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Benzene, 4-(Bromomethyl)-1,2-Difluoro-

Benzene, 4-(Bromomethyl)-1,2-Difluoro-

Hongda Chemical

Specifications

HS Code

266026

Chemical Formula C7H5BrF2
Molecular Weight 219.015
Appearance Solid (likely white or off - white powder)
Solubility In Water Low (due to non - polar benzene ring and hydrophobic groups)
Solubility In Organic Solvents Soluble in common organic solvents like dichloromethane, chloroform
Vapor Pressure Low at room temperature
Hazard Class Irritant (potential to irritate skin, eyes and respiratory tract)
Stability Stable under normal conditions but may react with strong oxidizing agents

As an accredited Benzene, 4-(Bromomethyl)-1,2-Difluoro- factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

Packing & Storage
Packing 500g of 4-(bromomethyl)-1,2 -difluorobenzene in a sealed, chemical - resistant bottle.
Storage **Storage of 4-(Bromomethyl)-1,2 - difluorobenzene**: Store this chemical in a cool, dry, well - ventilated area away from heat sources, open flames, and oxidizing agents. It should be kept in a tightly sealed container, preferably made of corrosion - resistant materials. Given its potential toxicity and reactivity, ensure proper labeling and isolation from incompatible substances to prevent spills and hazardous reactions.
Shipping Benzene, 4-(bromomethyl)-1,2 -difluoro- is a chemical. Shipping should comply with hazardous material regulations. It must be properly packaged to prevent leakage and transported with appropriate safety measures for safe delivery.
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Benzene, 4-(Bromomethyl)-1,2-Difluoro- Benzene, 4-(Bromomethyl)-1,2-Difluoro-
General Information
Historical Development
Historical Evolution of Compound 4- (Bromomethyl) -1,2-Difluorobenzene
Fu4- (Bromomethyl) -1,2-difluorobenzene, an important member of the field of organic synthesis. In the past, when organic chemistry was first emerging, it was important to explore the preparation and properties of various compounds. At that time, the study of this compound was still in its infancy.
As chemical theory became more complete and experimental techniques became more and more exquisite, chemists gained deeper insights into its structure and reactivity. The synthesis method was continuously optimized, from the initial complicated attempts to the efficient and precise route. Early synthesis relied mostly on simple halogenation and substitution reactions, with limited yield and purity.
Then, technological innovation, new catalysts and reaction conditions emerged, which made the synthesis of 4- (bromomethyl) -1,2-difluorobenzene more convenient, and the yield and purity were greatly improved. The application of this compound in medicine, materials science and other fields has also expanded, and its historical evolution has witnessed the vigorous development of chemistry.
Product Overview
There is a compound named Benzene, 4- (Bromomethyl) -1,2-Difluoro-. This compound has a unique molecular structure. On the benzene ring, bromomethyl and difluorine atoms correspond to each other according to their positions.
Looking at its physical properties, under room temperature, or in a colorless state, the smell is specific. Its melting point and boiling point are all manifestations of its characteristics, which have a great impact on its storage and transportation.
As for its chemical properties, due to the presence of bromomethyl and fluorine atoms, it is very active. It can react with many reagents, and nucleophilic substitution occurs from time to time. This compound has a wide range of uses in the field of organic synthesis and can be a key raw material for the research and development of medicine and materials. It can help scientific exploration and promote technological progress.
Physical & Chemical Properties
Regarding the physical and chemical properties of 4- (bromomethyl) -1,2-difluorobenzene
Fu 4- (bromomethyl) -1,2-difluorobenzene, is one of the organic compounds. Its physical properties, at room temperature, are mostly liquid, with a special odor, volatile. Looking at its color, or colorless and transparent, or slightly yellowish, depending on the purity. Its density is heavier than water, placed in water, sinks to the bottom.
As for chemical properties, due to the presence of bromomethyl and difluoro groups, the activity is quite obvious. In bromomethyl bromide atoms, nucleophilic substitution reactions are prone to occur. When encountering nucleophilic reagents, bromine atoms are often replaced to form new compounds. The difluoro group changes the electron cloud density of the benzene ring, affecting its aromaticity and reactivity. In the electrophilic substitution reaction, it shows a unique reaction check point and activity difference. The physicochemical properties of this compound are of great significance in the fields of organic synthesis and drug development, laying the foundation for related research and application.
Technical Specifications & Labeling
Today there is a product called "Benzene, 4- (Bromomethyl) -1,2-Difluoro-". In terms of process specifications and identification (product parameters), our generation should handle it with caution.
