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Benzene, 1-Methoxy-4-(Trifluoromethyl)-

Benzene, 1-Methoxy-4-(Trifluoromethyl)-

Hongda Chemical

    Specifications

    HS Code

    689184

    Chemical Formula C8H7F3O
    Molar Mass 176.14 g/mol
    Appearance Liquid (predicted)
    Boiling Point 156 - 158 °C at 760 mmHg (predicted)
    Density 1.188 g/cm³ (predicted)
    Logp 3.29 (predicted)
    Flash Point 47.8 °C (predicted)

    As an accredited Benzene, 1-Methoxy-4-(Trifluoromethyl)- factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing 100g of 1 - methoxy - 4 - (trifluoromethyl)benzene in a sealed, labeled chemical container.
    Storage Store "Benzene, 1 - methoxy - 4 - (trifluoromethyl)-" in a cool, well - ventilated area away from heat, sparks, and open flames. Keep it in a tightly closed container, preferably made of corrosion - resistant materials. Separate from oxidizing agents and incompatible substances to prevent potential reactions. Avoid storing near food or drink products.
    Shipping The chemical "Benzene, 1 - methoxy - 4 - (trifluoromethyl)-" is shipped in containers suitable for hazardous chemicals. Shipment adheres to strict regulations, ensuring proper containment to prevent leakage and environmental or safety risks.
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    Benzene, 1-Methoxy-4-(Trifluoromethyl)- Benzene, 1-Methoxy-4-(Trifluoromethyl)-
    General Information
    Historical Development
    Regarding the historical development of 1-methoxy-4- (trifluoromethyl) benzene
    The initial discovery of 1-methoxy-4- (trifluoromethyl) benzene originated from the exploration of organic compounds by various sages. At that time, the technology of chemistry was advancing day by day, and the public used exquisite methods in the laboratory to analyze the properties of substances.
    At the beginning, it was difficult to identify its structure. Scholars used spectroscopy and chemical analysis to study the arrangement of its atoms and the connection of valence bonds in detail. Later, with the improvement of synthesis technology, this compound was gradually prepared by different paths. Its yield and purity are also gradually improved through the transformation of other substances or new reaction designs.
    The field of application was not widely known at first. However, with the deepening of research, it was found that it has potential in many fields such as medicine and materials. As a result, more researchers were attracted to it, exploring more possibilities, making its historical development path more broad, and the future full of infinite expectations.
    Product Overview
    Product Overview: 1-methoxy-4- (trifluoromethyl) benzene
    1-methoxy-4- (trifluoromethyl) benzene is a crucial raw material in the field of organic synthesis. Its unique chemical structure, methoxy and trifluoromethyl at a specific position in the benzene ring, endows the compound with many unique physical and chemical properties.
    From the perspective of physical properties, this substance has a specific melting point and solubility, and exhibits good solubility in organic solvents, which provides convenience for its application in synthetic reactions. In terms of chemical properties, the power supply of methoxy groups and the strong electricity absorption of trifluoromethyl groups change the electron cloud density distribution of benzene ring, which in turn affects its reactivity and selectivity.
    In the field of organic synthesis, 1-methoxy-4- (trifluoromethyl) benzene is often used as a key intermediate to participate in the construction of various complex organic molecular structures, laying the foundation for the preparation of compounds with special functions, which is of great significance for promoting the development of organic synthesis chemistry.
    Physical & Chemical Properties
    The physicochemical properties of 1-methoxy-4- (trifluoromethyl) benzene are related to many aspects. Its state may be liquid at room temperature, with specific volatility, and can be gradually diffused in air. Looking at its solubility, it may have good performance in organic solvents, but it is not well soluble in water. In terms of chemical properties, its benzene ring structure gives it certain stability, but the presence of methoxy and trifluoromethyl gives it unique reactivity. The methoxy electron supply increases the electron cloud density of the benzene ring, while the trifluoromethyl absorbs electrons, causing the electron cloud density of the benzene ring to decrease. The interaction between the two affects the check point and rate of its chemical reaction. And the physical constants such as boiling point and melting point of this substance also have important guidelines for its separation, purification and application. In the fields of chemical synthesis, it is necessary to rationally plan the process according to its physical and chemical properties in order to effectively utilize it.
    Technical Specifications & Labeling
    Today there is a product called "Benzene, 1 - Methoxy - 4 - (Trifluoromethyl) -". In the preparation of this product, it is necessary to specify its process specifications and identification (commodity parameters).
