As a leading F05480 2,3,4,5,6-Pentafluorobenzenesulfonyl Chloride supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
F05480 2, 3, 4, 5, 6-Pentafluorobenzenesulfonyl What is the main use of Chloride
F05480 is 2,3,4,5,6-pentafluorobenzenesulfonyl chloride, which has a wide range of uses. In the field of organic synthesis, it is often used as a key reagent. Due to the high reactivity of the sulfonyl chloride group in its structure, it can react with many nucleophiles, thereby introducing pentafluorobenzenesulfonyl groups.
First, in medicinal chemistry, it can be used to construct compounds with specific physiological activities. The introduction of this group may improve the physical and chemical properties of drug molecules, such as solubility, stability, and even enhance the interaction with the target to improve the efficacy.
Second, in the field of materials science, 2,3,4,5,6-pentafluorobenzenesulfonyl chloride can participate in the preparation of special polymer materials. By polymerizing with monomers containing active hydrogen, the pentafluorobenzenesulfonyl group is introduced into the main chain or side chain of the polymer, giving the material unique properties, such as excellent thermal stability, chemical stability and electrical properties, to meet the needs of high-end materials.
Third, in the study of organic synthesis methodology, it serves as a unique reaction substrate to help develop novel synthesis strategies and reaction paths. Chemists can expand the boundaries of organic synthesis by exploring its reaction laws with different reagents, creating more diverse organic molecular structures.
In conclusion, 2,3,4,5,6-pentafluorobenzenesulfonyl chloride is of great value in many fields such as organic synthesis, drug research and development, and material preparation, providing a key material basis for related scientific research and industrial production.
F05480 What are the physical properties of 6-Pentafluorobenzenesulfonyl Chloride
F05480 is 2,3,4,5,6-pentafluorobenzenesulfonyl chloride. The properties of this substance are usually colorless to light yellow liquid, with a pungent smell and an uncomfortable smell. Its boiling point is about 175-177 ° C, and the boiling point may change under specific pressure. The melting point is about -10 ° C, and the density is about 1.85g/cm ³, which is higher than that of common organic solvents.
2,3,4,5,6-pentafluorobenzenesulfonyl chloride has special solubility. It can be dissolved in common organic solvents, such as dichloromethane, chloroform, ether, etc., and can be uniformly dispersed to form a uniform system. However, it reacts violently in contact with water, decomposes rapidly, and generates corresponding sulfonic acids and hydrogen chloride gases. This reaction is violent and dangerous.
In terms of chemical activity, 2,3,4,5,6-pentafluorobenzenesulfonyl chloride is chemically active, and the sulfonyl chloride group (-SO 2O Cl) is particularly active, which is easy to replace with compounds containing active hydrogen. If it reacts with alcohols, it can form sulfonates; when it reacts with amines, it can form sulfonamides, which are common reaction paths in organic synthesis.
Because of its high chemical activity, special attention should be paid when storing. It should be sealed and stored in a dry, cool and well-ventilated place, away from water and fire sources to prevent dangerous reactions. During transportation, relevant regulations should also be followed to ensure that the packaging is tight and prevent safety accidents caused by leakage.
F05480 What are the chemical properties of 6-Pentafluorobenzenesulfonyl Chloride
2,3,4,5,6-pentafluorobenzenesulfonyl chloride has unique chemical properties. This substance is highly corrosive. Due to its high activity of sulfonyl chloride groups, it reacts violently in contact with water, releasing hydrogen chloride gas, and the reaction is rapid, often accompanied by heat.
Its active chemistry is also reflected in the ease of nucleophilic substitution reactions with nucleophiles. For example, when encountering alcohols, hydroxyl oxygen atoms will attack the sulfur atoms of sulfonyl chloride with their nucleophilicity, and then the negative chlorine ions leave to form pentafluorobenzenesulfonates. When reacting with amines, amino nitrogen atoms act as nucleophilic reagents, replacing chlorine atoms to form sulfonamides.
