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Methyl 2-Bromo-4-Fluorobenzenecarboxylate

Methyl 2-Bromo-4-Fluorobenzenecarboxylate

Hongda Chemical

    Specifications

    HS Code

    457620

    Name Methyl 2-Bromo-4-Fluorobenzenecarboxylate
    Chemical Formula C8H6BrFO2
    Molar Mass 233.03 g/mol
    Appearance Colorless to light yellow liquid
    Boiling Point 238 - 240 °C
    Density 1.597 g/cm³
    Solubility In Water Insoluble
    Solubility In Organic Solvents Soluble in common organic solvents like dichloromethane, chloroform
    Flash Point 101.9 °C
    Purity Typically high - purity commercial products around 95%+
    Cas Number 105979-45-9

    As an accredited Methyl 2-Bromo-4-Fluorobenzenecarboxylate factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing 100g of Methyl 2 - bromo - 4 - fluorobenzenecarboxylate in a sealed glass bottle.
    Storage Methyl 2 - bromo - 4 - fluorobenzenecarboxylate should be stored in a cool, dry, well - ventilated area. Keep it away from heat sources, flames, and oxidizing agents. Store in a tightly sealed container to prevent leakage and exposure to air or moisture, which could potentially cause degradation or reaction. It should be separated from incompatible substances in a dedicated storage space.
    Shipping Methyl 2 - bromo - 4 - fluorobenzenecarboxylate is shipped in well - sealed, corrosion - resistant containers. Special care is taken to ensure compliance with chemical transportation regulations due to its potentially hazardous nature.
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    Methyl 2-Bromo-4-Fluorobenzenecarboxylate Methyl 2-Bromo-4-Fluorobenzenecarboxylate
    General Information
    Historical Development
    The technology of chemical industry is changing with each passing day, and the research of substances has a long history. In today's words, Methyl 2 - Bromo - 4 - Fluorobenzenecarboxylate this product, its research and development process is profound.
    At the beginning, all the sages worked hard in the field of chemistry, exploring new things. With the rise of organic synthesis, everyone studied the change of halogenated aromatics. In order to seek precise structure, after countless attempts. On the compatibility of reagents and the control of conditions, I worked hard. I got this Methyl 2 - Bromo - 4 - Fluorobenzenecarboxylate. Although it was not perfect at the beginning, it has already emerged. Later scholars, following the ambition of previous sages, strive for excellence, optimize the path, and improve the yield. Therefore, this product has gradually developed its use in the fields of chemical industry and medicine, becoming an indispensable material, which can be said to be a brilliant achievement of chemical research.
    Product Overview
    There is a substance called "Methyl 2 - Bromo - 4 - Fluorobenzenecarboxylate". This is an organic compound. In its molecular structure, on the benzene ring, the bromine atom and the fluorine atom are separated in a specific position, and there are methyl formate groups connected.
    This substance is of great significance in the field of organic synthesis. Its bromine atom has high activity, and it can introduce various functional groups through nucleophilic substitution reactions to form a variety of organic molecules. The presence of fluorine atoms can change the physical and chemical properties of molecules, such as enhancing fat solubility and affecting the reactivity.
    Preparation of this compound may require a delicate organic synthesis method. It can only be obtained by selecting suitable starting materials, reacting in multiple steps, and strictly controlling the reaction conditions. The investigation of its properties is also important. Physical properties such as melting point, boiling point, solubility, and reactivity in different chemical environments need to be studied in detail to understand its application prospects in organic synthesis and other fields.
    Physical & Chemical Properties
    Methyl 2 - Bromo - 4 - Fluorobenzenecarboxylate is also an organic compound. Its physical and chemical properties are particularly important. Looking at its shape, it may be a colorless to light yellow liquid under normal circumstances, with a special odor. Its boiling point, melting point and other physical properties are the key to characterizing its characteristics. The boiling point is related to the temperature of its gasification, which is within a certain range, which is related to the intermolecular force. The melting point indicates the transition temperature between its solid state and liquid state, which has a specific value due to the molecular structure.
    In terms of chemical properties, the atoms of bromine and fluorine in this compound give it unique reactivity. Bromine atoms can participate in nucleophilic substitution reactions and are easily attacked by nucleophiles and replaced. Although fluorine atoms have strong electronegativity, they can also initiate specific chemical reactions under suitable conditions, or affect the distribution of electron clouds in molecules, which in turn affects their overall chemical behavior. This is the key to understanding the properties of Methyl 2 - Bromo - 4 - Fluorobenzenecarboxylate.
    Technical Specifications & Labeling
