M-Difluorobenzene

Hongda Chemical

Specifications

HS Code	179177
Name	m-Difluorobenzene
Chemical Formula	C6H4F2
Molar Mass	114.09 g/mol
Appearance	Colorless liquid
Odor	Aromatic odor
Density	1.134 g/cm³ at 25 °C
Boiling Point	88 - 89 °C
Melting Point	-57 °C
Flash Point	-1 °C
Solubility In Water	Insoluble
Vapor Pressure	10.9 kPa at 25 °C
Logp	2.59

As an accredited M-Difluorobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

Packing & Storage

Packing	500g of M - difluorobenzene packaged in a sealed, corrosion - resistant container.
Storage	m -Difluorobenzene should be stored in a cool, well - ventilated area away from heat, sparks, and open flames. It should be kept in tightly - sealed containers made of compatible materials like steel or certain plastics. Store it separately from oxidizing agents and reactive substances to prevent potential chemical reactions. Ensure the storage area has proper spill - containment measures.
Shipping	M - difluorobenzene is shipped in tightly - sealed, corrosion - resistant containers. It's transported by specialized chemical carriers, following strict safety regulations to prevent leakage and ensure safe delivery due to its chemical properties.

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General Information

Historical Development

The industry of chemical industry has flourished through the ages. M-difluorobenzene has its origin. In the past, chemical experts studied the properties of substances and explored the integration and separation of elements. In the early days, in the field of organic synthesis, everyone searched for new quality and worked tirelessly.
At the beginning, there were ingenious thinkers who observed the wonders of the structure of benzene rings and thought about the change of fluorine. After repeated experiments, temperature and pressure were adjusted, and the properties of products were precipitated. Although many difficulties were encountered, they were determined to persevere. Finally, the synthesis method of M-difluorobenzene emerged in the academic world.
Since then, everyone has continuously refined its preparation method, optimized the process, and improved its yield. Its application in various chemical industries has gradually become widely known, such as medicine and materials, all rely on its quality to form new products, and its influence on the world has gradually increased, thus becoming an important chemical.

Product Overview

M-difluorobenzene is an organic compound. It is a colorless liquid with a special odor. The boiling point is moderate, and it has a wide range of uses in the field of organic synthesis.
The structure of this compound is above the benzene ring, and the difluorine atoms are arranged in phase. Its physicochemical properties are different from benzene due to the introduction of fluorine atoms. Fluorine atoms have strong electronegativity, which can change the polarity of molecules, affecting their dissolution and boiling points.
In the chemical industry, M-difluorobenzene is an important raw material. It can be used to create medicines, pesticides, and also to prepare special polymer materials. Because of its unique structure, it can give the product different properties. Based on it, through various reactions, it can form a variety of high-value compounds. It plays an important role in the research of organic chemistry and the production of industry, and is indispensable for the development of chemical industry.

Physical & Chemical Properties

M-difluorobenzene is also an organic compound. Its physical and chemical properties are particularly important. Looking at its physical properties, at room temperature, it is a colorless liquid with a unique smell. Its boiling point is about a certain value, which is related to the difficulty of its gasification. The melting point is also fixed, indicating the conditions for its solidification.
On its chemical properties, because it contains fluorine atoms, it has a certain activity. The high electronegativity of fluorine atoms makes the electron cloud distribution of molecules abnormal. It can participate in a variety of chemical reactions, such as the reaction of nucleophilic substitution. Due to the induction effect of fluorine atoms, the reaction activity can be different. In the field of organic synthesis, this compound is often a key raw material, contributing to a variety of useful products. With its unique physical and chemical properties, it has considerable applications in the chemical, pharmaceutical and other industries.

Technical Specifications & Labeling

M-difluorobenzene is also a chemical substance. Its process specifications and identification (product parameters) are quite important in the chemical industry.
To make this product, strict methods must be followed. The choice of raw materials, when the refined and pure, must be accurately proportioned. When reacting, temperature, pressure and other conditions must be strictly controlled. If heated to a moderate temperature, maintain a certain period of time to make the reaction sufficient.
In terms of identification, on the packaging, when the name of the product is "M-difluorobenzene", and the key parameters are listed in detail. Such as purity geometry, it should meet the industry standard; molecular weight is certain, clearly marked. There are also properties, whether it is a colorless liquid or not, and no matter what the smell is, it cannot be ignored. In this way, the user can clarify its properties and use it correctly to meet the needs of chemical production, scientific research, etc.

