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Benzene, 4-Chloro-2-Fluoro-1-(Trifluoromethyl)-

Benzene, 4-Chloro-2-Fluoro-1-(Trifluoromethyl)-

Hongda Chemical

Specifications

HS Code

627119

Chemical Formula C7H3ClF4
Molecular Weight 200.545 g/mol
Appearance Typically a colorless to light - colored liquid or solid (physical state may vary based on conditions)
Boiling Point Data may vary, but generally in a certain range depending on purity and pressure
Melting Point Specific melting point value depending on purity
Density Density value specific to the compound
Solubility In Water Low solubility in water, being an organic compound
Solubility In Organic Solvents Soluble in common organic solvents like dichloromethane, chloroform etc.
Vapor Pressure Vapor pressure value relevant to temperature conditions
Flash Point Flash point value indicating flammability risk
Logp LogP value indicating lipophilicity

As an accredited Benzene, 4-Chloro-2-Fluoro-1-(Trifluoromethyl)- factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

Packing & Storage
Packing 500g of 4 - chloro - 2 - fluoro - 1 - (trifluoromethyl)benzene in sealed chemical - grade bottles.
Storage Store "Benzene, 4 - chloro - 2 - fluoro - 1 - (trifluoromethyl)-" in a cool, well - ventilated area away from heat, sparks, and open flames. Keep it in a tightly - sealed container, preferably made of corrosion - resistant materials due to its chemical nature. Separate it from oxidizing agents and incompatible substances to prevent dangerous reactions.
Shipping Benzene, 4 - chloro - 2 - fluoro - 1 - (trifluoromethyl)- is a chemical. Shipping requires proper containment in approved containers, following hazardous material regulations to ensure safe transportation.
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Benzene, 4-Chloro-2-Fluoro-1-(Trifluoromethyl)- Benzene, 4-Chloro-2-Fluoro-1-(Trifluoromethyl)-
General Information
Historical Development
4-Chloro-2-fluoro-1- (trifluoromethyl) benzene is also an organic compound. Its initial research was covered by the transformation of halogenated aromatics studied by many scholars. At the beginning, it was difficult to explore the method of its synthesis. With their wisdom and ingenuity, chemists experimented with various paths, either by halogenation reaction or by substitution, to obtain this compound.
After years, the technique of synthesis has become more and more refined. In the past, it was difficult to operate, but it has gradually become a convenient and efficient method. It is widely used in the field of organic synthesis and is a key raw material for the creation of other compounds. The products derived from it have made extraordinary contributions to the pharmaceutical and pesticide industries. Looking at its historical evolution, it is a journey of chemical exploration, witnessing the unremitting efforts and wisdom of the academic community.
Product Overview
Today there is a substance called "Benzene, 4 - Chloro - 2 - Fluoro - 1 - (Trifluoromethyl) -". This is a fine chemical substance. It can be a colorless and transparent liquid or a crystalline state. It has special chemical properties and is widely used in the field of organic synthesis.
Its molecular structure is exquisite, and chlorine, fluorine and trifluoromethyl are cleverly connected to the benzene ring, giving it unique reactivity. Because it contains fluorine atoms, it has good stability and chemical resistance. In medicinal chemistry, it can be used as a key intermediate to help develop new drugs to fight many diseases. In the field of materials science, it can improve the properties of materials, such as enhancing their heat resistance and weather resistance. And because of its special structure, it can present a different reaction path in chemical reactions, opening up new directions for chemical research and leading researchers to explore more unknown possibilities.
Physical & Chemical Properties
The physical and chemical properties of Guanfu 4-chloro-2-fluoro-1- (trifluoromethyl) benzene are quite fascinating. Its color state, at room temperature or colorless liquid, has a specific smell. Looking at its boiling point, about a certain value, due to the intermolecular force, it has its unique performance compared with other similar compounds. Its melting point is also a certain value, which is related to the arrangement of the lattice and the attractive force between molecules.
As for the chemical properties, its chemical activity is unique due to the presence of chlorine, fluorine, trifluoromethyl and other groups. Chlorine atoms can participate in nucleophilic substitution reactions. Because of their high electronegativity, fluorine atoms affect the electron cloud distribution of molecules, change the electron cloud density of benzene rings, and then affect their reactivity. The existence of trifluoromethyl gives molecules special stability and hydrophobicity. These many properties are of great value in organic synthesis, drug development and other fields, and are really interesting objects in chemical research.
Technical Specifications & Labeling
Guanfu 4-chloro-2-fluoro-1- (trifluoromethyl) benzene, in the field of chemical industry, its technical specifications and identification (product parameters) are the key. To make this product, it is necessary to follow precise process procedures. The choice of raw materials must be pure and fine, and the proportion must be unpleasant. The temperature and pressure of the reaction should be carefully controlled. If it exceeds the limit, the quality of the product may be disturbed.
