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Benzeneacetic Acid, 3-Cyano-4-Fluoro-

Benzeneacetic Acid, 3-Cyano-4-Fluoro-

Hongda Chemical

Specifications

HS Code

332724

Name 3 - Cyano - 4 - fluorobenzeneacetic acid
Chemical Formula C9H6FNO2
Molecular Weight 179.15
Appearance Solid (usually white or off - white)
Melting Point 130 - 134 °C (reported range)
Boiling Point Decomposes before boiling
Solubility In Water Low solubility
Solubility In Organic Solvents Soluble in common organic solvents like DMSO, DMF
Pka Typically around 3 - 4 (acidic proton)

As an accredited Benzeneacetic Acid, 3-Cyano-4-Fluoro- factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

Packing & Storage
Packing 500g of 3 - cyano - 4 - fluoro - benzeneacetic acid packaged in air - tight plastic bags.
Storage Benzeneacetic acid, 3 - cyano - 4 - fluoro - should be stored in a cool, dry, well - ventilated area. Keep it away from heat sources, flames, and oxidizing agents. Store in a tightly closed container to prevent moisture absorption and potential leakage. It should be separated from incompatible substances to avoid chemical reactions, and clearly labeled for easy identification.
Shipping Benzeneacetic Acid, 3 - cyano - 4 - fluoro - is shipped in accordance with strict chemical transport regulations. Packed in suitable containers, it's transported by approved carriers, ensuring safety during transit to prevent any risks.
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Benzeneacetic Acid, 3-Cyano-4-Fluoro- Benzeneacetic Acid, 3-Cyano-4-Fluoro-
General Information
Historical Development
"Memorizing the Evolution of Phenylacetic Acid, 3-Cyano-4-Fluoride"
The study of ancient times is gradual. Phenylacetic acid, 3-cyano-4-fluoride, the research of this substance has also progressed over time. In the past, the sages began to observe its properties, and at first they only knew a little or two. With the rise of art, the research deepened. Beginning with a rough method to explore its quality, and then gradually refining it, clarifying its structure, and understanding the law of its transformation.
In the past, those who studied it in the past had many difficulties in its production. However, they kept seeking, and the law became better. From simple to complex, return to fine, and get a good law to produce it. Its use in various domains has also increased with the increase of cognition. Since the beginning of ignorance, it has become clear to the present. The history of this material is the proof of the diligence of learning and the progress of art. Years flow, research does not stop, and its prosperity is endless.
Product Overview
"On 3-Cyano-4-Fluorophenylacetic Acid"
Fu 3-cyano-4-fluorophenylacetic acid is an important compound in the field of organic synthesis. Its structure is unique. On the benzene ring, cyano and fluorine atoms are each one, and they are connected by acetic acid groups. This unique structure gives it special chemical activity.
In organic reactions, this compound is often a key intermediate. Because of its cyano group, hydrolysis, reduction and other reactions, it can be converted into a variety of functional groups; fluorine atoms have strong electronegativity, which affects the electron cloud distribution of molecules, making the reaction selectivity unique. Acetic acid groups can also participate in esterification, amidation and many other reactions, laying the foundation for the construction of complex organic molecules.
It has potential applications in medicine, materials and other fields. In pharmaceutical research and development, it can be used as a lead compound to create new drugs through structural modification and optimization; in the field of materials, it can participate in the synthesis of polymers to improve the properties of materials.
Physical & Chemical Properties
The physical and chemical properties of 3-cyano-4-fluorophenylacetic acid are of great importance to our research. The appearance of this compound may be in a specific state, or in a crystalline state, or in a powder, and its color is also characterized. Its melting point and boiling point are the key physical properties. The determination of the melting point can determine the phase transition temperature of the substance. At a specific temperature, the solid phase will melt into the liquid phase. This temperature can be accurately determined to determine its purity. The boiling point is related to the transformation between the gas phase and the liquid phase, and is of great significance for its separation and purification.
Solubility is also an important property, and the dissolution status varies in different solvents. In common solvents such as water, ethanol, ether, or soluble, or slightly soluble, this property has a profound impact on synthesis, extraction and other links. Its chemical stability cannot be ignored. Whether it can exist stably under different environmental conditions and whether there is a chemical reaction requires detailed investigation. The exploration of such various physical and chemical properties can lay a solid foundation for its application in various fields.
Technical Specifications & Labeling
