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Benzene, 1-Fluoro-2-Iodo-

Benzene, 1-Fluoro-2-Iodo-

Hongda Chemical

Specifications

HS Code

380341

Chemical Formula C6H4FI
Molar Mass 210.00 g/mol
Appearance Colorless to light - yellow liquid
Boiling Point Around 185 - 187 °C
Solubility In Water Insoluble (non - polar benzene ring dominates)
Solubility In Organic Solvents Soluble in common organic solvents like ethanol, ether
Vapor Pressure Low vapor pressure at room temperature

As an accredited Benzene, 1-Fluoro-2-Iodo- factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

Packing & Storage
Packing 100 - gram vial packaging for 1 - fluoro - 2 - iodobenzene chemical compound.
Storage 1 - fluoro - 2 - iodobenzene should be stored in a cool, dry, well - ventilated area, away from heat sources and ignition sources. Keep it in a tightly closed container, preferably made of corrosion - resistant materials. Store it separately from oxidizing agents, strong acids, and reactive substances to prevent potential chemical reactions. Ensure proper labeling for easy identification.
Shipping 1 - fluoro - 2 - iodo - benzene is a chemical that requires careful shipping. It should be packaged in well - sealed, appropriate containers. Shipments must comply with regulations for hazardous chemicals, ensuring proper handling to prevent spills and exposure.
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Benzene, 1-Fluoro-2-Iodo- Benzene, 1-Fluoro-2-Iodo-
General Information
Historical Development
In the field of chemical industry, there is a name "Benzene, 1 - Fluoro - 2 - Iodo -". Its origin can be traced back to the past. In the past, many wise people were in the research of chemistry, exploring step by step. At the beginning, the wonder of this thing was unknown, but with the passage of time, the heart of the researcher became stronger, and the method was also new.
At the beginning, scholars began to use exquisite methods in experiments to observe the changes of various compounds. After repeated trials and errors, they finally got the way to prepare it. At that time, although the preparation was difficult and the amount was meager, its uniqueness attracted attention. After
, with the evolution of science and technology, the preparation technology has improved the essence, and the output has gradually increased. It is used in various things in the chemical industry, and it has become more and more widely used. It can be used as a raw material for reactions, or to assist in the synthesis of other substances, and its effect is extraordinary. Looking at its historical development, it has started from the very beginning, and its importance to this day is actually the unremitting achievement of chemical research, and it can also be seen in the research of various sages.
Product Overview
《关于1 - 氟 - 2 - 碘苯之品述》

夫1 - 氟 - 2 - 碘苯者,有机化合物也。其形色,常温下或为无色至淡黄色之液体,具特殊之气味。观其分子结构,苯环之上,氟原子与碘原子各据一位,布局有序。

此品性质,因氟、碘二原子之引入而独具特色。氟原子电负性强,使分子电子云分布改变,影响其化学活性;碘原子体积较大,对分子空间位阻亦有影响。二者协同,致1 - 氟 - 2 - 碘苯于诸多反应中展现别样性能。

于有机合成之域,1 - 氟 - 2 - 碘苯用途颇广。可作关键中间体,参与诸多复杂有机分子之构建。经由特定化学反应,能引入其他官能团,拓展化合物之种类,为创制新颖有机材料、药物等奠定基础。

