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Difluoromethylbenzene

Difluoromethylbenzene

Hongda Chemical

Specifications

HS Code

440676

Chemical Formula C7H6F2
Molar Mass 128.12 g/mol
Appearance Colorless liquid
Boiling Point 116 - 117 °C
Melting Point −48 °C
Density 1.11 g/cm³
Flash Point 17 °C
Solubility In Water Insoluble
Vapor Pressure 3.92 kPa at 25 °C
Odor Aromatic odor

As an accredited Difluoromethylbenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

Packing & Storage
Packing Difluoromethylbenzene in 5 - liter sealed cans for chemical storage and transport.
Storage Difluoromethylbenzene should be stored in a cool, well - ventilated area, away from sources of ignition and heat. Keep it in a tightly - sealed container to prevent vapor leakage. Store it separately from oxidizing agents and reactive substances. Suitable storage cabinets made of materials compatible with the chemical should be used to ensure safety during storage.
Shipping Difluoromethylbenzene is shipped in accordance with strict chemical transport regulations. It's typically in specialized containers, safeguarded from heat and direct sunlight, and transported by carriers well - versed in handling hazardous chemicals.
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Difluoromethylbenzene Difluoromethylbenzene
General Information
Historical Development
I have tasted the industry of chemical industry, which is changing with each passing day, and the research of matter is very delicate. Today there are Difluoromethylbenzene this thing, and it is gradually showing its ability in various fields of chemical industry.
Trace back to its origin, at the beginning the understanding was still shallow, and the research was very few. However, the wise men were unremitting, and the poor reason was explored. After years of circulation, the skills were gradual. In the past, the method of synthesis was cumbersome and ineffective, and everyone thought hard about the way to change.
After years of research, new techniques gradually emerged, and the yield was improved. Its application is also gradually widening, and it is useful in medicine and materials. From the beginning of ignorance and exploration, to the present day, some achievements have been made, which is actually caused by the efforts of the researchers. In the future, it is expected that its development will be more vigorous, adding luster to the chemical industry.
Product Overview
"Product Description of Difluoromethylbenzene"
There is currently a product named difluoromethylbenzene (Difluoromethylbenzene). Its shape is colorless and clear liquid, with a special odor. Its properties are stable at room temperature and pressure, and it may be dangerous in case of open flames, hot topics, or.
The preparation of this product often involves fluorination methods, which are obtained from specific raw materials through various reactions. In the field of organic synthesis, it is widely used. It can be used as an intermediary for synthetic drugs, and may contribute to the development of anti-cancer and antibacterial drugs. It can also be used as a raw material for the synthesis of new materials, endowing the materials with unique properties, such as enhancing their stability and weather resistance.
However, its use should also be cautious. Due to its toxicity, it is necessary to take comprehensive protection during operation. The workplace must be well ventilated, and operators should wear protective clothing and protective equipment to prevent exposure and inhalation.
In short, difluoromethylbenzene has great potential in the chemical and pharmaceutical industry, and it should be used scientifically to ensure both safety and efficiency.
Physical & Chemical Properties
The physical and chemical properties of difluoromethylbenzene (Difluoromethylbenzene) are quite important to scholars. Its color is clear, like the dew of autumn morning, and the taste is light and slightly refreshing. At room temperature, it is liquid, agile like a spring, flowing but not stagnant. The boiling point is moderate, in various solvents, it has good solubility, like a fish getting water, and it blends seamlessly.
Its chemical activity is active, like a flower in spring, when encountering electrophilic reagents, it often reacts with substitution, just like a butterfly falling stamen, precise and ingenious. The bond of carbon and fluorine is very strong, giving it chemical stability, like a rock. Because of its unique characteristics, it has a wide range of uses in the field of medicine and agrochemical, like stars shining at night, indispensable. The researcher makes good use of its materiality, hoping to add luster to the well-being of the world.
Technical Specifications & Labeling
Fudifluoromethylbenzene is also an organic compound. The method of preparation should be based on precise process regulations. The ratio of raw materials must be carefully considered, and there can be no mistakes. The temperature and pressure of the reaction are also key elements and should be precisely controlled.
When preparing, the instrument must be clean and suitable, and the operation should be carried out according to regulations. After the reaction, the purification of the product is also very important to meet commercial standards.
