved considerable changes in the chemical reaction and physical properties, paving the way for subsequent applications.
    Synonyms & Product Names
    Today there is a thing called Methyl 3 - Fluoro - 4 - Nitrobenzenecarboxylate. This is a chemical product, and it also has various nicknames and commodity names in the industry. Although its names are different, they all refer to this thing.
    The chemical product, the naming method, either according to its structure or according to its characteristics. This Methyl 3 - Fluoro - 4 - Nitrobenzenecarboxylate, as can be known from its name, has fluorine, nitro and other groups, and has the structure of methyl ester. Due to the difference in use, origin, and R & D sequence, people have different names. All nicknames and commodity names are for the convenience of industry communication and identification of this product. When studying this substance, chemists need to understand what each name refers to, so as not to confuse it, so as to facilitate the development of experiments and the exchange of results. This is important for both chemical research and industrial applications.
    Safety & Operational Standards
    Code for safety and operation of methyl 3-fluoro-4-nitrobenzoate
    Fukmethyl 3-fluoro-4-nitrobenzoate is also a chemical research material. Its nature is related to safety, and it must be operated in accordance with regulations. This is an important matter that cannot be ignored.
    Look at its safety principle and store it first. It should be placed in a cool, dry and ventilated place, away from fires and heat sources. This is because the material may be in danger of explosion, and it may be unpredictable in case of fire. And it must be stored separately from oxidizing agents, reducing agents, acids, bases, etc., and must not be mixed with each other to prevent interaction and emergency.
    As for the operation, it is necessary to wear suitable protective gear. Operators should wear protective gloves to avoid skin contact and invasion; wear protective clothing to protect their bodies; wear protective glasses to keep their eyes safe. Operating in a well-ventilated environment, if conditions permit, it is advisable to set up a local exhaust device to quickly expel harmful gases and prevent their accumulation.
    Furthermore, during the use of the process, the action must be gentle to prevent its leakage. In case of leakage, take emergency measures as soon as possible. Cut off the fire source first to avoid fire. Small leaks can be absorbed by inert materials such as sand and vermiculite, and put into a closed container for proper disposal. If there is a large amount of leakage, the embankment should be blocked, and the pump should be transferred to a special collector for recycling or transported to a waste treatment site for disposal.
    In addition, the experimental record should not be taken lightly. Each step of operation, dosage, reaction conditions, etc. must be recorded in detail for inspection and future analysis.
    In short, the safety and operation standards of methyl 3-fluoro-4-nitrobenzoate are related to the safety of the researcher and the success or failure of the experiment. We should keep it in mind and act carefully to ensure that everything goes smoothly and is safe.
    Application Area
    Today there is a thing called Methyl 3 - Fluoro - 4 - Nitrobenzenecarboxylate. This compound has its uses in many fields.
    In the field of pharmaceutical research and development, because of its unique chemical structure, it may be the foundation for the creation of new drugs. It can be used as a key intermediate to help synthesize molecules with specific biological activities, which is expected to fight difficult diseases and bring good news to patients.
    In the field of materials science, it also has potential. With appropriate modification, it may endow materials with special optical and electrical properties. For example, the preparation of functional coating materials can improve the corrosion resistance and wear resistance of materials, and is widely used in aerospace, automobile manufacturing and other industries to ensure long-term stable operation of equipment.
    It can be seen that Methyl 3 - Fluoro - 4 - Nitrobenzenecarboxylate in the application fields of medicine and materials, with broad prospects, and is an important object of scientific research and exploration.
    Research & Development
    In modern times, chemistry has flourished, and new products have emerged in large numbers. Today, Methyl 3 - Fluoro - 4 - Nitrobenzenecarboxylate this product, and our generation has been working hard on it for a long time.
