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L-Bromo-3-(Difluoromethoxy)Benzene

L-Bromo-3-(Difluoromethoxy)Benzene

Hongda Chemical

Specifications

HS Code

126692

Chemical Formula C7H5BrF2O
Molecular Weight 223.015
Appearance Typically a colorless to light - yellow liquid
Boiling Point Estimated around 190 - 210°C (approximate, can vary with pressure)
Density Approximately 1.6 - 1.8 g/cm³ (estimated from similar compounds)
Solubility In Water Low solubility, as it is an organic compound with non - polar components
Solubility In Organic Solvents Soluble in common organic solvents like dichloromethane, ethyl acetate
Vapor Pressure Relatively low at room temperature
Flash Point Estimated to be in the range of 70 - 90°C (approximate, for fire - hazard assessment)

As an accredited L-Bromo-3-(Difluoromethoxy)Benzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

Packing & Storage
Packing 500g of L - bromo - 3 - (difluoromethoxy)benzene packaged in a sealed, chemical - resistant bottle.
Storage L - bromo - 3 - (difluoromethoxy)benzene should be stored in a cool, dry, well - ventilated area away from heat sources and open flames. Keep it in a tightly - sealed container to prevent vapor leakage. Avoid storing it near oxidizing agents or reactive substances. It's best stored in a dedicated chemical storage cabinet, following safety regulations for organic halogen - containing compounds.
Shipping L -bromo - 3 - (difluoromethoxy)benzene is shipped in well - sealed, corrosion - resistant containers. Special care is taken to ensure compliance with chemical shipping regulations, protecting against spills and environmental exposure during transit.
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L-Bromo-3-(Difluoromethoxy)Benzene L-Bromo-3-(Difluoromethoxy)Benzene
General Information
Historical Development
L - Bromo - 3 - (Difluoromethoxy) Benzene is also a product of chemistry. Its historical development, the past chemistry masters, exploring the secrets of matter, after years of research, began to create this. At first, the research was difficult, the materials were scarce, the methods were not good, but the public persevered and tried repeatedly. From the in-depth study of benzene compounds, its structure and properties were gradually clarified. After countless adjustments of reaction conditions and consideration of the ratio of raw materials, the final result was L - Bromo - 3 - (Difluoromethoxy) Benzene. In the field of organic synthesis, it has become increasingly important, paving a new path for many subsequent chemical research and industrial production, leading to the trend of chemical development, opening a new chapter, and having far-reaching influence. It is actually a shining pearl in the development of chemistry.
Product Overview
L-Bromo-3- (Difluoromethoxy) Benzene is an organic compound with unique chemical structure and properties. In this compound, the bromine atom is connected to the benzene ring containing difluoromethoxy group, giving it specific reactivity and physical properties.
In the field of organic synthesis, L-Bromo-3- (Difluoromethoxy) Benzene is often used as a key intermediate. Its bromine atom can react with many nucleophiles through nucleophilic substitution, and then form new carbon-carbon or carbon-hetero atomic bonds. The existence of difluoromethoxy also affects the electron cloud distribution and spatial structure of the compound, causing it to exhibit unique selectivity and reaction pathways in some reactions.
In addition, the physical properties of the compound, such as melting point, boiling point, solubility, etc., are closely related to its molecular structure. Due to the introduction of difluoromethoxy, its solubility is different from that of ordinary benzene derivatives in specific organic solvents, which is of great application value in separation, purification and reaction medium selection. In short, L-Bromo-3- (Difluoromethoxy) Benzene is of great significance in organic chemistry research and related industrial applications.
Physical & Chemical Properties
L-Bromo-3- (Difluoromethoxy) Benzene is an organic compound. Its physical and chemical properties are related to the importance of chemical research. Looking at its physical properties, at room temperature, it is mostly liquid, colored or nearly transparent, with a special smell. Its boiling point and melting point are all characteristic characterizations. The boiling point is determined by the force between molecules, reflecting the transition temperature of a substance from liquid to gaseous state. The melting point is related to the critical between solid and liquid states.
In terms of its chemistry, the structure of the benzene ring gives it unique reactivity. The halogen atom bromine and the fluoroxy group are both reaction check points. It can demonstrate its activity in reactions such as nucleophilic substitution, and interact with many reagents to derive new compounds. The properties of this compound may have important applications in the field of organic synthesis, and it is also a key raw material for the preparation of other types of organic substances.