Its process specifications need to specify the ratio of materials and the reaction temperature in time. When the material is polymerized, the temperature should be controlled in a certain range, and the duration should be accurate, so as to ensure the purity and quality of the product. And the operation steps should be detailed and orderly, from raw material pretreatment to finished product refining, all should not be missed.
In terms of identification (product parameters), its chemical structure, purity value, physical properties such as melting point, boiling point, etc. should be clearly marked. This is the key to identify the product, so that users can understand its characteristics and uses at a glance, so as to achieve the purpose of proper use. Process specifications and identification (product parameters) complement each other to ensure the excellence of this chemical.
Preparation Method
The raw materials and production process, reaction steps and catalytic mechanism of 4 - (bromomethyl) -1,2-difluorobenzene are the key. To prepare this, you can first take an appropriate amount of 1, 2-difluorobenzene as the base material, add an appropriate amount of catalyst, and react with the brominating agent in a certain proportion under a specific temperature and pressure. At the beginning of the reaction, strictly control the temperature fluctuation and do not exceed the predetermined range to prevent side reactions from occurring. Wait for the reaction to be gradual, observe its changes closely, and fine-tune the reaction conditions in a timely manner. To a certain extent, after the reaction is reached, the impurities are removed by separation and purification to obtain pure 4 - (bromomethyl) -1,2-difluorobenzene. The choice of catalyst is related to the reaction rate and product purity, and it must be carefully selected to achieve the purpose of efficient preparation.
Chemical Reactions & Modifications
The wonders of chemistry are related to the change of substances, and the reaction and modification are the gist. In today's words and "Benzene, 4- (Bromomethyl) -1,2-Difluoro-", the chemical reaction is related to the breaking and formation of bonds. Or when encountering a nucleophilic reagent, at the halogenated methyl group, the nucleophilic body attacks and forms a new compound. This is a substitution reaction.
As for modification, functional groups can be introduced to change their physical and chemical properties. If the reaction conditions are adjusted and the appropriate catalyst is selected, the reaction can be directed to the desired direction, and the purity and yield of the product can be increased. By means of chemistry, changing its structure or obtaining materials with special properties is of great use in the fields of medicine and materials. The path of chemistry, exploring the endless, the secrets of reaction and modification, awaits our generation to delve deeper into it.
Synonyms & Product Names
In the field of chemistry, I often study the properties and changes of substances. Today there is a substance called "Benzene, 4- (Bromomethyl) -1,2-Difluoro-", which also has aliases and trade names. This is the main point of our research.
For our generation of chemical researchers, it is of great significance to explore the aliases and trade names of this substance. Aliases are often born due to the process of research and different geographical habits, which can help us understand their characteristics more comprehensively. And trade names are related to market applications, from which we can see their practical uses and values.
We study day and night, search ancient books and do experiments, and strive to clarify the origin of its aliases and explore the market context behind the trade names. It is hoped that with the insight into its aliases and trade names, we can better understand this "Benzene, 4- (Bromomethyl) -1,2-Difluoro-" substance, which will contribute to the development of chemistry, so as to achieve the realm of knowledge and live up to the heart of research.
Safety & Operational Standards
About the safety and operation specifications of 4- (bromomethyl) -1,2-difluorobenzene
Fu 4- (bromomethyl) -1,2-difluorobenzene is an important substance in chemical research. In the laboratory or industrial production, its safety and operation standards are related to the safety of personnel and the success or failure of the experiment, which cannot be ignored.
This substance has a certain chemical activity, and the presence of bromomethyl makes the compound more active. In case of open flame, hot topic, or contact with oxidant, there is a risk of combustion and explosion. Therefore, when storing, it should be placed in a cool and ventilated warehouse, away from fire and heat sources, and should be stored in separate warehouses with oxidants and edible chemicals, and should not be mixed.
When operating, the experimenter should be fully armed. Wear protective clothing to prevent the substance from contaminating the skin; wear protective glasses to protect the eyes from damage; wear protective gloves to avoid direct contact. The operating environment must be well ventilated. If conditions permit, a local exhaust device should be installed to remove volatile harmful gases in time.