The method of identification can be obtained by spectroscopy, such as nuclear magnetic resonance and mass spectrometry. Observe its peak shape and data to prove its structure and purity. It can also test its physical properties, such as melting and boiling point, and compare with the standard to clarify its quality. According to this process specification and identification method, high-quality two-fluoromethylbenzene products can be obtained to meet the needs of all parties.
Preparation Method
The raw materials, production process, reaction steps and catalytic mechanism of difluoromethylbenzene are the key to the production of difluoromethylbenzene. Take an aryl halide as the base material, add an appropriate amount of difluoromethylation reagent, and mix the two according to a specific ratio. In a special reactor, adjust to a suitable temperature and pressure, such as temperature control at 60 to 80 degrees Celsius, and the pressure is about two to three standard atmospheric pressures. At the beginning of the
reaction, the aryl halide and the difluoromethylation reagent initiate a nucleophilic substitution reaction under the action of the catalyst. This catalyst has been carefully screened, and the activity and selectivity are excellent, which can effectively promote the reaction process. As the reaction advances, the molecular structure is rearranged and combined, and after several intermediate reactions, the final difluoromethyl
After the reaction is completed, through cooling, separation and purification steps, impurities are removed to obtain high-purity products. The whole preparation process is exquisite and all links are interlocked to obtain this chemical product.
Chemical Reactions & Modifications
The technology of chemical industry is changing with each passing day. In the research of compounds, there are new gains. In this Difluoromethylbenzene, its chemical reaction and modification are quite important in the academic community.
To make Difluoromethylbenzene, benzene derivatives are often used as the starting point, supplemented by fluorine-containing reagents, obtained by nucleophilic substitution and addition reactions. However, the initial method is mostly not good. The reaction conditions are harsh, high temperature and high pressure are required, and the yield is not abundant, and side reactions are frequent.
Later scholars devoted themselves to research, and improved methods gradually emerged. With a new type of intervention catalyst, the reaction barrier can be lowered, the reaction is mild, and the yield can be improved. And the reaction check point can be precisely adjusted to reduce by-products. This change is like a beacon in the field of organic synthesis, paving the way for the mass production and wider application of Difluoromethylbenzene.
Synonyms & Product Names
Difluoromethylbenzene, the name of the thing is also the same. Its name may have the same name, or it is related to the business name.
In this world, this thing has a use in the field of chemical industry. Its properties are special, or it is used in the manufacture of general materials, or it is the raw material for synthesizing other things.
Consider its same name, or it may be different due to region or school. As for the business name, the business name, the characteristics and uses of the thing, or another name, in order to attract customers and occupy a place in the market.
We study this thing, and we study its same name and business name, so as to clarify its overall picture in the world. It is of great benefit to its research and application. In this way, we can make better use of this thing and promote the process of transformation.
Safety & Operational Standards
Specifications for the safety and operation of difluoromethylbenzene products
Difluoromethylbenzene is also a chemical product. In today's chemical industry, its use is becoming more and more extensive, but its nature is special, and it is related to safety and operation regulations. Do not be careless.
#1. Storage rules
Store difluoromethylbenzene, must choose a cool, dry and well-ventilated place. Avoid open fires and hot topics, and stay away from fires. Because of its flammability, it is easy to cause disasters in case of fire. The reservoir must be sealed to prevent leakage. It is better to use glass or specific plastic utensils to prevent them from responding to the wall and causing qualitative changes. And the storage area should be set up with obvious warning signs to show its danger, so that everyone knows and be careful.
#2. The essentials of operation
To operate this operator, you must wear suitable protective equipment. Wear chemical-proof gloves to prevent skin contact; wear protective clothing to protect the body; wear a gas mask to prevent its gas from entering the body. Do it in the ventilation cabinet to keep the gas flowing smoothly and prevent the accumulation of toxic gas. When operating, handle it with care to prevent damage to the container. If there is a dumping or leakage, quickly cut off the fire source and prohibit it from being close to no one. Small leaks should be sucked up with sand, vermiculite, etc.; large leaks should be blocked by embankments and then disposed of according to regulations.