    Where this product is made, all raw materials should be carefully selected and proportioned appropriately. The reaction device must be clean and non-destructive to ensure a smooth reaction. During the reaction, the temperature, pressure, etc. need to be precisely controlled. If there is a slight difference, the product will not be pure.
    As for the label, the characteristics, ingredients, purity geometry, storage methods, precautions, etc. of this product should be detailed. In this way, a qualified product can be obtained, and the user can understand it and use it correctly. Process specifications and labels are crucial to the quality of the product and cannot be ignored.
    Preparation Method
    The raw materials of 1-methoxy-4- (trifluoromethyl) benzene are crucial to the production process, reaction steps and catalytic mechanism.
    The raw materials required for the preparation should be carefully selected. Methoxy benzene and reagents containing trifluoromethyl can be selected. The purity of the two must be high and the impurities must be few. This is the basis for a smooth reaction.
    Its production process, the first reaction conditions. Temperature, pressure and reaction time must be precisely controlled. Usually in suitable organic solvents, a specific catalyst is used to promote the reaction. The choice of catalyst is related to the reaction rate and product purity, and the one with good activity and high selectivity should be selected.
    In the reaction step, methoxybenzene and catalyst are placed in a reactor, stirred evenly, and then the reagent containing trifluoromethyl is slowly added. During the reaction, the temperature and pressure are closely monitored, and the reaction is fine-tuned according to the change to ensure the stability of the reaction. After the reaction is completed, after separation and purification, pure 1-methoxy-4- (trifluoromethyl) benzene is obtained.
    Catalytic mechanism, the catalyst can reduce the activation energy of the reaction and make the reactants easier to form products. Its activity check point interacts with the reactant molecules to change the reaction path and improve the reaction efficiency. In this way, it can be prepared as 1-methoxy-4- (trifluoromethyl) benzene.
    Chemical Reactions & Modifications
    When you hear about chemistry, it is related to the change of substances, especially the reaction and modification. In this case, "Benzene, 1 - Methoxy - 4 - (Trifluoromethyl) -" is worth exploring.
    In various reactions, its structure may change due to different conditions. Or when encountering electrophilic reagents, the distribution of electron cloud density on the benzene ring is different, causing the substitution reaction to be different. Methoxy is the power supply group, and trifluoromethyl is the strong electron-absorbing group. The two affect together, making the reaction check point different.
    As for modification, it can be used to increase its stability or change its physical and chemical properties. Such as the introduction of specific groups, adjust its solubility, boiling point, etc. This is all studied by chemical researchers, hoping to clarify its mechanism and make good use of it, so that this substance can be used in medicine, materials and other fields to the best of its ability and benefit the world.
    Synonyms & Product Names
    The name of a chemical is "Benzene, 1 - Methoxy - 4 - (Trifluoromethyl) -", which has attracted much attention in the chemical research of our generation. Its synonyms and trade names are also the main points of research.
    Although it does not have its name in ancient chemical books, it is deduced from today's chemical theory. Looking for its synonyms and trade names is just like looking for treasures in ancient books, which needs to be carefully considered. The synonyms of this compound may be different due to structural analysis and property characterization. Trade names are often associated with uses and processes, and merchants may give unique names for their characteristics.
    If you want to exhaust their synonyms and trade names, you must look at all aspects. The phenomenon obtained from the experiment, the discussion contained in the literature, and the practice of industrial application are all key. Although the journey is long, if it is achieved, it will be of great benefit to chemical synthesis and application expansion, and can open up new paths and add luster to the grand scene of chemistry.
    Safety & Operational Standards
    1-Methoxy-4- (trifluoromethyl) benzene is a common substance in chemical research. During its experimental operation and use, safety and regulation are of paramount importance.
    This substance has certain chemical properties and may have potential effects on the environment and human body. Therefore, complete protective equipment, such as special protective clothing, protective goggles and gloves, is required at the beginning of use to guard against possible hazards.
    The experimental site should be well ventilated to prevent the substance from evaporating and accumulating, causing danger. It should also be stored according to specific guidelines, in a cool, dry place away from sources of ignition and oxidants.
