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Benzenesulfonyl Chloride, 2-Fluoro-4-Methyl-

Benzenesulfonyl Chloride, 2-Fluoro-4-Methyl-

Hongda Chemical

Specifications

HS Code

218397

Chemical Formula C7H6ClFO2S
Molecular Weight 210.64
Appearance Typically a colorless to pale yellow liquid
Odor Pungent, irritating odor
Boiling Point Approximately 264 - 266 °C
Density Data may vary, but around 1.4 g/cm³
Solubility Insoluble in water, soluble in common organic solvents like dichloromethane, toluene
Flash Point Relatively high, potentially around 110 - 120 °C
Stability Reactive, especially towards nucleophiles; should be stored under inert conditions
Packing & Storage
Packing 500g of 2 - fluoro - 4 - methyl - benzenesulfonyl chloride in sealed, corrosion - resistant container.
Storage Store “2 - fluoro - 4 - methylbenzenesulfonyl chloride” in a cool, dry, well - ventilated area away from heat sources and open flames. Keep it in a tightly - sealed container, preferably made of corrosion - resistant materials due to its reactivity. Isolate it from incompatible substances like bases, oxidizing agents, and reducing agents to prevent dangerous reactions.
Shipping Benzenesulfonyl Chloride, 2 - fluoro - 4 - methyl - is shipped in well - sealed, corrosion - resistant containers. Strict safety protocols are followed to prevent spills, as it's a chemical requiring careful handling during transportation.
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Benzenesulfonyl Chloride, 2-Fluoro-4-Methyl- Benzenesulfonyl Chloride, 2-Fluoro-4-Methyl-
General Information
Historical Development
I have heard of the chemical industry, and there are many categories, and new products have emerged one after another. Today there are Benzenesulfonyl Chloride, 2-Fluoro-4-Methyl-this product, and its origin can also be investigated. At the beginning, the workers explored the way of chemistry, seeking new quality. After years of study, analytic properties, and reaction exploration, this product was gradually obtained.
Initial preparation, although the method is simple and ineffective, the yield is quite low. However, many experts continue to study and improve, and the temperature and pressure of the reaction, and the ratio of reagents are all explored in detail. Years have passed, and the preparation method has become more and more complete, the yield has gradually increased, and the quality is also excellent. Therefore, this product is widely used in various fields of chemical industry to help the prosperity of the industry, which is a clear proof of chemical evolution and a foundation for future generations.
Product Overview
A certain daily chemical essence, called 2-fluoro-4-methylbenzenesulfonyl chloride, has specific properties and is quite capable in the field of chemical industry. This agent is an important angle in organic synthesis, and is often involved in the preparation of aramid and aromatic esters.
Look at its shape, or it is a colorless to slightly yellow liquid with a pungent smell. Its degree of melting and boiling, density and other physical properties are all certain, which is a must-know for those who operate the reaction.
In the reaction, the base activity of its sulfonyl chloride is particularly high, and it is easy to interact with nucleophiles such as alcohols and amines. In case of alcohol, sulfonate will be formed, if in case of amine, sulfonamide will be formed. This is a common path for organic synthesis, paving the way for the creation of a variety of organic compounds. It is used in the pharmaceutical, pesticide, and material industries to display its extraordinary uses, helping the research and development of new products and promoting the progress of industry.
Physical & Chemical Properties
2-Fluoro-4-methylbenzenesulfonyl chloride is an important substance for chemical research. Its physical properties are colorless to slightly yellow liquids at room temperature, with a specific odor and certain volatility. Looking at its chemical properties, benzenesulfonyl chloride groups are active and easily react with nucleophiles. The introduction of fluorine atoms changes the electron cloud density of the molecule, resulting in abnormal reactivity and selectivity. The presence of methyl groups also affects the molecular spatial structure and electronic effects. In many organic synthesis reactions, 2-fluoro-4-methylbenzenesulfonyl chloride can participate in sulfonylation and other reactions. It is a key raw material for the preparation of compounds with special structures. It is widely used in pharmaceutical chemistry, materials science and other fields. In-depth investigation of its physicochemical properties will help to expand the diversity of organic synthesis pathways and products.
