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Benzenesulfonyl Chloride, 4-Fluoro-

Benzenesulfonyl Chloride, 4-Fluoro-

Hongda Chemical

Specifications

HS Code

373149

Chemical Formula C6H4ClFO2S
Molar Mass 194.61 g/mol
Appearance Colorless to light yellow liquid
Density 1.486 g/cm³ (approximate)
Boiling Point 245 - 247 °C
Solubility Insoluble in water, soluble in organic solvents like dichloromethane, chloroform
Flash Point 102.2 °C
Vapor Pressure Low at room temperature
Hazard Corrosive, causes burns to skin, eyes and respiratory tract

As an accredited Benzenesulfonyl Chloride, 4-Fluoro- factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

Packing & Storage
Packing 100g of 4 - fluoro - benzenesulfonyl chloride in a sealed, corrosion - resistant bottle.
Storage **Storage of 4 - Fluorobenzenesulfonyl Chloride**: Store 4 - fluorobenzenesulfonyl chloride in a cool, dry, well - ventilated area, away from heat sources and direct sunlight. Keep it in a tightly sealed container to prevent moisture ingress, as it is reactive towards water. Store it separately from incompatible substances like bases, amines, and reducing agents to avoid potential hazardous reactions.
Shipping 4 - Fluoro - benzenesulfonyl chloride is a chemical. Shipping requires proper containment in corrosion - resistant vessels. It must comply with hazardous chemical regulations, with careful handling to prevent spills and ensure safe transportation.
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Benzenesulfonyl Chloride, 4-Fluoro- Benzenesulfonyl Chloride, 4-Fluoro-
General Information
Historical Development
"The Historical Development of Benzenesulfonyl Chloride, 4-Fluoro-"
In the field of chemical industry, new substances are stacked, benzenesulfonyl chloride, 4-fluoro- is also one of them. At the beginning, the method of its preparation was not refined, and it only existed in a few Fang families.
At that time, all kinds of materials and equipment were simple, resulting in low yield and poor quality. However, a group of researchers were determined, and with the passage of time, the technology gradually improved. New materials and new machinery entered the process, the reaction conditions were precisely regulated, the output was improved, and the quality was also excellent.
Since its inception, it has been used in the pharmaceutical and material industries. The difficult research in the past has turned into the smooth road of today. Benzenesulfonyl chloride, 4-fluoro-has also gone from little known to widely used, becoming a shining pearl in the history of chemical industry.
Product Overview
About 4-Fluorobenzenesulfonyl chloride
4-fluorobenzenesulfonyl chloride is an important reagent for organic synthesis. Its shape is mostly colorless to light yellow liquid, with pungent odor, and can smoke in the air.
This substance is chemically active, and the sulfonyl chloride group (-SO ² Cl) has strong electrophilicity. It is often used as a sulfonation reagent in organic reactions, and can quickly react with nucleophiles such as alcohols and amines to form corresponding sulfonate esters or sulfonamides.
In the field of medicinal chemistry, through the reactions it participates in, a variety of biologically active pharmaceutical intermediates can be prepared. In the field of materials science, the introduction of sulfonyl groups can improve the physical and chemical properties of materials, such as improving the hydrophilicity and thermal stability of materials.
However, it should be noted that 4-fluorobenzenesulfonyl chloride is corrosive and can cause strong irritation to the skin, eyes and respiratory tract. When operating, it is necessary to follow strict safety procedures, work in good ventilation, and take proper protective measures.
Physical & Chemical Properties
"Description of Compounds"
4-fluorobenzenesulfonyl chloride is one of the organic compounds. Its physical properties, at room temperature, are mostly colorless to slightly yellow liquid, with pungent odor and pungent smell. Its boiling point is quite high, about a certain value. This characteristic makes it necessary to deal with it at a suitable temperature during distillation and separation operations.
When it comes to chemical properties, 4-fluorobenzenesulfonyl chloride is very active. Its sulfonyl chloride group has strong reactivity and is easy to react with many nucleophiles. In case of alcohols, it can form sulfonates; in case of amines, sulfonamides are formed. Due to the electron cloud distribution of sulfur atoms in its sulfonyl chloride, it is vulnerable to attack by nucleophiles and substitution reactions.
And because of its fluorine-containing atoms, fluorine has strong electronegativity, which causes the density distribution of molecular electron clouds to change, which affects its chemical activity and physical properties. 4-fluorobenzenesulfonyl chloride is widely used in the field of organic synthesis, and is an important raw material for the preparation of compounds with special structures.
Technical Specifications & Labeling
4-Fluorobenzenesulfonyl chloride is also a chemical substance. The quality of its technology is very important. Its physical properties, white in color and low in quality, are the best. The quality of its content must be determined by the method of precision. And the amount of its quality should be controlled by the grid, and the limit should not be exceeded.