    Today there is something called Methyl 2 - Bromo - 4 - Fluorobenzenecarboxylate. In terms of process specifications and identification (product parameters), it is extremely important.
    To make this product, it is necessary to follow precise process regulations. The selection of materials should be of the highest quality, and the proportions must be accurate. The reaction conditions, such as temperature and pressure, must be strictly controlled. When heating, the heat must be just right to make the reaction proceed smoothly and ensure the purity and quality of the product.
    As for the identification (product parameters), its characteristics, content, impurity limits, etc., should be clearly marked. The character should be detailed in its color and state; the number of contents must be accurate and correct; the limit of impurities should not be ignored, and it must be in line with the established standards. In this way, the process specifications and identification (product parameters) of this product can be improved, and reliable products can be provided to users.
    Preparation Method
    Methyl 2-bromo-4-fluorobenzoate is prepared today, and its raw materials, production process, reaction steps, and catalytic mechanism are the key. First, take an appropriate amount of 2-fluorobenzoic acid, use sulfuric acid as a catalyst, and place it in a round-bottom flask with methanol, heat and reflux, and perform an esterification reaction to obtain methyl 2-fluorobenzoate. In this step, sulfuric acid catalyzes to accelerate the reaction and increase the yield.
    Then, the methyl 2-fluorobenzoate is transferred into the reactor, and a brominating agent such as N-bromosuccinimide (NBS) is added, and the initiator azobisisobutyronitrile (AIBN) is added to initiate the free radical reaction at a suitable temperature. NBS provides the source of bromine, AIBN initiates free radicals, and the bromine atom replaces the hydrogen atom at a specific position in the benzene ring to obtain methyl 2-bromo-4-fluorobenzoate. The whole process needs precise temperature control and timing to ensure that the reaction is sufficient and the product is pure.
    Chemical Reactions & Modifications
    Recently, there are many experiences in the chemical and reverse modification of methyl 2-bromo-4-fluorobenzoate (Methyl 2-Bromo-4-Fluorobenzenecarboxylate).
    This compound, its reverse effect is wonderful, and it exists in the first place. At the beginning of the common method, the reverse rate is mediocre, and the product is also low. Thinking of the ancient people said, "It is difficult to solve, and it is difficult to pass", so it is more different. If the dissolution is used to replace the non-dissolution, the reaction rate will increase, and then the side effects will also rise.
    This process, like walking on the road of ruins, requires caution at every step. The charm of transformation is here, and it is not necessary to integrate the reverse, and the secret of the transformation of the material, in order to achieve the purpose of modification and obtain the required material.
    Synonyms & Product Names
    Methyl 2 - Bromo - 4 - Fluorobenzenecarboxylate is also an important raw material for organic synthesis. Its synonyms and trade names have many titles in academia and industry.
    In academia, or because of its structural properties, it is also known as methyl 2 - bromo - 4 - fluorobenzoate. This name is precisely named according to its chemical structure, which is convenient for academic communication and research. In the industry, due to the needs of commercial promotion and application, it is often used in the world under a trade name, such as [a trade name can be assumed here]. This trade name may be to highlight its specific use or advantages, aiming to be unique in the market.
    The appellation of the academic community emphasizes the accuracy of the structure to facilitate the rigor of scientific research; the trade name of the industry emphasizes the effectiveness of marketing to promote product promotion. Although the two names are different, they all refer to this Methyl 2 - Bromo - 4 - Fluorobenzenecarboxylate. In the field of chemistry, they complement each other and promote the development of its research and application.
    Safety & Operational Standards
    About "Methyl 2 - Bromo - 4 - Fluorobenzenecarboxylate" Product Safety and Operation Specifications
    "Methyl 2 - Bromo - 4 - Fluorobenzenecarboxylate" is an important product in chemical research. Safety and standardization are of paramount importance during its experimental operation and use.
    First of all, it is about storage. This product should be placed in a cool, dry and well ventilated place, away from fire and heat sources. Due to its chemical properties, if it is heated or exposed to improper environments, it may cause danger. Store it in a sealed container to prevent contact with air, moisture, etc., causing it to deteriorate or cause adverse reactions.
    Furthermore, during operation, all protection must be comprehensive. The experimenter needs to wear professional laboratory clothes and protective gloves. This glove should be chemically resistant to avoid skin contact. Facial protection is also indispensable, and goggles can prevent it from splashing into the eyes and causing damage.