Preparation Method

The method of preparing M-difluorobenzene is related to the raw materials and production process, reaction steps and catalytic mechanism. The raw materials are often taken from benzene-containing structures and fluorinated reagents. First, the benzene-containing raw materials and specific fluorinated reagents are mixed in a suitable reaction vessel to control temperature, pressure and other conditions. For example, at a moderate temperature, the two start the reaction, and through specific reaction steps, the molecular structure gradually changes.
In the reaction, the reaction rate and process need to be precisely regulated. The catalytic mechanism is also critical. The use of a suitable catalyst can speed up the reaction and improve the yield. The catalyst promotes the activation of the reaction activity check point and reduces the reaction energy barrier. After a series of steps, the raw material is gradually converted into M-difluorobenzene, and then through separation, purification and other processes to obtain pure products. This process must strictly abide by the operating specifications to ensure safe and efficient production.

Chemical Reactions & Modifications

Observing the chemical changes of M-difluorobenzene is really the key to academic research. The reaction process, initially by conventional methods, according to the established formula, the reactants touch each other, but the effect is not ideal, the yield is mediocre, and the quality of the product can also be improved.
Thinking about the change, the researcher examines its structure and its bond energy. Then change the reaction conditions, adjust the temperature, control the pressure, and use a new type of catalyst. This agent has specific activity, which can sensitize the reaction check point and promote the rearrangement of molecules.
After this change, the reaction trend is very different from the past. The yield has skyrocketed, and the purity of the product has also been greatly improved. It can be seen that the beauty of chemistry lies in the insight and change of the reaction. Good observation of physical properties and clever adjustment of conditions can turn the ordinary into magic, so that the output of M-difluorobenzene can reach a good state and pave the way for subsequent applications.

Synonyms & Product Names

Today there is a product called M-difluorobenzene. This is a chemical product and has a wide range of uses in various fields. Although it is a new name, it is also interesting to explore its namesake and the name of the commodity.
Ancient chemistry, although not as detailed as it is today, the properties of the substance have also been observed. M-difluorobenzene, or in the past has a different name. At that time, chemical substances were named according to their properties and sources. Today's M-difluorobenzene, the same name or related to the structure, because it contains difluoride and has a specific position in the benzene ring, so it may have a name based on this structural feature.
As for the name of the product, merchants often choose it according to its use and advantages. Or because it can be a key raw material in chemical synthesis and help to form many delicate products, it is named after its function; or because of its high quality and uniqueness, it is named after it with praise. Although time has passed and the science of chemistry has become increasingly advanced, exploring the same name and trade name of M-difluorobenzene can reveal the development of chemistry, and it is also helpful in the research of chemistry.

Safety & Operational Standards

There is M-difluorobenzene today, which is related to its safety and operating standards.
M-difluorobenzene has a certain chemical activity. When storing, be sure to keep it in a cool, dry and well-ventilated place. Keep away from fires and heat sources to prevent accidents. The container should also be tightly sealed and must not leak. This is the first priority to ensure storage safety.
When operating, the operator must be professionally trained and familiar with the operating procedures. Wear appropriate protective equipment, such as gas masks, chemical protective clothing, etc., to prevent its damage. The operation site should be equipped with corresponding fire equipment and leakage emergency treatment equipment, just in case.
If a leak unfortunately occurs, don't panic. When a small amount of leakage occurs, it can be absorbed by inert materials such as sand and vermiculite, and then properly disposed of. If a large amount of leakage needs to be contained by building a dike or digging a pit, covered with foam, to reduce its volatilization hazard. And quickly report to the relevant departments for coordinated treatment.
Furthermore, during use, the dosage should be strictly controlled and the ratio requirements should be followed. Do not change the operation process at will to prevent abnormal chemical reactions. At the same time, keep the operating environment clean and tidy. After the operation is completed, clean the equipment and site in time to eliminate latent risks.
Only by strictly adhering to these safety and operating standards can we ensure the safety of personnel, avoid accidents, and make everything go smoothly in the research and production of M-difluorobenzene.

