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What are the physical properties of 3-bromo-5-fluorobenzyl alcohol?
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The viscosity of this substance is slightly higher than that of ordinary water, and the flow rate can make it have a certain cohesion, unlike that of clear water, which is easy to disperse. Its density is special, and it is usually high in solution. Placed in the same container, it can be sank at the bottom, indicating that its amount is concentrated.
The boiling rate of this object is high, and it needs to be high in order to vaporize it. Under normal circumstances, the boiling rate of its boiling rate is set near a certain value, reflecting its high temperature. The melting rate also has characteristics. Under specific low temperature conditions, this object is dissolved and solidified by the liquid, and the absorption rate is obvious.
In terms of solubility, it can be well miscible in some soluble materials. For example, alcohol and ether compounds can be mixed in a certain proportion to form a homogeneous mixing system. However, for most soluble materials, especially water, their solubility is almost insoluble. When the two meet, they will be clearly separated and the boundaries will be clear.
The solubility of this material is weak, almost low. Whether it is in the low temperature or in some non-soluble solutions, it is usually placed in the low temperature to observe the flow of water, indicating that its parts can be freely moved and there are few particles.
In terms of optical properties, this material has a certain refractive index, and the light is incident at a specific angle, which can reveal the refractive image of the material. Through this object, the image of the object can be distorted to a certain extent, and its refractive ability is slightly different from that of the general transparent liquid, which can be regarded as one of the characteristics of this object.
What are the chemical properties of 3-bromo-5-fluorobenzyl alcohol?
3-Bromo-5-fluorobenzamide is an organic compound with the following chemical properties:
1. ** Basic **: The amide group (-CONH ²) in its molecule contains nitrogen atoms, has unshared electron pairs, and can accept protons from acids, showing a certain alkalinity. When reacting with strong acids, nitrogen atoms can be protonated to form corresponding salts. For example, react with hydrochloric acid, or generate [R-CONH 🥰] < Cl (R stands for 3-bromo-5-fluorophenyl).
2. ** Hydrolysis reaction **: Under acidic or alkaline conditions, amide groups are easily hydrolyzed. In acidic conditions, when co-heated with water, 3-bromo-5-fluorobenzoic acid and ammonium salts will be gradually hydrolyzed. Take hydrochloric acid as an example, the reaction formula is: R - CONH 2O + H 2O O + HCl $\ stackrel {\ triangle} {=} $R - COOH + NH Cl (R is 3 - bromo - 5 - fluorophenyl). Under basic conditions, the solution is co-heated with sodium hydroxide and hydrolyzed to produce sodium 3-bromo-5-fluorobenzoate and ammonia. The reaction formula is: R - CONH ³ + NaOH $\ stackrel {\ triangle} {=} $R - COONa + NH ↑ (R is 3-bromo-5-fluorophenyl).
3. ** Substitution reaction **: Bromine atoms and fluorine atoms on the benzene ring have certain activity due to the influence of electron clouds of the benzene ring and adjacent and para-site groups. Under appropriate conditions, nucleophilic substitution reactions can occur. For example, under the action of a strong base and a specific catalyst, bromine atoms can be replaced by nucleophiles such as hydroxy (-OH) and amino (-NH2O) to generate corresponding 3-hydroxy-5-fluorobenzamide or 3-amino-5-fluorobenzamide derivatives.
4. ** Halogen atom reaction characteristics **: Bromine atoms can participate in metal-catalyzed coupling reactions, such as Suzuki coupling reactions, Stille coupling reactions, etc. In the Suzuki coupling reaction, 3-bromo-5-fluorobenzamide and aryl boronic acid, under the action of palladium catalyst and base, can form biaryl compounds, realize the construction of carbon-carbon bonds, expand the complexity of molecular structures, and lay the foundation for the synthesis of more complex organic compounds. The fluorine atom has a significant impact on the electron cloud distribution and physicochemical properties of the molecule due to its large electronegativity, which makes the molecule more lipophilic and affects the absorption, distribution and metabolism of the compound in vivo.
What are the main uses of 3-bromo-5-fluorobenzyl alcohol?
3-Bromo-5-fluorotoluenonitrile is a key intermediate in organic synthesis, and has extremely important uses in many fields such as medicine, pesticides, and materials.
In the field of medicine, it can serve as a key starting material for the synthesis of many biologically active compounds. Due to the unique electronic effect and steric hindrance of fluorine and bromine atoms, it can significantly regulate the physicochemical properties and biological activities of compounds. For example, drug molecules that can build specific structures through a series of reactions can enhance the efficacy of drugs, improve selectivity, or reduce toxic and side effects by modifying the interaction between drugs and targets. For example, in the synthesis of some anti-tumor drugs, 3-bromo-5-fluorotoluonitrile participates in the reaction steps, which can precisely shape the structure of the drug molecule, so that it can better act on the specific target of tumor cells and interfere with the growth and proliferation process of tumor cells.