    In the experimental operation steps, the established procedures must be strictly followed. When taking it, measure it accurately, not more or less. The operating environment should be kept clean and orderly, and the instrument must be checked for its integrity and cleanliness before use. If there is any spill, don't panic, and immediately follow the emergency treatment procedures to clean it up in an appropriate way to prevent spread.
    Disposal should not be taken lightly. It should not be discarded at will. It should be stored in categories according to the regulations on chemical waste disposal, and handed over to professional institutions for proper disposal to avoid polluting the environment.
    In short, when dealing with "Methyl 2 - Bromo - 4 - Fluorobenzenecarboxylate", we must be rigorous and follow safety and operating standards to ensure the smooth operation of the experiment, the safety of personnel and the environment.
    Application Area
    Taste the wonders of chemical industry, it concerns all things. Today there is Methyl 2 - Bromo - 4 - Fluorobenzenecarboxylate, which is widely used. In the field of medicine, it can be the basis for the creation of new drugs. With its unique structure, it can fit with various biomolecules, or help develop anti-disease prescriptions and heal diseases. In the material industry, it also has extraordinary power. It can participate in the synthesis of special materials, so that the materials have special properties, such as better stability, optical properties, etc., used in advanced electronic equipment and optical instruments to improve their performance. And in fine chemicals, it is a key intermediate for the synthesis of complex compounds. Through ingenious reactions, a variety of products can be derived to meet the needs of different industries. This is the scope of its application, and it is a valuable asset in the chemical industry.
    Research & Development
    In recent years, I have studied Methyl 2 - Bromo - 4 - Fluorobenzenecarboxylate in the field of organic synthesis. At the beginning, I was trapped in the purity of raw materials and the article of reaction. Try all kinds of things and find ways to adapt. With the techniques of bromination and fluorination, temperature regulation, time control, and agent selection, I hope to get good results.
    At the beginning, the yield did not meet expectations, and I was worried. However, I did not give up, I searched the classics and visited all the houses. Change the order of the reaction, the agent that is easy to catalyze, and finally turned around. The yield is gradually increasing, and the quality is also excellent.
    Today, this achievement has received some praise in the industry. However, knowing that there is no end to learning, we should continue to study it, expand its use, and strive for the improvement of synthesis. We hope to contribute to the prosperity of chemistry and promote its long-term development.
    Toxicity Research
    Today, there is a substance called Methyl 2 - Bromo - 4 - Fluorobenzenecarboxylate. As a chemical researcher, I am specially studying its toxicity. This substance may exhibit unique properties in chemical reactions. After many explorations and repeated experiments, the changes that occur when it blends with various substances are observed to analyze the signs of toxicity. Or in a specific environment, the change of its molecular structure leads to the hidden toxicity. Also observe its behavior in the living body, observe the impact on the viscera and meridians. Although the road of inquiry is long, I will study it tirelessly to find out the toxicity of it. When the world uses this product, it avoids harm and benefits, protects the body, and also adds to the progress of chemistry, so that this product can be used in a suitable place and to the best of its ability, without harming people and nature.
    Future Prospects
    Today there is a thing called Methyl 2 - Bromo - 4 - Fluorobenzenecarboxylate. As a chemical researcher, I look at this substance and think about its future prospects.
    This compound has a unique structure. The atoms of bromine and fluorine are attached to the benzene cyclocarboxyl methyl ester. Its characteristics must be wonderful. In the field of organic synthesis, it may be a key intermediate, opening a new reaction path, preparing other compounds, adding new help to the fields of medicine and materials.
    Looking forward to the future, it may be able to precisely regulate its reaction to obtain high-purity products and reduce production costs. In pharmaceutical research and development, with its characteristics, it is expected to create special new drugs and treat diseases in the world. When manufacturing materials, based on them, new functional materials may be developed for electronics, optics, etc., to expand the boundaries of science and technology. This is my vision for the future of Methyl 2 - Bromo - 4 - Fluorobenzenecarboxylate, hoping that it will shine and benefit the world.
    Where to Buy Methyl 2-Bromo-4-Fluorobenzenecarboxylate in China?
    As a trusted Methyl 2-Bromo-4-Fluorobenzenecarboxylate manufacturer, we deliver: Factory-Direct Value: Competitive pricing with no middleman markups, tailored for bulk orders and project-scale requirements. Technical Excellence: Precision-engineered solutions backed by R&D expertise, from formulation to end-to-end delivery. Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
    Frequently Asked Questions

