What are the main uses of 1- (methylthio) -4- (trifluoromethyl) benzene?
(Methylsilyl) - (triethylsilyl) benzene is widely used in chemical industry. It is used to make various organosilicides, which can be used as an active silicon source. In the process of organic synthesis, it has to build a variety of silicon-carbon bonds, expand the category of compounds, and assist in the development of new materials.
First, in the polymerization reaction, (methylsilyl) - (triethylsilyl) benzene can be a monomer or an auxiliary agent. When it is a monomer, after polymerization, a polysilylbenzene chain is formed. This chain has specific electrical and optical properties and can be used to make optoelectronic materials, such as organic Light Emitting Diode (OLED), solar cells, etc. The light-emitting layer of OLED is made of silicon-containing polymer, which can increase the luminous efficiency, lifespan, and display quality; it can be used in solar cells to optimize the photoelectric conversion efficiency. When used as an auxiliary agent, it can adjust the polymerization reaction rate, product structure and properties, such as regulating the molecular weight and distribution of the polymer, so that the product can meet specific needs.
Second, in the field of organic synthesis chemistry, it is a key intermediate. By means of various chemical reactions, such as nucleophilic substitution, electrophilic substitution, coupling reaction, etc., different functional groups can be introduced to obtain organosilicon compounds with complex structures. In pharmaceutical chemistry, such compounds may have unique biological activities, providing opportunities for the development of new drugs. Some studies have started with (methylsilyl) - (triethylsilyl) benzene, and through a series of reactions, organosilicon drug lead compounds with anti-tumor activity have been obtained, which are used to create new anti-cancer drugs.
Third, in terms of material surface modification, (methylsilyl) - (triethylsilyl) benzene also has wonderful uses. It can be chemically modified on the surface of the material to change the surface properties. On the surface of metal materials, the introduction of silicon can increase its corrosion resistance, because silicon can form a protective film and resist external corrosive media; on the surface of polymer materials, it can adjust the wettability and adhesion. If the surface of the material is hydrophobic, it can be used in waterproof coatings; or increase the surface adhesion and facilitate the preparation of composite materials.
What are the physical properties of 1- (methylthio) -4- (trifluoromethyl) benzene?
(1) Properties of this substance
1- (methylphenyl) -4- (trifluoromethyl) benzene, which is an organic compound. Looking at its morphology, under room temperature and pressure, it is mostly colorless to slightly yellow liquid, with a clear appearance and no visible impurities. It has a special smell. Although it is difficult to describe accurately, it is somewhat similar to the smell of common aromatic hydrocarbons, which is both aromatic and slightly irritating.
(2) Physical property correlation
When it comes to physical properties, its boiling point varies slightly according to different conditions and is roughly in a certain temperature range. Due to the intermolecular force, the structure of methyl phenyl and trifluoromethyl in the molecule makes the intermolecular force at a certain level, which determines its boiling point. The melting point also has a corresponding value. At this temperature, the substance changes from liquid to solid.
Furthermore, density is also one of the important physical properties. Compared with water, its density is either greater than or less than that of water, depending on the molecular structure and the relative mass and spatial arrangement of the constituent elements. In terms of solubility, it exhibits good solubility in organic solvents such as ethanol and ether. Due to the principle of "similar miscibility", the structure of the compound has a certain similarity with the molecular structure of organic solvents, so it can be miscible with each other. However, its solubility in water is poor, because the molecular polarity is quite different from that of water molecules, it is difficult for the two to combine with each other. The physical properties of 1 - (methylphenyl) -4 - (trifluoromethyl) benzene are determined by its molecular structure. The presence of phenyl gives it certain aromatic properties, while the substitution of methyl and trifluoromethyl alters the molecular electron cloud distribution and spatial configuration, which in turn affects the intermolecular forces, and finally presents the above physical properties. This is the relationship between its internal structure and external physical properties.
What are the chemical properties of 1- (methylthio) -4- (trifluoromethyl) benzene?
(Methylsilyl) - (triethylsilyl) benzene has unique chemical properties and several characteristics.
First, it has certain stability. The benzene ring structure gives it the stability of the foundation. Although methylsilyl and triethylsilyl change their electron cloud distribution, they do not break the benzene ring conjugate system. Therefore, under mild conditions, it is not easy to react violently.
Second, the introduction of silicon groups makes the compound silicophilic. The characteristics of silicon elements cause it to have an affinity for silicon-containing reagents or reaction check points with silicon atoms. It can be used as a check point for nucleophilic reagents or electrophilic reagents in specific reactions, leading to the formation of new chemical bonds.
Third, its electronic effect is significant. Methylsilyl group and triethylsilyl group are the power supply subgroups, which can increase the electron cloud density of the benzene ring. The change of the electron cloud density affects the substitution reaction on the benzene ring. During the electrophilic substitution reaction, the reactivity increases and the substitution check points are different. The power supply subgroups increase the electron cloud density of the adjacent and para-sites of the benzene ring more, so the electrophilic reagents are more likely to attack the adjacent and para-sites and generate the adjacent and para-site substitution products.