As for the label, the product parameters should be specified in detail. From its physicochemical properties, such as color, state, taste, to precise purity and content, it should be clearly marked. On the package, warning words are also indispensable to indicate the importance of safety. In this way, the production, circulation, and use of this product can be orderly and safe, and it can be used to the fullest extent in the chemical industry to demonstrate its value.
Preparation Method
If you want to make 4-chloro-2-fluoro-1- (trifluoromethyl) benzene, you should carefully investigate the method of its preparation. The first thing to do is to identify the raw materials used, which is fundamental. Find suitable starting materials, such as aromatic hydrocarbons with specific substituents, etc., as the starting point.
In the preparation process, the reaction step is the key. The halogenation method can be selected first, and chlorine and fluorine atoms can be introduced, and the substitution position can be precisely positioned according to the different reaction conditions and reagents. With appropriate halogenation reagents, temperature control and control can make the reaction proceed in an orderly manner.
Furthermore, the structure of trifluoromethyl can be constructed, and special reagents and reaction paths can be used to achieve this purpose. In this process, the catalytic mechanism can not be ignored. Suitable catalysts may accelerate the reaction and increase the yield. Such as metal catalysis and other means, can be skillfully used to make the reaction smooth, and finally get the product of 4-chloro-2-fluoro-1 - (trifluoromethyl) benzene.
Chemical Reactions & Modifications
Yu Taste is dedicated to the study of chemical substances, focusing on "Benzene, 4 - Chloro - 2 - Fluoro - 1 - (Trifluoromethyl) -" this substance, especially its chemical reaction and modification.
To observe its reaction, it often requires delicate conditions to control. The slight change in temperature and humidity, or the deviation of the reaction. Its molecular structure is unique, and the order of chlorine, fluorine and trifluoromethyl affects the reactivity. In order to make it go the desired way, the choice of catalyst is very important. The appropriate one can promote the reaction to advance, and the inferior one can cause the stagnation.
As for modification, this is the key to improving its performance. After many attempts, with the intervention of specific reagents, its chemical properties can be fine-tuned, such as enhancing stability or changing chemical activity. However, the road to modification is full of thorns, and every step needs to be careful to prevent the slightest mistake. Only by unremitting research and detailed observation of the reaction mechanism can we gradually achieve the best conditions and achieve results in the field of chemistry.
Synonyms & Product Names
There is a chemical substance, named "Benzene, 4 - Chloro - 2 - Fluoro - 1 - (Trifluoromethyl) -". It is also known as an alias and a trade name.
The alias is appointed by chemists according to its structure and characteristics, which is convenient for academic communication. The trade name is determined by the merchant, hoping to recognize the advantages of its product and attract the attention of customers.
This chemical, containing chlorine, fluorine and other elements, has a delicate structure. In various fields of chemical industry, it is either a raw material or an auxiliary agent, and its functions are quite unique. However, its aliases and trade names also vary from time to time and from place to place. People in all walks of life should know its name in detail, so that they can walk freely in the path of chemistry and make good use of this substance in order to achieve their success and avoid its harm.
Safety & Operational Standards
"Benzene, 4 - Chloro - 2 - Fluoro - 1 - (Trifluoromethyl) - Safety and Operation Specifications"
Benzene, 4 - Chloro - 2 - Fluoro - 1 - (Trifluoromethyl) - This chemical product is related to safety and operation standards, and it is the most important thing for our chemical researchers.
In terms of storage, a cool, dry and well-ventilated place must be selected. Because of its certain chemical activity, if it is placed in a high temperature and humid place, it may cause qualitative change and cause unexpected changes. It needs to be separated from oxidizing agents, reducing agents and other foreign substances, and must not be mixed to prevent interaction and dangerous changes.
As for the operation, the operator must wear the appropriate protective equipment. The first protective clothing can withstand the possible splashing and protect the body. In addition, goggles can prevent it from entering the eyes and avoid eye injuries. Masks are also indispensable to prevent its volatilized gas from entering the body to ensure the safety of breathing. The operation process must be strictly followed by the regulations, and it must not be easier without authorization. When stirring, control its rate, do not make it too hasty, to prevent overreaction. When heating, it is also necessary to precisely control the temperature, and keep an appropriate degree according to its materialization.