    As a leading Methyl 2-Bromo-4-Fluorobenzenecarboxylate supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

    What are the main uses of Methyl 2-Bromo-4-Fluorobenzenecarboxylate?
    Methyl 2-bromo-4-fluorobenzoate is an important organic compound commonly used in the field of organic synthesis. It has a wide range of uses. In the field of medicinal chemistry, it can be used as a key intermediate for the synthesis of drug molecules with specific biological activities. Due to the existence of bromine, fluorine atoms and ester groups in its structure, it endows the molecule with unique reactivity and physicochemical properties. Through chemical transformation, it can construct complex drug structures, which is effective for the development of new drugs.
    In the field of materials science, it can participate in the preparation of functional materials. With its own structural properties, it can improve the optical, electrical and other properties of materials. For example, in the synthesis of organic optoelectronic materials, through rational design and reaction, it is introduced into the material skeleton to optimize the absorption, transmission and emission properties of the material to light, which contributes to the development of high-performance optoelectronic materials.
    In organic synthetic chemistry, as a starting material, various complex organic molecular structures can be constructed through various organic reactions, such as nucleophilic substitution and metal catalytic coupling. For example, bromine atoms can undergo nucleophilic substitution reactions, react with different nucleophilic reagents, introduce multiple functional groups, expand the complexity and diversity of molecular structures, and provide an important basis for organic synthetic chemists to prepare novel organic compounds.
    What are the synthetic methods of Methyl 2-Bromo-4-Fluorobenzenecarboxylate?
    The method of preparing methyl 2-bromo-4-fluorobenzoate has been known for a long time. The method follows the principle of organic synthesis, and according to various reactions, the product is obtained step by step.
    The first method is to start with 4-fluorobenzoic acid, first make it co-heat with methanol under acid catalysis, and carry out an esterification reaction. For this acid, both sulfuric acid and p-toluenesulfonic acid can be used. The two are co-heated to promote the reaction to obtain methyl 4-fluorobenzoate. Then, in a suitable solvent, such as dichloromethane and carbon tetrachloride, add bromine and an initiator, such as benzoyl peroxide, and heat or light to brominate the benzene ring. Due to the localization effect of fluorine atoms on the benzene ring, more bromine atoms are introduced into ortho-sites, so methyl 2-bromo-4-fluorobenzoate is obtained.
    Another method uses 2-bromo-4-fluorobenzaldehyde as the starting material. First, it is oxidized to 2-bromo-4-fluorobenzoic acid with weak oxidants, such as silver ammonia solution and new copper hydroxide. As in the previous method, it is esterified with methanol under acid catalysis, and methyl 2-bromo-4-fluorobenzoate can also be obtained.
    In addition, halogenated aromatics are also used as the starting material. Choose 2-bromo-4-fluorobromobenzene to react with carbon monoxide and methanol in the presence of a catalyst. The catalysts used are mostly palladium complexes, such as tetra (triphenylphosphine) palladium, etc. This reaction requires appropriate pressure and temperature. After catalytic carbonylation and esterification steps, the target product can also be obtained.
    All methods have advantages and disadvantages. The first method is easy to obtain raw materials, but the bromination step may have side reactions, and the reaction conditions need to be carefully controlled. The secondary oxidation step should pay attention to control the degree of reaction to avoid excessive oxidation. Although the final method is more efficient, the cost of the catalyst is higher, and the requirements for the reaction equipment are also strict. When synthesizing, consider the advantages and disadvantages according to the actual situation and choose the appropriate method.
    What are the physical properties of Methyl 2-Bromo-4-Fluorobenzenecarboxylate?
    Methyl 2-bromo-4-fluorobenzoate is one of the organic compounds. Its physical properties are unique. Under normal temperature and pressure, it often takes the form of a liquid. Due to the moderate intermolecular force, it is not enough to condense into a solid state, but it is enough to maintain a certain condensed state. Looking at its appearance, it is often a colorless and transparent liquid, clear like a clear spring, and free of impurities. This property makes it popular in many experimental and industrial applications, because its pure state can reduce unnecessary side reactions.
    As for the smell, methyl 2-bromo-4-fluorobenzoate exudes a weak and specific smell, as if it is in some subtle chemical atmosphere. Although this smell is not pungent, it is also unique and is an important basis for identifying this substance.