#3. Emergency measures
If someone touches the skin with difluoromethylbenzene, quickly flush it with a large amount of water to remove the stained clothes when flushing. If it enters the eye, quickly open the eyelids, flush it with flowing water or normal saline, and seek medical attention as soon as possible. If it is inhaled by mistake, move it to a fresh place of air to promote breathing. If breathing is sleepy, apply artificial respiration and seek medical attention as soon as possible. In case of fire, use dry powder, carbon dioxide, and sand to extinguish the fire. Do not use water, because it is insoluble and lighter than water, and water flushing will spread the fire.
In summary, although the use of difluoromethylbenzene can benefit the industry, safety and operation regulations are the top priorities. All practitioners should keep it in mind and walk in their daily lives to ensure safety.
Application Area
In the process of research and development, this compound is often an important raw material. Because of its special properties, it can make the material have special effects, or increase the effect, or change the way of the material, helping to cure diseases and save people.
In the field of materials science, Difluoromethylbenzene also has its uses. It can be used to synthesize new materials, such as polymer materials with special properties, or to increase the quality and anti-corrosion of materials, etc., and the power of material innovation. And in the process of transformation, based on this basis, it may be able to develop efficient and low-toxicity products, and ensure the production of crops. In short, Difluoromethylbenzene in the multi-purpose domain, there are effects that cannot be ignored.
Research & Development
I have tasted the field of chemical industry, new things have emerged one after another, Difluoromethylbenzene, and recently the research has been quite hot. We devote ourselves to this, observe its nature, and investigate its source.
At the beginning, it was difficult to make, the rate was small and the quality was not pure. However, everyone was unremitting, and they tried all kinds of methods to improve their skills. Gradually, the quantity of production increased, and the quality was also good.
Looking at its use today, it shows its ability in all industries. The genus of medicine is the foundation of making good medicines, or helping to treat diseases; the domain of materials, adding new qualities, can make different materials.
Our generation should continue to follow the will of the saint and study unremitting. Expect to think new, expand its use, and expand its path, so as to promote this product to flourish and advance, and to build immortal power in the chemical industry, create infinite benefits, and seek blessings for future generations.
Toxicity Research
I am committed to the toxicity research of Difluoromethylbenzene products. This substance is gradually used in many fields of industry, but its toxicity is unknown, and I am worried about it.
I carefully observed its materialization and tested it with various experiments. Take all kinds of creatures, set up a control group, and administered different doses Difluoromethylbenzene. Looking at its behavior and physiological changes, the records are detailed.
At the beginning, small doses were administered, and no significant abnormalities were seen in the creatures. And the dose gradually increased, but it was a clue. The tested creatures were either slow to move, or reduced eating, and even had damage to their organs.
From this point of view, Difluoromethylbenzene have a certain toxicity. Although it is widely used, it is safe to prevent it. In the future, we should delve into the mechanism of toxicity, seek protection measures, and ensure that everyone is born in a safe environment. Do not let this substance cause harm to the world.
Future Prospects
In the field of medicine,
can pave the way for the creation of new drugs. Its special structure may be in precise contact with biomolecules, helping to develop special drugs and cure various diseases.
In the field of materials, it is also expected to emerge. With its characteristics, it may be able to produce new types of materials with excellent properties, such as better stability, chemical resistance, etc., which will contribute to the innovation of materials.
Although the road of scientific research is full of thorns, we chemical researchers should explore its secrets with perseverance. With unremitting research, we will make difluoromethylbenzene shine in the future, benefit the world, and make outstanding contributions to human progress.
Where to Buy Difluoromethylbenzene in China?
As a trusted Difluoromethylbenzene manufacturer, we deliver: Factory-Direct Value: Competitive pricing with no middleman markups, tailored for bulk orders and project-scale requirements. Technical Excellence: Precision-engineered solutions backed by R&D expertise, from formulation to end-to-end delivery. Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
Frequently Asked Questions