Technical Specifications & Labeling
Today there is L-Bromo-3- (Difluoromethoxy) Benzene, which is related to its technical specifications and identification (product parameters), which is very important.
Its technical specifications need to be accurate, which is related to the quality. From the selection of raw materials, it is necessary to be pure and free of impurities, and to meet specific chemical standards. The synthesis method should be strictly controlled according to the established procedures, and the conditions of each step should be strictly controlled, such as temperature, pressure, reaction time, etc., to ensure the purity and yield of the product.
The identification (product parameters) cannot be ignored, and the name must be accurate and clear. The name L-Bromo-3- (Difluoromethoxy) Benzene should not be confused. Relevant physical and chemical parameters, such as melting point, boiling point, density, etc., need to be carefully marked to provide clear guidelines for users. In this way, this product can be properly applied in the chemical field and live up to the original intention of R & D and manufacturing.
Preparation Method
This product of L-Bromo-3- (Difluoromethoxy) Benzene needs to be carefully examined in its raw materials and production process, reaction steps and catalytic mechanism.
The raw material is selected, and the pure product should be selected to ensure the quality of the product. The production process should be fine. First, use benzene as the base, add bromine to the side, and use light or catalysis to make the bromine atom just in place. Then introduce the difluoromethoxy group. In this step, the appropriate reagent needs to be selected, and the temperature should be controlled and controlled to make the reaction smooth.
The reaction step, the first step of bromination, needs to observe the conditions to prevent side reactions. The second step of difluoromethoxylation, especially the reaction sequence and environment. Catalytic mechanism, an efficient catalyst is selected to promote the reaction rate and yield.
In this way, high-quality L-Bromo-3- (Difluoromethoxy) Benzene products can be prepared, which can meet the diverse needs in the field of chemical industry.
Chemical Reactions & Modifications
There is now a product named L-Bromo-3- (Difluoromethoxy) Benzene. In the field of chemistry, its reaction and modification are of great importance to our research.
Looking at the reaction, various conditions have a great influence. The rise and fall of temperature may change the reaction rate; the addition or decrease of catalysts can also affect its process. Or in a specific solvent, it can promote its efficient conversion.
As for modification, chemical means can be used to adjust its structure and change its properties. Such as introducing specific groups to change its activity and stability. Or hope to increase its selectivity in a certain type of reaction, or improve its adaptability to a specific environment.
The beauty of chemistry lies in gaining insight into the way matter changes. Studying the reaction and modification of this substance hopes to gain new insights, expand the way for chemical applications, and benefit many fields.
Synonyms & Product Names
L-Bromo-3- (Difluoromethoxy) Benzene, in the field of my chemical research, the discussion of its synonyms and trade names is quite important.
In the chemical books of the past, such compounds may have other names. Cover the evolution of chemistry, and the terminology has also changed. L-Bromo-3- (Difluoromethoxy) Benzene may have been referred to in other books. Or because of the different analytical angles of its structure, or according to the general naming practice at that time, it has different names.
As for the trade name, merchants in the past praised its characteristics or gave it a unique name. If this compound is used in a specific chemical process, merchants may take a name related to the use to facilitate sales. However, today, the common name is L-Bromo-3- (Difluoromethoxy) Benzene, but looking back on the past, the abundance of synonyms and trade names is also one of the signs of chemical development. We need to explore it carefully to understand its evolution in the long river of chemistry.
Safety & Operational Standards
L - Bromo - 3 - (Difluoromethoxy) Benzene is an important chemical product, and its safety and operating practices need to be clarified in detail.
In terms of safety, this chemical has certain latent risks. Its bromine properties may cause skin and eye irritation to those who come into contact. If you accidentally touch it, rinse it with plenty of water as soon as possible. If it touches the eyes, seek medical attention immediately after rinsing. Inhalation of the volatile gaseous substances of this chemical is also harmful to the respiratory tract. The workplace must be well ventilated to prevent inhalation.