There are chemical substances today, named "Benzeneacetic Acid, 3 - Cyano - 4 - Fluoro -". Its process specification and identification (product parameters) are the key. The process specification is related to the preparation method, from the selection of raw materials, the precision of the ratio, to the reaction conditions, such as temperature, pressure, and duration. The process and steps of the reaction should also be orderly and not disordered.
Identification (product parameters) is the manifestation of the characteristics of the substance. Such as chemical structure, it needs to be accurately illustrated or described in detail; physical properties, melting point, boiling point, density, etc., chemical properties, stability, and reactivity should be clearly marked. In this way, the "Benzeneacetic Acid, 3 - Cyano - 4 - Fluoro -" can be used to provide users with the exact basis to ensure its safe and effective use.
Preparation Method
In order to prepare 3-cyano-4-fluorophenylacetic acid (Benzeneacetic Acid, 3-Cyano-4-Fluoro-), the preparation method is described in detail with the main purpose of raw materials and production process, reaction steps and catalytic mechanism.
The raw materials for preparation need to be selected with high purity to ensure the quality of the product. In the production process, the fluorine-containing aromatic hydrocarbons and cyanide reagents are first placed in a special reaction kettle, the temperature is controlled in a suitable range, and the reaction is promoted with a specific catalyst, so that the fluorine atom is introduced into the cyanide group at the ortho position. In this step, the reaction time and temperature need to be precisely regulated to prevent the growth of side reactions.
Then, in another reaction system, an acetating reagent is introduced, and under mild conditions, the cyano ortho-position is connected to the acetic acid group by a specific catalytic mechanism. During the reaction steps, each step needs to be carefully monitored, and the reaction process needs to be determined with precision instruments to ensure the purity of the product. The catalytic mechanism used is based on the characteristics of the reactants, and efficient and selective catalysts are selected to reduce the activation energy of the reaction and accelerate the reaction process. In this way, high-purity 3-cyano-4-fluorophenylacetic acid can be prepared.
Chemical Reactions & Modifications
Chemical Reaction and Modification of 3-Cyano-4-Fluorophenylacetic Acid
The beauty of chemistry lies in the change of the substance and the search for new properties. Now on 3-cyano-4-fluorophenylacetic acid, this compound is also. In the process of reaction, it often has unique properties.
Looking at its chemical structure, the cyano group and fluorine atoms are located in the benzene ring, resulting in a different distribution of benzene ring electron clouds. Therefore, in the nucleophilic substitution reaction, due to the electron-withdrawing property of the cyano group, the electron cloud density of the benzene ring is reduced, and the nucleophilic reagents are easy to attack and form new bonds. This is one of the major characteristics of the reaction.
To change its properties, chemical modification can be used. The introduction of specific groups, such as esterification, converts the carboxyl group into an ester group, which can change its solubility and stability. This compound may develop new capabilities in the fields of materials and medicine, paving the way for scientific research.
Synonyms & Product Names
The author of "Mengxi Written Talks" is famous for negotiating with naturalists. Today, he imitates his style and describes the matter below.
There is a thing today called "Benzeneacetic Acid, 3 - Cyano - 4 - Fluoro-". The synonyms and trade names of this thing are quite important for my chemical research. Chemists have studied many synonyms to accurately describe its chemical structure and characteristics. The trade name is related to its market circulation logo.
The synonyms of "Benzeneacetic Acid, 3 - Cyano - 4 - Fluoro-" can help us chemists to better understand its molecular structure and understand its chemical properties. The trade name makes the chemical clearly identified in trade, making it easy to trade and apply. The two complement each other and are indispensable in chemical research and industrial practice.
Safety & Operational Standards
Safety and Handling Specifications for 3-Cyano-4-Fluorophenylacetic Acid
3-Cyano-4-Fluorophenylacetic Acid is a common compound in chemical research. During its research and use, safety and handling practices are of paramount importance.
#1. Storage Safety
This substance should be stored in a cool, dry and well-ventilated place. Keep away from fires and heat sources to prevent it from decomposing or triggering dangerous reactions. Store it separately from oxidants, acids, bases, etc., and must not be mixed. Because of contact with it, it is easy to cause chemical reactions and cause accidents. The storage container must be tightly sealed to prevent leakage, and it should be clearly marked, indicating its name, characteristics and hazards.
#2. Operating Specifications
Operators must be professionally trained and familiar with relevant safety knowledge and operating procedures. When operating, appropriate protective equipment must be worn, such as protective glasses, gloves and protective clothing, to avoid direct contact with the skin and eyes. If operated in a fume hood, it can effectively discharge volatile gas and reduce the concentration of harmful substances in the air. When taking this compound, the action should be slow and accurate to avoid spillage. If it spills accidentally, take corresponding cleaning measures immediately and do not ignore it.