As a leading Difluoromethylbenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

What are the main uses of Difluoromethylbenzene?
Difluoromethylbenzene is also an organic compound. Its use is quite extensive, and it has diverse properties, which is related to many fields.
In the process of pharmaceutical synthesis, difluoromethylbenzene has a great effect. It can be a key intermediate, helping to form various specific drugs. Because of the unique properties of fluorine atoms, drug molecules can have better biological activity, metabolic stability and fat solubility. Therefore, difluoromethylbenzene can be used as a base to make antibacterial, antiviral, anti-tumor and other drugs to treat human diseases and protect the health of all living beings.
In the field of materials science, it can also be seen. For example, the preparation of special polymer materials, difluoromethylbenzene participates in it, which can change the properties of materials. Make the material have higher heat resistance, chemical corrosion resistance and mechanical strength. These materials with excellent performance can be used in aerospace, electronic and electrical appliances and other important places. Aerospace equipment needs to be able to withstand harsh environments, and the materials made of difluoromethylbenzene can play this important role; electronic and electrical components need to be stable and durable, and this material can also meet its requirements.
In the creation of pesticides, difluoromethylbenzene is also indispensable. With this as a raw material, high-efficiency and low-toxicity pesticides can be made. The introduction of fluorine atoms can enhance the toxic power of pesticides to pests, reduce their harm to the environment, and reduce the impact on beneficial organisms. In this way, it can not only protect crops from the invasion of pests, but also maintain the balance of ecology and protect the vitality of the earth.
In summary, difluoromethylbenzene is important in the fields of medicine, materials, pesticides, etc., and has made great contributions to human well-being and technological progress.
What are the physical properties of Difluoromethylbenzene?
For difluoromethylbenzene, it is also an organic compound. Its physical properties are quite important, and I will describe them in detail today.
First of all, under normal circumstances, difluoromethylbenzene is a colorless liquid, which is clear in appearance and has no variegated color. Its taste also has a special aromatic aroma, and it may smell a little pungent, but it is not a pungent smell.
As for its boiling point, it is about a certain range. The number of boiling points is related to the difficulty of its gasification. At an appropriate temperature, the liquid state can be converted to a gaseous state. This temperature is the boiling point, and its value can help us know its thermal stability and volatilization characteristics.
Melting point is also one of its important physical properties. When the temperature drops to a certain value, difluoromethylbenzene condenses from liquid to solid state, and this temperature is the melting point. Knowing the melting point, when storing and using, it can be adjusted according to the temperature to ensure its stable state.
For density, the density of difluoromethylbenzene is also fixed. This value is related to the floating and sinking situation when it is mixed with other substances. Measured by the mass of a unit volume, it can help our generation to use it accurately in experiments or production.
In terms of solubility, difluoromethylbenzene has good solubility in organic solvents. It can be miscible with common organic solvents such as ethanol and ether. After miscibility, it can provide a uniform environment for various chemical reactions. However, in water, its solubility is poor and it is difficult to miscible with water, which is caused by the difference in the force between the two molecules.
Vapor pressure is also one of its characteristics. The magnitude of vapor pressure is related to temperature and reflects its tendency to volatilize. When the temperature increases, the vapor pressure increases, and the volatilization rate also accelerates. This is of important guiding significance for the volatilization, distillation and other processes of chemical production.
In summary, the physical properties of difluoromethylbenzene are key elements in many fields of chemical industry and scientific research. If you are familiar with it, you can make good use of it to help production and research activities.
What is the chemistry of Difluoromethylbenzene?
Difluoromethylbenzene is also an organic compound. Its chemical properties are specific, and it is worth studying.
The first part of its substitution reaction. Because the benzene ring has an electron cloud density, it is easy to be substituted when it encounters electrophilic reagents. Under appropriate conditions, the halogenating agent can make halogen atoms enter the benzene ring, or through nitrification and sulfonation, the nitro group and sulfonic acid group can also be connected to the benzene ring. Among them, the check point and rate of the reaction depend on the localization effect of difluoromethyl. Difluoromethyl is an electron-withdrawing group, which mostly causes new groups to enter the interposition of the benzene ring.