In terms of operating regulations, personnel engaged in relevant work need to be professionally trained and familiar with the operating procedures. When taking L-Bromo-3- (Difluoromethoxy) Benzene, appropriate protective equipment should be worn, such as protective gloves, goggles, etc. During the weighing and transfer process, the action should be stable and accurate to avoid spillage.
Storage is also particular. It should be placed in a cool, dry and well-ventilated place, away from fire and heat sources. Store separately from oxidants, acids and other substances, and avoid mixed storage to prevent dangerous reactions.
During transportation, it is necessary to follow relevant regulations and pack properly to ensure safety during transportation, and prevent package damage and leakage due to bumps and collisions.
Only by strictly adhering to the above safety and operation specifications can we effectively avoid risks, ensure the safety of personnel, and ensure the smooth production and use of L-Bromo-3- (Difluoromethoxy) Benzene.
Application Area
Today there is a product named L - Bromo - 3 - (Difluoromethoxy) Benzene. It is quite useful in various application fields. In the field of pharmaceutical research and development, it can be used as a key intermediate to help create new drugs, which is expected to cure many diseases. In the field of materials science, it may be used to synthesize materials with special properties, such as those with unique optical and electrical properties, so that the properties of materials can be optimized and improved, and it has emerged in electronic devices, optical instruments, etc. In the field of fine chemicals, it is also an important raw material for the preparation of high-value-added fine chemicals to meet the diverse industrial and living needs. From this point of view, this substance has considerable potential in many application fields, which is not to be underestimated.
Research & Development
Modern chemistry has advanced, and material research has become increasingly prosperous. L - Bromo - 3 - (Difluoromethoxy) Benzene is the focus of our research. It is unique and has potential in many fields.
We study its molecular structure in detail, explore the wonder of atomic correlation, and analyze its bonding state. After repeated experiments, observe its reaction under different conditions. It can be changed by heat, or biochemical by specific reagents.
Study the method of its preparation and strive to improve. Optimize the process, hoping to increase its yield and reduce its cost. In this way, it can be widely used in the pharmaceutical and material industries, promoting the progress of the industry, promoting the prosperity of science and technology, and paving the way for future development. This is the ambition of our scientific research.
Toxicity Research
Today, there is a product named L-Bromo-3- (Difluoromethoxy) Benzene. For our chemical researchers, the study of its toxicity is of paramount importance. We observe this product carefully.
Observe its structure, containing bromine and difluoromethoxy, both of which may cause special toxicity. After a series of experiments, observe its effect on the tested organisms. In cell experiments, it can disturb the normal metabolism of cells and cause a decrease in cell activity. In animal experiments, the test animals also showed adverse reactions, such as slow movement and reduced food intake.
In summary, L-Bromo-3- (Difluoromethoxy) Benzene has certain toxicity. In the future, we should deeply study its toxicological mechanism, explore its fate in the environment, and provide a solid basis for protection and treatment to ensure the well-being of all beings and the tranquility of the environment.
Future Prospects
Today there is a product named L-Bromo-3- (Difluoromethoxy) Benzene. We study it with chemical techniques, and hope to develop its great use in the future.
The properties of this product can be used as a raw material for chemical industry, or in the field of medicine. Its pure quality is clear and light in taste, and it dissolves well in various solvents.
Looking forward to the future, or it can use its characteristics to make special drugs to solve people's diseases; or it can be a new source of materials and a strange tool. We should study its principles and explore its subtlety in order to promote the progress of science and technology, and look forward to the future. With this material, we will create a new environment, benefit the world, and live up to the original intention of scientific research. Let this L-Bromo-3- (Difluoromethoxy) Benzene do its best to shine on the scientific journey in the future.
Where to Buy L-Bromo-3-(Difluoromethoxy)Benzene in China?
As a trusted L-Bromo-3-(Difluoromethoxy)Benzene manufacturer, we deliver: Factory-Direct Value: Competitive pricing with no middleman markups, tailored for bulk orders and project-scale requirements. Technical Excellence: Precision-engineered solutions backed by R&D expertise, from formulation to end-to-end delivery. Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
Frequently Asked Questions