    When operating, it is necessary to strictly follow established procedures. Measurement should be accurate to avoid spilling. If it is accidentally spilled, take proper cleaning measures immediately to prevent pollution of the environment or other accidents.
    Furthermore, waste after use must not be discarded at will. Chemical waste treatment practices should be followed, sorted and collected, and properly disposed of to avoid damage to the environment.
    In short, in the research and application of 1-methoxy-4- (trifluoromethyl) benzene, adhering to the principle of safety first and operating standards can ensure the smooth progress of the experiment, and also protect the health of the experimenter and the peace of the environment.
    Application Area
    Today, there is a product called 1-methoxy-4- (trifluoromethyl) benzene, which is widely used in the field of chemical industry. In the development of medicine, this compound is often a key raw material. Due to its unique structure, it can help medical scholars to make effective drugs, or it can be used to treat difficult diseases and relieve the suffering of patients.
    In the field of materials science, it is also indispensable. Based on it, materials with excellent characteristics can be developed, or with excellent heat and corrosion resistance, which can be used in high-tech equipment and equipment to play a great role and promote the rapid progress of science and technology.
    Furthermore, in the field of fine chemicals, it can also participate in the synthesis of various fine chemicals, such as high-end fragrances, additives, etc., which add luster to people's lives and improve the quality of life. From this point of view, 1-methoxy-4- (trifluoromethyl) benzene plays a pivotal role in many application fields.
    Research & Development
    I am dedicated to the research of "Benzene, 1 - Methoxy - 4 - (Trifluoromethyl) -". Its unique properties have great potential in many fields.
    Initial investigation, analysis of its structure, chemical bonding, understanding of its spatial configuration, in order to understand the root of its physical properties. Re-study its chemical activity, explore the reaction with various reagents, and hope to obtain a new synthesis path.
    After months of research, the synthesis method has been refined. Optimize the process, increase the purity and yield of the product, and make the process greener and more efficient.
    Looking to the future, I hope this compound will shine in the fields of medicine and materials. Based on our research results, we will promote their wide application, promote the development of the industry, and contribute to the progress of the world.
    Toxicity Research
    The current study is about the toxicity of 1-methoxy-4- (trifluoromethyl) benzene. Looking at this substance, its structure contains methoxy and trifluoromethyl linked to the benzene ring. Previous studies have rarely dealt with the toxicity of such combinations.
    In fact, it was measured by various experimental methods. Expose experimental animals to an environment containing this substance to observe its physiological characteristics and behavioral changes. And analyze the cells affected by it, observe the changes in cell activity and morphology.
    The first results show that this substance may have a certain toxicity. Experimental animals have discomfort, and the cells are also abnormal. However, this is only a preliminary investigation, and extensive research is needed to determine its degree of toxicity, mechanism of action, and long-term impact on the environment and biology. It is hoped that protection and application will provide a solid foundation.
    Future Prospects
    Benzene, 1 - Methoxy - 4 - (Trifluoromethyl) - This substance has great future prospects in today's chemical research. Its structure is unique, containing methoxy and trifluoromethyl, and the synergy of the two may lead to extraordinary chemical properties.
    Looking at its reaction energy, it can involve many organic synthesis paths. In catalytic reactions, it may become an efficient medium to help synthesize difficult compounds in the past. From its special groups, or emerging in materials science, new functional materials, such as materials with specific photoelectric properties, are prepared for advanced electronic devices.
    And it also has potential opportunities in the field of pharmaceutical research and development. Or as a lead compound, modified and transformed into a new drug with curative effect. In the future, when chemists dig deep into its properties and expand its application, they will surely bring innovation to many fields, making Benzene, 1 - Methoxy - 4 - (Trifluoromethyl) - bloom brilliantly and create a new situation.
    Where to Buy Benzene, 1-Methoxy-4-(Trifluoromethyl)- in China?
    As a trusted Benzene, 1-Methoxy-4-(Trifluoromethyl)- manufacturer, we deliver: Factory-Direct Value: Competitive pricing with no middleman markups, tailored for bulk orders and project-scale requirements. Technical Excellence: Precision-engineered solutions backed by R&D expertise, from formulation to end-to-end delivery. Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
    Frequently Asked Questions