In addition, it can also participate in some reactions on aromatic rings. Although the benzene ring is replaced by multiple fluorine atoms and the electron cloud density is reduced, some electrophilic substitution reactions can still be carried out under suitable conditions and the assistance of catalysts. However, due to the electron-withdrawing effect of fluorine atoms, the reactivity is different from that of ordinary benzene series.
2,3,4,5,6-pentafluorobenzenesulfonyl chloride has a wide range of uses in the field of organic synthesis. It can be used to prepare a variety of organic compounds containing special functional groups, providing important raw materials and tools for the research of organic synthesis chemistry and the development of related industries.
F05480 What is the synthesis method of 6-Pentafluorobenzenesulfonyl Chloride
To prepare 2,3,4,5,6-pentafluorobenzenesulfonyl chloride (2,3,4,5,6-Pentafluorobenzenesulfonyl Chloride), the following ancient method can be used:
Take pentafluorobenzene as the starting material, inject an appropriate amount of dichloromethane into a specific reactor as a solvent, so that the pentafluorobenzene is evenly dispersed. After that, slowly add chlorosulfonic acid, this process needs to be carefully controlled, and the temperature of the system should be maintained in an ice-water bath between 0-5 ° C. The molar ratio of chlorosulfonic acid to pentafluorobenzene should be 1.2-1.5:1, this ratio can ensure that the reaction is fully carried out. After adding, remove the ice-water bath, slowly warm the reaction system to room temperature, and continue to stir the reaction for 3-5 hours. During this period, pay close attention to the reaction process, and the degree of reaction can be monitored by thin-layer chromatography (TLC).
When the reaction is completed, pour the reaction liquid into crushed ice, and the precipitation will slowly precipitate out. Filtrate with a Brinell funnel, collect the precipitation, and wash it repeatedly with an appropriate amount of ice water to remove impurities. Subsequently, the resulting crude product is recrystallized with a mixed solvent of n-hexane-ethyl acetate, and the volume ratio of the mixed solvent is about 3-5:1. The recrystallization process requires heating and reflux to dissolve the crude product, then slowly cool it to room temperature, and then refrigerate it to make the crystallization complete. Filtration again, collect the crystals, and dry them in a vacuum drying oven at 40-50 ° C. To obtain a pure 2,3,4,5,6-pentafluorobenzenesulfonyl chloride product. In this process, many steps need to be carefully controlled, and any mistakes will affect the purity and yield of the product.
F05480 2, 3, 4, 5, 6-Pentafluorobenzenesulfonyl Chloride What are the precautions in storage and transportation
2,3,4,5,6-pentafluorobenzenesulfonyl chloride is a very active chemical substance. When storing and transporting, care must be taken to prevent accidents.
First, storage is essential. This substance should be stored in a cool, dry and well-ventilated place, away from fire and heat sources. Because it is more sensitive to heat, it is easy to decompose when heated, which can cause danger. The temperature should be strictly controlled within a specific range, usually not exceeding 30 ° C. It needs to be stored separately and should not be mixed with oxidants, alkalis, etc., to prevent chemical reactions. Because of its strong oxidizing and corrosive properties, if it comes into contact with reducing substances or alkaline substances, it is easy to trigger violent reactions. Clear warning signs should be set up at the storage place to remind personnel to pay attention to safety.
Second, transportation regulations. Make sure that the packaging is intact before transportation. Packaging materials must be able to effectively resist vibration, collision and friction, and prevent material leakage caused by container rupture. During transportation, relevant transportation regulations and standards should be strictly followed. Transportation vehicles should be equipped with corresponding fire equipment and leakage emergency treatment equipment. Transportation personnel must undergo professional training and be familiar with the dangerous characteristics of the substance and emergency treatment methods. During transportation, pay close attention to changes in environmental factors such as temperature and humidity to avoid long-term transportation in high temperature and humid environments. If a leak occurs during transportation, emergency measures should be taken immediately to evacuate the surrounding personnel. It is strictly forbidden for fire to approach, and timely report to relevant departments.