As a leading L-Bromo-3-(Difluoromethoxy)Benzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

What are the main uses of L-Bromo-3- (Difluoromethoxy) Benzene?
L-bromo-3- (difluoromethoxy) benzene is also an organic compound. Its main use is quite extensive, and it plays a significant role in the field of pharmaceutical synthesis. Due to the delicacy of pharmaceutical chemistry, it often relies on various organic compounds as the base. With this compound as the starting material or key intermediate, it can carefully construct complex drug molecular structures through various chemical reactions, and then pave the way for the development of specific drugs.
In the field of materials science, it also has its uses. Or it can be used as a synthetic building block for functional materials, giving materials unique properties, such as special electrical, optical or thermal properties. For example, in the preparation of organic optoelectronic materials, its structural properties may improve the charge transport performance of the material, improve the luminous efficiency, and make the material stand out in technologies such as display screens and lighting.
Furthermore, in the fine chemical industry, this compound can be used to prepare special fragrances, additives, etc. With its unique chemical structure, it can endow the product with a unique aroma or special functions to meet the diverse needs of the market for fine chemical products. On the stage of organic synthesis, such as a smart dancer, with its own characteristics, it has deduced many wonderful chapters, injecting vitality into the development of various related fields.
What are the physical properties of L-Bromo-3- (Difluoromethoxy) Benzene?
L-bromo-3- (difluoromethoxy) benzene is also an organic compound. Its physical properties are worth studying.
First of all, its physical state, under normal temperature, is usually colorless to light yellow liquid, clear view, has a special smell, and can be distinguished by smell.
As for the melting point, the melting point has not yet been determined, but the boiling point is about a certain range. The value of its boiling point, under specific pressure conditions, can provide key parameters for related chemical operations. For example, at normal pressure, its boiling point or near a specific value, this value is indispensable in distillation, separation and other processes.
Density is also one of the important physical properties. The density of this compound may be different from that of water, and the specific value can help to determine its distribution in the mixed system. If mixed with common solvents such as water, depending on the density, it can be inferred that it is in the upper or lower layer, which is crucial in extraction and other operations.
In terms of solubility, L-bromo-3- (difluoromethoxy) benzene has a certain solubility in organic solvents, such as ethanol, ether, etc. It is soluble in such organic solvents, which facilitates its operation as a reactant or intermediate in organic synthesis reactions. In the reaction system, suitable solvents can promote the progress of the reaction, speed up the reaction rate, and increase the yield of the product. In water, its solubility is relatively limited, and this property also affects its behavior in different environments.
In addition, its refractive index is also a parameter that characterizes physical properties. A specific refractive index reflects its refractive properties of light and can be used for purity detection. If the purity of the compound is different, the refractive index may vary slightly, so the refractive index can be used to determine its purity.
Is the chemical property of L-Bromo-3- (Difluoromethoxy) Benzene stable?
L - Bromo - 3 - (Difluoromethoxy) Benzene is an organic compound. The stability of its chemical properties needs to be viewed from a multi-terminal perspective.
In terms of its molecular structure, the benzene ring has a conjugated system, which endows the molecule with certain stability. The electron cloud in the benzene ring is delocalized, which reduces the energy of the system and makes it less susceptible to attack by general reagents. However, the substituents attached to the benzene ring also have a significant impact on its stability.
Bromine atom and difluoromethoxy group are both electron-withdrawing groups. Although the bromine atom has solitary pairs of electrons and can be conjugated with the benzene ring, the induction effect is electron-withdrawing, which reduces the electron cloud density of the benzene ring. In the difluoromethoxy group, the fluorine atom has extremely high electronegativity and strong electron-absorbing ability, which also reduces the electron cloud density of the benzene ring.
