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Methyl 2-Fluoro-4-Nitrobenzenecarboxylate

Methyl 2-Fluoro-4-Nitrobenzenecarboxylate

Hongda Chemical

    Specifications

    HS Code

    858030

    Chemical Formula C8H6FNO4
    Molar Mass 199.14 g/mol
    Appearance Solid (usually a pale - colored solid)
    Melting Point Data may vary, but typically in a certain temperature range e.g. around 60 - 80°C (approximate)
    Boiling Point Data may vary, but would be relatively high due to its structure
    Solubility In Water Low solubility in water as it is an organic compound with non - polar and polar groups in a balance that disfavors water solubility
    Solubility In Organic Solvents Soluble in common organic solvents like dichloromethane, chloroform, ethyl acetate
    Density Data may vary, but around 1.4 - 1.6 g/cm³ (approximate)
    Flash Point Data may vary, but a flammable organic compound with a flash point relevant to its combustibility
    Vapor Pressure Low vapor pressure as it is a solid at room temperature and has relatively strong intermolecular forces

    As an accredited Methyl 2-Fluoro-4-Nitrobenzenecarboxylate factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing 100g of Methyl 2 - fluoro - 4 - nitrobenzenecarboxylate packaged in a sealed plastic bottle.
    Storage Methyl 2 - fluoro - 4 - nitrobenzenecarboxylate should be stored in a cool, dry, well - ventilated area. Keep it away from heat sources, open flames, and incompatible substances like strong oxidizers and reducing agents. Store in a tightly - sealed container to prevent moisture absorption and potential leakage, ensuring its stability and minimizing risks.
    Shipping Methyl 2 - fluoro - 4 - nitrobenzenecarboxylate, a chemical, is shipped in accordance with strict hazardous material regulations. It's carefully packaged to prevent leakage, transported by approved carriers with proper safety documentation.
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    Methyl 2-Fluoro-4-Nitrobenzenecarboxylate Methyl 2-Fluoro-4-Nitrobenzenecarboxylate
    General Information
    Historical Development
    I have heard of methyl 2-fluoro-4-nitrobenzoate, which originated from the research of Western chemistry. In the past, Western wise men studied the principles of chemistry and the properties of poor substances. At the beginning, I had not heard of this product, but after many experiments, I used various tricks and combined its molecules to form this new thing.
    At the beginning, the wise men explored the secrets of chemistry, mixed with drugs, adjusted its temperature, and controlled the time. Although there were many mistakes, they made unremitting efforts. After years have passed, the method of making this methyl 2-fluoro-4-nitrobenzoate has been obtained.
    Since then, it has gradually shown its ability in the fields of medicine and materials. Based on it, people have developed new techniques and promoted the progress of chemistry. This product has become an essential item for chemical research and is used in this world, becoming increasingly widespread.
    Product Overview
    Today there is a product called Methyl 2 - Fluoro - 4 - Nitrobenzenecarboxylate. This is a key product in organic synthesis, and has extraordinary uses in many fields such as medicine and materials. It is crystalline, light yellow in color, and has unique physical and chemical properties.
    Synthesis of this product requires a multi-step and delicate reaction. First, a specific benzene derivative is used as the starting material, and fluorine and nitro functional groups are precisely introduced by clever fluorination and nitrification techniques. After esterification, this product is finally obtained. During the reaction, temperature, pressure and the ratio of reactants need to be strictly controlled to maintain its yield and purity.
    This product has a delicate structure. The introduction of fluorine atoms changes its electron cloud distribution and increases its chemical activity. The presence of nitro groups adds to the diversity of its reactions. Methyl ester groups give it specific solubility and reaction check points. With such a unique structure, Methyl 2 - Fluoro - 4 - Nitrobenzenecarboxylate can play an indispensable role in various synthetic pathways, which is a treasure of chemical research and industrial production.
    Physical & Chemical Properties
    There is a substance today called "Methyl 2 - Fluoro - 4 - Nitrobenzenecarboxylate". Its physical properties are either solid at room temperature, white or white, like powder, smelling it, and odor is very small. Moderate density, placed in water, insoluble, but soluble in specific organic solvents, such as ethanol and ether.
    In terms of its chemical properties, it is quite active due to its fluorine content, nitro and ester groups. Nitro has strong oxidizing properties, and may react violently when exposed to reducing agents. Ester groups are hydrolyzed in acid-base environments, which are easy to hydrolyze. Under acidic conditions, hydrolysis is slow; when alkaline, hydrolysis is rapid. The presence of fluorine atoms changes the density of the electron cloud of the benzene ring, which affects its electrophilic substitution reaction activity. This substance is widely used in the field of chemical synthesis and can be a key intermediate in many organic synthesis.
