As a leading Benzeneacetic Acid, 2-Bromo-4-Fluoro- supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
What are the physical properties of 2-bromo-4-fluorophenylacetic acid?
The physical properties of 2-% hydroxy-4-enheptanedioic acid are as follows:
This substance is mostly white and crystalline at room temperature. When it is pure, the appearance is clean, and the crystals are regular and orderly. Smell it, few odors are emitted, and there is no special odor.
In terms of solubility, it has a certain solubility in water. Water is also the solvent of all things. 2-Hydroxy-4-enheptanedioic acid is soluble with water, but not infinitely miscible. This is because there are both hydrophilic hydroxyl groups and hydrophobic carbon chain parts in the molecular structure. In polar organic solvents, such as ethanol and acetone, its solubility is better. Ethanol, due to its polarity and hydrogen bonding, can interact with 2-hydroxy- 4-enheptanedioic acid to promote its dissolution.
The melting point has been determined by many experiments, and it is about a certain temperature range. When the temperature rises to the melting point, the substance gradually melts from a solid state to a liquid state. This process requires absorption of a certain amount of heat to overcome the lattice energy. The characteristics of its melting point are closely related to the intermolecular forces. Hydrogen bonds, van der Waals forces, etc. are intertwined to determine the melting point.
The density of the substance is also a specific value. For density, the mass per unit volume of the substance is also the same, and this value reflects the tightness of the arrangement of particles inside the substance. The density of 2-hydroxy-4-enheptanedioic acid makes it exhibit corresponding sedimentation or suspension characteristics when mixed with other substances in a specific environment.
As for the refractive index, it is also an important parameter to characterize its optical properties. When light passes through this substance, due to the influence of the internal structure of the substance on the speed of light propagation, the light is refracted, and the refractive index is a measure of its degree of refraction. This property is of great significance in optical analysis and identification.
What are the chemical properties of 2-bromo-4-fluorophenylacetic acid?
Ethyl 2-% 4-ethyl butyrate has the following properties:
This compound has the properties of an ester. Its molecule contains an ester group (-COO-), so it can be hydrolyzed. Under acidic conditions, 2-4-ethyl butyrate is hydrolyzed, and the ester group is cracked to produce 2-4-ethyl butyrate ethanol. Its inverse formula is generally: 2 - ethyl - 4 - ethyl butyrate + H _ 2O $\ xrightleftharpoons [H ^{+}]{}$ 2 - 4 - ethyl butyric acid + C _ 2O H _ OH. However, under the normal condition, the hydrolysis is more complete, and the ester group is reversed to generate 2 - 4 - ethyl butyrate ethanol, which is irreversible.
2 - 4 - ethyl butyrate (-OH) also makes it specific. In case of carboxylic acid or its derivatives, under the action of catalysis, the carboxylic group (-COOH) can be combined with water to form a new ester.
In addition, because it contains a multi-active group, it can be substituted and reversed. The atom of the alkyl group can be replaced by other atoms or groups, such as the atom of the alkyl group, etc., to derive a variety of compounds.
And because of the presence of carbon in the alkyl group, it has certain flammability. Under the appropriate conditions, it can generate oxygen, generate carbon dioxide, generate water, and release energy.
The chemical properties of 2-ethyl-4-ethyl butyrate make it useful in a wide range of fields, such as chemical synthesis, chemical synthesis, etc. It can be used for the synthesis of more complex compounds.
What are the main uses of 2-bromo-4-fluorophenylacetic acid?
2-% hydroxy- 4-allylbenzoic acid, which was mentioned in the ancient times of "Tiangong Kaiwu" or not explicitly mentioned, is widely used in today's chemical use.
In the field of organic synthesis, it is an important intermediate. It can be converted into many organic compounds with special functions through specific chemical reactions. For example, by esterification reaction, it can be combined with alcohols to form corresponding ester compounds. Such esters are often used as fragrance components in the fragrance industry to give fragrances a unique aroma and add their flavor level.
In the field of pharmaceutical chemistry, 2-hydroxy- 4-allylbenzoic acid also has potential value. Due to the activity check point of its molecular structure, it can be used as a lead compound for structural modification and optimization. By introducing different functional groups to change their physicochemical properties and biological activities, new drugs may be developed for the treatment of specific diseases.