If this substance leaks accidentally, do not panic. Quickly start the ventilation device to reduce its concentration in the air. Small leaks can be adsorbed by inert materials such as sand and vermiculite, and properly collected and disposed of. Large leaks need to be contained and contained, and professional people should be invited to dispose of them according to scientific methods.
These are Benzene, 4 - Chloro - 2 - Fluoro - 1 - (Trifluoromethyl) - The importance of safety and operating standards, we should keep in mind and practice it to ensure the smooth progress of the experiment and the well-being of personnel.
Application Area
Today there is a product called "4-chloro-2-fluoro-1- (trifluoromethyl) benzene". This product has wonderful uses in many fields.
In the field of medicine, it can be a key raw material. Doctors develop medicines, or use their properties to make a cure for disease. Because of its unique structure, it can interact with human biomolecules, or can regulate physiological functions and heal diseases.
In the field of materials, it also has potential. It can participate in the creation of new materials, or increase the stability of materials, or improve their optical and electrical properties. Make materials suitable for electronic devices, optical instruments, etc., to help the progress of science and technology.
In agriculture, it may contribute to the creation of pesticides. With its chemical characteristics, it can be used to repel insects and prevent diseases, protect the growth of crops, and ensure the hope of a bumper harvest.
"4-chloro-2-fluoro-1 - (trifluoromethyl) benzene" is widely used, and can play an important role in the fields of medicine, materials, and agriculture, bringing many benefits to the world.
Research & Development
I have been dedicated to the research of 4-chloro-2-fluoro-1- (trifluoromethyl) benzene for a long time. This substance has unique characteristics and has great potential in the field of organic synthesis. I have studied it with ancient methods to observe its reaction mechanism and explore its structural mysteries. After months of experiments, I have observed its changes under different conditions, and tried to use various reagents to interact with it, hoping to find new uses for it.
At the beginning, the reaction was mostly unsatisfactory, and the yield was quite low. However, I was not discouraged. I have been able to obtain high-purity products stably.
I intend that this product may shine in the fields of medicine and materials in the future. The follow-up will further expand the research, hoping to provide useful reference for the academic and industrial circles, so as to promote their development and contribute to the chemical industry.
Toxicity Research
In the genus of benzene, there are 4-chloro-2-fluoro-1- (trifluoromethyl), and we have dedicated ourselves to studying its toxicity. The structure of this compound is unique, containing halogen atoms and fluoromethyl groups, and it may be fat-soluble and easy to enter the body.
Taste all kinds of biological effects, observe its metabolic behavior in the body and its impact on organs. Observe the cellular level, see that it may cause cell morphological changes and interfere with physiological functions. And observe its effects on the nervous system and circulatory system to investigate the root cause of toxicity.
Although research has not been done, it is known that it can be toxic at specific concentrations. In the future, the mechanism of its action should be deeply explored, and the relationship between dose and effect should be analyzed in detail, so as to obtain a complete understanding, so as to prevent its harm in production and life and ensure the well-being of everyone.
Future Prospects
The future outlook concerns the product of 4-chloro-2-fluoro-1- (trifluoromethyl) benzene. This compound has already emerged in the field of chemistry today. Its unique structure seems to hold infinite possibilities.
Looking forward to the future, it may shine in materials science. With its special chemical properties, it may be able to give birth to new functional materials, injecting new vitality into the fields of electronic devices, optical instruments and so on. In the process of drug development, it is also expected to become a key cornerstone. With ingenious modification and design, innovative drugs with excellent efficacy and low side effects may be born, benefiting thousands of patients.
Furthermore, in the field of green chemistry, this product may lead a new path. Help to develop more environmentally friendly and efficient synthetic processes, reduce energy consumption and pollution, and conform to the general trend of future sustainable development. Our chemical researchers, with the heart of exploration, should explore deeply, hope that this compound will bloom brightly in the future, and create immortal power for human well-being and scientific and technological progress.
Where to Buy Benzene, 4-Chloro-2-Fluoro-1-(Trifluoromethyl)- in China?
As a trusted Benzene, 4-Chloro-2-Fluoro-1-(Trifluoromethyl)- manufacturer, we deliver: Factory-Direct Value: Competitive pricing with no middleman markups, tailored for bulk orders and project-scale requirements. Technical Excellence: Precision-engineered solutions backed by R&D expertise, from formulation to end-to-end delivery. Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
Frequently Asked Questions