    Technical Specifications & Labeling
    Today there is a product called Methyl 2 - Fluoro - 4 - Nitrobenzenecarboxylate. It is very important to study the process specification and identification (product parameters).
    The process specification of this product needs to follow the precise process. Since the selection of raw materials, it is necessary to be pure and free of impurities, which meets specific standards. The reaction conditions, such as temperature, pressure, duration, etc., need to be carefully controlled. High or low temperature, unstable pressure, can lead to impure products or poor yield.
    As for the identification (product parameters), it should be recorded in detail. If the proportion of ingredients, it should be accurate to the decimal place. Appearance properties must be clearly described, and color and state cannot be omitted. In addition, parameters such as purity and stability must also be clearly marked for user inspection to ensure that they are properly applied in various fields and achieve the expected effect. Process specifications and identification (product parameters) complement each other and are the basis for the quality of the product.
    Preparation Method
    The method of preparing methyl 2-fluoro-4-nitrobenzoate is related to the raw materials and production process, reaction steps and catalytic mechanism.
    First take an appropriate amount of 2-fluorobenzoic acid as raw material, use sulfuric acid as a catalyst, and place it in a reaction kettle with methanol. The temperature is controlled in a moderate range, about 60 to 80 degrees Celsius, which is an esterification reaction. During this time, the acid and alcohol are catalyzed to form methyl 2-fluorobenzoate.
    Then, methyl 2-fluorobenzoate and mixed acid (nitric acid and sulfuric acid in a specific ratio) are slowly mixed at low temperature, about 0 to 10 degrees Celsius, to initiate a nitrification reaction. After this step, methyl 2-fluoro-4-nitrobenzoate can be obtained. After the reaction is completed, the pure product is obtained by separation and purification. The whole process, the ratio of raw materials, temperature control, and reaction time are all key, which are related to the purity and yield of the product.
    Chemical Reactions & Modifications
    Today's scholars of chemistry, explore Methyl 2 - Fluoro - 4 - Nitrobenzenecarboxylate this thing. Its transformation and change are the focus of our research. Looking at the response of this compound, there may be some inconveniences of the old method, so we think about changing it. The method of the past, in terms of yield, purity, etc., may not be perfect.
    We should find a new way to change it. Such as adjusting the temperature and pressure of the reaction, and choosing a catalyst, hoping to promote the speed of the reaction and increase the quantity of the product. Or explore a new way to respond, avoid difficult steps, and simplify the process of making it. And consider the environment of the response, seeking green and clean methods. In this way, we hope to be able to adapt and change Methyl 2 - Fluoro - 4 - Nitrobenzenecarboxylate, and get better results, which is beneficial to the field of various uses.
    Synonyms & Product Names
    Today there is a thing called Methyl 2 - Fluoro - 4 - Nitrobenzenecarboxylate. In the field of chemical industry, there are many names. Or according to its nature, or according to its use, each has its own name.
    The name of this thing's chemistry is established, but there are also many commercial names in the market. Chemical industries, depending on their needs, have different names. The thing shown by this name has a wide range of uses in the art of synthesis. Its isomers, or similarities, are also important for chemical research.
    To understand this thing, it is necessary to investigate its nature and study its name carefully. The name of the same division reveals the secret of the structure; the name of the commodity is related to the practical road. Compared with the two, although the names are different, they are both Methyl 2 - Fluoro - 4 - Nitrobenzenecarboxylate. In the study of chemistry, clear names can explore its essence and know its function, so as to benefit the progress of chemical industry and the rise of science and technology.
    Safety & Operational Standards
    About 2-fluoro-4-nitrobenzoate methyl ester product safety and operating specifications
    Fu 2-fluoro-4-nitrobenzoate methyl ester is also a common product in the chemical industry. Its properties are special, related to safety and operating standards, and must not be ignored.
    At the safe end, this substance has certain dangers. Contact with skin or cause irritation, if it is not careful into the eyes, it is especially harmful. Rinse with plenty of water as soon as possible and seek medical treatment. Its volatile gas and inhalation are also harmful to health, so the place of operation must be well ventilated to prevent gas accumulation. When storing, it should be placed in a cool, dry and ventilated place, away from fire and heat sources, to prevent accidents.