然使用之际,亦当留意其安全性。因其具一定化学活性,或对人体与环境存潜在影响,操作时需依规范流程,确保安全无虞。
Physical & Chemical Properties
1-Fluoro-2-iodobenzene is an organic compound. It has unique physical and chemical properties. Looking at its physical properties, at room temperature, it is a colorless liquid with a special odor and certain volatility. Its boiling point and melting point also have fixed numbers, which are related to its intermolecular forces.
On its chemical properties, due to the existence of benzene rings, it has aromatic properties. The substitution of fluorine and iodine causes the distribution of electron clouds to change. The change of electron cloud density of benzene ring affects the activity of electrophilic substitution reaction. The electronegativity difference between fluorine and iodine makes the molecular polarity different, which in turn affects its solubility. In many chemical reactions, this substance exhibits unique reaction paths and characteristics, and is the key object of chemical research in the field of organic synthesis and other fields.
Technical Specifications & Labeling
The name of this substance is "Benzene, 1 - Fluoro - 2 - Iodo -". In terms of process specifications and identification (product parameters), it is crucial.
Looking at this substance, the process specifications need to be clear and synthesized, starting from the ratio of raw materials, such as fluoride, iodide and benzene, the reaction conditions should also be detailed, and the temperature, pressure and catalyst dosage should not be ignored. The control of reaction time is related to the purity and yield of the product.
In terms of identification (product parameters), its physical properties should be detailed, such as melting point, boiling point, density, and chemical properties should also be described, such as stability and reactivity. The standard of purity is the most important thing, and it is related to its application. In this way, this "Benzene, 1 - Fluoro - 2 - Iodo -" product can be used in industry and scientific research with accuracy and safety.
Preparation Method
To prepare 1-fluoro-2-iodobenzene, the method is as follows:
Raw materials and production process: Select pure benzene, and an appropriate amount of fluoride and iodide as raw materials. First, place the benzene in a special reactor, measure the fluoride and iodide with a precise meter, and slowly inject it into the kettle according to a specific ratio.
Reaction steps: Heat up to a suitable temperature, about [X] degrees Celsius, and apply moderate stirring at the same time to promote uniform mixing of materials. During the reaction process, pay close attention to changes in temperature and pressure to ensure a smooth reaction. After several hours of reaction, wait for the substances in the kettle to fully react.
Catalytic mechanism: The specific catalyst can effectively reduce the activation energy of the reaction, accelerate the reaction rate, and improve the product generation efficiency. After the reaction is completed, the pure 1-fluoro-2-iodobenzene product can be obtained through a series of separation and purification methods.
Chemical Reactions & Modifications
The theory of chemical adaptation
View the wonders of chemistry, with all kinds of changes, related to the change of substances, and the principle of adaptation cannot be ignored. Today, it is important to talk about the chemical reaction and modification of "Benzene, 1 - Fluoro - 2 - Iodo -".
In the past, the reaction of this substance often follows the old rules and changes according to the established method. If you want to find a new environment, you must think about the way of modification. The chemical response, or due to the ease of conditions, such as temperature, pressure, and catalytic agents, is in an abnormal state. To change the properties of this substance, you can start from its structure. The structure of the benzene ring is stable and has potential, and the position of fluorine and iodine has a great influence. If the reaction conditions are adjusted, the catalysis is selected appropriately, or the change of its bonds can be induced, so that the new substance can be produced and has a different character.
The modification is not achieved overnight, and the mechanism must be carefully studied and tried. We hope to think new, break the traditional limit, and make "Benzene, 1 - Fluoro - 2 - Iodo -" in the field of chemistry, develop new capabilities, and open up different paths for various applications.
Synonyms & Product Names
In this world, there is a chemical substance named "Benzene, 1 - Fluoro - 2 - Iodo -", which is quite important in all things chemical. Considering this thing, there are similar names and commodity names.
Those who have the same and different names, so distinguish their quality and clarify their nature. According to the principle of chemistry, the name is so, in order to accurately remember its structural composition. The name of a commodity is related to production and sales. Merchants take profit as their business, and want their names to appear in the city and be easy to recognize, so they are easy to remember and fit the market conditions.
Although they refer to the same thing, the use of the two is different. The names of similarities and differences are mostly used for theoretical discussions and experimental descriptions to ensure their accuracy; the names of commodities are for trade circulation and hope that they are widely known. The two complement each other and are indispensable in the research and application of chemical substances. Only by understanding this can we get the whole thing.
Safety & Operational Standards
About "1-Fluoro-2-iodobenzene" Product Safety and Operation Specifications
Today's discussion of "1-fluoro-2-iodobenzene" is related to its safety and operation specifications, and cannot be ignored. This is a product often involved in chemical research. In experiments, strict regulations should be followed.
First, it is safe. This product has a certain chemical activity. It encounters or reacts with other objects. If its vapor enters the body, it may hurt the lungs through breathing; it may also cause discomfort when it touches the skin. Therefore, it should be placed in a cool and well-ventilated place to avoid open flames and hot topics to prevent accidents. And it should be isolated from strong oxidants, strong alkalis, etc., to avoid disasters.
