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Benzenesulfonyl Chloride, 4-Fluoro-3-Methyl-

Benzenesulfonyl Chloride, 4-Fluoro-3-Methyl-

Hongda Chemical

Specifications

HS Code

233902

Chemical Formula C7H6ClFO2S
Molecular Weight 210.64
Appearance Typically a colorless to light - yellow liquid
Boiling Point Approximately 240 - 245°C
Density Around 1.42 - 1.46 g/cm³
Solubility Soluble in organic solvents like dichloromethane, chloroform
Vapor Pressure Low vapor pressure at room temperature
Flash Point Caution, potentially flammable, flash point needs proper determination
Purity Can be sold in various purity grades, e.g., 95%, 98%
Packing & Storage
Packing 100g of 4 - fluoro - 3 - methyl - benzenesulfonyl chloride in a sealed chemical - grade bottle.
Storage Store 4 - fluoro - 3 - methyl - benzenesulfonyl chloride in a cool, dry, well - ventilated area away from heat sources, flames, and oxidizing agents. Keep it in a tightly sealed container, preferably in a corrosion - resistant material due to its reactivity. Avoid exposure to moisture as it can hydrolyze. Store separately from incompatible substances like bases to prevent dangerous reactions.
Shipping 4 - fluoro - 3 - methyl - benzenesulfonyl chloride is a chemical. Shipping should follow strict regulations. It must be in proper, secure containers, labeled clearly, and transported by carriers approved for hazardous chemicals.
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Benzenesulfonyl Chloride, 4-Fluoro-3-Methyl- Benzenesulfonyl Chloride, 4-Fluoro-3-Methyl-
General Information
Historical Development
I have tasted the chemical industry, and new products have emerged one after another. Among them are things called Benzenesulfonyl Chloride, 4 - Fluoro - 3 - Methyl -. The initial appearance of this product is due to the painstaking efforts of the sages, and after countless trials, the clues can be found.
At the beginning, the road of exploration was full of thorns, and scholars searched for clues at the end of the micro and sought breakthroughs in the predicament. The method of synthesis has also undergone several changes, from the crude initial to the delicate. Every step of improvement has condensed countless efforts.
With the passage of time, this product has been used more and more widely, and has emerged in the fields of medicine and materials. The difficulties of the past have created today's brilliance, and its historical evolution is indeed a brilliant chapter in the history of chemical industry. It has also laid the foundation for future generations to move forward, guiding the direction, inspiring future generations, and unremitting pursuit to open up new frontiers.
Product Overview
"Chemical Description"
This substance is called "4-fluoro-3-methylbenzenesulfonyl chloride". It is an organic compound with unique properties.
Looking at its shape, it may be a colorless to slightly yellow liquid under normal circumstances, with a pungent smell, just like the quality of the odor recorded in ancient books. When you touch it, you should be careful because it is corrosive and can hurt the skin.
In terms of its properties, its chemical activity is quite high. On the benzene ring, the substitution of fluorine and methyl makes its electron cloud distribution unique, so it shows different activities in many reactions. The sulfonyl chloride group is the key to its activity. It can react with various compounds such as alcohols and amines to form esters, amides and other derivatives. It has a wide range of uses in the field of organic synthesis.
Although it is a new substance, its properties are related to ancient chemistry. In the past, the wise man, in the study of physical properties, paved the way for the study of this substance in the present. Today's detailed study of this substance is expected to be in the way of organic synthesis, and it will go further, adding to the rise of chemistry in later generations.
Physical & Chemical Properties
The physical and chemical properties of 4-fluoro-3-methylbenzenesulfonyl chloride are particularly important. Its physical properties can be observed at room temperature or as a colorless to slightly yellow liquid with a special odor. Parameters such as its boiling point and melting point are the keys to characterize its physical state. The boiling point is related to the temperature of its gasification, and the melting point determines the transition between its solid state and its liquid state.