In the field of materials science, this compound can also play a role. It can participate in polymerization reactions and become the structural unit of polymers. The formed polymer may have special physical properties, such as good thermal stability, mechanical properties, etc., and may provide unique performance advantages in the preparation of high-performance materials such as engineering plastics, composites, etc., to meet the diverse needs of different fields for material properties.
Although there is no direct record in "Tiangong Kaiwu", based on modern chemical knowledge, 2-hydroxy- 4-allylbenzoic acid has important uses in organic synthesis, medicine, materials and other fields, and plays an important role in promoting the development of various fields.
What are the synthesis methods of 2-bromo-4-fluorophenylacetic acid?
There are several methods for the synthesis of 2-hydroxy-4-methoxyphenylacetic acid. One method is to start with p-methoxybenzaldehyde, first with malonic acid in pyridine, with piperidine as the catalyst, Knoevenagel condensation reaction. This reaction also involves the action of the aldehyde group with the active methylene phase of malonic acid to decarboxylate to obtain trans-p-methoxycinnamic acid. After that, with an appropriate reducing agent, such as palladium carbon catalyzed by hydrogen reduction and double bond hydrogenation, 2-hydroxy-4-methoxyphenylacetic acid can be obtained.
Another method uses p-methoxyphenylacetonitrile as the starting material. First, it is hydrolyzed under alkaline conditions, and the nitrile group is converted to a carboxyl group to obtain p-methoxyphenylacetic acid. Then, in a suitable reaction system, the hydroxyl group is introduced into the ortho position. Halogenation can be used, such as halogenation with bromine under appropriate conditions, to obtain o-brominated p-methoxyphenylacetic acid, and then nucleophilic reagents, such as alcohol solution of sodium hydroxide, can be used through substitution reaction, and the hydroxyl group replaces the bromine atom, then the target product is obtained.
Another person uses p-methoxybenzene as a raw material. First, acetyl chloride is catalyzed by Lewis acid such as aluminum trichloride to perform a Fu-gram acylation reaction to obtain p-methoxyacetophenone. p-Methoxyacetophenone is obtained by α-halogenation reaction, such as N-bromosuccinimide (NBS) under the action of light or initiator. Then through hydrolysis, oxidation and other steps, the ketone group and halogen atoms can be converted to obtain 2-hydroxy-4-methoxyphenylacetic acid. Each method has its own advantages and disadvantages, depending on the ease of availability of raw materials, reaction conditions, and high or low yield.
What are the precautions for storing and transporting 2-bromo-4-fluorophenylacetic acid?
2-% heptyl-4-butyric acid is an organic compound. When storing and transporting, many matters must be paid attention to.
When storing, the first environment. It should be placed in a cool and ventilated warehouse, away from fire and heat sources. Because of its certain chemical activity, it is easy to cause danger when heated or exposed to open flames. The temperature of the warehouse should be controlled within a suitable range to prevent its properties from changing due to excessive temperature.
Furthermore, it should be stored separately from oxidants and bases, and mixed storage should not be avoided. The chemical properties of 2-% heptyl-4-allyl butyric acid make it meet with oxidizing agents, or cause severe oxidation reactions; when mixed with alkalis, it will also undergo chemical reactions, cause deterioration of substances, and/or be associated with danger.
Storage containers are also essential. A well-sealed container must be used to prevent it from evaporating and escaping into the environment, which will not only damage substances, but also endanger the safety of the environment and personnel. And the container material should be compatible with 2-% heptyl-4-allyl butyric acid and will not chemically react with it.
When transporting, ensure that the container does not leak, collapse, fall, or damage. The transportation vehicle should be equipped with the corresponding variety and quantity of fire fighting equipment and leakage emergency treatment equipment. Protect from sun exposure, rain and high temperature during transportation. If the package is damaged during transportation, 2-% heptanobutyric acid may leak, or cause harm to the transportation environment and surrounding personnel.
Transportation follows the specified route, do not stop in residential areas and densely populated areas. This is to avoid its leakage or accidents, causing serious harm to many people. Transport personnel should also be familiar with the characteristics of 2-% heptanobutyric acid and emergency treatment methods, so that in case of emergencies, they can respond quickly and correctly.