When operating, protective gear is necessary. Operators need to wear gas masks to protect their breathing; wear protective clothing to protect themselves from harm; wear chemical protective gloves to protect their hands. Do it in the fume hood, so that the harmful gas can quickly disperse and not stay in the room.
When taking it, the action should be slow and stable, and avoid sprinkling. The amount of control must be accurate, according to the needs of the experiment, not more or less. If it is accidentally spilled, clean it up as soon as possible. For small amounts, use sand, vermiculite, etc. to absorb and collect in a safe container; for large amounts, block it with an embankment, and then remove it by appropriate methods.
During the reaction, keep a close watch on the situation, and changes in temperature and pressure cannot be ignored. According to the characteristics of the reaction, adjust the conditions to ensure that it runs smoothly and avoid the risk of loss of control.
At the waste place, also follow the regulations. Do not discard it at will. According to the method of chemical disposal, collect it by classification, and hand it over to qualified persons to deal with it, so as to ensure that the environment is harmless.
To sum up, the safety and operation specifications of "1-fluoro-2-iodobenzene" are all essential for the stability of the experiment, the safety of personnel, and the environment. Do not slack off. Keep it in mind and do everything.
Application Area
Fu 1-fluoro-2-iodobenzene is also an organic compound. In the field of chemical industry, it has a wide range of uses. In the process of pharmaceutical creation, it can be used as an intermediate to help synthesize special drugs to treat various diseases. If it is an antibacterial agent or an analgesic drug, it depends on its participation in the structure of molecules.
In the field of material research and development, it also has its own influence. It can help form special materials, or have unique photoelectric properties, used in electronic devices to make display and sensing more efficient. It is a key building block in the field of organic synthesis. Through various reactions, a variety of products can be derived, expanding the chemical industry and promoting the progress of the industry. From this point of view, 1-fluoro-2-iodobenzene has important value in various application fields, and it is indispensable for chemical research and development.
Research & Development
Wutao is dedicated to the research of 1-fluoro-2-iodobenzene, which has great potential in many fields. Looking at its structure, the substitution of fluorine and iodine atoms endows it with unique chemical properties.
At the beginning of the study, its synthesis path was explored. After repeated attempts, suitable raw materials and catalysts were selected to optimize the reaction conditions, and a more efficient synthesis method was finally obtained. The yield was gradually increased, laying the foundation for subsequent research.
Then, its physical and chemical properties were investigated. Parameters such as melting point and boiling point were measured to study its solubility in different solvents. Its chemical reactivity was also observed, and it showed unique reactivity and selectivity in nucleophilic substitution, coupling and other reactions.
Looking to the future, 1-fluoro-2-iodobenzene is expected to shine in the fields of materials science and medicinal chemistry. It can be used to prepare new functional materials to improve the electrical and optical properties of materials; in drug research and development, with its special structure, it has become a key intermediate to help create new drugs with high efficiency and low toxicity. I will continue to study and promote the development and application of this substance.
Toxicity Research
The toxicity of 1-fluoro-2-iodobenzene, a derivative of benzene, is a matter of great importance to our chemical researchers. The properties of this substance are related to the safety of use, so detailed investigation is essential.
View 1-fluoro-2-iodobenzene has a unique molecular structure, and the position of fluorine and iodine affects its properties. Fluorine has strong electronegativity, while iodine has a large atomic radius. The two are on the benzene ring, making the chemical activity of this substance different from that of benzene.
After experiments, its effect on organisms was observed. Taking small animals as an experiment, an appropriate amount of 1-fluoro-2-iodobenzene was administered, and it was seen that its physiology had changed. It may disturb the metabolism of cells, or hinder the conduction of nerves, which are all signs of toxicity. However, the depth of its toxicity also depends on the amount. A small amount is less harmful, and a large amount is life-threatening.
Therefore, when using 1-fluoro-2-iodobenzene, it is necessary to be careful and study the toxicity carefully, so as to ensure the safety of use, avoid disasters, and achieve the good of chemical research and application.
Future Prospects
I have dedicated myself to studying chemical substances, and recently focused on the substance "Benzene, 1 - Fluoro - 2 - Iodo -". Thinking about its future development, I am looking forward to it.
This substance has unique properties and may have extraordinary potential in the chemical industry. In the future, it may emerge in the synthesis of materials, and use its characteristics to help develop new high-performance materials, which can be used in many cutting-edge fields such as electronics and aviation.
It is also expected to play a key role in the creation of medicine, becoming a key intermediate for the synthesis of special drugs, and contributing to human health and well-being. Although there may be difficulties and obstacles ahead, I firmly believe that with time, through unremitting research and exploration, we will be able to tap its infinite potential, shine on the future scientific stage, and bring many benefits to the world.
Where to Buy Benzene, 1-Fluoro-2-Iodo- in China?
As a trusted Benzene, 1-Fluoro-2-Iodo- manufacturer, we deliver: Factory-Direct Value: Competitive pricing with no middleman markups, tailored for bulk orders and project-scale requirements. Technical Excellence: Precision-engineered solutions backed by R&D expertise, from formulation to end-to-end delivery. Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
Frequently Asked Questions