    At the beginning, to obtain this compound, the road to synthesis is full of thorns. The choice of raw materials, the degree of proportions, and the temperature of the reaction all need to be carefully considered. After several years of repeated tests, or because the conditions are not consistent, the product is impure; or due to reaction blockade, the harvest is very limited. However, we have not dared to slack off, adhering to our tenacity, and studying the truth.
    Today, the synthesis method is gradually maturing, and the yield has also improved. However, there are still improvements, such as the reduction of energy consumption and the simplicity of the process, which are all the directions for our generation to study in the future. We should work hard to move forward, hoping that this product will shine in the fields of medicine and materials, and contribute to the development of chemistry, so as to reach a new realm and live up to the research.
    Toxicity Research
    Today there is a product called "Methyl 3 - Fluoro - 4 - Nitrobenzenecarboxylate", and our main purpose is to study its toxicity. This product has a unique position among chemical substances. Toxicity research is crucial, related to the safety of use and human health.
    After many experiments, its toxicity characterization is gradually becoming clear. In biological organisms, it may disturb their normal metabolism and disrupt their physiological functions. However, to know the details, more research is needed. The methods used in the experiment all follow the rules of science and strive to be accurate.
    Although what we have obtained today is only the tip of the iceberg, our chemists will make unremitting efforts to explore its toxicity mechanism and provide solid evidence for the proper use and safe disposal of this substance in the future, so as to ensure the well-being of everyone and the safety of the environment.
    Future Prospects
    I have dedicated myself to the research of methyl 3-fluoro-4-nitrobenzoate, knowing that it has great potential in the future. Looking at this compound today, its structure is exquisite, its properties are unique, and it may emerge in the field of medicine. In time, with in-depth research, new specific drugs may be developed to save patients from pain.
    Furthermore, in the field of materials science, methyl 3-fluoro-4-nitrobenzoate may become a key raw material for the construction of high-performance materials. With clever design and synthesis, it is expected to produce new materials with excellent performance, bringing innovation opportunities to the construction, electronics and other industries.
    Although the future is full of thorns, I firmly believe that by upholding the spirit of research and unremitting exploration, we will be able to explore more potential of methyl 3-fluoro-4-nitrobenzoate, bloom its bright light, and contribute to human well-being.
    Where to Buy Methyl 3-Fluoro-4-Nitrobenzenecarboxylate in China?
    As a trusted Methyl 3-Fluoro-4-Nitrobenzenecarboxylate manufacturer, we deliver: Factory-Direct Value: Competitive pricing with no middleman markups, tailored for bulk orders and project-scale requirements. Technical Excellence: Precision-engineered solutions backed by R&D expertise, from formulation to end-to-end delivery. Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
    Frequently Asked Questions

    As a leading Methyl 3-Fluoro-4-Nitrobenzenecarboxylate supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

    What is Methyl 3-Fluoro-4-Nitrobenzenecarboxylate?
    Methyl 3-fluoro-4-nitrobenzoate, an important intermediate in organic synthesis. In the field of medicinal chemistry, its use is crucial. The construction of many drug molecules often relies on its participation in reactions. Because its structure contains fluorine atoms, nitro groups and ester groups, these functional groups give it unique chemical activities.
    In the process of drug development, chemists can prepare derivatives with specific pharmacological activities by making various chemical modifications to the compound. For example, by adjusting the substituent group, the lipid solubility of the drug and the affinity with the target can be changed, thereby improving the efficacy or reducing side effects.
    In the field of materials science, methyl 3-fluoro-4-nitrobenzoate is also used. Due to its structural properties, it can be used as a starting material for the synthesis of special functional materials. With the help of appropriate reactions, it is introduced into polymers or other material systems to impart specific optical, electrical or thermal properties to the material.
    In addition, in the fine chemical industry, this compound can be used to prepare high-end coatings, pigments and other products. Using its chemical activity, it can synthesize additives with special properties to improve product quality and performance. Overall, although methyl 3-fluoro-4-nitrobenzoate is an organic small molecule, it plays an indispensable role in many fields and promotes the development and progress of related industries.