In the field of pesticides, this compound can be used as an important building block for the synthesis of high-efficiency and low-toxicity pesticides. The introduction of fluorine atoms usually enhances the lipophilicity of pesticides, making it easier to penetrate the waxy layer on the surface of pests and improve the efficacy. For example, in the synthesis of new insecticides, 3-bromo-5-fluorotoluonitrile can be chemically converted into an active ingredient with a unique insecticidal mechanism, showing high activity against specific pests, and at the same time, it is relatively friendly to the environment and non-target organisms, which is in line
In the field of materials, 3-bromo-5-fluorotoluenonitrile can be used to prepare functional polymer materials. By polymerizing with other monomers, special functional groups such as fluorine and bromine can be introduced into the polymer main chain or side chain, endowing the material with excellent thermal stability, chemical stability and optical properties. For example, when preparing high-performance liquid crystal materials, the polymer structure formed by its participation in the reaction can exhibit unique phase transition temperatures and liquid crystal properties, which can be used in new display materials.
What are the synthesis methods of 3-bromo-5-fluorobenzyl alcohol?
To prepare ethyl 3-hydroxy-5-enheptanoate, you can start with the well-known organic synthesis method. There are several common methods as follows.
First, it can be synthesized by diethyl malonate. Diethyl malonate has active methylene. First, it is formed by strong bases, such as sodium ethyl alcohol, to form carbon negative ions. Then it reacts with suitable halogenated hydrocarbons to introduce the corresponding hydrocarbon group. After a series of steps such as hydrolysis and decarboxylation, the target product can be obtained. If halogenated propylene is reacted with diethyl malonate after treatment, and then hydrolyzed and decarboxylated by heating under acidic conditions, a carboxylic acid containing an alkenyl bond can be obtained, and then esterified with ethanol to obtain 3-hydroxy- ethyl 5-enheptanoate.
Second, the Grignard reagent method is used. First, a Grignard reagent is made from a suitable halogenated hydrocarbon, such as allyl magnesium halide. Then it reacts with a carbonyl compound, such as acetaldehyde, and is added to obtain an alcohol. After oxidation, the alcohol hydroxyl is oxidized to a carbonyl group, and then a carboxyl group is introduced, and then esterified with ethanol. Specifically, allyl magnesium halide and acetaldehyde are added to obtain allyl ethanol, oxidized to allyl acetaldehyde by a suitable oxidant, such as PCC, and then reacted with an aldehyde group by sodium cyanide to introduce a cyanyl group. After hydrolysis, carboxylic acid is obtained, and the target ester is esterified with ethanol.
Third, the Claisen condensation reaction can be considered. Select suitable esters, such as ethyl acetate and ethyl acrylate, under the catalysis of strong bases, such as sodium ethanol, Claisen condensation occurs to obtain β-ketoate. After reduction, hydrolysis, acidification and other steps, the target product can be obtained. During the reaction, the reaction conditions are controlled so that the condensation orientation occurs. When reducing, a suitable reducing agent is selected, such as sodium borohydride, and the carbonyl group is accurately reduced to a hydroxyl group. After proper treatment, a pure 3-hydroxyl-5-enheptanoic acid ethyl ester can be obtained.
This method has advantages and disadvantages. In actual synthesis, it is necessary to make a careful choice according to many factors such as the availability of raw materials, the ease of control of reaction conditions, and the purity requirements of the product.
What should be paid attention to when storing and transporting 3-bromo-5-fluorobenzyl alcohol?
Those who hide 3-5-methyl ether should pay attention to all kinds of things. This is a special problem, so you should be careful when you hide it. It should be placed in a dry place to avoid the exposure of sunlight and the invasion of water and fire. When the sun is exposed, you may be afraid of its nature; if the water and fire are close, it will be dangerous. And it is densely hidden to prevent the air and air from the outside from connecting, causing damage.
There is also a need to hide it. Those who are aware of its nature should be careful. The package must be kept tight so that there is no risk of leakage. If it is leaked outside, it will not only lose its effectiveness, but also endanger the people and things around it. On the way, avoid shocks and high. Earthquakes or damage to the package, high-quality and easy-to-induce.
Furthermore, people who are not safe will be affected by the damage, and they will know how to deal with the danger. In case of an accident, they can tolerate it and avoid serious trouble. The equipment of the ship and other equipment of the ship should also be cleaned and dyed, so as not to mix with other things, so as not to affect them. In this way, 3-5-methyl ether can be stored in the water, and its properties are not low, and it is safe and effective to use.