As a leading Benzene, 1-Fluoro-2-Iodo- supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

What are the physical properties of Benzene, 1-Fluoro-2-Iodo-?
1-Fluoro-2-iodobenzene is also an organic compound. Its physical properties are quite important and are detailed as follows.
Looking at its properties, under normal temperature and pressure, 1-fluoro-2-iodobenzene is in the form of a colorless to light yellow liquid. The characteristics of this color state can be visually distinguished by the naked eye.
As for its boiling point, it is about 184-186 ° C. The boiling point is the temperature at which a substance changes from liquid to gaseous state. This boiling point value shows that to make 1-fluoro-2-iodobenzene boil and vaporize, the temperature needs to be raised to about 184-186 ° C.
The melting point is about -31 ° C. The melting point is the temperature limit at which a substance changes from a solid state to a liquid state. At this temperature, 1-fluoro-2-iodobenzene is in a solid state, and above this temperature, it gradually converts to a liquid state.
The density of 1-fluoro-2-iodobenzene is about 1.884 g/mL (25 ° C). In density, the mass per unit volume of the substance is also. This density value reflects the difference in mass of the substance in the same volume compared to other common substances such as water.
In terms of solubility, 1-fluoro-2-iodobenzene is insoluble in water. Water is a common solvent, and this compound has poor miscibility with water. However, it is soluble in most organic solvents, such as ethanol, ether, etc. Organic solvents have the ability to dissolve organic compounds. This solubility characteristic has far-reaching implications in many fields such as organic synthesis, and is related to the location of the reaction and the separation and purification of the product.
In addition, 1-fluoro-2-iodobenzene is volatile and can evaporate slowly in the air. The existence of volatility makes it necessary to pay attention to the ventilation of the environment during storage and use to ensure the safety of operation and the stability of material properties.
What are the chemical properties of Benzene, 1-Fluoro-2-Iodo-?
1-Fluoro-2-iodobenzene, an organic compound whose molecules are composed of a benzene ring, a fluorine atom, and an iodine atom. This compound has the following chemical properties:
First, electrophilic substitution reaction. The benzene ring is rich in electrons and has a high electron cloud density, which is vulnerable to attack by electrophilic reagents. Since both fluorine and iodine are electron-withdrawing groups, the electron cloud density of the benzene ring will be reduced, so that the electrophilic substitution reaction activity will decrease compared with benzene. However, due to the positioning effect of the two, the electrophilic reagents mainly attack the benzene ring in the position of interposition with fluorine and iodine. In case of halogenation reaction, under the action of suitable catalysts, the halogen atom of the electrophilic reagent can replace the hydrogen atom Although the fluorine atom is connected to the benzene ring, the carbon-fluorine bond energy is quite high and relatively stable, but under certain conditions, such as high temperature and the presence of strong nucleophiles, nucleophilic substitution reactions can still occur, and the fluorine atom is replaced by other groups. The carbon-iodine bond energy attached to the iodine atom is relatively small, the activity is high, and the nucleophilic substitution reaction is more likely to occur. Under the action of some nucleophiles, the iodine atom can be replaced by nucleophilic groups such as hydroxyl and amino groups.
Third, redox reaction. Under the action of specific oxidants, the benzene ring can be oxidized, such as strong oxidants can cause reactions such as ring opening of the benzene At the same time, 1-fluoro-2-iodobenzene may also participate in reduction reactions. For example, the substituents on the benzene ring or the benzene ring itself are reduced under the action of suitable reducing agents.
Fourth, react with metal reagents. 1-fluoro-2-iodobenzene can react with certain metal reagents to form organometallic compounds. This organometallic compound has a wide range of uses in organic synthesis and can be used to form reactions such as carbon-carbon bonds, and then synthesize more complex organic compounds.
What are the main uses of Benzene, 1-Fluoro-2-Iodo-?
1-Fluoro-2-iodobenzene is one of the organic compounds. It has a wide range of main uses and plays an important role in the field of organic synthesis.
First, it can be used as a key intermediate for the synthesis of organics with special structures. Due to the unique activities of fluorine and iodine atoms on the benzene ring, chemists can use various chemical reactions, such as nucleophilic substitution reactions, to cleverly connect other functional groups to build organic molecules with complex structures and specific properties. This is particularly critical when creating new drug molecules. Physicians who want to develop new drugs with specific pharmacological activities often rely on such compounds as starting materials and synthesize them through multiple steps to obtain the final product with the required physiological activity.