Application Area

M-difluorobenzene is also a chemical product. It is widely used. In the field of medicine, it can be used as a raw material for pharmaceuticals, to assist in the research of new drugs, to treat various diseases, and to solve the suffering of the world. In the agricultural world, it can make agricultural agents, protect crops from insect disasters, and ensure the hope of a bumper harvest. And in the collar of materials, it can be used as an auxiliary agent for special materials, imparting unique properties and increasing the efficiency of its use. In the chemical industry, it has an important position. Or to help the smooth flow of reactions, or to adjust the quality of products. This is the use of M-difluorobenzene, which benefits people's livelihood and promotes the prosperity of industry. It is an indispensable thing in chemical production.

Research & Development

Taste the chemical industry, with each passing day, new products emerge one after another. Today there is M-difluorobenzene, and my generation has been studying it for years.
At the beginning, I explored the method of its synthesis, but often encountered obstacles. The ratio of raw materials and reaction conditions need to be carefully weighed. Or the temperature is slightly different, the product is not desired; or the dosage of reagents is poor, and the reaction is difficult. However, we have not given up, and we have tried repeatedly, just like the ancients' "perseverance".
Gradually gain something, optimize the synthesis path, and improve the purity and yield of the product. Thinking about the application of this product, it can be used in the fields of medicine and materials. Research and develop new drugs, with its characteristics, enhance the efficacy; make new materials, with its advantages, improve performance.
Looking to the future, the research and development of M-difluorobenzene still has a wide world. If you are swimming against the current, you should make unremitting efforts to contribute to the prosperity of the chemical industry, hoping to benefit the world and live up to your research intentions.

Toxicity Research

Tasting the harm of poisons is related to people's livelihood. Today, in the case of M-difluorobenzene, toxicological research is carried out in detail.
M-difluorobenzene has a special nature. After research, its poison can invade the body of living beings. If humans and animals touch it, or enter the body through breathing, or penetrate through the skin, it will cause disaster. In the experimental white mice, exposed to M-difluorobenzene, they initially showed restlessness, followed by physiological violations, and organ damage. Its liver, the center of metabolism, is damaged by it and its function is disordered; its brain, the master of thought, is invaded by it and confused.
And its poison to the environment also leaves a hidden danger. Dispersed in the atmosphere, pollute the air inhaled by people; into the water and soil, contaminate the source of all living beings. Therefore, when studying its toxicity, we must be cautious, observe the wide range of its harm, explore and prevent strategies, and ensure the safety of all things. This is the heavy responsibility of our researchers.

Future Prospects

M-Difluorobenzene is also a thing of transformation. Today, there are still many things to look forward to in the future. Its unique characteristics are available in many fields.
Not yet, or it may be used in research and development. Its special features may help new technologies and new ways to cure diseases. And in the field of materials science, it is also expected to show great colors. It can be added to the new materials to make the materials have better performance.
Or in the future, M-Difluorobenzene can be used as a raw material for manufacturing, pushing the sub-device to a more delicate and efficient direction. Its development prospects, such as the early rise of the dynasty, are full of hope, and it will surely be able to make a colorful chapter in the future technological progress.

Where to Buy M-Difluorobenzene in China?

As a trusted M-Difluorobenzene manufacturer, we deliver: Factory-Direct Value: Competitive pricing with no middleman markups, tailored for bulk orders and project-scale requirements. Technical Excellence: Precision-engineered solutions backed by R&D expertise, from formulation to end-to-end delivery. Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.

Frequently Asked Questions

As a leading M-Difluorobenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

What are the main uses of M-Difluorobenzene?