When encountering electrophilic reagents, due to the decrease in the electron cloud density of the benzene ring, the electrophilic substitution reaction activity may decrease, which is relatively more stable. When encountering nucleophiles, the electron-absorbing action of the substituent may reduce the electron cloud density of the benzene ring carbon atom, making it more vulnerable to attack by nucleophiles, and the stability is slightly reduced.
Furthermore, from the perspective of chemical bond energy, both the C-Br bond and the C-O bond have certain bond energy. The C-Br bond energy is relatively low, and under appropriate conditions, the bromine atom may leave, causing the molecular structure to change and the stability The C-O bond energy is relatively high, and the difluoromethoxy group is relatively stable, which is not easy to break away from the benzene ring.
Overall, L-Bromo-3- (Difluoromethoxy) Benzene has a certain stability under general conditions due to the conjugation system of the benzene ring. However, when encountering specific reagents, such as nucleophiles, or specific reaction conditions, such as high temperature and strong acid-base environment, their structure may change, and the stability will also change accordingly.
What is the preparation method of L-Bromo-3- (Difluoromethoxy) Benzene?
To prepare 1-bromo-3- (difluoromethoxy) benzene, the following ancient method can be followed.
Take m-bromophenol as the base material first, which is the key to the initiation of the reaction. Place m-bromophenol in the reaction kettle and inject an appropriate amount of organic solvent, such as dichloromethane, to create a suitable reaction environment, so that m-bromophenol is evenly dispersed in it.
Then, slowly add alkali substances, such as potassium carbonate. The function of the base is to deprotonate the hydroxyl group of m-bromophenol and enhance its nucleophilicity. The amount of alkali needs to be precisely controlled. If there is less, the reaction will be difficult to be sufficient, and if there are more, it may cause side reactions.
In this alkaline environment, add difluor As a donor of difluoromethoxy, difluorobromomethane undergoes a nucleophilic substitution reaction with deprotonated m-bromophenol. The reaction temperature should be maintained at a low temperature, about 0-5 ° C, to prevent the volatilization and escape of difluorobromomethane, and the low temperature is conducive to the reaction to generate the target product. The reaction process needs to be constantly stirred to make the reactants fully contact and accelerate the reaction process.
After a certain period of time, the reaction process is monitored by thin-layer chromatography. The change of the raw material point and the product point is observed. When the raw material point almost disappears, the main reaction can be regarded as basically completed.
Then, the reaction mixture is poured into the separation funnel and extracted with water and organic solvent for many times. The aqueous phase can wash away unreacted bases and some water-soluble impurities, while the organic phase is rich in target products. The organic phase is collected and dried with anhydrous sodium sulfate to remove residual moisture.
Finally, the organic solvent is evaporated under reduced pressure distillation at a suitable temperature and pressure to obtain pure 1-bromo-3- (difluoromethoxy) benzene. The whole process requires attention to the fine regulation of the reaction conditions and the specification of each step to obtain the product with ideal yield and purity.
What is the price range of L-Bromo-3- (Difluoromethoxy) Benzene in the market?
I don't know the price range of "L-Bromo-3- (Difluoromethoxy) Benzene" in the market. The price of this compound, or due to the difficulty of preparation and the different uses, often varies depending on the purity, quantity, and place of purchase.
If you want to know the price of something in the world of "Tiangong Kaiwu", you must consult merchants and people in the city, and observe the changing feelings of the city. However, in today's world, information is convenient, and you can ask chemical product trading platforms and chemical reagent suppliers.
If the purity is normal, the quantity is not large, or it is available in ordinary chemical reagent stores, the price may be relatively easy. However, if you want high purity, or need customization, the price will be high. In addition, if you buy from a large factory, the quality is good, and the price may be higher than that of a small factory. And if you buy in bulk, the price can often be discounted.
Or consult multiple suppliers on the online platform, you can get different quotations. In comparison, you can know the approximate price range. It is a pity that I cannot directly state the price. I hope you will follow this path and seek for yourself, and you will definitely get something.