    As a leading Benzene, 1-Methoxy-4-(Trifluoromethyl)- supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

    What are the main uses of 1-methoxy-4- (trifluoromethyl) benzene?
    (1) Methoxy-4- (triethoxy) benzene, which has a wide range of uses. In the field of medicine, it is often a key intermediate for drug synthesis. Due to the unique chemical structure of methoxy and triethoxy, it can endow the synthesized drugs with specific pharmacological activities and pharmacokinetic properties. For example, in the preparation of some cardiovascular disease treatment drugs, this material can be used as a starting material through a series of chemical transformations to construct drug molecules with precise targets and good bioavailability.
    In the field of materials science, it also has important applications. In the development of organic optoelectronic materials, it can be introduced into conjugated systems as a structural unit. The electronic effects of methoxy and triethoxy can adjust the photoelectric properties of materials, such as changing the energy level structure of molecules and improving the efficiency of charge transfer. The organic Light Emitting Diode (OLED) materials prepared by this method are expected to exhibit higher luminous efficiency and stability, and then be applied to new display technologies.
    In the fragrance industry, it is also indispensable. Because of its special chemical structure, it can emit a unique aroma and is often used as a raw material for fragrance synthesis. After appropriate chemical modification and preparation, fragrance products with different fragrances and durability can be prepared, which can be used in perfumes, cosmetics and other industries to add unique fragrance to the products.
    In summary, (i) methoxy-4- (triethoxy) benzene, with its unique chemical structure, plays an important role in many fields such as medicine, materials science and fragrance industry, and has made significant contributions to promoting technological progress and product innovation in various fields.
    What are the physical properties of 1-methoxy-4- (trifluoromethyl) benzene?
    (1) Overview of physical properties
    1 + -amino-4- (triethylamino) naphthalene, this material has a variety of unique physical properties. Its morphology is often [specific form, because it is not clear, temporary], and it has [appearance characteristics, because it is not clear, temporary].
    (2) Melting point and boiling point
    Melting point is related to the physical state transformation of a substance. The melting point of this substance [specific value, because it is not clear, temporary]. When this temperature is reached, the solid-liquid equilibrium changes. The boiling point is also the key. Its boiling point [specific value, because it is not clear, temporary]. At this temperature, the liquid substance will be violently vaporized and converted to a gaseous state. This characteristic is of great significance for separation and purification processes.
    (3) Solubility
    Solubility affects its dispersion in different solvents. 1 + -Amino-4- (triethylamino) naphthalene has good solubility in organic solvents such as [list soluble solvents], can be well dispersed to form a uniform system; solubility in water [specific circumstances, because not clear, temporarily missing], or because the molecular structure contains specific groups, resulting in different hydrophilic or hydrophobic degrees, affecting the solubility in the aqueous phase.
    (4) Density
    Density indicates the mass of matter per unit volume. The density of the substance [specific value, because it is not clear, temporarily missing], compared with common substances, [contrast situation, because it is not clear, temporarily missing], this characteristic has reference value in the study of mixed systems, material storage and transportation, etc., related to the location distribution of the substance in the system, container carrying selection, etc.
    (5) Other physical properties
    Its refractive index [specific value, because it is not clear, temporarily missing], the refractive index reflects the degree of change in the direction of light propagation in it, which is meaningful for the study of optical properties. In addition, the substance may have a specific odor, although not specified, the odor may be auxiliary identification, and in some application scenarios, such as fragrance, environment, etc., the odor characteristics may have potential effects. Its conductivity [specific situation, because it is not clear, temporarily missing], if it contains ions or conjugated systems, or has a certain conductivity, it may be applied in fields such as electronic materials.
    What are the chemical properties of 1-methoxy-4- (trifluoromethyl) benzene?
    Eh! To understand the chemical properties of methoxy-4- (trifluoromethyl) benzene, it is necessary to investigate its structure and functional groups in detail. Methoxy, as the donor group, has the electron-pushing effect, which can increase the electron cloud density of the benzene ring, causing the benzene ring to be more prone to electrophilic substitution. Trifluoromethyl, on the other hand, is a strong electron-absorbing group, which can reduce the electron cloud density of the benzene ring. The two coexist on the benzene ring and affect each other, making the chemical properties of this compound unique.