M-difluorobenzene has a wide range of uses. First, it is used as a raw material for organic synthesis. The art of organic synthesis is related to the creation of thousands of substances. M-difluorobenzene is used in it, which can be used as a basic material. After many chemical reactions, other organic compounds can be derived. For example, through substitution reactions, other functional groups can be introduced to obtain new compounds with special properties and functions, which are useful in the fields of medicine, pesticides, materials, etc.
Second, it has made extraordinary contributions in the field of medicine. Pharmaceutical research and development requires the search for efficient and safe drugs. M-difluorobenzene can be a key intermediate for the synthesis of specific drugs. Molecules with unique pharmacological activities can be prepared by fusing with other compounds in a specific chemical path, or they can be used as antibacterial and antiviral drugs, or have a miraculous effect on the treatment of specific diseases.
Third, it also plays a role in the field of materials science. Today's material science pursues high-performance, multi-functional materials. M-difluorobenzene participates in the synthesis of polymer materials, or has excellent thermal stability, chemical stability, or unique electrical and optical properties. These materials can be used in electronic devices, optical instruments, etc., to improve their performance and quality.
Fourth, it is also used in pesticides. Pesticides are designed to protect crops from pests and diseases. Using M-difluorobenzene as the starting material, pesticide ingredients with high insecticidal, bactericidal or herbicidal activities can be synthesized to ensure a bumper harvest in agricultural production and maintain a stable supply of food.

What are the physical properties of M-Difluorobenzene?

M-difluorobenzene is an organic compound. It has many physical properties, which are detailed by you today.
First of all, under room temperature and pressure, M-difluorobenzene is a colorless and transparent liquid, which is clear in appearance and free of impurities. Its smell is unique and aromatic, but this taste also contains a certain irritation, so be careful when smelling.
When it comes to boiling point, it is about 88-89 ° C. When the temperature reaches this point, M-difluorobenzene gradually converts from liquid to gaseous state, which is crucial in chemical operations such as separation and purification. Its melting point is about -57 ° C, and the temperature drops to that, and the substance solidifies from liquid to solid. The change in shape also shows the difference in its physical properties.
The density of M-difluorobenzene is about 1.116 g/cm ³, which is slightly heavier than that of water. If it is juxtaposed with water, it will sink underwater, which is due to the difference in density. Its solubility is also characteristic. It is slightly soluble in water, but it can be miscible with organic solvents such as ethanol, ether, and acetone. This characteristic makes M-difluorobenzene widely used in the field of organic synthesis. It is often used as a solvent to assist in the progress of various organic reactions.
Furthermore, the vapor pressure of M-difluorobenzene cannot be ignored. At a specific temperature, the value of its vapor pressure determines the difficulty of volatilization. When the appropriate temperature rises, the vapor pressure increases and the volatilization rate accelerates. During storage and use, this factor needs to be considered to prevent volatilization, escape and potential safety hazards.
The dispersion force, dipole-dipole force and other intermolecular forces of M-difluorobenzene jointly affect its physical properties. The dispersion force causes weak attractive forces between molecules, while the dipole-dipole force is generated by molecular polarity. The two cooperate to affect its boiling point, melting point, solubility and many other aspects.

What are the chemical properties of M-Difluorobenzene?

M-difluorobenzene is also an organic compound. It is active and reacts with various substances. Due to its fluorine-containing atoms, it has unique chemical properties.
M-difluorobenzene has high stability. The presence of fluorine atoms increases its bond energy and stabilizes the molecular structure. This makes it difficult to react violently with other substances under normal conditions. In case of specific reaction conditions and reagents, a variety of chemical reactions can also occur.
First, electrophilic substitution reactions can occur. Benzene rings are electron-rich and vulnerable to attack by electrophilic reagents. In the presence of appropriate catalysts, electrophilic substitution reactions such as halogenation, nitrification, and sulfonation can occur. If catalyzed by bromine in iron or iron tribromide, bromine atoms can replace hydrogen atoms on the benzene ring to obtain derivatives of bromodifluorobenzene.
Second, M-difluorobenzene can participate in the coupling reaction catalyzed by metals. Under the action of metal catalysts such as palladium and nickel, it can react with halogenated hydrocarbons, borate esters and other reagents to form carbon-carbon bonds or carbon-heteroatom bonds. This is an important means for building complex molecular structures in organic synthesis.
Third, because of its high electronegativity of fluorine atoms, it can affect the polarity and solubility of molecules. M-difluorobenzene has good solubility in organic solvents, but poor solubility in water. This property needs to be considered in detail when separating, purifying and selecting the reaction medium.
Fourth, M-difluorobenzene can undergo a reduction reaction under certain conditions. If a suitable reducing agent is used, the benzene ring can be partially hydrogenated to obtain a partially hydrogenated product. The properties of this product are different from those of the original M-difluorobenzene.
In summary, M-difluorobenzene has unique chemical properties and is widely used in organic synthesis, materials science and other fields due to these properties.