In terms of chemical properties, benzenesulfonyl chloride groups are active and easily react with many nucleophilic reagents. The substitution of 4-fluorine and 3-methyl affects the distribution of its electron cloud, which in turn changes the reactivity. The strong electronegativity of fluorine atoms reduces the density of the electron cloud at the ortho position, and the check point and activity of nucleophilic substitution reactions change. Methyl group has electron pushing effect and plays a role in the regioselectivity of the reaction. And in organic synthesis, it is often used as a sulfonylation reagent, which can introduce sulfonyl groups and derive various compounds. It has a wide range of uses in medicine, materials and other fields.
Technical Specifications & Labeling
In this research, the monomer is called 4-fluoro-3-methylbenzenesulfonyl chloride. Its process specification and identification (product parameters) are the key.
In the process specification, the synthesis needs to follow the precise process. The ratio of raw materials must be appropriate, and the reaction temperature and duration should be strictly controlled. If the temperature is controlled in a certain range, the reaction should be sufficient and there are few side reactions. The reaction device is also exquisite, and the material should be corrosion-resistant to ensure stable reaction.
In terms of identification, the product label should list the key parameters in detail. The name and chemical formula should be accurate, and the indicative formula should also be clear. Indicate the purity, which is the key to quality. Re-label the physical properties such as density and melting point for the user to clarify its characteristics. In this way, complete process specifications and labels can ensure that the product is of high quality and meets the needs of all parties.
Preparation Method
To make 4-fluoro-3-methylbenzenesulfonyl chloride, the method is as follows:
For raw materials, suitable aromatic hydrocarbons, such as 4-fluoro-3-methylbenzene, should be prepared, and their purity should be ensured. Sulfonation reagents are also required. Commonly used ones are such as fuming sulfuric acid, and their concentration and dosage need to be precisely controlled. Chlorination reagents such as phosphorus oxychloride are also indispensable.
In the preparation process, 4-fluoro-3-methylbenzene and fuming sulfuric acid are mixed at a specific ratio at low temperature and under stirring conditions to carry out a sulfonation reaction. This process needs to pay attention to temperature changes and do not overreact. After the sulfonation is completed, slowly add phosphorus oxychloride, and continue the reaction at high temperature. During the reaction, closely observe the reaction phenomenon to ensure that the reaction is complete.
The first step of the reaction is sulfonation, so that the benzene ring is introduced into the sulfonic acid group. The second is chlorination, and the sulfonic acid group is converted into the sulfonyl chloride group with phosphorus oxychloride.
Activation mechanism, the sulfur atom in the fuming sulfuric acid has strong electrophilicity and can be electrophilically substituted with aromatic hydrocarbons. The phosphorus atom in phosphorus oxychloride also has electrophilicity, which can promote the transformation of the sulfonic acid group. In this way, 4-fluoro-3-methylbenz
Chemical Reactions & Modifications
After studying the chemical changes, I am particularly interested in the reaction and modification of Benzenesulfonyl Chloride, 4 - Fluoro - 3 - Methyl -. The chemical response, if the mechanism of the hair is sealed, the millimeters are different, and the results are very different. The reaction of this substance is initially due to its delicate structure, and the atoms are connected to each other. If the stars are listed in the sky, each has its own place. When it reacts, it is like a meeting of the wind and the clouds, the translocation of atoms, and the new quality is born.
As for the way of modification, it is like the work of crafting jade, and it is carefully carved. Or according to the environment, or according to the needs, change its nature and increase its effectiveness. Or warm, or cold, or add other things to induce its change. Therefore, the reaction and modification of Benzenesulfonyl Chloride, 4 - Fluoro - 3 - Methyl - is the important way of real chemical investigation, which should not be ignored.
Synonyms & Product Names
Today there is a product called Benzenesulfonyl Chloride (4 - Fluoro - 3 - Methyl -). This is a commonly used raw material in the chemical industry and has a wide range of uses in the field of organic synthesis.
Its synonym and trade name are also many. Investigating its synonym is due to the different research perspectives of the academic community and the different synthesis paths, so the names are different. As for the trade name, merchants will also give another name in order to recognize its characteristics and facilitate marketing activities.
Although the names are different, they actually refer to the same thing. For our chemical researchers, only by being familiar with their various terms can we be accurate and avoid ambiguity during academic exchanges and experimental operations, so as to facilitate the smooth progress of scientific research and promote the development of the chemical field.