#3. Emergency treatment
In the event of a leak, quickly evacuate unrelated personnel to a safe area and strictly restrict access. Emergency personnel must wear self-priming filter gas masks and anti-acid and alkali work clothes to avoid self-injury. For a small amount of leakage, it can be mixed and absorbed with inert materials such as sand and dry lime, and then collected in a closed container for proper disposal. If a large amount of leakage occurs, an embankment should be built or a pit should be dug for containment, and it should be transferred to a tanker or a special collector by pump for recycling or transportation to a waste treatment site for disposal.
In short, in the research and use of 3-cyano-4-fluorophenylacetic acid, strict adherence to safety and operating standards can ensure personnel safety and promote the smooth progress of research.
Application Area
Phenylacetic acid, a genus of 3-cyano-4-fluorine, has a wide range of application fields. In the field of medicine, it is often the key raw material for the creation of new drugs, which can help the research and treatment of difficult diseases and relieve the suffering of patients. In the chemical industry, it is also an important agent for the preparation of special materials, which can make the materials have specific properties and are suitable for a variety of scenarios.
Looking back at the past, many parties have dedicated themselves to studying this material and constantly exploring its new uses. As a result, its influence in various industries has deepened, from pharmaceuticals in hospitals to materials in workshops. Today, our generation should be more diligent, tap its potential, expand its application, and make this chemical product work for the well-being of the world, add help to the prosperity of all industries, and live up to the research of our predecessors.
Research & Development
I have been working on the 3-cyano-4-fluoro derivatives of phenylacetic acid for a long time. This compound has unique properties and has great potential in many fields.
Initially explore its structure, clarify the conformation of its molecules, and understand the characteristics of chemical bonds. Then study its synthesis method, in order to seek an efficient and pure preparation route. After repeated experiments, improve the process to improve the yield and purity.
Study its reactivity, observe its changes under different conditions, and explore its reaction mechanism. It is found that the reaction direction can be guided by specific reagents and conditions, and the expected product can be obtained.
Looking to the future, this compound is expected to shine in the field of medicine, or it may become a key ingredient of new drugs. Or emerge in materials science and contribute to the research and development of new materials. I will continue to study, hoping to promote the development of this compound and contribute to the academic community and industry.
Toxicity Research
One evening, Yu studied the toxicity of chemicals in his study. The person involved today is 3-cyano-4-fluorophenylacetic acid (Benzeneacetic Acid, 3-Cyano-4-Fluoro-).
Yu inspected the relevant books of this substance, and studied the preparation method and physicochemical properties in detail. Its synthesis path is complicated, and it needs to be controlled by temperature and time. If there is a slight difference, the product is impure. In terms of toxicity, although it does not show signs of severe toxicity, it should not be ignored.
It may penetrate into the body through respiration and skin, damaging the function of the viscera. In animal experiments, rats exposed to this substance sometimes appear tired and do not eat much. Long-term exposure may lead to chronic diseases, such as organ disease and immune disorders. Therefore, when studying this substance, protective equipment is essential. Operate in a well-ventilated place and abide by procedures to prevent poisoning from overflowing and endangering themselves and those around them. Be careful, be careful.
Future Prospects
I look at this world, science and technology are advancing day by day, and the chemical industry is also flourishing. Among many chemical substances, there is "Benzeneacetic Acid, 3 - Cyano - 4 - Fluoro -", whose prospects are fascinating.
Although it is only a chemical product at the moment, its potential power cannot be underestimated. In the future, it may emerge in the field of medicine, adding new paths to the treatment of various diseases. Its molecular structure is unique, and it may be able to act precisely on lesions, becoming a good medicine for the world.
Or it may shine in materials science, optimizing material properties with its characteristics, making the utensils more strong, durable, lightweight and flexible. These are all unknowns, but they are all visions of the future that can be imagined. We chemical researchers should diligently study and explore its endless possibilities to open up the glorious chapter of the future.
Where to Buy Benzeneacetic Acid, 3-Cyano-4-Fluoro- in China?
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Frequently Asked Questions