    When it comes to operating specifications, first and foremost, the operator should be familiar with the properties of this object and how to deal with it. In the operation room, appropriate protective equipment, such as protective clothing, gloves and goggles, must be worn to ensure your own safety. When taking it, the action should be steady and accurate to avoid spilling. If there is any spill, clean it up quickly according to the established method, and do not spread it.
    During reaction operation, strictly control the temperature, time and material ratio. This is all about the success or failure of the reaction and safety. The experimental equipment must be clean and dry before use to prevent impurities from affecting the reaction. After operation, properly dispose of the remaining materials and waste, and do not discard them at will according to environmental protection regulations.
    In short, the safety and operation specifications of methyl 2-fluoro-4-nitrobenzoate are for chemical industry, and they should be kept in mind and carried out with caution to ensure the smooth production and the safety of personnel.
    Application Area
    Methyl 2-fluoro-4-nitrobenzoate, this substance is widely used in the field of organic synthesis. It can be used as a key intermediate to create a variety of bioactive compounds.
    In pharmaceutical research and development, it can be used to synthesize drug molecules with specific structures, or it can exhibit antibacterial, anti-inflammatory and other drug effects, and seek well-being for human health. In the field of pesticides, the construction of new pesticide ingredients through it is expected to enhance the prevention and control efficiency of pests and pathogens, and protect the growth of crops.
    And because of its fluorine and nitro functional groups, it endows the product with unique physical and chemical properties, which can optimize material properties. For example, it is used to prepare polymer materials with special functions to improve their stability and heat resistance. From this point of view, methyl 2-fluoro-4-nitrobenzoate has important value and broad prospects in various application fields.
    Research & Development
    There is a compound called Methyl 2 - Fluoro - 4 - Nitrobenzenecarboxylate. We take research and development as our business to explore the mystery of this compound.
    Observe its structure, fluorine, nitro are connected to benzene ring, which affects its chemical properties. After repeated experiments, its reactivity was observed. Under specific conditions, it interacted with various reagents to obtain different products.
    During the research process, the reaction conditions were carefully measured, and temperature, pressure and catalyst were all key. Under suitable conditions, the purity and yield of the product were considerable. And explore its application in the field of organic synthesis, or it can become a key intermediate for new materials and drug synthesis.
    With continued research, it is expected to expand its application scope, shine in the fields of materials science, medicinal chemistry, etc., promote the research and development of this compound to a new height, and contribute to scientific progress.
    Toxicity Research
    Today, there is a product called Methyl 2 - Fluoro - 4 - Nitrobenzenecarboxylate, which is very critical to our chemical investigation. Our generation has devoted himself to studying its toxicity, which is related to the safety of many fields.
    Detailed investigation of this product, the existence of fluorine and nitro groups in its molecular structure may cause unique toxic effects. After a series of experiments, it was observed that it interacted with biological systems, and the changes in cell morphology and physiological functions were observed.
    Although the conclusions obtained are not complete, they have begun to emerge. Its toxicity may be due to the interference of specific biomolecules, causing metabolic disorders. Follow-up research, when striving for excellence, to clarify the full picture of its toxicity, to provide a solid foundation for application and prevention, to protect the world from its harm, and to move forward steadily in the path of chemistry.
    Future Prospects
    I have a thing now, named Methyl 2 - Fluoro - 4 - Nitrobenzenecarboxylate. Looking at its properties and chemical qualities, it has unique characteristics.
    In the future development, it is expected to be used in various ways. It may be used in medicine to create, assist in the research of new drugs, cure various diseases, and save people's pain. In the field of materials, it can also be a source of new materials, additive properties, and expand its use.
    Our generation of scientific researchers should study it in depth. Explore its mysteries, understand its mechanism, and hope to develop its potential with innovative methods. Make this material shine in the future, be used by the world, benefit the country and the people, and become a career for thousands of years. This is our vision.
    Where to Buy Methyl 2-Fluoro-4-Nitrobenzenecarboxylate in China?
    As a trusted Methyl 2-Fluoro-4-Nitrobenzenecarboxylate manufacturer, we deliver: Factory-Direct Value: Competitive pricing with no middleman markups, tailored for bulk orders and project-scale requirements. Technical Excellence: Precision-engineered solutions backed by R&D expertise, from formulation to end-to-end delivery. Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
    Frequently Asked Questions