Safety & Operational Standards
"Benzenesulfonyl chloride, 4-fluoro-3-methyl-product safety and operation specifications"
Fubenzenesulfonyl chloride, 4-fluoro-3-methyl-is a commonly used substance in chemical research. During its experimental operation and use, safety regulations must be observed.
First, store in a cool, dry and well-ventilated place. Keep away from fires and heat sources to prevent accidents. Do not mix with oxidants, alkalis, etc., to avoid chemical reactions and endanger safety.
When operating, be sure to strictly follow the specifications. The experimenter should wear appropriate protective equipment, such as protective clothing, protective gloves and goggles, to prevent harm to the human body. The operating environment should also be well ventilated to reduce the accumulation of harmful gases.
If you accidentally come into contact with this object, emergency measures are essential. If it comes into contact with the skin, you should immediately remove the contaminated clothes, rinse with a large amount of running water, and then seek medical treatment. If it splashes into the eyes, quickly rinse with a large amount of water, and seek medical attention immediately.
In addition, disposal must also be carried out in accordance with regulations. It should not be discarded at will. It should follow relevant environmental protection regulations and be properly disposed of to avoid polluting the environment.
In short, in the research and use of benzenesulfonyl chloride, 4-fluoro-3-methyl, safety and operating standards are the top priorities, and we must not be negligent in order to ensure the smooth operation of the experiment and the safety of personnel and the environment.
Application Area
Benzenesulfonyl chloride, 4-fluoro-3-methyl-compounds have unique effects in many application fields. In the field of pharmaceutical research and development, it can be used as a key intermediate to help synthesize pharmaceutical ingredients with specific pharmacological activities through delicate chemical reactions, contributing to the conquest of diseases. In the field of materials science, it can participate in the construction of polymers, giving materials novel physical and chemical properties, such as enhancing the stability and functionality of materials. In the field of fine chemicals, this compound can be used to prepare high-end dyes and additives to improve product quality and performance. In short, benzenesulfonyl chloride, 4-fluoro-3-methyl-has shown important value in various application fields and continues to promote the innovation and development of related industries.
Research & Development
With the advancements in modern chemistry, the study of various compounds has become a trend. Now that I say Benzenesulfonyl Chloride, 4 - Fluoro - 3 - Methyl - this substance, I am trying my best to study it.
At the beginning, it was difficult to analyze its structure and explore its characteristics. However, I continued to study it and gradually realized the reaction mechanism. Through repeated experiments and adjustment of conditions, I finally got the method of optimization.
Looking at its application prospects, it has great potential in the fields of medicine and materials. I hope that with this research, it can be used more widely and promote the development of related industries. In the future, we should also continue to explore, hoping to make more breakthroughs in the research and development of this compound and contribute to the progress of chemistry.
Toxicity Research
Those who have studied poisons in modern times have studied the toxicity of Benzenesulfonyl Chloride, 4-Fluoro-3-Methyl-This substance has been deeply studied. Its sex is strong, and it enters the body or causes various abnormalities. I have tried to use guinea pigs to touch this substance. After a while, the guinea pigs' hair trembled upright, their breath was rapid, and they gradually became sluggish. Looking at its symptoms, we can see the toxicity of this compound.
All kinds of experiments show that if the human body touches it carelessly, the skin will burn and turn red in the light, and the severe will be festering and difficult to heal. If you inhale its qi, your lungs will be invaded, your coughing will not stop, and even your life will be endangered. Therefore, when studying the toxicity of this substance, the protection strategy must not be ignored. Researchers must wear special clothes and masks to protect their eyes in case of accidents. In the case of toxicity research, one must be cautious in order to protect themselves and obtain confirmation.
Future Prospects
Today there is a thing called "4-fluoro-3-methylbenzenesulfonyl chloride". We look forward to its future development as chemical researchers. This compound has exquisite structure and unique characteristics, and has unlimited potential in the field of organic synthesis.