What are the production methods of M-Difluorobenzene?

M-difluorobenzene, as well as organic compounds, can be prepared by various methods.
One is the halogenation method. Using m-dichlorobenzene as the starting material, it reacts with potassium fluoride under specific reaction conditions. In this case, a phase transfer catalyst, such as a crown ether, is often required to improve the rate and efficiency of the reaction. In potassium fluoride, fluoride ions nucleophilically attack the chlorine atom of m-dichlorobenzene, and after substitution reaction, m-difluorobenzene is obtained. This reaction requires strict conditions such as reaction temperature, pressure and catalyst dosage. If the temperature is not suitable, the reaction rate may be delayed and the yield is not high; improper pressure will also affect the reaction process.
The second is the borate ester method. First, under the action of palladium catalyst, m-dibromobenzene and borate ester undergo Suzuki coupling reaction to form m-diborate benzene derivative. Then, this derivative is fluorinated with fluorination reagents, such as Selectfluor, etc., to obtain m-difluorobenzene. This method has high selectivity and can effectively reduce the occurrence of side reactions. However, palladium catalysts are expensive and cost is a major consideration in industrial production.
The third is direct fluorination. Using benzene as raw material, with the help of specific fluorination reagents, such as elemental fluorine or fluorine-containing compounds, in the presence of appropriate reaction media and catalysts, the benzene ring is directly fluorinated to obtain m-difluorobenzene. However, the direct fluorination reaction activity is extremely high, the reaction is not easy to control, and it is often accompanied by polyfluorination and other by-products, so the reaction conditions and technical requirements are extremely high.
The above preparation methods have their own advantages and disadvantages. Halogenated raw materials are relatively easy to obtain, but the reaction conditions are harsh; borate ester method has good selectivity, but high cost; although direct fluorination method seems direct, it is difficult to control. In actual production, it is necessary to weigh the advantages and disadvantages according to specific needs and conditions, and choose the appropriate method.

What should be paid attention to when storing and transporting M-Difluorobenzene?

M-difluorobenzene is also an organic compound. When storing and transporting it, many matters must be paid attention to.
The most important storage environment. It should be placed in a cool and ventilated warehouse, away from fires and heat sources. This is because M-difluorobenzene is flammable. In case of open flames and hot topics, it is easy to cause the risk of combustion and explosion. The temperature of the warehouse should not exceed 37 ° C, in case the temperature is too high to cause its volatilization to increase and increase the danger.
Furthermore, it should be stored separately from oxidants, acids, bases, etc., and should not be stored in mixed storage. Due to M-difluorobenzene's active chemical properties, it is easy to chemically react with various substances, which can cause dangerous accidents.
Packaging also needs to be cautious. Packaging containers must be sealed to prevent leakage. The packaging materials used should be able to withstand a certain pressure and have good corrosion resistance to ensure the stability of M-difluorobenzene during storage.
As for transportation, transportation vehicles must be equipped with corresponding varieties and quantities of fire fighting equipment and leakage emergency treatment equipment. During driving, ensure that the container does not leak, collapse, fall or damage. The trough (tank) used during transportation should have a grounding chain, and holes can be set in the trough to baffle to reduce static electricity generated by shock.
In addition, during transportation, avoid sun exposure, rain exposure, and high temperature. When transporting by road, follow the prescribed route and do not stop in residential areas and densely populated areas. When transporting by rail, it is strictly forbidden to slip. In this way, it is necessary to ensure the safety of M-difluorobenzene storage and transportation.