Technical Specifications & Labeling
Fu2-fluoro-4-methylbenzenesulfonyl chloride is an important reagent for organic synthesis. Its technical specifications are related to the quality and application of the product. Looking at its material properties, it should be a colorless to slightly yellow liquid with a specific odor. Its content needs to reach a certain standard to meet the requirements of high-quality products.
The identification method is related to many parameters. The boiling point is an important indicator, and a specific boiling point range can prove its purity. And its refractive index is also the key. Under a specific temperature, the refractive index is stable in a certain range, which can be verified for authenticity.
Furthermore, the content of impurities must be strictly controlled. Such as moisture, heavy metals and other impurities, if the content is too high, it will affect the performance of the product. It is necessary to strictly abide by the technical specifications and identification methods to obtain high-quality 2-fluoro-4-methylbenzenesulfonyl chloride products to meet the needs of chemical, pharmaceutical and other fields.
Preparation Method
The method of preparing 2-fluoro-4-methylbenzenesulfonyl chloride is related to the raw material and production process, reaction steps and catalytic mechanism.
To make this product, first take an appropriate amount of 2-fluoro-4-methylbenzene as the starting material and place it in the reactor. According to a certain ratio, slowly add chlorosulfonic acid, which is a key step. During this period, strict temperature control is required to ensure a smooth reaction. Chlorosulfonic acid reacts with 2-fluoro-4-methylbenzene, and the sulfonic acid group cleverly replaces the specific hydrogen atom on the benzene ring.
In order to promote the efficient reaction, an appropriate amount of specific catalysts can be added to optimize the catalytic mechanism. During the reaction process, the degree of reaction is carefully monitored, and whether the reaction is as expected is determined by specific testing methods. After the reaction is complete, the product is carefully separated and purified through a series of post-processing processes, such as extraction, distillation, etc., and finally the pure 2-fluoro-4-methylbenzenesulfonyl chloride is obtained.
Chemical Reactions & Modifications
Taste the wonders of chemistry, endless changes, related to the change of substances, is the key to knowing things. In this sentence, the chemical reaction and modification of Benzenesulfonyl Chloride, 2 - Fluoro - 4 - Methyl - is the focus of our research.
Looking at the reaction, the product can be different due to different conditions. Or combine with other things, or its own structure is easier, depending on the temperature, the combination of reagents, etc. When modifying, it aims to adjust its properties and increase its use. or stabilize, or add activity to suit different needs.
The mystery of this requires careful investigation, based on experiments, guided by theory, to clarify the mechanism of its reaction, and to understand the method of its modification, in order to explore the true meaning in the field of chemistry, so that this substance can be used to its full potential and contribute to the progress of the world.
Synonyms & Product Names
Today there is a thing called Benzenesulfonyl Chloride (2 - Fluoro - 4 - Methyl -). This thing is very important in my chemical research. Its aliases are also numerous, all of which are related to functions and characteristics.
Watching the words of various sages in the past, the name of a chemical thing often varies from time to time, place and person. This 2 - fluoro - 4 - methylbenzenesulfonyl chloride, in different books and the hands of Fang family, has a small difference in title. However, its essence is the same.
The name of its commodity is also set up according to the needs of merchants and the use of the market. Either take its convenience or show its characteristics, aiming to make it easy for users to know and easy for business people to remember. Although the name is unique, it is the same in fact, all referring to the quality of this chemistry. We study its nature and study its use. We should focus on its essence, and not be confused by various names. In this way, we can obtain its true meaning and move forward step by step on the road of chemistry, which is beneficial.
Safety & Operational Standards
About 2-fluoro-4-methylbenzenesulfonyl chloride product safety and operating specifications
Fu 2-fluoro-4-methylbenzenesulfonyl chloride, chemical substances are also useful in experimental and industrial fields. However, its nature is also risky, so safety and operating standards should not be careless.
This substance is irritating, touching the skin, can cause redness, swelling, and pain; if it enters the eye, it will hurt the eyes especially. If inhaled in the lungs, or cause respiratory discomfort, cough, asthma, etc. Therefore, during operation, protective gear is indispensable.
When handling, you must wear protective clothing, which is dense and strong, and can resist its damage. You must wear protective gloves on your hands, preferably rubber or plastic, to prevent it from contacting the skin. The eyes must be equipped with protective glasses, transparent and solid, to prevent splashing. The mask is also indispensable. Choose a filter type, which can filter its gas and keep breathing safe.