Furthermore, its addition reaction. Although the benzene ring is famous for its stability, it can still be added with hydrogen under strong conditions. For example, under suitable catalyst, temperature and pressure, hydrogen can be gradually added to benzene ring, and finally products such as hexahydrodifluoromethyl cyclohexane are obtained.
In addition, difluoromethyl is also active. Its carbon-fluorine bond has a certain polarity, or involves some nucleophilic substitutions. Nucleophilic reagents can attack the carbon of difluoromethyl, so that fluorine atoms are gradually replaced. This process requires suitable reaction media and conditions to promote the anterograde reaction.
And difluoromethylbenzene also exhibits in the oxidation reaction. In case of strong oxidants, both benzene ring and difluoromethyl are oxidized. Oxidation of benzene ring can cause ring destruction to produce carboxylic acids, etc.; oxidation of difluoromethyl, or obtain carboxyl, carbonyl and other
In short, difluoromethylbenzene has multiple chemical properties, and it is of great research and application value in the fields of organic synthesis and materials science.
What are the preparation methods of Difluoromethylbenzene?
There are various methods for the production of difluoromethylbenzene, and now it is Jun Chen's.
First, the halogenated aromatic hydrocarbon method. Start with halogenated benzene, so that it can meet the difluoromethylation reagent in a suitable environment. For example, with difluoromethyl halides and suitable bases and catalysts, in an organic solvent, temperature control should be used. The halogen atom in halogenated benzene is active, and it is easy to be replaced by difluoromethyl to form difluoromethylbenzene. In this way, the best catalyst and base should be selected to increase the rate of reaction and reduce the generation of side reactions.
Second, Grignard's reagent method. The first preparation of benzene's reagent is to use magnesium and halogenated benzene in ether solvents. After that, the benzene reagent and the difluoromethyl halide or the difluoromethylation reagent will be converted into difluoromethylbenzene through a series of conversions. This way needs to be strictly controlled in the anhydrous and anoxic environment to prevent the decomposition of the Grignard reagent, and select the appropriate reagent to promote the smooth process.
Third, the diazosalt method. Using aniline as the base, through the technique of diazotization, it becomes a diazosalt. After the diazosalt meets the difluoromethylation reagent, under suitable conditions, the diazoyl group is replaced by difluoromethyl to obtain difluoromethylbenzene. The key to this method is to control the diazotization step and select the difluoromethylation reagent to increase the selectivity of the reaction.
Fourth With the power of transition metal catalysts, such as palladium, nickel, etc., benzene derivatives can be combined with difluoromethylation reagents. Transition metals can activate substrates, reduce reaction energy barriers, and promote the introduction of difluoromethyl into the benzene ring. This approach relies on high-efficiency catalysts and ligands to optimize reaction conditions, yield and selectivity.
All these methods have advantages and disadvantages. Users should choose according to the preparation of raw materials, cost calculation, product requirements, etc., in order to improve the preparation of difluoromethylbenzene.
What are the precautions in storage and transportation of Difluoromethylbenzene?
For difluoromethylbenzene, all precautions must be kept in mind during storage and transportation.
This is a chemical substance, either active or active. When storing, it is advisable to choose a cool, dry and well-ventilated place. Because of its fear of heat and humidity, if it is placed in a high temperature or humid place, it may cause qualitative change and even be dangerous. The warehouse temperature should be controlled within an appropriate range, not too high, in order to prevent its volatilization from intensifying, causing the concentration to exceed the safe limit, and there is a risk of explosion.
Furthermore, the storage place should be kept away from fire and heat sources. This substance is flammable, and it is easy to cause combustion when exposed to open flames and hot topics. Therefore, around the warehouse, fireworks are strictly prohibited, and electrical equipment must also have explosion-proof function to prevent the generation of electric sparks and cause disasters.
As for the transportation, do not slack off. Make sure that the container is well sealed and free of leakage. During the handling process, pack and unload lightly, and do not subject the container to severe collision or vibration, so as to avoid damage and leakage of difluoromethylbenzene. Transportation vehicles should also be equipped with corresponding fire protection equipment and leakage emergency treatment equipment for emergencies. And the transportation route should be well planned to avoid densely populated areas and important facilities to reduce the harm of leakage.
In addition, those involved in storage and transportation must have professional training and be familiar with the characteristics and safe operation practices of difluoromethylbenzene. Daily operations, according to the rules, must not be arbitrary. In this way, to ensure the stability of storage and transportation, to avoid accidents.