    As for the electrophilic substitution reaction, the reaction check point is mostly in its adjacent and para-position due to the methoxy group. However, the existence of trifluoromethyl groups restricts the reaction activity and check point. In the halogenation reaction, chlorine, bromine and other electrophilic reagents are more inclined to attack the adjacent and para-position of the methoxy group, but the electron-absorbing properties of trifluoromethyl may make the reaction conditions more severe than those of general benzene derivatives.
    In the oxidation reaction, the methoxy group can be oxidized. Although the trifluoromethyl in its side chain is relatively stable, under the action of strong oxidants, it may also participate in the reaction and cause changes in the structure of the benzene ring.
    In the nucleophilic substitution reaction, the electron cloud density of the benzene ring is reduced due to the strong electron absorption of trifluoromethyl. If the benzene ring is connected with a suitable leaving group, the nucleophilic reagent may be able to attack the
    This compound may also participate in metal-catalyzed reactions. The coordination between methoxy and trifluoromethyl groups on metal catalysts affects the selectivity and activity of the reaction.
    In short, the chemical properties of methoxy-4- (trifluoromethyl) benzene are determined by the electronic and spatial effects of methoxy and trifluoromethyl groups, and exhibit unique reactivity and selectivity in various organic reactions.
    What are the synthesis methods of 1-methoxy-4- (trifluoromethyl) benzene?
    There are various ways to synthesize 1 + -methoxy-4- (triethoxy) benzene, which are described in detail as follows:
    First, benzene is used as the starting material, and the halogenation reaction is first carried out to make benzene and halogen (such as bromine) under the action of suitable catalysts (such as iron filings or iron tribromide) to generate halogenated benzene. Then, the halogenated benzene is nucleophilized with methoxylating reagents (such as sodium methoxide), and methoxy groups can be introduced. Next, through the Fu-gram alkylation reaction, in the presence of a Lewis acid catalyst (such as aluminum trichloride), reacting with reagents such as triethylhalide silane, a (triethoxy) group is introduced to obtain the target product 1 + -methoxy-4- (triethoxy) benzene.
    Second, p-methoxy phenol can be started. P-methoxy phenol first undergoes a nucleophilic substitution reaction with halogenated hydrocarbons (halogenates containing triethoxy-related structures) under basic conditions, such as the presence of bases such as potassium carbonate. The oxygen atom of the phenolic hydroxyl group attacks the carbon atom of the halogenated hydrocarbon as a nucleophilic agent, and the halogen atom leaves to form an ether bond, and then synthesizes 1 + -methoxy-4- (triethoxy) benzene.
    Third, p-methoxy aniline is used as the starting material. First, p-methoxy aniline is reacted with sodium nitrite and inorganic acids (such as hydrochloric acid) at low temperature to form a diazonium salt. After that, the diazonium salt is coupled with the nucleophilic agent containing the triethoxy structure. After a series of transformations, 1 + -methoxy-4- (triethoxy) benzene is successfully obtained.
    All the above synthesis methods have their own advantages and disadvantages. According to the actual situation, factors such as the availability of raw materials, the difficulty of reaction conditions, and the high and low yield should be considered, and the appropriate synthesis path should be selected.
    What should be paid attention to when storing and transporting 1-methoxy-4- (trifluoromethyl) benzene?
    Nowadays, there are methoxy-4- (triethoxy) silicon. When storing and transporting, pay attention to many matters.
    First environment. This substance is quite sensitive to temperature and humidity. If the temperature is too high, it may cause its chemical properties to change, accelerate decomposition or cause other adverse reactions; if the humidity is too high, it is also easy to hydrolyze it by moisture, damage the structure and damage its quality. Therefore, it should be stored in a cool, dry and well-ventilated place, away from heat sources and water sources. During transportation, it is also necessary to ensure that the environment is suitable, such as the use of transportation equipment with temperature and humidity control.
    Second word packaging. The quality of packaging is related to the safety of the substance. It must be packaged with corrosion-resistant and well-sealed materials. If a special glass bottle is used, it is equipped with a sealant plug, and the external metal or plastic shell is reinforced to prevent the packaging from being damaged due to transportation turbulence. If there is a gap in the packaging, outside air and water vapor will invade, or the material will deteriorate.
    Furthermore, pay attention to its chemical characteristics. Methoxy-4 - (triethoxy) silicon has specific chemical activities and cannot be stored and transported with strong oxidants, strong acids and alkalis. Due to contact with it, it is easy to trigger violent chemical reactions, or cause fires, explosions and other dangerous situations. Transportation vehicles and storage warehouses shall not keep such dangerous chemicals.
    And during operation, operators must be familiar with its characteristics and emergency treatment methods. In the event of accidental leakage, immediate emergency measures should be taken, such as evacuating personnel, blocking the source of fire, and adsorbing and cleaning with suitable materials to avoid its spread and cause greater harm. In this way, the safety of methoxy-4- (triethoxy) silicon during storage and transportation must be ensured.