The method of storage is also important. It should be placed in a cool, dry and well-ventilated place, away from fire and heat sources. It should be placed separately from oxidants, alkalis, etc., and should not be mixed to prevent dangerous reactions.
In the operation room, ventilation equipment must be complete, so that the air is smooth and harmful gas can dissipate quickly. If there is a leak, cut off the fire source first and evacuate the personnel quickly. When there is a small leak, cover it with inert materials such as sand and vermiculite and collect it in a closed container. If there is a large leak, the embankment will be blocked, and it will be transferred to a special container with a pump for subsequent proper disposal.
All these are the safety and operation standards of 2-fluoro-4-methylbenzenesulfonyl chloride. Practitioners should observe them carefully in order to protect themselves and the environment.
Application Area
There is now a compound called 2-fluoro-4-methylbenzenesulfonyl chloride. This compound is quite useful in many application fields.
In the field of organic synthesis, it can be used as a key reagent. Through a specific reaction path, it can interact with compounds containing active hydrogen to construct novel organic molecular structures. For example, when combined with alcohols, sulfonate products can be formed, which are of great significance in both organic synthesis and materials science and are often used to prepare functional materials.
In the field of drug development, due to its unique chemical structure, or can participate in the construction of drug molecules, it provides the possibility for the creation of drugs with specific pharmacological activities, and contributes to the development and progress of pharmaceutical science.
From this perspective, 2-fluoro-4-methylbenzenesulfonyl chloride has broad application prospects and potential value in organic synthesis and drug development.
Research & Development
In recent years, I have been researching various chemical compounds, especially Benzenesulfonyl Chloride, 2-Fluoro-4-Methyl-this substance. At the beginning, I explored its properties and deconstructed it. Although it encountered difficulties, I persevered. Observe its application to various chemical reactions, and study the effect of different conditions on yield and purity.
After repeated tests, we have obtained a good method to make it. Optimize the process, control temperature, pressure and the amount of various agents, the yield gradually increases, and the quality is also improved. And study its application in new areas, and hope to expand the way.
Looking at it now, this research has made progress, but the road ahead is still far away. In order to better understand its nature and expand its use, it is necessary to continue to study it, with the hope of more pioneering projects in the field of chemical industry, in order to promote its long-term development.
Toxicity Research
In the field of chemical industry, the study of harmful substances is crucial. Today, in terms of 2-fluoro-4-methylbenzenesulfonyl chloride, the study of its toxicity should not be ignored.
In the process of experiment, observe its impact on various things. Or touch the skin, observe the changes of the skin, whether there is redness, swelling or ulceration; or enter the body of animals, explore its physiological signs, such as the shape of organs and the difference in behavior.
In the environment, when exposed to water, light, and heat, the changes occur, and whether there are new toxins. After repeated experiments, the situation was recorded in detail, and the toxicity of 2-fluoro-4-methylbenzenesulfonyl chloride was confirmed, which was used as a detailed evidence to ensure its safety and avoid its risks.
Future Prospects
Guanfu 2-fluoro-4-methylbenzenesulfonyl chloride has an unlimited future prospect in the field of chemical research. Its structure is exquisite and its characteristics are unique, making it a key material in the process of organic synthesis.
In terms of its reactivity, it can be combined with various reagents to derive other novel compounds, which can be used in the creation of medicine, or it can open up a new path for the treatment of difficult diseases. Looking back at the past, many drug research and development relied on exquisite synthesis. With the ability of this material, it may help medicine practitioners to produce more efficacious and safe medicines in the future.
Furthermore, in the field of materials science, it also has potential. Through a unique process, it can be integrated into new materials to endow materials with different properties, such as enhancing their stability and improving their optical properties. In this way, in the fields of electronics and optics, it can be a driving force for innovation.
Therefore, 2-fluoro-4-methylbenzenesulfonyl chloride is like an uncut jade. In the future scientific development, it will definitely bloom and add brilliance to human well-being.
Frequently Asked Questions
What are the chemical properties of 2-fluoro-4-methylbenzenesulfonyl chloride?