    As a leading Methyl 2-Fluoro-4-Nitrobenzenecarboxylate supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

    What are the main uses of Methyl 2-Fluoro-4-Nitrobenzenecarboxylate?
    Methyl 2-fluoro-4-nitrobenzoate has a wide range of uses. In the field of pharmaceutical synthesis, it is often used as a key intermediate. For example, when creating specific antimalarial drugs, with its unique chemical structure, it can undergo a series of delicate chemical reactions to build a core framework of drug activity, laying the foundation for the development of high-efficiency antimalarial drugs. In the field of pesticides, it is also an important synthetic raw material. For example, in the synthesis of a new type of insecticide, the molecular structure it participates in the construction gives the insecticide excellent insecticidal activity and good environmental compatibility, which helps agricultural pest control and improves crop yield and quality. In the field of materials science, methyl 2-fluoro-4-nitrobenzoate also has outstanding performance. Through clever chemical modification and polymerization, polymer materials with special optical and electrical properties can be prepared for the manufacture of advanced optical devices and electronic components, injecting new vitality into the development of materials science. Due to its diverse and important uses, this compound plays a pivotal role in many fields such as chemical industry, medicine, agriculture and materials.
    What are the synthetic methods of Methyl 2-Fluoro-4-Nitrobenzenecarboxylate?
    There are various methods for the synthesis of 2-fluoro-4-nitrobenzoate. One method can start with 2-fluoro-4-nitrobenzoic acid. Take the acid first, place it in a suitable reaction vessel, add an appropriate amount of methanol, and then add a little concentrated sulfuric acid as a catalyst. Then, heat the mixture to make it esterified. Control the temperature within a certain range, usually about 60-80 degrees Celsius, and continue to stir to make the reaction fully proceed. After the reaction is completed, cool it, dilute it with an appropriate amount of water, and then extract it with an organic solvent such as ether. The extraction solution is dried by anhydrous sodium sulfate, distilled under reduced pressure to remove the solvent, and the crude product of methyl 2-fluoro-4-nitrobenzoate can be obtained. Refined by column chromatography or recrystallization, the pure product can be obtained.
    Another method can first prepare 2-fluoro-4-nitrobenzoyl chloride. Take 2-fluoro-4-nitrobenzoic acid, place it in a reaction bottle with thionyl chloride, add a little N, N-dimethylformamide (DMF) as a catalyst. Heat to reflux to convert the acid to acid chloride. After the reaction is completed, the excess sulfoxide chloride is removed by reduced pressure distillation. The resulting 2-fluoro-4-nitrobenzoyl chloride is then reacted with methanol in the presence of a base such as triethylamine. At a low temperature, such as 0-5 degrees Celsius, the acid chloride is dropped into a solution containing methanol and triethylamine, dripped, warmed to room temperature, and continued to stir for a period of time. After the reaction, it is washed with dilute hydrochloric acid, and then dried and distilled to obtain the target product. And these two methods have their own advantages and disadvantages. The former step is relatively simple, but the reaction conditions need to be precisely controlled. Although the latter step is slightly complicated, the yield may be better. The synthesizer should use it according to the actual situation.
    What are the physical properties of Methyl 2-Fluoro-4-Nitrobenzenecarboxylate?
    Methyl 2-fluoro-4-nitrobenzoate is an important compound in organic chemistry. Its physical properties are unique and it has important uses in chemical, pharmaceutical and other fields.
    Looking at its properties, at room temperature, it is mostly white to light yellow crystalline powder. This form is easy to store and transport, and it is easy to disperse in many reaction systems, which is conducive to chemical reactions.
    When it comes to melting point, it is about a specific temperature range. This property can help identify the purity of the compound. The melting point of pure products is relatively fixed. If it contains impurities, the melting point may change. By accurately measuring the melting point, its quality can be preliminarily judged.
    In terms of solubility, it has good solubility in organic solvents such as ethanol and ether, but very little solubility in water. This characteristic makes it possible to choose a suitable organic solvent to dissolve according to the reaction requirements during organic synthesis to construct a homogeneous reaction system and improve the reaction efficiency.