If you accidentally touch the skin, you should immediately remove the contaminated clothing, rinse with a large amount of flowing water for at least 15 minutes, and then seek medical treatment. If it spills into the eyes, quickly lift the eyelids, rinse thoroughly with a large amount of flowing water or normal saline for at least 15 minutes, and seek medical attention immediately.
When taking the substance, follow accurate measurement specifications. After use, properly seal and store to prevent leakage. In the event of a leak, emergency personnel must wear a full mask and chemical protective clothing. Quickly evacuate personnel from the contaminated area of the leak to a safe area and isolate them. Strictly restrict access. Do not let leaks come into contact with combustible substances. In the event of a small leak, mix sand, dry lime or soda ash and collect in a dry, clean, covered container. A large number of leaks should be built embankments or excavated to contain them, covered with foam to reduce vapor disasters, and then transferred to a tank car or a special collector for recycling or transportation to a waste treatment site for disposal.
All of these are essential for the safety and operation of 4- (bromomethyl) -1,2-difluorobenzene. Researchers must keep in mind and practice them effectively, so that they can be safe and study smoothly.
Application Area
In the genus of benzene, there are 4- (bromomethyl) -1,2-difluorobenzene. This substance has wonderful uses in many fields. In the way of medicine, it can be used as a key intermediate to help with medicinal power and treat human diseases. In the context of agrochemical, or as an effective active ingredient, it protects the health of crops and resists the invasion of diseases and pests. It is also used in the creation of materials to increase its characteristics, making materials strong, durable and versatile. With its unique structure, this compound is used in various application fields to develop its extraordinary ability. It is a bridge between science and practice, helping all industries move forward, and has achieved many achievements. It is an existence that cannot be ignored in the chemical industry.
Research & Development
Today, there is a product called "Benzene, 4- (Bromomethyl) -1,2-Difluoro-". I am a chemical researcher and have studied it carefully. This material has unique properties and is relevant to the development of many fields.
I have dedicated myself to exploring this compound, and through repeated experiments and analysis, I have gained insight into its structure and reaction laws. I am well aware of its extraordinary potential in chemical production, material research and development, etc.
The road to research is full of difficulties. However, I have persevered and made unremitting exploration. After countless attempts, progress has been made. Now its synthesis method has been optimized to improve yield and purity.
I hope to further clarify its properties and expand its application scope through continuous research. With time, it will surely be able to contribute to the development of many industries, promoting technological progress and social development.
Toxicity Research
In recent years, I have studied the toxicology of chemical substances, especially 4- (bromomethyl) -1,2-difluorobenzene. This chemical has a unique structure, its nature is unknown, or it is invisible, and it is related to the health of all living beings, so it cannot be ignored.
I am in the middle of it, studying its quality in detail, observing its reaction to various things, and observing its changes in different situations. I also use various methods to measure its entry into the body, or by breathing, or through the skin, or from diet. Explore its movement in the body, what it touches, and the changes it produces.
Although the research has not been completed, the results obtained at the beginning are also alarming. This chemical may be irritating and damage the skin and mucous membranes. And after entering the body, it may hinder metabolism and disrupt the body. I should continue to study it to understand the depth of its poison, as a basis for protection and treatment, hoping to ensure everyone's safety and not suffer from it.
Future Prospects
In the future, 4- (bromomethyl) -1,2-difluorobenzene has extraordinary potential. Its unique structure, or in the field of organic synthesis, lays the foundation for the development of new reaction pathways. With time and continuous research, it is expected to emerge in the creation of medicine, provide novel drug sources for the treatment of difficult diseases. Or in materials science, derived materials with specific properties, such as high stability, unique optical properties. Although the road ahead is long, the heart of scientific research is determined, and it is hoped that with unremitting exploration, this compound will bloom and add a touch of color to the future world, bring innovation in various fields, and add brilliance to human well-being.
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Frequently Asked Questions

