M-Bromo (Trifluoromethoxy) Benzene, which is m-bromotrifluoromethoxy benzene, has a wide range of uses and is very useful in the field of organic synthesis.
First, it is often a key intermediate in pharmaceutical synthesis. When creating a specific drug molecule, its structural characteristics can introduce unique functional groups, which in turn affect the activity, selectivity and pharmacokinetic properties of the drug. For example, in the development of some antibacterial and antiviral drugs, it is used to construct key structural fragments, so that the drug can act more accurately on the target and improve the efficacy.
Second, it also plays a role in the field of materials science. Because of its fluorine-containing groups, it endows materials with unique physical and chemical properties, such as improving the chemical stability, weather resistance and surface properties of materials. It can be used to prepare high-performance coatings, special plastics, etc., to improve the quality and performance of materials.
Third, it is also indispensable in the synthesis of pesticides. Compounds with high-efficiency insecticidal, bactericidal or herbicidal activities can be derived, providing a strong guarantee for agricultural production. With its structural modification, the biological activity of pesticides is optimized with environmental compatibility, and the impact on the ecological environment is reduced.
In short, m-bromotrifluoromethoxylbenzene has important applications in many fields such as medicine, materials, and pesticides, promoting technological progress and innovation in various fields.

There are several methods for synthesizing M-bromo (trifluoromethoxy) benzene.
First, m-bromophenol is used as the starting material. M-bromophenol and trifluoromethylation reagents, such as trifluoromethyl sulfonyl chloride (CF < SO < Cl), under alkaline conditions, the base can be selected from potassium carbonate, etc., in a suitable solvent, such as N, N-dimethylformamide (DMF), heating and stirring the reaction. In this reaction, the phenolic hydroxyl oxygen atom of m-bromophenol attacks the sulfur atom of trifluoromethylsulfonyl chloride, and the chloride ion leaves, thereby introducing the trifluoromethoxy group in the benzene ring to form the target product M-bromo (trifluoromethoxy) benzene.
Second, it can be started from m-bromoaniline. First, m-bromoaniline is subjected to diazotization reaction. Sodium nitrite and hydrochloric acid are treated with m-bromoaniline at low temperature (such as 0-5 ° C) to form diazonium salts. Then, the diazonium salts react with trifluoromethoxylation reagents, such as metal salts of trifluoromethanol (such as potassium trifluoromethanol). The diazonium group is replaced by trifluoromethoxy group, and after a series of transformations, M-bromo (trifluoromethoxy) benzene is finally obtained. This method requires attention to the control of the diazotization reaction conditions. If the temperature is too high, it is easy to cause the decomposition of diazonium salts.
< br M-bromobenzoic acid is first reduced by a reduction reaction, such as lithium aluminum hydride (LiAlH), to m-bromobenzyl alcohol. M-bromobenzyl alcohol is then reacted with a trifluoromethoxylation reagent, such as trifluoromethyltrimethylsilane (CF 🥰 SiMe 🥰), under the action of an appropriate catalyst, such as tetrabutylammonium fluoride (TBAF). In this reaction, the trifluoromethyl part of trifluoromethyltrimethylsilane is substituted with the hydroxyl group of m-bromobenzyl alcohol under the action of a catalyst to form M-bromo (trifluoromethoxy) benzene.
The above synthesis methods have their own advantages and disadvantages. In practical application, it is necessary to comprehensively consider the availability of raw materials, the difficulty of reaction conditions, and the cost. Choose the appropriate method.

M-bromo (trifluoromethoxy) benzene is one of the organic compounds. Its physical properties are quite unique, let me tell you one by one.
Looking at its properties, under normal temperature and pressure, it is mostly a colorless to light yellow transparent liquid, which is a sign of its appearance. It has a certain degree of volatility and can be slowly emitted in the air.
When it comes to the boiling point, it is about a certain temperature range. The cover contains bromine atoms and trifluoromethoxy groups in its molecular structure, which have a great influence on the intermolecular forces, so the boiling point is fixed. However, the specific value must be determined by accurate experiments, and it is also affected by factors such as environmental pressure. The melting point of
also has a corresponding value. This value reflects the critical temperature of the transition from solid to liquid, which is also restricted by the interaction between molecules. The density of
cannot be ignored. Due to the large mass of bromine atoms in the molecule, and the structure of trifluoromethoxy also contributes to the density, its density is relatively higher than that of common hydrocarbons.
In terms of solubility, it has good solubility in organic solvents, such as common ethanol, ether, dichloromethane, etc. This is based on the principle of similarity and miscibility. Because its molecular structure has a certain polarity, it can interact with polar organic solvents. In water, the solubility is poor, and the proportion of its hydrophobicity is larger.
In addition, its refractive index is also a specific value, which has important reference value for identifying the compound and analyzing its purity. In short, the physical properties of M-bromo (trifluoromethoxy) benzene are closely related to its unique molecular structure, and have important applications in many fields such as organic synthesis.

M-bromo (trifluoromethoxy) benzene is also an organic compound. It has the dual characteristics of halogenated aromatics and ethers, which is due to the bromine atom and trifluoromethoxy group in its structure.
In terms of reactivity, the bromine atom has the activity of nucleophilic substitution. The capped bromine atom is a good leaving group, and it is prone to nucleophilic substitution when encountering nucleophilic reagents. If a strong alkali alkoxide or phenol salt is co-reacted with it, the bromine atom can be replaced by an alkoxy group or a phenoxy group to obtain the corresponding ether compound. This reaction is very important in the organic synthesis of building carbon-oxygen bonds.
Trifluoromethoxy gives this substance unique electronic and spatial effects. Trifluoromethoxy is a strong electron-withdrawing group, which can reduce the electron cloud density of the benzene ring and weaken the electrophilic substitution activity of the benzene ring. However, the electron cloud density of the ortho and para-position is also reduced more than that of the meta-position, so the electrophilic reagents are more inclined to attack the meta-position. At the same time, the steric resistance of the trifluoromethoxy group is relatively large, which affects the selectivity and rate of the reaction in some reactions.
In addition, the physical properties of m-bromo (trifluoromethoxy) benzene are also worthy of attention. Its solubility varies with molecular polarity, and it has good solubility in organic solvents such as dichloromethane and tetrahydrofuran, which is conducive to its participation in organic reactions. Its physical constants such as boiling point and melting point are also affected by molecular structure, providing a basis for its separation and purification. In short, m-bromo (trifluoromethoxy) benzene has complex and unique chemical properties, and has important application value in the field of organic synthesis.

For M-bromo (trifluoromethoxy) benzene, the market price range often changes due to multiple reasons. Looking at the examples of past transactions, it depends on the quality, supply and demand, source and market conditions.
If its quality is pure, the price may be high. If there are many impurities, the price will drop. And the supply and demand situation greatly affects its price. If more supply is less, the price will rise; if supply exceeds demand, the price will be suppressed.
And its source is different, the price is also different. From the famous factory, those with fine craftsmanship and high quality, the price is often high; from the ordinary workshop, the price may be close to the people.
In the past, the price of this compound may range from tens to hundreds of yuan per gram. However, the market situation is ever-changing, and the old price should not be stuck. The price of chemical raw materials may change recently due to the rise and fall of raw materials, policy regulations, and logistics costs. To know the exact price, it is advisable to consult the chemical material supplier or visit the chemical trading platform to get the current actual price.