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What is the main use of this product "Benzenemethanol, 5 - Bromo - 2 - Fluoro - α - Methyl -"?
"Benzenemethanol, 5 - Bromo - 2 - Fluoro - α - Methyl -" This compound has bromine, fluorine and methyl-modified benzyl alcohol in its name. It is widely used in the field of medicine and is often a key intermediate for the synthesis of special drugs. Due to the introduction of bromine and fluorine atoms, it can adjust the physical and chemical properties and biological activities of drug molecules, or increase their lipid solubility, help drugs penetrate biofilms, and better reach the target of action; or change the distribution of molecular electron clouds, affect their ability to bind to receptors, and improve drug efficacy.
In the field of materials science, it can be used as a basic raw material for the construction of new functional materials. The properties of bromine and fluorine can give materials unique optical and electrical properties. For example, materials containing this compound may have specific fluorescence emission characteristics, which can be found in the fields of optical sensors, Light Emitting Diodes, etc.; or because of its special electronic structure, the material has good electrical properties and is applied to semiconductor materials.
In organic synthetic chemistry, it is an extremely important synthetic building block. Because of its diverse activity check points in the structure, chemists can use various chemical reactions, such as nucleophilic substitution, coupling reactions, etc., to further derive organic compounds with complex structures and different functions, providing an important cornerstone for the development of organic synthetic chemistry, promoting organic synthetic chemistry to continuously expand the boundaries and create more novel compounds.
What are the physical properties of "Benzenemethanol, 5 - Bromo - 2 - Fluoro - α - Methyl -"?
"5-Bromo-2-fluoro - α - methylbenzyl alcohol" This material has many physical properties. At room temperature, it is mostly solid or liquid, and the state depends on the specific intermolecular force. If the attractive force between molecules is strong, such as containing multiple hydrogen bonds or large van der Waals forces, it is usually solid; if the attractive force is weak, it is liquid.
Looking at its color, when it is pure, it is mostly colorless or slightly colored. However, if it contains impurities, the color may vary. As for the smell, it has a special aromatic smell. Because of the benzene ring structure, this taste is not pungent, but special aromatic.
In terms of solubility, this substance has good solubility in organic solvents such as ethanol and ether. Due to the principle of "similar miscibility", its molecules have certain hydrophobicity and are compatible with the structure of organic solvents. However, in water, the solubility is not good. Due to the strong polarity of water molecules, the interaction force with the organic molecule is weak.
When it comes to the melting boiling point, due to the presence of halogen atoms such as bromine and fluorine, the intermolecular force increases. The relative mass of bromine atoms is large, and the electronegativity of fluorine atoms is strong, which increases the attractive force between molecules, so the melting boiling point is higher than that of benzyl alcohol.
In terms of density, it may be different from water, or greater than water, sinking underwater; or less than water, floating on water, which is precisely determined by molecular composition and structure. Under specific conditions, it may be volatile, and it can slowly evaporate in a ventilated place and escape into the air.
What is the chemical synthesis method of "Benzenemethanol, 5 - Bromo - 2 - Fluoro - α - Methyl -"?
The chemical synthesis method of "5-bromo-2-fluoro - α - methylbenzyl alcohol" is an important task studied by chemical experts. This synthesis method often follows a number of paths.
One, can start from the corresponding halogenated aromatics. First, the halogenated aromatics are metallized, such as interacting with magnesium to form Grignard reagents. Take 5-bromo-2-fluorotoluene as an example, and react with magnesium in anhydrous ether or tetrahydrofuran to obtain the corresponding Grignard reagents. Then, the Grignard reagent is reacted with formaldehyde or paraformaldehyde, and through nucleophilic addition reaction, hydroxymethyl is introduced at the α position of the aromatic ring to obtain the target precursor. Subsequent adjustment of appropriate reaction conditions, such as acidification treatment, to obtain 5-bromo-2-fluoro - α - methylbenzyl alcohol.
Second, it can also be started from aromatic aldehyde. First, 5-bromo-2-fluorobenzaldehyde is used as the raw material to carry out methylation reaction. Suitable methylation reagents, such as the combination of iodomethane and base, can be selected. The alkali can be selected from a strong base such as sodium hydride. In a suitable solvent, such as dimethylformamide, the aldehyde group is methylated at the α position. Then, the obtained α-methyl aromatic aldehyde is reduced. Usually sodium borohydride or lithium aluminum hydride are used as reducing agents. In a low temperature and suitable solvent system, the aldehyde group is reduced to hydroxymethyl, and the final result is "5-bromo-2-fluoro - α - methylbenzyl alcohol".
Third, there is still a way to use the reaction of aryl halides with enol ethers. First, 5-bromo-2-fluorophenyl halogen and enol ether are coupled under palladium catalysis to form an intermediate with enol ether structure. Subsequently, a series of reactions such as hydrolysis and reduction of this intermediate are carried out. First hydrolyze the enol ether structure to carbonyl group, and then reduce the carbonyl group to hydroxymethyl group, and adjust the α-position methyl group to achieve the purpose of synthesizing the target product.
During the synthesis process, it is necessary to pay attention to the precise control of the reaction conditions, such as temperature, pH, reaction time, etc., and the products in each step need to be carefully separated and purified to ensure the purity and yield of the final product.
What is the price range for "Benzenemethanol, 5 - Bromo - 2 - Fluoro - α - Methyl -" on the market?
I have heard that you are inquiring about the price range of "Benzenemethanol, 5 - Bromo - 2 - Fluoro - α - Methyl -" in the market. The price of this product is difficult to determine, and the price varies due to many reasons.
First, the purity of the product is essential. If the purity is very high, it is almost flawless, and the price is high; if it contains impurities, the price is slightly reduced. And the preparation method also affects the purity and cost, which in turn affects the price.
Second, the supply and demand of the market determines the price. If there are many people who want it, and the supply is small, the price will rise; if the supply exceeds the demand, the price may fall.
Third, the purchase quantity is also the key. If you buy in bulk, or if you buy in large quantities, the price will be discounted; if you buy sporadically, the price may be higher.
Fourth, the regional differences of the city cannot be ignored. In different places, the price is also different due to the difference in transportation costs and taxes.
To sum up, in order to determine the price, you need to consider various factors in detail. If you want to know the details, you can consult the chemical raw material supplier, or check the industry information, trading platform, to get a more accurate price range.
"Benzenemethanol, 5 - Bromo - 2 - Fluoro - α - Methyl -" is available from manufacturers.
There are many manufacturers related to "5-bromo-2-fluoro - α - methyl benzyl alcohol", but I don't know the details. Because there are many factories in the world, it is difficult to describe them.
There may be a large factory with well-equipped equipment and skilled skills. It has considerable scale and experience in the production of such compounds. It may focus on quality and control the purity and quality of products with strict standards.
There are also small factories. Although the scale is not as large as that of large factories, they specialize in one place and seek excellent products with unique methods. Or in cost control and process innovation, it is unique.
However, if you want to find the exact manufacturer, you should explore it in many ways. If you are inquiring about the experts in the chemical industry, they may know the advantages and disadvantages of many manufacturers based on experience. You can also look at the classics and newspapers of the industry, which may have the introduction of the manufacturer and the promotion of the product.
You can also use the convenience of the Internet to search for relevant information. However, the network information is complex, and it is necessary to screen it in detail to distinguish the truth from the false, in order to obtain a reliable manufacturer. In short, if you want to obtain "5-bromo-2-fluoro - α - methyl benzyl alcohol", you need to collect information and choose carefully.