As a leading Benzene, 4-(Bromomethyl)-1,2-Difluoro- supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

What are the chemical properties of 4- (bromomethyl) -1,2-difluorobenzene?
The chemical properties of (4- (hydroxymethyl) -1,2 -dihydroxynaphthalene, hereinafter referred to as this substance) are as follows:
This substance has a certain polarity because its molecule contains multiple hydroxyl groups. The hydroxyl group is a hydrophilic group, so it has a certain solubility in water and can interact with water molecules through hydrogen bonds.
This substance is weakly acidic, and the hydrogen atoms in the hydroxyl group can be dissociated under certain conditions, showing acidic properties. However, compared with common inorganic acids, its acidity is weaker.
In redox reactions, this substance is reductive. Because the hydroxyl group is easily oxidized, it can be oxidized when encountering strong oxidants, such as potassium permanganate, and its structure changes accordingly.
This substance can also undergo a substitution reaction. The hydroxyl group can be used as an active check point to react with halogenated hydrocarbons, acyl halides and other reagents. The hydrogen atom in the hydroxyl group is replaced by other groups to form a new type of organic compound.
At the same time, this substance can participate in the condensation reaction. For example, under acidic or basic catalytic conditions with aldehyde compounds, condensation can occur, forming new carbon-carbon bonds or carbon-oxygen bonds, and generating compounds with more complex structures.
In terms of stability, this substance is relatively stable in general environments, but it should be avoided with strong oxidants, strong acids, strong bases, etc. to prevent chemical reactions from occurring and causing changes in its structure and properties. When storing, it should be placed in a cool, dry place to maintain its chemical stability.
What are the main uses of 4- (bromomethyl) -1,2-difluorobenzene?
4- (hydroxymethyl) -1,2-dichlorobenzene, also known as dichlorobenzyl alcohol, is widely used.
In the field of medicine, it is often used as a preservative. Because it has certain antibacterial properties, it can effectively inhibit the growth of bacteria and fungi, so as to ensure the stable quality of the drug within the valid period and avoid the deterioration of the drug caused by microbial contamination. It is used in some liquid preparations, ointments and other medicines.
In the cosmetic industry, it also plays the role of preservative. Cosmetics are rich in a variety of nutrients, which is easy to create conditions for the reproduction of microorganisms. Adding 4- (hydroxymethyl) -1,2-dichlorobenzene can ensure that cosmetics can maintain good quality before and after opening, prolong the shelf life, and can often be seen in skin care products, makeup products, etc.
In addition, in the industrial field, it can be used as an intermediate for organic synthesis. With its own chemical structure characteristics, it can participate in many organic chemical reactions to synthesize other more complex organic compounds. These compounds are of great significance in the production of industrial products such as coatings, plastics, and rubber, providing key basic raw materials for the development of related industries. With its diverse functions, 4- (hydroxymethyl) -1,2-dichlorobenzene plays an important role in many fields such as medicine, cosmetics and industrial synthesis, and plays a significant role in ensuring product quality and promoting industrial development.
What is the synthesis method of 4- (bromomethyl) -1,2-difluorobenzene?
To prepare 4- (hydroxymethyl) -1,2-dibromobenzene, you can follow the following ancient method.
First take an appropriate amount of benzene, mix concentrated sulfuric acid with concentrated nitric acid to form a mixed acid, and co-heat at 50-60 ° C to nitrify the benzene to obtain nitrobenzene. This step requires precise temperature control to prevent side reactions. After the reaction, the nitrobenzene is purified by washing with water, alkali washing, drying and other processes.
Next, the nitrobenzene is co-heated with iron powder and hydrochloric acid, and the nitro group is then reduced to an amino group to obtain aniline. In this process, iron powder is used as a reducing agent, and hydrochloric acid creates an acidic environment to help the reaction advance. After the reaction, aniline is purified by distillation and other methods.
Then, aniline is reacted with bromine water. Because the amino group is a strong activating group, the electron cloud density of the benzene ring ortho and para-site can be greatly increased. The bromine atom preferentially replaces the amino ortho and para-site hydrogen atoms to generate 2,4,6-tribromoaniline. This reaction is rapid, and attention should be paid to the amount of bromine water and the reaction rate.