    What are the synthetic methods of Methyl 3-Fluoro-4-Nitrobenzenecarboxylate?
    The method of making methyl 3-fluoro-4-nitrobenzoate often follows several paths. First, the esterification reaction is carried out with 3-fluoro-4-nitrobenzoic acid and methanol as raw materials, and acid is added as a catalyst. Among them, sulfuric acid, p-toluenesulfonic acid, etc. can be used as catalysts. During the reaction, the two are placed in a suitable container, the catalyst is added, and the reflux is heated. After some time, the reaction is completed, and the pure product is obtained by conventional separation methods, such as extraction, distillation, recrystallization, etc.
    Second, 3-fluoro-4-nitrobenzoyl chloride and methanol are used as the starting materials. This reaction is easier to carry out than the former, because the activity of acid chloride is higher than that of carboxylic acid. 3-Fluoro-4-nitrobenzoyl chloride is slowed into methanol, or acid binding agents such as pyridine and triethylamine are present to remove the hydrogen chloride generated by the reaction. The reaction is mild, and after completion, the product can also be obtained after separation and purification.
    Furthermore, the reaction of 3-fluoro-4-nitrobenzoic anhydride with methanol can also be prepared. Under appropriate conditions, the anhydride bond of benzoic anhydride and methanol breaks and forms an ester with methanol. This approach requires attention to the control of reaction conditions to achieve optimal yield and purity.
    All these methods have advantages and disadvantages. The availability of raw materials, the level of cost, the difficulty of reaction conditions, the purity and yield of the product are all factors to be considered. Experimenters should choose the optimal method to prepare methyl 3-fluoro-4-nitrobenzoate according to the actual situation.
    What are the physical properties of Methyl 3-Fluoro-4-Nitrobenzenecarboxylate?
    Methyl 3-fluoro-4-nitrobenzoate is one of the organic compounds. Its physical properties are quite impressive.
    Under normal temperature and pressure, it is usually a solid state, mostly white to light yellow crystalline powder. This state is easy to store and transport, because it is relatively stable and not easy to deteriorate due to conventional environmental factors.
    When it comes to the melting point, the melting point of this compound is about a specific range, which is of great significance for its phase transition under different temperature conditions. The existence of the melting point defines the critical temperature between solid and liquid states. When the temperature rises near the melting point, the solid state structure gradually disintegrates, and the intermolecular forces change, and then it converts into a liquid state. This property can be used as a key parameter in many chemical processes and experimental operations for separation, purification and other steps.
    The boiling point is also an important physical property. The boiling point characterizes the temperature conditions required for the compound to transform from liquid to gaseous state. When the boiling point is reached, a large number of bubbles form and escape inside the liquid, and the phase state of the substance undergoes major changes. By knowing the boiling point, the temperature can be precisely controlled during distillation, rectification, etc., to achieve effective separation from other substances.
    In terms of solubility, methyl 3-fluoro-4-nitrobenzoate exhibits a certain solubility in common organic solvents, such as some aromatic hydrocarbons and halogenated hydrocarbon solvents. This property is of great significance in organic synthesis reactions. As a reaction medium, a solvent needs to be able to effectively dissolve the reactants in order to promote sufficient contact and collision between molecules, and then promote the smooth progress of the reaction. At the same time, solubility also affects the separation and purification of the product. Reasonable selection of solvents can achieve efficient separation according to the difference in solubility of the product and impurities.
    Density is also one of its physical properties. Density reflects the mass of the substance per unit volume, which is helpful for material accounting in actual operation. For example, when preparing a certain amount of product, the volume of the required raw material can be accurately measured according to the density to ensure that the reaction is carried out in the expected proportion, improving the reaction efficiency and product quality.