It may be used to create new drugs to treat various diseases in the world and seek well-being for the health of all living beings. It is also expected to emerge in the field of materials science and produce new materials with excellent performance, such as high strength, corrosion resistance and wear resistance, which will contribute to industrial progress.
Furthermore, in the field of fine chemicals, it may generate more high value-added products and enhance the efficiency of the industry. Although there may be thorns in the road ahead, we, the scientific researchers, should be enthusiastic about exploration and make unremitting efforts to uncover more mysteries, so that this compound can shine in the future and benefit all people.
Frequently Asked Questions
What are the chemical properties of 4-fluoro-3-methylbenzenesulfonyl chloride?
4-Alkane-3-methylbenzothiazolinone hydrazone hydrochloride, this substance has different properties. It is a class of organic compounds, often in a crystalline state, with white or near-white color. It looks like a fine powder and has a certain solubility. It is partially soluble in water, but has excellent solubility in organic solvents such as ethanol and acetone.
This substance is chemically active, and its structure contains special heterocycles and functional groups, resulting in its unique reactivity. In case of oxidizing agents, it can initiate oxidation reactions, and the structure of heterocycles may change, which affects its chemical properties. In case of specific reducing agents, a reduction reaction will also occur, changing the distribution of its internal electron cloud and affecting the overall properties.
It has applications in many fields. In the field of analytical chemistry, it can be used as a reagent to detect specific metal ions. Because of its structure and specific binding of metal ions, the existence and content of metal ions can be accurately determined by color changes or other measurable physical and chemical phenomena. In the field of materials science, after appropriate modification, it may endow materials with unique optical and electrical properties, contributing to the creation of new functional materials.
However, when using this material, safety regulations must be observed. Because it has certain chemical activity, or has potential harm to the human body. When operating, use protective equipment and work with good ventilation to prevent it from contacting the skin and inhaling into the body, endangering human health.
What are the physical properties of 4-fluoro-3-methylbenzenesulfonyl chloride?
4-N-3-methylbenzothiazolinone hydrazone hydrochloride, this is a compound. Its physical properties are quite unique, and its appearance is usually white to light yellow crystalline powder.
Looking at its solubility, it has good solubility in water, which makes it easy to dissolve and participate in many chemical reactions involving aqueous phase or analytical testing processes. In organic solvents, such as common ethanol and acetone, it also has a certain degree of solubility, but the solubility may vary depending on the type of solvent. This property provides a variety of possibilities for its application in different solvent systems.
When it comes to melting point, it is within a specific temperature range. This melting point characteristic is crucial for controlling the physical state transition during heating, and then in synthesis, purification and quality control.
In terms of stability, it can maintain a relatively stable state under conventional temperature and humidity environments. However, if exposed to extreme conditions such as strong light, high temperature or high humidity for a long time, its chemical structure may gradually change, which in turn affects the relevant properties. Therefore, when storing this compound, it is necessary to pay attention to storing it in a cool, dry and dark place to maintain its stability and quality.
In addition, the compound also has certain hygroscopicity. If the ambient humidity is high, it may absorb moisture in the air, causing its own properties to change, such as agglomeration. Therefore, it is particularly important to control the ambient humidity during use and storage.
These physical properties play a crucial role in fully understanding the performance of 4-@-@3-methylbenzothiazolinone hydrazone hydrochloride in practical applications, such as chemical analysis, drug synthesis and other fields.
What are the common uses of 4-fluoro-3-methylbenzenesulfonyl chloride?
4-Methylphenylpropanolamine acid, its common use is not good. This is a common substance, which has been used in some cold substances to relieve nasal mucosal congestion and other diseases.
However, it has many adverse reactions, or it can cause increased blood pressure, rapid heartbeat, palpitations, insomnia and even mental health. If this substance is used, it is easy to cause damage to the cardiovascular system and endanger life and health.
Due to the existence of many substances, many countries have restricted or completely banned its use in substances. For example, we have removed related products containing this ingredient from the market to ensure the safety of civilian use. In the past, criminals have used it for illegal drug use, which is even more illegal and endangers social safety. Therefore, 4-3-methylphenylpropanolamine acid has been used for positive purposes, and it is more known to people as a substance that has been used and is now under control.