The chemical properties of 2-% tibia-4-methylbenzaldehyde nitrile halide are in need of investigation in organic chemistry. This compound has many functional groups such as aldehyde group, nitrile group, halogen atom and methyl group, and each functional group endows it with unique properties. The properties of the
aldehyde group allow it to participate in the oxidation reaction. If it encounters a strong oxidant, it can be oxidized to a carboxyl group; if it encounters a weak oxidant such as Torun reagent, it can react with a silver mirror to produce a bright silver mirror; when it interacts with Feilin reagent, it produces a brick-red cuprous oxide precipitation. The aldehyde group can also participate in the reduction reaction and can be reduced to an alcohol hydroxyl group. And the carbon-oxygen double bond of the aldehyde group is electrophilic, and it is easy to undergo addition reaction with nucleophilic reagents. For example, acetals can be formed with alcohols under acidic catalysis.
Nitrile groups are also active in nature, and hydrolysis can occur under acidic or basic conditions. When acidic hydrolyzed, Mr. To form amides, and then hydrolyzed to carboxylic acids and ammonium salts; alkaline hydrolysis results in carboxylic salts and ammonia. Nitrile groups can also be reduced under specific conditions to form amine compounds.
Halogen atom In this compound, the carbon-halogen bond connected to it is polar due to the large electronegativity of the halogen atom. In nucleophilic substitution reactions, halogen atoms are easily replaced by nucleophilic reagents. For example, in alkaline aqueous solutions, halogen atoms can be replaced by hydroxyl groups to form compounds containing hydroxyl groups; in alcohol solutions, if there is a strong base, elimination reactions can occur to form products containing unsaturated bonds.
Although methyl is relatively stable, under certain conditions, such as high temperature or catalyst, its α-hydrogen can be replaced by halogen atoms, resulting in free radical substitution reactions.
In summary, 2-tibia-4-methylbenzaldehyde nitrile halogen contains a variety of functional groups and has diverse chemical properties. It can be used as an important intermediate in the field of organic synthesis, participating in many organic reactions and constructing complex organic molecular structures.
What are the physical properties of 2-fluoro-4-methylbenzenesulfonyl chloride?
The physical properties of 2-% Jiang-4-methylbenzothiazolinone hydrazone hydrochloride are as follows:
This substance is mostly crystalline solid at room temperature, and the appearance is white, like the first snow in winter, and the texture is pure. Its crystalline morphology is regular, with occasional shimmering under light, just like stars looming.
In terms of melting point, it is about a specific temperature range. At this temperature, the substance gradually melts from solid to liquid, and this property has a great impact on its state maintenance in different environments and related applications. In some processes that require precise temperature control, its melting point characteristics become a key consideration.
Solubility is also one of the important physical properties. In water, it exhibits a certain solubility and can slowly blend with water to form a uniform mixed system. Just like fine sand thrown into a stream, although it does not disappear instantaneously, it can gradually disperse in it. In some organic solvents, its solubility is better, and it can quickly dissolve with the solvent, just like a fish entering water without hindrance. This solubility characteristic makes it unique in the preparation of various solutions and the selection of chemical reaction media. It can choose the appropriate solvent according to specific needs to maximize its effectiveness.
In addition, its density also has its own characteristics. Under the same volume conditions, it is lighter or heavier than many common substances. This characteristic cannot be ignored in the material ratio, mixing and product design. It is related to the overall quality and performance balance. Taken together, these physical properties form a unique "face" that plays an indispensable role in a wide range of applications.
What are the main uses of 2-fluoro-4-methylbenzenesulfonyl chloride?
Sodium bisulfite, also known as vitamin K3, has the following main uses:
Vitamin K3 plays a crucial role in the coagulation process. The coagulation mechanism of the human body depends on the coordinated operation of many coagulation factors, and vitamin K3 is an essential substance for the synthesis of coagulation factors Ⅱ、Ⅶ、Ⅸ、Ⅹ. When the human body lacks vitamin K3, the synthesis of these coagulation factors will be hindered, resulting in prolonged coagulation time and easy bleeding symptoms. Therefore, in the medical field, it is often used to prevent and treat bleeding disorders caused by vitamin K deficiency, such as neonatal bleeding, vitamin K deficiency caused by intestinal malabsorption, and hypothromboplasminemia.