    In addition, the stability of the compound is affected to a certain extent by physical properties. In the solid state, the molecules are arranged tightly and orderly, and the chemical activity is relatively low. However, in the liquid state or after being dissolved in a specific solvent, the molecular movement intensifies and it may be more likely to participate in chemical reactions. Therefore, understanding its physical properties is essential to control the reaction conditions and ensure the safety and stability of the experiment and production process.
    What are the chemical properties of Methyl 3-Fluoro-4-Nitrobenzenecarboxylate?
    Methyl 3-fluoro-4-nitrobenzoate, this is an organic compound with unique chemical properties. Its structure is based on the skeleton of benzoate, and the methyl group is connected to the carboxyl group to form an ester bond. There are fluorine atoms at the 3rd position and nitro substitutions at the 4th position on the benzene ring.
    First of all, its physical properties are usually solid or liquid, depending on specific conditions. Its melting point and boiling point are affected by intermolecular forces. The molecular polarity is enhanced by the presence of fluorine and nitro groups, causing the intermolecular forces to increase. The melting boiling point is higher than that of similar structures but there is no such polar group.
    In terms of chemical properties, ester groups have hydrolytic properties. Under acidic conditions, the hydrolysis into 3-fluoro-4-nitrobenzoic acid and methanol is reversible and adjusted according to the conditions when it reaches equilibrium; under alkaline conditions, the hydrolysis is easier to form 3-fluoro-4-nitrobenzoate and methanol, and the reaction is more complete.
    Nitro groups on the benzene ring reduce the electron cloud density of the benzene ring, with electron-absorbing induction and conjugation effects, resulting in a decrease in the electrophilic substitution activity of the benzene ring, especially in the ortho-para position. Although fluorine atoms are highly electronegative and have electron-absorbing induction effects, due to the conjugation effect between the p-orbital and the large π bond of the benzene ring, the effect on the electron cloud density of the benzene ring is complex. Overall, the effect on the electrophilic substitution activity of
    Nitro groups can be reduced. Commonly used reducing agents such as iron and hydrochloric acid, catalytic hydrogenation, etc., can gradually reduce nitro groups to amino groups to obtain 3-fluoro-4-aminobenzoate. This product is an important intermediate in organic synthesis and can participate in a variety of reactions, such as reacting with acyl chloride to form amides.
    Ester groups can undergo ester exchange reaction with alcohols. Under the catalysis of acids or bases, they can exchange alkoxy groups with another alcohol to form new esters and original alcohols. This reaction can be used to synthesize ester compounds with specific structures. In summary, methyl 3-fluoro-4-nitrobenzoate has various reaction properties and application potential in the field of organic synthesis due to its unique structure.
    What is the price of Methyl 3-Fluoro-4-Nitrobenzenecarboxylate in the market?
    The price of methyl 3-fluoro-4-nitrobenzoate in the market is difficult to determine. Its price often changes due to many reasons, such as the quality of the quality, the state of supply and demand, the method of production, and the market domain.
    First discuss the quality of the quality. If the product is pure and free of impurities, the price will be higher; if it contains impurities and the quality is inferior, the price will be lower. This is common sense. If the quality is good, it will be used widely. If there are many seekers, the price will be high.
    The state of supply and demand is also important. If there are many seekers in the market, and the supply is scarce, the supply is in a state of shortage, and the price will inevitably rise; on the contrary, if the supply exceeds the demand, the merchant will sell his goods at a lower price.
    The method of making the system also affects its price. If the method of making the system is difficult, it requires more financial, human and material resources, the cost is high, and the price is also high; if the method of making the system is simple, the cost will drop, and the price will also drop.
    Furthermore, the city is different, and the price is also different. In prosperous places, it is necessary to use more, and the transaction cost may be high, and the price may be expensive; in remote places, the demand is small, and the price may be low.
    In the past, the price of methyl 3-fluoro-4-nitrobenzoate fluctuates every time, either due to changes in raw material prices or changes in market conditions. If you want to know the current price, you should consult the chemical material merchant or visit the relevant trading platform to get a close price.