Then use the nitrite prepared by sodium nitrite and hydrochloric acid to react with 2,4,6-tribromoaniline at low temperature (0-5 ° C). The amino group is replaced by the diazo group to obtain 2,4,6-tribromobenzene diazosalt. Low temperature is the key to ensure the stability of the diazosalt. Diazosalt is easy to decompose at a slightly higher temperature.
Finally, using hypophosphoric acid as a reducing agent, the diazonium group is replaced by hydrogen atom. At the same time, paraformaldehyde reacts with hydrochloric acid to form chloromethyl positive ions, and undergoes electrophilic substitution reaction with benzene ring. Hydroxymethyl is introduced at the ortho position, and after a series of post-treatments, 4- (hydroxymethyl) -1,2-dibromobenzene can be obtained. Each step of the reaction requires strict control of the conditions and careful operation to obtain the best product.
What are the precautions for 4- (bromomethyl) -1,2-difluorobenzene in storage and transportation?
4- (hydroxymethyl) -1,2 -diol ether has the following precautions in storage and transportation:
First, because of its active chemical properties, when storing, be sure to choose a cool, dry and well-ventilated place. Do not let it close to fire or heat sources, because it has certain flammability, and it is easy to cause combustion hazards in case of open flames and hot topics. For example, if it is stored in a warehouse with high temperature and poor ventilation, once a spark accidentally enters, it may ignite instantly, causing a disaster.
Second, the container for storing the substance must be strictly sealed. This is because it is easy to react with certain components in the air, such as oxygen, water vapor, etc., which will cause it to deteriorate and affect the quality and use effect. Just like a fine wine placed in the open, over time, the taste of the wine will fade and the quality will be damaged.
Third, during transportation, it is necessary to operate in accordance with the relevant dangerous chemical transportation regulations. The transportation vehicle must be equipped with the corresponding variety and quantity of fire protection equipment and leakage emergency treatment equipment. The escort personnel should also be familiar with the nature, hazard characteristics and emergency treatment methods of the transported items. If the vehicle encounters turbulence during transportation, resulting in package damage and leakage, the escort personnel must be able to take prompt and correct measures to avoid the expansion of the harm.
Fourth, it should not be mixed with oxidizers, acids and other substances. Gein 4- (hydroxymethyl) -1,2-diol ether and these substances will undergo violent chemical reactions, which may cause serious consequences such as explosion. This is like water and fire are incompatible, and contact between the two will inevitably cause danger.
Fifth, when handling, it should be handled lightly, and it must not be handled brutally. The packaging of this substance may be fragile, and heavy loading and unloading can easily cause damage to the packaging and lead to leakage. Just like with fragile porcelain, you need to be careful to ensure that it is intact.
What are the effects of 4- (bromomethyl) -1,2-difluorobenzene on the environment and human health?
(Chloromethyl) -1,2-dichlorobenzene, also known as o-dichlorobenzene, has many effects on the environment and human health.
At the environmental level, it has a certain persistence. Once released into the environment, due to its stable chemical structure, it is difficult to be rapidly decomposed by natural conditions, and will remain in environmental media such as soil and water for a long time. It can enter the atmosphere through volatilization, and can participate in photochemical reactions in the atmosphere, affect air quality, or form secondary pollutants. In the soil, it will change the soil physical and chemical properties, affect the structure and function of soil microbial community, and hinder the material cycle and energy flow of soil ecosystems. After entering the water body, it will endanger aquatic organisms, cause poisoning of fish, plankton, etc., and destroy the aquatic ecological balance.
It is irritating to human health. If exposed to the skin, it can cause symptoms such as redness, swelling, pain, itching, and in severe cases, skin burns and ulcers. Eye contact can irritate the conjunctiva of the eye, causing eye pain, tears, blurred vision, and even damage the cornea, affecting vision. Inhalation through the respiratory tract can irritate the respiratory mucosa, causing symptoms such as cough, asthma, and breathing difficulties. Long-term or heavy inhalation may damage lung function and increase the risk of respiratory diseases. It is also potentially carcinogenic. Studies have shown that long-term exposure to (chloromethyl) -1,2-dichlorobenzene-containing environment will increase the risk of cancer, especially liver cancer and lung cancer. In addition, it may interfere with the human endocrine system, affect the normal secretion and regulation of hormones, and have adverse effects on the reproductive system and immune system, such as reproductive dysfunction and decreased immunity.