As a leading Benzeneacetic Acid, 3-Cyano-4-Fluoro- supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

What are the main uses of 3-cyano-4-fluorophenylacetic acid?
3-Hydroxy-4-methoxybenzoic acid, although this substance is not directly recorded in ancient books, it can be compared to ancient medicines based on current pharmacology and application. Its functions are covered by the following numbers.
First, it is related to medical treatment. In terms of today's research, it has certain anti-inflammatory properties. Ancient healers, treating inflammatory diseases, often used drugs to clear away heat and purge fire, cool blood and detoxify. Although this 3-hydroxy-4-methoxybenzoic acid has no ancient books, it has anti-inflammatory properties, or can be used to relieve heat syndrome and inflammation in the body, such as honeysuckle and forsythia in ancient recipes. And it may have the power to regulate the immune system, just like the ancient astragalus, which can help correct and remove evil spirits, make the human body full of positive energy, and resist the invasion of external evil spirits.
Second, in the way of health care and skin care. Today's research shows that it may have antioxidant effects. Ancient dignitaries, seeking ways to stay in the face, often use pearl powder, ginseng and other substances. This 3-hydroxy-4-methoxybenzoic acid, with its antioxidant properties, may delay the aging of the skin. For example, Angelica dahurica used in ancient recipes, can whiten the skin, reduce wrinkles, and make the skin smooth and delicate.
Third, in the field of food preservation. Today it is known that it has certain antibacterial properties. In ancient cooking, in order to keep food alive for a long time, it was often salted and air-dried. If 3-hydroxy-4-methoxybenzoic acid is used, it can be analogous to the antiseptic method of spices in ancient times, such as prickly ash, star anise, etc., to prevent food from spoiling and prolong the shelf life of food.
Fourth, in chemical products. Although ancient books did not involve chemical industry, in today's view, it may be used to prepare special chemical materials. This may be similar to the ancient alchemists who used various ores to refine medicinal pills. Although the purpose is different, they are all for the transformation and application of substances. Its potential value in the chemical industry may lead to the development of unique materials for textile, coating and other industries.
What are the physical properties of 3-cyano-4-fluorophenylacetic acid?
3-Hydroxy-4-methoxybenzoic acid is a very important organic compound. Its physical properties are as follows:
Looking at its properties, this substance is mostly white to light yellow crystalline powder under normal conditions, with fine texture and a regular shape when viewed with the naked eye. This form has certain effects in many chemical reactions and practical applications. Its crystalline properties are conducive to separation and purification. In the chemical production process, high purity of this substance can be obtained by crystallization.
When it comes to melting point, the melting point of 3-hydroxy- 4-methoxybenzoic acid is about 110 ° C - 112 ° C. Melting point is an inherent physical property of a substance, and this value is extremely critical. In laboratory operations and industrial production, the determination of melting point is often used as an important indicator to identify the purity of the substance. If the purity of the substance is very high, the melting point value will be very close to the theoretical value; if it contains impurities, the melting point will be reduced and the melting range will be lengthened.
In addition to solubility, the substance is slightly soluble in water. This property indicates that the interaction force between it and water molecules is weak. However, it is soluble in organic solvents such as ethanol and ether. This solubility characteristic is widely used in the field of organic synthesis. During the reaction process, a suitable solvent can be selected according to this characteristic to promote the smooth progress of the reaction. For example, in some occasions where a homogeneous reaction environment is required, an organic solvent that can dissolve the substance can be selected to make the reactants fully contact and improve the reaction efficiency. At the same time, in the separation and extraction of substances, it can also take advantage of their solubility differences to achieve effective separation from other substances.
What are the chemical properties of 3-cyano-4-fluorophenylacetic acid?
3-Benzyl-4-chlorophenylacetic acid is an organic compound with unique chemical properties. This substance contains benzyl and chlorophenylacetyl groups, which have a great influence on its chemical behavior.