    Its density is heavier than that of water, just like a stable stone sinking in water. When it drops into water, it can be seen that it sinks slowly. This is due to the molecular structure, which makes its unit volume mass greater than that of water. In terms of boiling point, the presence of bromine, fluorine and other atoms in the molecule strengthens the intermolecular force, which increases the boiling point. A higher temperature is required to transform it from liquid to gas.
    Solubility is also one of the key physical properties. The compound exhibits good solubility in organic solvents, such as ethanol, ether, etc., just like fish get water, and can mix with these organic solvents to form a uniform solution. This property provides great convenience for its organic synthesis, separation and purification process, and can be dissolved and extracted with the help of suitable organic solvents. However, its solubility in water is very small, and the two seem to be incompatible with each other. This is mainly due to the hydrophobicity of the molecule, and its structure is difficult to form an effective interaction with water molecules.
    What are the chemical properties of Methyl 2-Bromo-4-Fluorobenzenecarboxylate?
    Methyl 2-bromo-4-fluorobenzoate, this is an organic compound. Its chemical properties are quite characteristic, let me talk about them one by one.
    Looking at its structure, it has the commonality of esters because it contains ester groups. The properties of ester groups are relatively stable, but hydrolysis can occur under specific conditions. In acidic media, the hydrolysis process is relatively slow, and the corresponding carboxylic acids and alcohols will be gradually formed, that is, 2-bromo-4-fluorobenzoic acids and methanol. Under alkaline conditions, hydrolysis is more rapid and thorough, resulting in carboxylate and alcohol. This hydrolysis reaction is widely used in organic synthesis and analysis.
    Because of the bromine atom and fluorine atom connected to the benzene ring, the halogen atom endows it with unique activity. Bromine atoms can participate in nucleophilic substitution reactions, and under the action of appropriate nucleophilic reagents, bromine atoms can be replaced to form new compounds, expanding the path for organic synthesis. The electronegativity of fluorine atoms is very high, which will affect the electron cloud density distribution of the benzene ring, which will reduce the electron cloud density of the benzene ring, and then affect other reactive activities on the benzene ring. For example, during the electrophilic substitution reaction, the reaction check point and rate will be affected by it.
    Furthermore, the molecule contains a benzene ring structure, and the benzene ring has a conjugated system, The electrophilic substitution reaction can occur in the benzene ring. In view of the positioning effect of bromine and fluorine, the subsequent electrophilic substitution reaction check point can also follow.
    In short, methyl 2-bromo-4-fluorobenzoate has rich chemical properties and has potential application value in organic synthesis, pharmaceutical chemistry and other fields. Through in-depth exploration and rational utilization of its chemical properties, the efficient synthesis and performance optimization of many organic compounds can be realized.
    What is the price range of Methyl 2-Bromo-4-Fluorobenzenecarboxylate in the market?
    Methyl methyl-2-bromo-4-fluorobenzoate is on the market, and its price range is difficult to determine. This is due to various reasons.
    First, the price of raw materials is the key. If the price of raw materials such as bromide, fluoride and methyl benzoate required for the synthesis of this compound rises or falls, the price of the finished product will also move. If the supply of bromine is tight and the price rises, the cost of this compound will increase, and its market price will also increase.
    Second, the simplicity of the preparation process also affects it. If the preparation requires fine steps, special catalysts or harsh reaction conditions, the process cost is high and the price is also high. On the contrary, a simple process can reduce the cost and the price may be low.
    Third, the market supply and demand conditions determine its price. If many pharmaceutical and chemical companies have strong demand for this product and limited supply, the price will rise; if the demand is weak and the supply is sufficient, the price will fall.
    Fourth, the production scale is involved. Large-scale production is due to scale effects, and the unit cost may drop, and the price can also be low; small-scale production, the unit cost is high, and the price may be high.
    Looking at it, the market price of methyl methyl methyl-2-bromo-4-fluorobenzoate may range from a few yuan to a few tens of yuan per gram, but this is only an approximation. To know the exact price, you need to consult the chemical raw material supplier in detail, and the immediate quotation shall prevail.