In animal husbandry, vitamin K3 is also widely used. If there is a lack of vitamin K3 in animal feed, animals may experience abnormal coagulation and slow growth. Adding an appropriate amount of vitamin K3 to the feed can ensure the normal coagulation function of animals, promote their growth and development, and improve the health level and production performance of animals.
In addition, vitamin K3 is also used as an important reagent in some biochemical studies. Because of its key role in the coagulation mechanism and related physiological processes, researchers often use vitamin K3 to conduct experimental studies when exploring many physiological and pathological mechanisms such as coagulation and cell metabolism, in order to further clarify the mystery of life activities and the mechanism of disease occurrence and development.
What is the preparation method of 2-fluoro-4-methylbenzenesulfonyl chloride?
To prepare 2-hydrocarbon-4-methylbenzothiazole bromide, the following method can be used.
First take an appropriate amount of sulfur-containing compounds, such as thiophenols or mercaptans, and place them in the reaction kettle with the corresponding halogenated hydrocarbons. The halogenated hydrocarbons need to have a suitable structure to facilitate the subsequent reaction. Add an appropriate amount of basic catalysts, such as potassium carbonate, sodium carbonate, etc., to promote the reaction. The reaction temperature is controlled in a moderate range, about 50 to 80 degrees Celsius. The reaction time depends on the reaction process, which probably takes 3 to 6 hours. The nucleophilic substitution reaction occurs between the two to generate a sulfur-containing intermediate.
Then, this intermediate is mixed with o-methylaniline, and an appropriate amount of acid catalyst, such as p-toluenesulfonic acid, is added to accelerate the reaction. The reaction system is heated to 100 to 120 degrees Celsius, and the reaction is continued at this temperature for 5 to 8 hours. The cyclization reaction occurs to form the parent nuclear structure of 2-hydrocarbon-4-methylbenzothiazole.
After the cyclization reaction is completed, cool the reaction mixture to room temperature, and then slowly add a brominating agent dropwise, such as bromine or a mixture of hydrobromic acid and oxidant, to carry out the bromination reaction. Pay attention to the reaction temperature during bromination, and it should be controlled between 0 and 10 degrees Celsius to prevent side reactions. After the dropwise addition is completed, continue to stir for 1 to 2 hours to ensure complete reaction.
At the end of the reaction, pour the reaction liquid into a large amount of ice water, and precipitate out. Collect the precipitate by filtration and wash it several times with an appropriate amount of cold water to remove impurities. The resulting solid crude product can be purified by recrystallization, select a suitable solvent, such as ethanol, acetone, etc., dissolve the crude product, then slowly cool down to allow crystals to precipitate, filter again, and dry to obtain a pure 2-hydrocarbon-4-methylbenzothiazole bromide. During the whole process, careful operation is required, and attention is paid to the control of reaction conditions to ensure the purity and yield of the product.
What are the precautions for 2-fluoro-4-methylbenzenesulfonyl chloride in storage and transportation?
2-% heptyl-4-methylbenzothiazolinone hydrazone in storage and transportation, when all things are carefully observed, must not be ignored.
When this substance is stored, the first environment is dry. If the environment is humid, moisture is easy to interact with it, or cause its characters to mutate, which will damage the quality. It should be placed in a well-ventilated place with smooth air to avoid turbid gas stagnation and prevent qualitative change. Temperature is also critical and should be controlled within an appropriate range. Overheating may accelerate its reaction, and overheating may affect its structural stability.
Furthermore, the storage place should be kept away from fire sources and strong oxidants. This substance may be flammable to a certain extent. In case of fire, it will be dangerous, and strong oxidants can also react violently with it, causing disasters.
As for transportation, the packaging must be solid and reliable. If the packaging is negligent, vibrations and collisions during transportation can cause it to leak, pollute the environment and endanger everyone. When handling, it is also necessary to operate with caution, handle it with care, and avoid rough packaging to prevent damage.
In the transportation vehicle, it should also be maintained in a dry and ventilated state, as required by the storage environment. And it should be separated from fire sources, heat sources and incompatible substances, and must not be mixed and mixed. Transportation personnel should also be familiar with the characteristics of this substance and emergency measures. In case of emergencies, they can respond quickly and reduce damage hazards. In this way, Fangbao 2-% heptyl-4-methylbenzothiazolinone hydrazone is safe during storage and transportation.