, above the package, the information such as name, content, and location should be clearly discernible. The need for hiding is also clear, such as avoiding fire and preventing moisture. In this way, the use of this substance can be made safe and effective, and it can be used in general.
Preparation Method
To prepare 4-fluorobenzene sulfonyl chloride, the method is as follows:
Prepare the raw materials, fluorobenzene and chlorosulfonic acid are the main ones. With fluorobenzene as the base, slowly inject chlorosulfonic acid into it, and control the temperature during the period, so as not to be impatient. The phase of the two is combined, and it should be substituted. The hydrogen of fluorobenzene is replaced by the sulfonyl chloride group.
When appropriate, place the device in a cold place to prevent it from being hot and out of order. When it is finished, slowly pour it into ice water to make the precipitate. Then use the technique of fractionation to extract its pure quality.
The device should be strong and clean, so as not to mix and damage the product A temperature control device is also indispensable, so that it should be at an appropriate temperature. In this way, 4-fluorobenzenesulfonyl chloride can be obtained.
Chemical Reactions & Modifications
There are many changes in the way of chemistry, among which there are things, called 4-fluorobenzenesulfonyl Chloride (4-Fluoro-), whose chemical reaction and modification are worth exploring.
Fu 4-fluorobenzenesulfonyl chloride is active and often involves nucleophilic substitution. In the alkaline environment, its chlorine atom is easily attacked by nucleophilic reagents, causing the sulfonyl group to be connected to other groups. However, although its properties are alive, there are also inconveniences, and the conditions for it need to be strictly controlled, and the side reactions are raw, resulting in impure products.
In order to change its properties, scholars have worked hard. Or adjust the temperature and pressure, or select the appropriate solvent and catalyst to optimize the reaction and increase the purity and rate of the product. If a special catalyst is used to guide it, the reaction rate can be improved, and the secondary reaction can also be reduced. This is the research of the chemical industry of 4-fluorobenzenesulfonyl chloride.
Synonyms & Product Names
In the "Compendium of Materia Medica", it was said: "All medicines are born, and all have realms." Today, this thing is called 4-fluorobenzenesulfonyl Chloride (Benzenesulfonyl Chloride, 4-Fluoro-), which also has various names.
This thing is also known as many, or according to its nature, or according to its shape. Its synonym is p-fluorobenzenesulfonyl chloride, which is named after the counterposition of the fluorine atom in its structure; and 4-fluorobenzenesulfonyl chloride, which is precisely named according to its chemical structure, which is convenient for academic research. Merchants sell it in the market, or have a trade name, but they all refer to the same thing.
4-fluorobenzenesulfonyl chloride is widely used in the field of chemical industry. It can be used as a raw material for organic synthesis and can help many reactions. It is just like a good tool in the hands of skilled craftsmen and is the key to the synthesis of fine chemicals. Although the names are different, their essence is the same, and they are all indispensable in the chemical industry.
Safety & Operational Standards
"4-Fluorobenzenesulfonyl chloride"
The chemical substance 4-fluorobenzenesulfonyl chloride is also often used in chemical research and industrial production. However, its properties are dangerous, so it is very important to know the safety and operation standards.
Its substances are corrosive, and it will cause burns if they touch the skin and mucous membranes. Therefore, when handling this substance, use it in front of protective equipment, such as corrosion-resistant clothing and gloves, and wear protective goggles to prevent it from splashing into the eyes. If you accidentally touch the skin, rinse it with plenty of water immediately, followed by appropriate medicine; if it enters the eyes, you need to rinse it with water urgently and seek medical attention immediately.
And it is easy to disperse in the air, causing environmental pollution, and harmful inhalation. It is appropriate to operate in a well-ventilated place, or use a fume hood to prevent its gas accumulation. If you inhale it carelessly, leave the scene quickly and go to a place with fresh air. If you feel unwell, you need to seek medical attention.
The method of storage should not be ignored. When placed in a cool, dry and ventilated place, avoid fire and heat sources. And store it separately with oxidants, alkalis and other substances to prevent its reaction from causing danger.
As for the operation, the action should be slow and careful, and do not let spills. If there is a spill, clean it up in an appropriate way to avoid its spread and cause greater danger.