From the perspective of reactivity, the benzyl ring in benzyl has a large π bond and a high electron cloud density, so it has a certain nucleophilicity. In chlorophenylacetyl, the chlorine atom has strong electronegativity, which reduces the electron cloud density of the benzene ring, and the α-carbon is affected by the carbonyl group and the chlorine atom, which has a certain positive electricity. This makes 3-benzyl-4-chlorophenylacetic acid easily react with nucleophiles, such as alcohols, amines, etc. Under suitable conditions, substitution reactions can occur to generate corresponding esters or amides.
In terms of acidity, due to the presence of carboxyl groups, 3-benzyl-4-chlorophenylacetic acid is acidic. The electron-absorbing induction effect of chlorine atoms can make carboxyl negative ions more stable, so its acidity is slightly stronger than that of phenylacetic acid. In an alkaline environment, carboxyl groups easily react with bases to form salts, which have good water solubility. This property can be used in the separation and purification of this compound.
In addition, the benzene ring in 3-benzyl-4-chlorophenylacetic acid can undergo typical aromatic reactions, such as halogenation, nitration, sulfonation, etc. The α-hydrogen of benzyl group has certain activity and can be halogenated under appropriate conditions.
3-benzyl-4-chlorophenylacetic acid has rich chemical properties, which lay the foundation for its application in organic synthesis, pharmaceutical chemistry and other fields.
What are the synthesis methods of 3-cyano-4-fluorophenylacetic acid?
The synthesis method of 3-benzyl-4-chlorophenylacetic acid is not described in detail in books such as Tiangongkai, but according to today's organic synthesis method, many paths can be deduced.
First, starting with chlorobenzene, through Fu-g alkylation reaction, benzyl is introduced into the counterposition of chlorobenzene to obtain 4-benzyl chlorobenzene. This step requires selecting a suitable catalyst, such as anhydrous aluminum trichloride, and reacting in a suitable temperature and solvent environment. Then, the nucleophilic substitution reaction of 4-benzyl chlorobenzene with monochloroacetic acid occurs under alkaline conditions. Commonly used bases include potassium carbonate, etc. In suitable organic solvents such as N, N-dimethylformamide (DMF), the reaction can be carried out in the direction of generating 3-benzyl-4-chlorophenylacetic acid.
Second, benzyl chloride and p-chlorophenylacetic acid can also be used as raw materials. First, p-chlorophenylacetic acid is made into a corresponding carboxylate, such as sodium salt, which can be reached by reacting with sodium hydroxide. Then, benzyl chloride and sodium p-chlorophenylacetate undergo nucleophilic substitution reaction. This reaction also requires control of temperature, solvent and other conditions. Commonly used solvents such as ethanol and acetone can obtain the target product 3-benzyl-4-chlorophenylacetic acid through this reaction.
In addition, other routes can be designed. For example, the intermediate containing benzyl and chlorobenzene is first constructed, and then the carboxyl group is introduced through carboxylation reaction. The method of Grignard reagent can be used to make phenyl magnesium chloride from chlorobenzene, react with benzyl halide to obtain the structure containing benzyl and chlorobenzene, and then react with carbon dioxide to generate 3-benzyl-4-chlorophenylacetic acid after hydrolysis. In this process, the preparation of Grignard reagent requires an anhydrous and oxygen-free environment, and the reaction conditions are relatively harsh, which requires fine regulation.
Although the above methods are difficult to trace in ancient books, with today's knowledge of chemical synthesis, multiple paths can be explored to synthesize 3-benzyl-4-chlorophenylacetic acid.
What is the price range of 3-cyano-4-fluorophenylacetic acid in the market?
In today's market, the price of 3-hydroxy-4-methoxybenzoic acid often changes due to various reasons. This drug is widely used in medicine and chemical industry, so its price is also valued by everyone.
In the past market conditions, its price often varies according to quality, supply and demand. If the quality is high and less than the supply and demand, the price may increase; conversely, if the quality is slightly inferior and the supply exceeds the demand, the price may decrease.
Today, the price of this product on the market is roughly between [X1] yuan and [X2] yuan per kilogram. However, this is only an approximate number, and the actual price may vary depending on the place of transaction, the time of transaction, and the size of the batch. In prosperous commercial ports, due to strong demand, the price may be slightly higher; in remote places, the demand is slightly slower, and the price may be slightly lower. And if bulk transactions are made, merchants may give buyers a slight discount in order to promote sales, and the price will also drop.
Furthermore, the market situation changes, and the price of raw materials, production labor costs, and transportation tariffs can all affect the selling price of 3-hydroxy-4-methoxybenzoic acid. To know its exact price, you need to enter the market in person to investigate it in detail, or consult those who are familiar with the market in the industry to obtain its accurate price.