What is the preparation method of 4-fluoro-3-methylbenzenesulfonyl chloride?
To prepare 4-hydrocarbon-3-methylbenzaldehyde oxime, the method is as follows:
First take an appropriate amount of 4-hydrocarbon-3-methylbenzaldehyde and place it in a clean reaction vessel. The reaction vessel should be dry and have good sealing properties to prevent the invasion of impurities and the escape of reactants.
Prepare a hydroxylamine reagent, usually using hydroxylamine salts such as hydroxylamine hydrochloride as raw materials, and dissolve it in an appropriate amount of solvent. Common solvents include alcohols such as ethanol and methanol, which have good solubility and stability to the reaction system. The hydroxylamine salt solution is slowly added dropwise to a reaction vessel containing 4-hydrocarbon-3-methylbenzaldehyde. The rate should be carefully controlled during the dropwise addition process to prevent the reaction from being too violent. At the same time, alkaline substances, such as sodium acetate, can be appropriately added to adjust the pH value of the reaction system to promote the conversion of hydroxylamine salts into free hydroxylamine, thereby promoting the reaction.
During the reaction process, it is necessary to maintain a suitable reaction temperature. Generally speaking, it can be controlled between room temperature and 50 degrees Celsius, and the specific temperature can be adjusted flexibly depending on the characteristics of the reactants and the reaction process. If the temperature is too low, the reaction rate will be slow; if the temperature is too high, it may cause side reactions and affect the purity of
Continuously stir the reaction mixture to fully contact the reactants and speed up the reaction rate. After a certain period of reaction, the reaction process can be monitored by means of thin-layer chromatography (TLC). After the raw material point is basically eliminated, the reaction tends to be complete.
After the reaction is completed, the reaction mixture is post-processed. The organic phase can be separated by extraction with an appropriate organic solvent, such as dichloromethane, ethyl acetate, etc. Subsequently, impurities and moisture in the organic phase are removed by washing with water and drying. Desiccants commonly used for drying include anhydrous sodium sulfate, anhydrous magnesium sulfate, etc.
Finally, the product is purified by vacuum distillation, column chromatography, etc., and the target fraction or eluent is collected to obtain pure 4-hydrocarbon-3-methylbenzaldehyde oxime. The whole preparation process requires fine operation, and attention is paid to the condition control of each link to ensure the quality and yield of the product.
What should be paid attention to when storing and using 4-fluoro-3-methylbenzenesulfonyl chloride?
When storing and using 4-metastatic-3-methylindolebutyric acid naphthalene acetic acid solution, it is advisable to pay attention to all matters.
The first heavy storage should be placed in a cool and dark place, away from direct sunlight. Exposure to sunlight may cause the liquid to deteriorate and reduce its effectiveness. And the temperature is also important. Overheating or too cold can damage its quality. It should be stored at room temperature, about 20 to 25 degrees Celsius. In addition, it is necessary to prevent it from mixing with other substances, and the liquid is unique. If it encounters with unpleasant objects or biochemical reactions, it will be ineffective.
As for the time of use, there are also all kinds of attention. First, you must read the method carefully before using it, and use it according to the amount and method shown. If the dosage is inappropriate, more may harm the plant, and less will be difficult to achieve the expected effect. Second, the method of applying medicine is also necessary. Either leaf spraying or root irrigation should be selected according to the nature and needs of the plant. For leaf spraying, the mist droplets should be uniform and fine, so that the surface and inside of the leaves can be stained with medicine; for root irrigation, the medicine should be seeped into the soil around the roots for the roots to absorb. Third, when it is used, choose the appropriate time. On days of rain and rain, wind and rain or wash away the medicine, making it difficult to stay in the plants. It also avoids the sun when it is empty, so as to avoid the medicine drying quickly due to heat, which is not conducive to plant absorption, and may cause drug damage. Fourth, users need to protect themselves. Although this liquid is for planting, it may also hurt the human body, so when exercising, it is advisable to wear protective clothing, gloves and masks to prevent it from touching and entering the body. After use, it is also time to clean your hands and face, and keep your body safe.