As a leading Benzene, 4-Chloro-2-Fluoro-1-(Trifluoromethyl)- supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

What are the physical properties of 4-chloro-2-fluoro-1- (trifluoromethyl) benzene?
4-Bromo-2-chloro-1- (trichloromethyl) benzene-based organic compounds, its physical properties are as follows:
This compound is mostly solid at room temperature, due to the relatively large intermolecular force. Looking at its color, it is often white or off-white, which is related to the absorption and reflection characteristics of light by its molecular structure. Its odor may have a certain irritation, because it contains halogen atoms, halogenated aromatics often have this characteristic.
When it comes to the melting point, due to the presence of halogen atoms with relatively large atomic mass such as bromine and chlorine in the molecule, the intermolecular force is enhanced, resulting in its melting boiling point is not low. Among them, the bromine atom has a large radius and high relative atomic mass, which contributes significantly to the intermolecular force, and the chlorine atom also has an enhancement effect, so the melting boiling point is higher than that of the general benzene series.
In terms of density, the relative atomic mass of bromine and chlorine atoms is large, so that the density of the compound is greater than that of water. In common organic solvents, such as ether and dichloromethane, due to the characteristics of benzene ring and halogen atom in the structure, there is a certain solubility. The benzene ring is a non-polar structure. Although the halogen atom is polar, the overall structure makes the compound soluble in organic solvents by intermolecular force.
The physical properties of 4-bromo-2-chloro-1- (trichloromethyl) benzene are determined by its unique molecular structure, which is of great significance for its application in chemical production, scientific research and experiments.
What are the chemical properties of 4-chloro-2-fluoro-1- (trifluoromethyl) benzene?
4-Bromo-2-chloro-1- (trichloromethyl) benzene, this material is dry and has the general properties of halogenated aromatics. Its color is colorless to slightly yellow, its state is liquid, and it smells pungent.
In terms of chemical activity, the bromine and chlorine atoms in this halogen are quite active. Bromine and chlorine atoms are highly electronegative, resulting in a decrease in the electron cloud density of the benzene ring, which decreases the activity of the electrophilic substitution reaction of the benzene ring. However, in the case of nucleophilic reagents, bromine and chlorine atoms are easily replaced. For example, in the presence of nucleophilic reagents such as sodium alcohol, nucleophilic substitution can occur, and the bromine and chlorine atoms are replaced by alkoxy groups to form corresponding ethers.
It has good solubility in organic solvents, such as ether, benzene, chloroform, etc. Due to the polarity of the molecule, its solubility in water is very small.
And because it contains halogen atoms, it is easy to decompose and release toxic gases such as hydrogen halide when heated or exposed to strong oxidants. In case of fire, it burns violently and is accompanied by a lot of smoke.
In addition, this substance is harmful to the human body. If inhaled its volatile gas, it can hurt the respiratory tract, causing coughing, asthma, etc.; if the skin touches it, it can cause irritation and burns; if accidentally entered the eyes, it is particularly harmful and damages the eye tissue. When handling this substance, it must strictly follow safety procedures, be carried out in a well-ventilated place, and be equipped with protective equipment to prevent harm.
What are the main uses of 4-chloro-2-fluoro-1- (trifluoromethyl) benzene?
4-Bromo-2-chloro-1- (trichloromethyl) benzene is an important raw material for organic synthesis and has critical uses in many fields.
First, in the field of medicinal chemistry, it can be used as an intermediate for the synthesis of specific drugs. By performing a series of chemical modifications and reactions on the compound, molecular structures with specific pharmacological activities can be constructed. For example, in the development of some drugs with antibacterial and anti-inflammatory properties, 4-bromo-2-chloro-1- (trichloromethyl) benzene can be used as a starting material to gradually synthesize target drug molecules through the introduction of specific functional groups, contributing to the cause of human health.
Second, in the field of materials science, it can be used to prepare special polymer materials. By polymerizing with other monomers, polymer materials can be endowed with unique properties. For example, it can improve the heat resistance and chemical corrosion resistance of the material. In this way, the prepared materials can be applied to aerospace, electronics and other fields that require strict material properties, and meet the development needs of high-tech industries.
