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What are the chemical properties of Benzenethiol, 2,5-Difluoro-?
2% 2C5 -difluorothiophenol, this material has unique chemical properties. Its properties are mostly colorless to light yellow liquid with pungent odor.
In terms of chemical activity, due to the fluorine atom and thiol group connected to the benzene ring, the fluorine atom has strong electronegativity, causing the electron cloud density of the benzene ring to change, resulting in uneven distribution of the electron cloud of the molecule. Mercapto (-SH) has high activity and is prone to oxidation reactions. It can be slowly oxidized to disulfide in air. And because of its acidic hydrogen, it can react with bases to form corresponding salts.
It is active in nucleophilic substitution reactions. The fluorine atom on the benzene ring can be used as a leaving group and replaced by other nucleophilic reagents. When conditions are suitable, it can efficiently construct new carbon-heteroatom bonds, which can be used in the field of organic synthesis to prepare a variety of complex compounds containing sulfur and fluorine substitution. At the same time, it can participate in the coupling reaction catalyzed by transition metals, couple with halogenated aromatics or olefins, expand the molecular structure, and has a wide range of uses in pharmaceutical chemistry, materials science, etc. It can provide key intermediates for the development of new drugs and functional materials.
What are the main uses of Benzenethiol, 2,5-Difluoro-
Phenylthiophenol, 2,5-difluoro - This substance has a wide range of uses. In the field of medicinal chemistry, it is often a key raw material for the synthesis of specific drugs. Due to its unique chemical structure, it can precisely interact with specific targets in organisms, helping to develop innovative drugs for difficult diseases, such as anti-tumor and antiviral drugs.
In the field of materials science, it also plays an important role. It can be chemically modified to prepare functional materials with special properties, such as materials with unique regulation of electron transmission and optical properties. It is used in organic semiconductors, optoelectronic devices and other fields to improve device performance and stability.
In the field of organic synthesis, it can be called an important organic synthesis intermediate. With its active functional groups, it can participate in many organic reactions, realize the construction of complex organic compounds, provide an effective way for the synthesis of new organic molecules, and expand the variety and application range of organic compounds.
In the fine chemical industry, it is often used to prepare high value-added fine chemicals, such as special fragrances, additives, etc. To give products unique aroma or specific properties, to meet the diverse needs of different industries and consumers. In short, thiophenol, 2,5-difluoro-with its special chemical structure and reactivity, plays a key role in many fields, promoting technological progress and innovation development in various industries.
What is the synthesis method of Benzenethiol, 2,5-Difluoro-?
There are currently methods for preparing 2,5-difluorobenzene thiophenol, which are described below.
First take 2,5-difluorobromobenzene as the starting material, which is the basis of the reaction. It is placed in an anhydrous ether environment with magnesium chips to initiate a Grignard reaction. When magnesium chips encounter 2,5-difluorobromobenzene, in case of a good opportunity, the two interact to form 2,5-difluorobenzene magnesium bromide. In this step of the reaction, attention should be paid to the anhydrous environment, because water can disrupt the order of the reaction and cause the reaction to fail to meet expectations.
After obtaining 2,5-difluorobenzene magnesium bromide, carbon disulfide is introduced. Carbon disulfide fuses with 2,5-difluorophenylmagnesium bromide, and the nucleophilic addition reaction occurs between the two. At this time, the molecular structure gradually changes, and the sulfur atom gradually enters the system to construct a new intermediate. This reaction step requires moderate temperature control. If the temperature is not appropriate, the rate and direction of the reaction can change.
The intermediate is obtained, and then it is treated with dilute acid. Under the action of dilute acid, the intermediate is decomposed and converted, and the final product is 2,5-difluorothiophenol. The concentration and dosage of dilute acid are both key. Too high or too low concentration, too much or too little dosage can affect the purity and yield of the product.
There are other methods. It can be started from 2,5-difluoronitrobenzene, and the nitro group is first converted into an amino group through a reduction reaction to obtain 2,5-difluoroaniline. In this reduction process, suitable reducing agents and reaction conditions can be selected to achieve efficient reduction.
2,5-difluoroaniline reacts with thiocyanate to form 2,5-difluorobenzene thiocyanate. Then, 2,5-difluorobenzene thiocyanate is treated with suitable reagents to convert it into 2,5-difluorobenzene thiophenol. This path step is slightly complicated, but if the reaction conditions are properly controlled, satisfactory results can also be obtained.
The method of preparing 2,5-difluorothiophenol, the above two are more common. In actual operation, the optimal method should be selected according to the availability of materials, cost, equipment conditions and other factors.
Benzenethiol, 2,5-Difluoro - what is the price range in the market?
I don't know what the market price range of 2,5-difluorothiophenol is. This compound is not a commonly used compound that I am familiar with, and the market price is easy to change for a variety of reasons.
Or you can explore its price from various ways. First, ask chemical raw material suppliers. Many supplier websites may have quotations, but different suppliers may have different prices due to factors such as product purity, packaging, and purchase volume. Second, look at the chemical product trading platform. This platform gathers the quotations of various merchants and can provide reference for the price range. Third, check industry information and market survey reports. Such resources may contain price analysis of the product in a specific period, but they may be time-sensitive.
Because I do not have the exact market data, it is difficult to specify its price range. If you want to know the exact price, you need to go to the above channels for detailed investigation and integrate multi-channel information to obtain a more accurate market price range of 2,5-difluorothiophenol.
What are the manufacturers of Benzenethiol, 2,5-Difluoro-?
The manufacturer of benzothiophenol, 2,5-difluoro-this substance, has been involved in many industry leaders throughout the ages. In the past, in the field of fine chemicals, there were several well-known factories that dedicated themselves to the manufacture of this product with their exquisite skills and unremitting research.
Among them, there is a factory named [Factory Name 1], which has a long-standing reputation. Since its establishment, it has focused on the research and production of fluorine-containing fine chemicals. The factory has brought together a group of talents, refined chemical technology, and committed to the production of benzothiophenol, 2,5-difluoro-with advanced equipment and rigorous technology. Its products are of high quality, praised in the industry's internal ads, exported to many places, and favored by all merchants.
There is also [factory name 2], which is also a leader in the industry. The factory adheres to the concept of innovation and constantly explores ways to optimize production. It is extremely strict in the selection of raw materials and the control of production processes. With the persistent pursuit of quality, the phenylthiophenol, 2,5-difluoro-, has occupied a place in the market, established solid cooperation with many large enterprises, and made great contributions to the development of the industry.
Looking at the moment, new enterprises have also sprung up like mushrooms after a rain. [ Factory name 3] is one of them. Although it has been established for a short time, it has quickly emerged in the field of phenylthiophenol and 2,5-difluoro-production with its novel technology and flexible operation model. This factory pays attention to the balance of environmental protection and efficiency, and the products produced not only meet the quality standards, but also have remarkable aspects in green production. It is expected to become an important force in the industry in the future.
In summary, the manufacturer of phenylthiophenol and 2,5-difluoro-production has both an established powerhouse that has been precipitated over the years, and a vibrant emerging enterprise. Together, we promote the development and progress of this product.