In short, in the research and use of 4-fluorobenzenesulfonyl chloride, this safety and operation specification must be followed to ensure people's safety and stability, and the research is smooth.
Application Area
About the application field of 4-fluorobenzenesulfonyl chloride
4-fluorobenzenesulfonyl chloride is useful in various fields. In the field of pharmaceutical research and development, it is often a key raw material for synthesizing drugs. For example, when preparing specific targeted anticancer drugs, 4-fluorobenzenesulfonyl chloride can participate in the construction of drug active structures, and with its unique chemical properties, it can precisely act on specific targets of cancer cells to improve drug efficacy.
It also has important value in materials science. Taking the preparation of high-performance polymer materials as an example, 4-fluorobenzenesulfonyl chloride can be used as a modifier to introduce special functional groups to optimize the properties of polymers, such as enhancing the heat resistance and mechanical strength of materials.
In the field of pesticide creation, 4-fluorobenzenesulfonyl chloride can be used to synthesize high-efficiency and low-toxicity pesticides. With its chemical activity, the synthesized pesticides can kill pests more effectively, while reducing the impact on the environment, which is in line with the needs of the current green agriculture development.
Research & Development
In modern times, chemistry has flourished, and various substances have been explored more and more deeply. Today there is Benzenesulfonyl Chloride, 4 - Fluoro - This thing, I have studied it for a long time.
Its properties are also unique, and it often plays a key role in chemical reactions. At the beginning, the knowledge is not deep, only its appearance can be seen. Then after years of investigation, I took various experiments as the path, and with the help of precision instruments, I gradually understood it.
I observe the state of its integration with other objects, observe the rate and conditions of its reaction, record the data in detail, and repeatedly investigate. Every new acquisition is a joy and inexplicable. Therefore, this thing has great prospects in the fields of medicine and materials.
Although the road ahead is long and there are many difficulties, but I uphold the heart of research and unremitting exploration. Hope to be able to impoverish its mysteries, add bricks and tiles to the academic world, and promote the development of this material to benefit everyone.
Toxicity Research
In modern times, chemistry has flourished, and the study of toxicants is the most serious. Today, the study of the toxicity of 4-fluorobenzenesulfonyl chloride is related to the health of people's livelihood and cannot be ignored.
Test 4-fluorobenzenesulfonyl chloride, which is irritating. When it touches the skin, it can cause redness, swelling and burning pain; when it enters the eyes, it damages the vision, which is very harmful. If inhaled through the respiratory tract, the lungs and organs are invaded, and coughing and shortness of breath occur.
And it is difficult to decompose in the environment and persists for a long time. Or pollute the soil and cause the decline of vegetation; or contaminate the water source, which is harmful to the aquatic life.
Therefore, its toxicity must be studied with caution. During the experiment, the protection is comprehensive, and the depth of its poison is explored according to the scientific method, seeking a good response to ensure the well-being of everyone and the tranquility of the environment.
Future Prospects
In today's world, the art of chemistry is advancing day by day, and all kinds of new things are appearing. Today there is 4-fluorobenzenesulfonyl chloride, which has infinite potential in the field of chemistry.
Looking at its future, it must be used in the field of medicine to show its skills. Or to make special drugs to treat serious diseases and save people from diseases. In the field of materials, it is also expected to give birth to novel materials, which are strong and specific, and are widely used. For example, in aviation, it makes the equipment sophisticated.
Or in the process of scientific research, it will be the foundation of new methods, open up the unknown, and lead the new direction of chemistry. Over time, after everyone's research, it will surely bloom, contribute to human well-being, and become an important tool for future development.
Where to Buy Benzenesulfonyl Chloride, 4-Fluoro- in China?
As a trusted Benzenesulfonyl Chloride, 4-Fluoro- manufacturer, we deliver: Factory-Direct Value: Competitive pricing with no middleman markups, tailored for bulk orders and project-scale requirements. Technical Excellence: Precision-engineered solutions backed by R&D expertise, from formulation to end-to-end delivery. Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
Frequently Asked Questions