Furthermore, it also plays an important role in pesticide chemistry. It can be used as a key intermediate for the synthesis of new pesticides to develop high-efficiency, low-toxicity and environmentally friendly pesticides. Such pesticides can precisely act on pests, effectively prevent and control pests and diseases, and reduce the negative impact on the environment and non-target organisms, ensuring the sustainable development of agriculture. With its unique chemical structure, 4-bromo-2-chloro-1- (trichloromethyl) benzene has shown broad application prospects in the fields of medicine, materials, and pesticides, and is of great significance for promoting the development of related industries.
What are the synthesis methods of 4-chloro-2-fluoro-1- (trifluoromethyl) benzene?
To prepare 4-bromo-2-chloro-1- (trichloromethyl) benzene, the following ancient method can be used.
The method of electrophilic substitution is first proposed. Starting with benzene derivatives, because the benzene ring is electron-rich, it is easy to interact with electrophilic reagents. First, the benzene ring is exposed to brominating reagents under appropriate conditions. If liquid bromine is used as the bromine source and iron tribromide as the catalyst, bromine atoms can be introduced into the benzene ring to obtain bromobenzene. This step requires temperature control and time control to prevent the generation of polybrominates.
Then, the bromobenzene is reacted with the chlorinated reagent. Chlorine gas is used as the chlorination source and aluminum chloride as the catalyst. After electrophilic substitution, chlorine atoms are introduced into the benzene ring to obtain bromochlorobenzene. During operation, it is advisable to strictly control the reaction conditions under the protection of inert gas to ensure that chlorine atoms are connected at the desired position.
Then, if you want to introduce trichloromethyl, you can use the method of free radical substitution. Bromochlorobenzene is co-heated with chloroform and an initiator, and an initiator such as benzoyl peroxide is commonly used. The initiator is thermally decomposed into a free radical, and chloroform is induced to produce a trichloromethyl radical, which reacts with bromochlorobenzene to obtain 4-bromo This process has strict requirements on the reaction environment, and should avoid the interference of impurities and accurately control the temperature.
Or you can first react with benzene, chloroform and catalyst, and introduce trichloromethyl through Friedel-Crafts alkylation to obtain (trichloromethyl) benzene. Subsequently, bromination and chlorination reactions are performed in sequence, and the conditions are as described above. The electrophilic substitution method can also prepare the target product. When
is prepared, after each step of the reaction, it is necessary to make good use of separation and purification techniques, such as distillation, recrystallization, column chromatography, etc., to remove impurities and improve the purity of the product. And the reaction conditions of each step, such as temperature, pressure, reagent ratio, etc., need to be carefully adjusted to make the reaction proceed as expected to obtain high purity 4-bromo-2-chloro-1 - (trichloromethyl) benzene.
What are the precautions for 4-chloro-2-fluoro-1- (trifluoromethyl) benzene during storage and transportation?
The storage and transportation of 4-alkane-2-ene-1- (trienyl methyl) naphthalene are related to safety and cannot be ignored.
When storing, the first choice of environment. It should be placed in a cool and ventilated place, away from fire and heat sources. This is because the material is flammable, in case of open fire and hot topic, it may cause the risk of combustion and endanger the surrounding area. And the temperature of the warehouse should be controlled to a suitable degree to prevent the temperature from being too high, causing instability and causing accidents.
Furthermore, the storage place should be isolated from oxidants, acids, etc. The nature of the substance, when it encounters them, or causes severe reactions, such as the risk of explosion, damage to people and objects. Therefore, in the planning of the warehouse, it must be carefully separated and must not be mixed.
During transportation, the vehicle should be equipped with corresponding fire extinguishing equipment to prepare for accidents. When driving, you must avoid densely populated places to prevent the risk of leakage and endanger the public. And the speed of the vehicle should be stable, do not start and stop in a hurry, so as not to cause the material to shake and damage the container.
As for the container, it must be strong and sealed. If there is a leak in the container, the substance will evaporate outside, one will pollute the environment, and the other will increase the risk of fire and explosion. Therefore, before shipment, the container must be carefully inspected. If there is a slight defect, it should be replaced immediately.
The escort should be familiar with the properties of this substance and know the emergency method. If there is a situation on the way, it can be disposed of quickly and the damage can be minimized.
Storage and transportation of 4-alkane-2-ene-1- (trienyl methyl) naphthalene, all aspects need to be cautious to ensure safety.