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What are the main uses of 6-amino-2,3-difluorophenyl ethanol?
6-Amino-2,3-dihydroxyacetophenone plays an important role in many fields.
In the field of medicine, it is a key intermediate for drug synthesis. The preparation of many biologically active compounds and drugs is based on this. For example, in the development and production of some anti-inflammatory and antibacterial drugs, 6-amino-2,3-dihydroxyacetophenone can participate in the construction of the core structure of the drug, endowing the drug with specific pharmacological activities, which is of great significance for the treatment and prevention of diseases.
In the chemical industry, it is an important raw material for organic synthesis and can participate in the synthesis of various organic compounds. With its special chemical structure, it can react with other reagents such as condensation and substitution to generate organic products with different properties and uses, such as fine chemicals such as dyes and fragrances used to produce specific properties, to improve the quality and performance of products.
In the field of materials science, 6-amino-2,3-dihydroxyacetophenone also shows potential value. It can be introduced into the material system as a functional additive to improve some properties of materials. For example, adding this substance to polymer materials can enhance the stability and oxidation resistance of materials, thereby expanding the application range of materials. In conclusion, 6-amino-2,3-dihydroxyacetophenone plays a key role in many fields such as medicine, chemical industry and materials science due to its unique chemical structure and reactivity, and plays a significant role in promoting technological development and product innovation in various fields.
What are the physical properties of 6-amino-2,3-difluorophenyl ethanol?
6-Hydroxy-2,3-dihydrobenzofuranone is one of the organic compounds. Its physical properties are unique and detailed as follows:
- ** Appearance and Properties **: It is often in the state of white to light yellow crystalline powder, with fine texture. When viewed in sunlight, it may have a faint luster. This appearance characteristic not only makes it easy to distinguish among many chemical substances, but also lays the appearance foundation for its application in different fields.
- ** Melting Boiling Point **: The melting point is in a specific temperature range, which is of great significance for its processing and application under specific process conditions. When the temperature rises to the melting point, the substance gradually melts from a solid state to a liquid state, and the intermolecular force changes. The boiling point also has a corresponding value, which reflects the conditions for the transformation between gaseous and liquid states. This property is particularly critical in chemical operations such as distillation and purification.
- ** Solubility **: In common organic solvents, such as ethanol, acetone, etc., it exhibits a certain solubility. This means that in chemical reactions or formulation preparations using these organic solvents as a medium, 6-hydroxy-2,3-dihydrobenzofuranone can be uniformly dispersed in it, thus effectively participating in the reaction or performing its specific functions. However, its solubility in water is relatively limited, which limits its direct application in aqueous systems, but also prompts it to shine in oil-soluble or organic solvent system products.
- ** Density **: Has a specific density value, which determines its distribution in the mixed system. In the liquid mixture system, depending on the density, 6-hydroxy-2,3-dihydrobenzofuranone is either in the upper layer or at the bottom, which has a profound impact on the stability and separation operation of the mixture.
- ** Odor **: Usually emits a weak and special odor, although not pungent, it is unique. This odor needs to be taken into account when applying the product, especially in the field of odor sensitivity, such as food, cosmetics and other industries, its odor characteristics may affect the overall sensory quality of the product.
What are the chemical properties of 6-amino-2,3-difluorophenyl ethanol?
6-Hydroxy-2,3-dihydrobenzofuranone, which has the characteristics of light color, high melting point and good stability. It has phenolic hydroxyl groups, can form salts, and complexes with metal ions. It is used as a chelating agent for metal ions in the chemical and pharmaceutical fields. And phenolic hydroxyl groups are active, can undergo esterification and etherification reactions, and can be synthesized into esters and ethers in organic synthesis.
The carbonyl groups of 6-hydroxy-2,3-dihydrobenzofuranone can participate in nucleophilic addition, such as acetals or ketals with alcohols, to protect carbonyl groups or build complex structures in organic synthesis. And because of its conjugated system, it has a certain UV absorption, which can be used for content determination and purity analysis.
In addition, 6-hydroxy-2,3-dihydrobenzofuranone also has biological activity, which is of concern in the field of pharmaceutical research and development, or can be used as a lead compound to develop drugs. Its unique chemical structure and diverse reactivity make it have broad application prospects and research value in many fields such as chemical industry, medicine, materials science, etc., and can provide important raw materials and research basis for innovative development in related fields.
What are the synthesis methods of 6-amino-2,3-difluorophenyl ethanol?
To prepare 6-hydroxy-2,3-dihydrobenzofuranone, the following ancient methods can be followed:
First, the starting material is o-hydroxy phenylacetic acid. Schilling o-hydroxy phenylacetic acid and acetic anhydride are co-heated, and after acylation, o-acetoxyphenylacetic acid is obtained. Then in the presence of a suitable catalyst, such as concentrated sulfuric acid or p-toluenesulfonic acid, the reaction of intramolecular cyclization is carried out. In this process, the acetoxy group interacts with the carboxyl group, loses water to form a ring, and then obtains 6-hydroxy-2,3-dihydrobenzofuranone. This path step is slightly simpler, but it is necessary to pay attention to the reaction temperature and the amount of catalyst to prevent side reactions.
Second, resorcinol is used as the starting material. The resorcinol is first reacted with chloroacetic acid in an alkaline environment to obtain resorcinol oxyacetic acid. After that, it is treated with a suitable dehydrating agent, such as phosphorus pentoxide or phosphorus oxychloride, to promote intramolecular cyclization and dehydration, and finally obtain the target product. In this approach, the control of the alkaline environment and the choice of dehydrating agent are crucial, which are related to the success or failure of the reaction and the purity of the product.
Third, 2-hydroxyphenylpropionic acid is used as the starting material. The 2-hydroxyphenylpropionic acid is co-heated with an appropriate amount of acid catalyst, such as hydrobromic acid or sulfuric acid, and the intramolecular esterification reaction occurs first to form a lactone structure. After appropriate oxidation steps, such as treatment with mild oxidants such as manganese dioxide, the lactone structure can be oxidized to 6-hydroxy-2,3-dihydrobenzofuranone. In this route, the oxidation step needs to be carefully regulated to avoid excessive oxidation and damage to the product.
All methods have advantages and disadvantages. In practice, the choice should be based on factors such as the availability of raw materials, reaction conditions, product purity and yield.
What is the price range of 6-amino-2,3-difluorophenyl ethanol in the market?
6-Hydroxy-2,3-dihydrobenzofuranone, the price of this product in the market is not fixed. The change in its price is related to many reasons.
The first one is the difficulty and cost of making it. If it requires breeding methods, expensive materials, and consumes a lot of energy, its price will be high. If you want to get a pure product, or need exquisite methods and high skills, it will increase your cost, and the price will also rise.
The second one is the situation of demand. If you ask for more of this product in the industry, but if you supply less, the price will rise. If a certain region uses it as a key material to make special medicines or refined products, the need is very urgent, and the production is limited, the price will increase. On the contrary, if the supply exceeds the demand, the producers will compete to sell, and the price will drop.
Furthermore, the rules of the city and the guidance of the government also have an impact. The movement of the big market, like the rise and fall of the market, can shift the demand for this product and cause the price to change. Politicians issue regulations, or encourage production, or limit use, can all affect its price.
However, it is difficult to determine the price of it now. With no detailed market information, it is difficult to stop the current situation of supply and production. But it can be deduced that if it is used in the market of fine chemical and pharmaceutical research and production, the price may be high, or tens to hundreds of gold per gram; if the production technology advances, the supply will increase, and the price may decrease. In short, its price varies due to market conditions. To know the exact number, you need to look at the real-time market conditions.