Fourth, the spatial effect cannot be ignored. Triethylsilyl groups are large in volume and have significant steric resistance. This steric resistance affects the reactants' proximity to the activity check point of the benzene ring during the reaction. For example, in the nucleophilic substitution reaction, the large volume of triethylsilyl group may hinder the nucleophilic reagent from approaching the benzene ring, causing the reaction rate to change, and even affecting the selectivity of the reaction products, so that the reaction tends to generate products with small steric resistance.
Fifth, in the field of organic synthesis, (methylsilyl) - (triethylsilyl) benzene can be used as an important intermediate. With the reactivity of silicon groups and the stability of benzene rings, other functional groups can be introduced through various chemical reactions to construct complex organic molecular structures, opening up a broad path for organic synthesis chemistry.
What are the synthesis methods of 1- (methylthio) -4- (trifluoromethyl) benzene?
To prepare 1- (ethylphenyl) -4- (trifluoroethyl) naphthalene, the following ancient method can be used:
First push the Fu-gram reaction. First take an appropriate amount of naphthalene, use a suitable Lewis acid such as anhydrous aluminum trichloride as a catalyst, add ethylphenyl halide in a suitable reaction vessel, control the temperature and stir, so that the naphthalene and ethylphenyl halide are alkylated by Fu-gram to obtain 1- (ethylphenyl) naphthalene. This step requires attention to the amount of catalyst and the reaction temperature to avoid excessive alkylation.
Then, place 1- (ethylphenyl) naphthalene in another reaction system and introduce a reagent containing trifluoroethyl. Trifluoroethyl halide can be selected, and it is still catalyzed by Lewis acid, and the alkylation reaction is carried out again to obtain 1- (ethylphenyl) -4- (trifluoroethyl) naphthalene. In this step, due to the special properties of trifluoroethyl, the reaction conditions may need to be carefully adjusted to achieve the ideal yield and selectivity.
Palladium-catalyzed coupling reaction can also be used. First, the naphthalene is derived from suitable halogenated naphthalenes, such as 1-halogenated naphthalenes, with ethylphenylboronic acid, with palladium complex as catalyst, and in the presence of base, through Suzuki-Miyaura coupling reaction to obtain 1- (ethylphenyl) naphthalene. Then, 1- (ethylphenyl) naphthalene is converted into a suitable halide through a specific reaction, and then with trifluoroethylboronic acid or its derivatives, under palladium catalysis, through coupling reaction to obtain the target product. This approach requires strict reaction conditions, and the choice and dosage of catalyst, the type and dosage of base are all related to the success or failure of the reaction.
In addition, the derivative of naphthalene can be considered as the starting material and transformed into a functional group in multiple steps. For example, the naphthalene is first introduced into a suitable functional group through electrophilic substitution, and the structure of ethylphenyl and trifluoroethyl is gradually constructed through a series of reactions such as reduction and oxidation, and finally 1- (ethylphenyl) -4- (trifluoroethyl) naphthalene is obtained. Although this method is cumbersome, it requires relatively mild reaction conditions and can be selected according to raw materials and actual needs.
What are the precautions for 1- (methylthio) -4- (trifluoromethyl) benzene during storage and transportation?
(1) The caution of storage is also
First, this medicine (1- (ethylphenyl) -4- (trifluoroethyl) benzene), which is sexual or active, should be stored in a cool and dry place. If it is in a warm and humid place, it may come into contact with the surrounding moisture and heat, causing the drug to mutate. For example, the ancient red sand, when stored in a dry place, will last for a long time. If it is placed in a tidal place, it will easily lose its properties. The same is true for this medicine.
Second, prevent it from mixing with various sundries. The characteristics of this medicine are unique, or it may change in combination with other things. In the past, those who had combined medicines accidentally made all kinds of medicines mixed, causing the drug to lose all its power, or even produce poison. Therefore, this medicine must be placed in a separate place, and the logo is clear to prevent misuse.
(2) When transporting this medicine, the first thing to do is to be stable. It must be fixed to prevent bumps and spills. In the past, there was a car transporting medicine, which was bumpy on the way, causing the medicine bottle to break, and the medicine was scattered on the ground, which not only damaged the medicine, but also endangered people and animals. This medicine should be protected by a thick pad, and the car will travel slowly and steadily.
Furthermore, avoid fire and electricity. This medicine may have the risk of explosion, and both fire and electricity can cause it to change. Gunpowder in ancient times exploded in case of fire. Although this is not gunpowder, it must be prevented. In the place of transportation, fireworks are strictly prohibited, and electrical appliances are avoided to prevent accidents.
Also, the escort must choose someone who is familiar with the medicinal properties. They should know the benefits of this medicine, and in case of emergencies, they can handle it properly. If there is a leak of medicine, know how to collect it and how to solve it with medicine, so as to be safe.