As a leading Benzenesulfonyl Chloride, 4-Fluoro- supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

What are the physical properties of 4-fluorobenzenesulfonyl chloride?
"Mercury, its essence is agile and lively, its shape is like a bead, and its color is as white as silver, so it gets this name. It is one of the metals, and its properties are different from others."
Mercury, that is, mercury, is a liquid metal. Under normal temperature and pressure, it is in a flowing state, like a ball rolling, and shimmering silver light. Its melting point is extremely low, only -38.87 ° C, and its boiling point is only 356.6 ° C. Due to its extremely low melting point, it is always a liquid in ordinary temperature environments, and it does not flow. This is a significant physical property of mercury.
Furthermore, mercury has a high density, reaching 13.59 grams/cubic centimeter, which is much denser than common metals such as iron and copper. Due to its high density, if accidentally sprinkled, it will quickly disperse into many fine mercury beads, rolling around, making it extremely difficult to collect completely.
Mercury also has a large surface tension, which is often integrated into round mercury beads and is not easy to adhere to the surface of other objects. And mercury has good electrical conductivity. Although it is liquid, it can conduct electricity like a solid metal, and is widely used in the electrical field.
However, mercury is volatile. In a room temperature environment, it will slowly evaporate into mercury vapor, which is highly toxic. If inhaled by the human body, it is easy to cause mercury poisoning, damage the nervous system, kidneys and other organs, and endanger life and health. Therefore, when using mercury, you must be extremely cautious to ensure safety.
What are the chemical properties of 4-fluorobenzenesulfonyl chloride?
"Tiangong Kaiwu" says: "The finless porpoise is black in color, often swims in the river, and has a smart nature, which is amazing to everyone. The oil and gas of the finless porpoise has various characteristics."
The oil and gas produced by the finless porpoise is the first to be flammable. If it is close to the fire, it will ignite immediately, and the flame is bright and intense. It can be used as a lighting aid. In the past, when there were few candles and few lamps, it was quite useful. When sailing at night, the road ahead will be slightly brighter.
Second, its oil and gas have anti-corrosion properties. Applied to the wood, it can slow down the decay of the wood and make the wood durable. Wooden boats are often coated with this oil, which can keep them in the water for a long time, less susceptible to water erosion and insect moths, and prolong the service life of the boat.
In addition, finless porpoise oil and gas have a healing effect. If a person is injured by a fall, the skin and flesh are blue and purple, take a little oil and gas, apply it to the wound, and gently rub it, which can promote blood circulation and dissipate blood stasis, slow pain and reduce swelling. There are often people who heal by this method in the folk, and it is quite effective.
However, finless porpoise is a spiritual thing in the river. At present, it is also known that its number is gradually decreasing. In order to ensure the continuation of the finless porpoise population, it must not be hunted and killed for its oil and gas benefits. When observing the rules of nature and protecting this
What are the main uses of 4-fluorobenzenesulfonyl chloride?
In "Tiangong Kaiwu", the swim bladder is the swim bladder, and its main uses are as follows:
The nature of the swim bladder is very tough. Its first service is to use it to make glue. Where the bow is used to bridge the gap between the bow body and the string, the glue of the Duolai River swim bladder. This adhesive is very good, and it can make all parts of the bow closely connected to ensure that it does not break when it is relaxed, so as to maintain good performance. It is effective in shooting and other things.
In addition, the swim bladder is also very useful in the repair and splicing of wood. If the wood has the risk of loosening the tenon and mortise and separating the parts, gluing the river swim bladder can make it as strong as ever. Its adhesive force is strong, which can withstand the test of time and external forces, so that the wooden ware can remain intact for a long time.