    Boiling point is also one of its important physical properties. Under a specific pressure, the corresponding boiling point is reached, and the compound changes from liquid to gaseous state. The boiling point data is of great significance for distillation, purification and separation of the compound, and suitable distillation conditions can be set accordingly to obtain high-purity products.
    In addition, the density of this compound is also a specific value. This parameter is crucial when it comes to the conversion of mass and volume, especially in the process of accurate measurement in industrial production. Accurate knowledge of density can ensure accurate feeding amount, thereby ensuring stable product quality.
    The physical properties of this compound are of great significance to its research and application. Whether it is laboratory synthesis or industrial production, it is necessary to master these properties in detail in order to better control the reaction process, optimize product quality, and expand its application in different fields.
    What are the chemical properties of Methyl 2-Fluoro-4-Nitrobenzenecarboxylate?
    Methyl 2-fluoro-4-nitrobenzoate, this is an organic compound. Its chemical properties are unique, let me tell them one by one.
    First of all, its physical properties are usually solid, and the color state may vary depending on the purity. Stable at room temperature and pressure, but under specific conditions, the properties will change.
    When it comes to chemical activity, the reaction is rich because the molecule contains a variety of functional groups. The ester part of the carboxyl group can be hydrolyzed, and it follows different mechanisms in acidic or alkaline environments. Acidic hydrolysis is slow and reversible; basic hydrolysis is rapid and complete, resulting in carboxylate and alcohol.
    The fluorine atom has strong electronegativity, which causes the electron cloud density of the benzene ring to change, which affects the activity and check point of the electrophilic substitution reaction. It decreases the density of the adjacent and para-position electron clouds, and the electrophilic reagents are easy to attack the interposition, which is an important reaction characteristic.
    The nitro group also has strong electron absorption, which works synergistically with the fluorine atom to strengthen the electron cloud migration of the benzene ring. It not only affects the electrophilic substitution, but also makes the benzene ring more sensitive to oxidants. In case of strong oxidants, the benzene ring may be damaged.
    At the same time, this compound can participate in the nucleophilic substitution reaction. Esteryl carbons have certain positive electricity, The chemical properties of methyl 2-fluoro-4-nitrobenzoate are determined by the interaction of its functional groups. In the field of organic synthesis, it has a wide range of uses due to its unique reactivity. It can be used as an intermediate. After various reactions, complex and functional organic compounds can be prepared.
    What is the price range of Methyl 2-Fluoro-4-Nitrobenzenecarboxylate in the market?
    The price range of methyl 2-fluoro-4-nitrobenzoate on the market is difficult to say exactly. This is because the price of this compound is affected by many factors.
    First, purity is the key factor. If the purity is extremely high, it is close to the high purity of scientific research grade, and its price is high. Because the preparation of high-purity compounds is complicated, it needs to be purified many times, and the cost naturally increases. For example, if you want to obtain a product with a purity of more than 99%, the price may be several times different from that of 95% purity.
    Second, market supply and demand also have a great impact. If at a certain time, many chemical companies or scientific research institutions have a sudden increase in demand for methyl 2-fluoro-4-nitrobenzoate, and the supply is limited, the price will rise; on the contrary, if the supply exceeds the demand, the price will decline.
    Third, the preparation cost also affects the price. The price fluctuation of raw materials, the energy source and labor cost of the synthesis process are all related to the final selling price. If raw materials are scarce and expensive, or the synthesis process requires special conditions and expensive reagents, the cost will be high, and the price will also rise.
    In terms of the general range, in the chemical raw material market, the price per kilogram of ordinary industrial-grade purity may range from hundreds to thousands of yuan. If it is high purity for scientific research, the price per gram may reach tens of yuan or even higher. However, this is only a rough estimate, and the actual price should depend on specific market conditions and product characteristics.