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What is the chemical property of Benzeneacetic Acid, 2-Bromo-4- (Trifluoromethyl) -?
2-Bromo-4- (trifluoromethyl) phenylacetic acid is a genus of organic compounds. Looking at its structure, there is one bromine atom, one trifluoromethyl group and one phenylacetic acid group on the benzene ring.
Physical properties of this compound, at room temperature, or as a solid, but the specific melting and boiling point depends on its purity and external conditions. Its solubility may be good in organic solvents such as ethanol and ether, but poor in water. Because it is an organic molecule, its polarity is not strong.
As for chemical properties, bromine atoms are quite active and can participate in nucleophilic substitution reactions. Nucleophiles, such as sodium alcohols, amines, etc., can interact with bromine atoms to make them leave and form new compounds.
Trifluoromethyl, which has strong electron-absorbing properties, can affect the electron cloud density of the benzene ring, so that the electron cloud density of the benzene ring is reduced, and the electrophilic substitution activity of the benzene ring is decreased. The meta-site is relatively more prone to electrophilic substitution.
Carboxyl groups are also active in nature and can form salts with bases, such as reacting with sodium hydroxide to obtain corresponding sodium salts. Under acid catalysis, esterification reactions with alcohols can occur to form ester compounds.
This compound has a wide range of uses in the field of organic synthesis, or is a key intermediate for the preparation of complex organic compounds, assisting organic chemists in constructing multi-structural organic molecules.
What are the main uses of Benzeneacetic Acid, 2-Bromo-4- (Trifluoromethyl) -?
2-Bromo-4- (trifluoromethyl) phenylacetic acid has a wide range of uses. In the field of pharmaceutical synthesis, it is a key intermediate. In the process of drug development, it is often used as a starting material to construct complex molecular structures with specific pharmacological activities through delicate chemical reaction steps. For example, in the preparation of some antidepressant drugs, 2-bromo-4- (trifluoromethyl) phenylacetic acid participates in the reaction steps that play a decisive role in the activity and selectivity of the final drug molecule, which can precisely regulate the interaction between the drug and the target in the body, thereby improving the efficacy and reducing side effects.
In the field of pesticide creation, it also plays an indispensable role. With its unique chemical structure, it can be used as an important building block for the synthesis of new and efficient pesticides. Through reasonable structural modification and derivatization, the obtained pesticides show excellent control effects on specific pests and diseases. For example, for some stubborn pests, the synthetic pesticides based on this can interfere with the physiological and metabolic processes of pests, inhibit their growth and reproduction, and have little impact on the environment, which is in line with the current concept of green environmental protection.
In the field of materials science, 2-bromo-4- (trifluoromethyl) phenylacetic acid also has unique applications. It can be used as a key modifier in the synthesis of functional materials, giving materials special properties. For example, in the preparation of some polymer materials, the introduction of this substance can improve the thermal stability, chemical resistance, and optical properties of the material, expanding the application range of the material in electronic devices, optical instruments, and other fields.
What is the synthesis method of Benzeneacetic Acid, 2-Bromo-4- (Trifluoromethyl) -?
The method of synthesizing 2-bromo-4- (trifluoromethyl) phenylacetic acid can be carried out according to the following steps.
First, 4- (trifluoromethyl) acetophenone is used as the starting material. In the reaction vessel, an appropriate amount of 4- (trifluoromethyl) acetophenone and bromine are added, and an appropriate solvent such as glacial acetic acid is used as the medium. Under mild heating and stirring conditions, the two are brominated. During this process, bromine atoms selectively replace hydrogen atoms at specific positions on the benzene ring to generate 2-bromo-4- (trifluoromethyl) acetophenone. Pay attention to the reaction temperature and the amount of bromine to prevent the occurrence of side reactions such as excessive bromination.
After the bromination reaction is completed, the obtained 2-bromo-4- (trifluoromethyl) acetophenone is oxidized after preliminary treatment such as cooling and separation. Suitable oxidants can be selected, such as alkaline oxidation systems such as potassium permanganate. Under heating and stirring conditions, the carbonyl group of acetophenone is oxidized to a carboxyl group, thereby converting it into 2-bromo-4- (trifluoromethyl) phenylacetic acid.
After the reaction is completed, by adjusting the pH value of the reaction solution, the product is precipitated in solid form. Pure 2-bromo-4- (trifluoromethyl) phenylacetic acid can be obtained by filtration, washing, drying and other operations. During the whole synthesis process, strict control of the reaction conditions of each step, such as temperature, reagent dosage, reaction time, etc., can ensure the yield and purity of the product.
Benzeneacetic Acid, 2-Bromo-4- (Trifluoromethyl) - What is the price range in the market?
Wen Jun inquired about the price range of 2-bromo-4- (trifluoromethyl) phenylacetic acid in the market. However, the price of this product often changes for many reasons, and it is difficult to give an exact price.
One is related to the manufacturer. Different manufacturers have different pricing due to differences in technology and cost control. A well-known factory with excellent craftsmanship has excellent product quality and high price; an emerging or small-scale factory is a market share, price or close to the people.
Second, the amount has a great impact. If you buy in bulk, the unit price can often be discounted due to economies of scale; if you buy only a small amount, the unit price will increase in order to maintain operating costs.
Third, the market supply and demand situation is the key. When demand exceeds supply, prices are prone to rise; if supply exceeds demand, merchants may reduce prices.
Fourth, the cost of raw materials also affects the price. The price of raw materials required to produce this product fluctuates, and the price of the product also fluctuates.
Overall, if you buy in small quantities, the price per gram may range from tens of yuan to hundreds of yuan; if you buy in large quantities, the price per gram may be reduced to a few yuan to tens of yuan. However, this is only a rough guess. The actual price still needs to be checked in detail with the relevant chemical product suppliers or on the chemical trading platform.
What are the storage conditions for Benzeneacetic Acid, 2-Bromo-4- (Trifluoromethyl) -?
2-Bromo-4- (trifluoromethyl) phenylacetic acid, this is an organic compound. The method of hiding it is related to its properties and is crucial.
Because of its specific chemical properties, it should be placed in a cool, dry and well-ventilated place. If it is placed in a high temperature or humid place, it may cause it to deteriorate or cause chemical reactions. For example, high temperature or promote its decomposition, humid gas may cause it to hydrolyze, resulting in impaired purity and reduced effectiveness.
And it needs to be kept away from fire and heat sources. This compound may be flammable, and it is dangerous to encounter open flames, hot topics, or brew fires. It should also be stored in isolation from oxidizing agents to prevent oxidation reactions, damage to its quality, and even cause danger.
The storage place should be equipped with the corresponding variety and quantity of fire fighting equipment and leakage emergency treatment equipment. If there is a leak, it can be dealt with in time to avoid greater harm. The containers used should also be well sealed to avoid excessive contact with the air and prevent it from reacting with the components in the air.
During the storage process, it should also be checked regularly to see if its state has changed to ensure its quality and safety. In this way, 2-bromo-4- (trifluoromethyl) phenylacetic acid can be properly preserved so that it can play its due role when used.