And the glue made by Jiang bladder is also indispensable for the mounting of calligraphy and painting. The calligraphy and painting paper is light and fragile, and multiple layers of paper need to be bonded when mounting. The adhesive property of Jiang bladder is mild, which can be firmly bonded without damaging the paper, and it can be stored for a long time. It can ensure that the painting and calligraphy pass through the years and the mounting work is still in good condition, so that the beauty and preservation period of calligraphy and painting can be improved.
In addition, in some exquisite handmade products, such as the production of various exquisite boxes, the bonding of handicrafts, etc., Jiang bladder glue is also favored by craftsmen because of its unique stickiness and quality, helping them to create exquisite and firm utensils.
What are the preparation methods of 4-fluorobenzenesulfonyl chloride?
To make the silvery liquid of the river mussels, there are three ancient methods, which are as follows.
First, pick the mussels on the bank of the clear stream, and choose the one with a good shape and a moist shell. Place it in a large urn, fill it with water, cover it with a straw mat, and wait for a few days until it spits out the silt. Then take the mussel meat, grind the juice with a cloth, and serve it in a crock pot. Prepare a little mercury, put it in the mussel juice, and stir it slowly with mahogany branches, waiting for it to dissolve. In the meantime, you must avoid sunlight, lest it change. When the two are mixed into one, the liquid will be formed, the color is light silver, and the brilliance is faint.
Second, take a number of mussel shells, wash and bake them dry, grind them into fine powder, the finer the better. Place in an iron kettle and stir-fry slowly over a gentle fire until its color turns slightly yellow. At this time, slowly inject turpentine oil, stir while injecting, so that the clam powder and oil are evenly mixed. Continue to stir-fry for a while, until it is thick as a paste, remove from the fire and cool. Take a little lead pill again, grind it finely and adjust it, and then warm it over a slight fire, so that the materials are permeable. The resulting liquid is coated with the mussel body, which can show silver brilliance and last for a long time.
Third, find the shell of the old mussel, soak it in rice swill for seven days, and change the swill once a day. Take it out when it expires, expose it to the scorching sun, until its shell is brittle. Use the pestle mortar to form a powder and sift it very fine. Put this powder and white wax in a copper pot and boil it over charcoal fire. When the white wax is completely melted, the two are integrated into one, and cease fire. Wait for it to cool down a little, pour it into a porcelain bowl, and wait to set. When used, melt it with warm water and apply it to the mussels, it will be the color of silver, just like heaven, shiny and radiant.
4-Fluorobenzenesulfonyl chloride requires attention during storage and transportation
4 - It is hard and poisonous to hide in the environment.
First of all, the hidden environment must be dry, clean and transparent. Because it is easy to be invaded by moisture, if the environment is wet, it will affect its efficacy, or even cause toxicity to increase. And the source of fire is high. In this case, it may decompose or explode, endangering life and safety.
Furthermore, the storage container should not be ignored. It is appropriate to use dense ceramic jars, glass bottles, etc., which can not only effectively isolate air and moisture, but also prevent the loss of food. Do not use gold containers to prevent the chemical and biochemical reactions of the material and improve the performance.
For the first time, the package must be fixed. Wrap it with soft things first, such as cotton wool, cotton, etc., to avoid shaking and collision. Then place it in the solid box and fill it with shock-proof materials around to ensure that it is not damaged during the journey.
Human operation also needs to be careful.
Hiding and moving, those who pick up the stone should wear anti-dumping equipment, such as gloves, masks, etc., to avoid the material directly connecting to the respiratory tract of the skin, in order to prevent poisoning.

The process of hiding the stone should be well-packed. In and out of the box, quantity, storage, etc., in order to track the direction of the material. Once there is a problem, it can be checked and handled to ensure the safety of the stone. Efficacy.