Second, in the field of materials science, 1-fluoro-2-iodobenzene also contributes. It can be integrated into the structure of polymer materials by means of polymerization. Due to its atomic properties of fluorine and iodine, the properties of materials can be improved, such as improving the thermal stability and chemical stability of materials, or endowing materials with unique electrical and optical properties, making the materials suitable for special applications such as electronic devices and optical coatings.
Furthermore, in chemical research, it is often used as a model compound to help chemists deeply explore the electronic effects and spatial effects of substituents on benzene rings. By studying the various reaction mechanisms involved, we can deepen our understanding of the nature of organic reactions and contribute to the development of organic chemistry theory. In short, although 1-fluoro-2-iodobenzene is a niche compound, it has important uses in many fields such as organic synthesis, materials science and chemical research.
What are the preparation methods of Benzene, 1-Fluoro-2-Iodo-?
The method of preparing 1-fluoro-2-iodobenzene has been known for a long time. In the past, Fang family used the following methods to do it.
First, use o-fluoroaniline as the starting material. First, it is placed in a low temperature environment with sodium nitrite and hydroiodic acid, and the reaction of diazotization is carried out. When o-fluoroaniline encounters sodium nitrite, it is aminized with the help of hydroiodic acid to form a diazonium salt. Subsequently, the diazonium group is replaced by an iodine atom, and 1-fluoro-2-iodobenzene is obtained. This process requires careful temperature control. Low temperature can keep the stability of the diazonium salt and avoid the risk of decomposition, so that the reaction can proceed smoothly.
Second, take o-iodobenzoic acid as the starting material. First, it is reduced to an acid chloride, which can be used as a reagent such as thionyl chloride. Then, the acid chloride and the fluorinating agent, such as potassium fluoride, are co-heated in a suitable solvent. This reaction requires a good solvent to make the fluorinating agent evenly dispersed and improve the reaction efficiency. The carbonyl group of the acid chloride is fluorinated, and then decarboxylated to obtain 1-fluoro-2-iodobenzene. The step of decarboxylation is the control of the conditions, which is crucial, which is related to the purity and yield of the product.
Third, benzene is used as the starting material. First, it is halogenated and iodine atoms are introduced to obtain iodobenzene. Iodobenzene is then fluorinated. Under specific catalyst and reaction conditions, fluorine atoms are attached to adjacent positions to form 1-fluoro-2-iodobenzene. During halogenation, the choice of halogenating agent, reaction temperature and time control all affect the yield and purity of iodobenzene. During fluorination, the activity and selectivity of the catalyst affect the formation of 1-fluoro-2-iodobenzene.
All these preparation methods have advantages and disadvantages. According to the availability of raw materials, the cost, and the purity requirements of the product, Fangjia should carefully select them in order to make the preparation smooth and obtain the best 1-fluoro-2-iodobenzene.
Benzene, 1-Fluoro-2-Iodo- What are the precautions during storage and transportation?
For 1-fluoro-2-iodobenzene, all precautions need to be paid attention to during storage and transportation.
It is chemically active. When storing, it must be in a cool, dry and well-ventilated place. Because the substance is prone to danger when exposed to heat, open flame or oxidant, it must be kept away from heat and fire sources, and cannot be stored with strong oxidants. The warehouse temperature should be controlled within an appropriate range to prevent the temperature from being too high and causing its chemical properties to change and cause accidents.
During transportation, the packaging must be solid and stable to prevent damage and leakage. Choose suitable transportation tools and follow relevant transportation regulations. The handling process should be handled with caution to avoid collisions and drops to prevent damage to the packaging.
Furthermore, 1-fluoro-2-iodobenzene may be toxic and irritating. Storage and transportation personnel should be equipped with protective equipment, such as gas masks, protective gloves and protective clothing, to protect their own safety. In the event of an unfortunate leak, they should be handled according to the established emergency procedures, evacuate personnel in time, and seal off the site to avoid the spread of pollution.
In short, during the storage and transportation of 1-fluoro-2-iodobenzene, safety regulations and operating procedures should be strictly followed, and no slack should be allowed to ensure that personnel safety and the environment are not endangered.