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Benzene, 1-(Chloromethyl)-4-Fluoro-2-(Trifluoromethyl)-

Benzene, 1-(Chloromethyl)-4-Fluoro-2-(Trifluoromethyl)-

Hongda Chemical

    Specifications

    HS Code

    538710

    Chemical Formula C8H5ClF4
    Molar Mass 226.57 g/mol

    As an accredited Benzene, 1-(Chloromethyl)-4-Fluoro-2-(Trifluoromethyl)- factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing 500g of 1-(chloromethyl)-4-fluoro-2-(trifluoromethyl)benzene in a sealed chemical - grade bottle.
    Storage Store “Benzene, 1-(chloromethyl)-4-fluoro-2-(trifluoromethyl)-” in a cool, well - ventilated area away from heat, sparks, and open flames. Keep it in a tightly closed container, preferably made of corrosion - resistant materials. Isolate from oxidizing agents and incompatible substances. Adhere to local regulations for proper chemical storage.
    Shipping The chemical "Benzene, 1-(chloromethyl)-4-fluoro-2-(trifluoromethyl)-" must be shipped in accordance with strict hazardous materials regulations. Use appropriate, well - sealed containers to prevent leakage during transit.
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    Benzene, 1-(Chloromethyl)-4-Fluoro-2-(Trifluoromethyl)- Benzene, 1-(Chloromethyl)-4-Fluoro-2-(Trifluoromethyl)-
    General Information
    Historical Development
    Those who have heard of the benzene family of 1- (chloromethyl) -4-fluoro-2- (trifluoromethyl) are also interested in the historical evolution of their products. In the past, chemists explored various products and gradually paid attention to this. At the beginning, the understanding of its structure and characteristics was still shallow, but many scholars worked tirelessly. Over the years, the analytical methods have become more refined, and the synthesis methods have gradually improved. From the initial exploration of ignorance, to the ability to accurately control its synthesis conditions and clarify its properties, everyone has worked hard. The use of this compound in various fields of chemical industry has also expanded with the in-depth understanding. Looking at its historical development is really a drop in the long river of chemical evolution, witnessing the wisdom and hard work of the Fang family, laying the foundation for more exploration in future generations.
    Product Overview
    Today there is a substance called 1 - (chloromethyl) -4 - fluoro-2 - (trifluoromethyl) benzene. In this substance, the benzene ring is the base, one side is connected with chloromethyl, the para-position has a fluorine atom, and the ortho-position is connected with trifluoromethyl. Its unique properties may have other uses in the chemical industry. The stable structure of the benzene ring endows it with a certain degree of chemical inertness, but the existence of chloromethyl allows it to participate in many nucleophilic substitution reactions. The introduction of fluorine atoms and trifluoromethyl gives it special physical and chemical properties, such as higher fat solubility and stability. This compound may have potential application value in the research and development of new materials, drug synthesis, etc., and can be used as an object of exploration and research to clarify its more characteristics and uses.
    Physical & Chemical Properties
    "Description of Compounds"
    Now there is a substance named 1- (chloromethyl) -4-fluoro-2- (trifluoromethyl) benzene. Its physical properties are transparent and liquid-like, and its stability exists at room temperature. Its boiling point is suitable for a certain number, due to the intermolecular force. The density is fixed, which is related to its molecular stacking.
    On its chemical properties, the benzene ring has a conjugated π bond, which makes it easy to electrophilic substitution. Chloromethyl is active and can participate in the reaction of nucleophilic substitution. Fluorine and trifluoromethyl add their electronegative negatives, changing the electron cloud distribution of the benzene ring, which has a deep impact on the reaction activity. It can meet with alkali and change with nucleophiles. Its unique nature is widely used in organic synthesis.
    Technical Specifications & Labeling
    Today there is a product called "Benzene, 1- (Chloromethyl) -4-Fluoro-2- (Trifluoromethyl) -". In my pursuit of chemical research, the technical specifications and identification (commodity parameters) of this substance are crucial.
    To clarify its technical specifications, it is necessary to carefully observe various reaction conditions, such as temperature, pressure, and the exact proportion of reagents used. When preparing, the precision of the instrument cannot be ignored, which is related to the purity and yield of the product.
    When it comes to the identification (commodity parameters), it is necessary to clarify its physical properties, such as color, odor, and melting point. Chemical properties also need to be remembered in detail, such as which substances are prone to react with, and what is the stability. The two, technical specifications and identification (commodity parameters), complement each other, and are key elements for our generation to explore and use this object.
    Preparation Method
    To prepare 1 - (chloromethyl) - 4 - fluoro - 2 - (trifluoromethyl) benzene, the method is as follows:
    Prepare raw materials, select fluorobenzene and trifluoromethyl substitution reagents, and set the reactor according to the appropriate ratio. The temperature is controlled in a certain interval, and a catalyst is added to promote the reaction of the two to obtain the intermediate containing the target substance. This is the first step of the reaction.
    times, the intermediate is mixed with the chloromethylation reagent, and the reaction conditions are adjusted. After the chloromethylation step, the crude product of 1 - (chloromethyl) - 4 - fluoro - 2 - (trifluoromethyl) benzene is obtained. After
    , the crude product is separated and purified to remove impurities and obtain The whole process requires precise temperature control and time control, and the conditions are adjusted according to the reaction characteristics to ensure high efficiency and high yield. In this way, the desired product can be obtained.
    Chemical Reactions & Modifications
    A chemist often studies the change of substances. In today's words, "Benzene, 1- (Chloromethyl) -4-Fluoro-2- (Trifluoromethyl) -" This substance. The beauty of its chemical reaction is related to the change of substances and the change of properties.
    In the past, the study of the chemical reaction of this substance often encountered problems. The rate of reaction is slow, and the yield has not reached a good state. However, the researchers did not give up, and they tried their best.
    In the method of catalysis, they tried new agents repeatedly. After many trials, a method of catalysis was obtained, which can increase the rate of chemical reaction, and the yield is also improved.
    Looking at its properties, at the beginning, the stability of this substance was not good, and it was easy to change in special circumstances. After the reform, the molecular structure was adjusted with new techniques, and the stability was greatly increased.
    This is the result of the unremitting efforts of those who transform it. In the future, the research on this object will be deeper, so as to promote its wide use in various domains and benefit the world.
    Synonyms & Product Names
    The "Compendium of Materia Medica" contains 1,892 kinds of medicines. However, there are many things in the world and many categories, and there are still many that have not been fully recorded. Today there is a chemical substance called "Benzene, 1- (Chloromethyl) -4-Fluoro-2- (Trifluoromethyl) -". Its alias and trade name are also relevant to academic and practical use.
    This substance, in the field of chemical research, is aliased or derived from its structural properties to accurately describe its chemical composition. The trade name is determined, or both practical and market, and strives to be concise and easy to remember and highlight its characteristics. The alias aims to accurately convey its essence during academic communication, while the trade name focuses on commercial promotion, making it easy for relevant practitioners and users to recognize and remember.
    Although the ancient Materia Medica failed to cover this matter, today's chemical research should carry on the spirit of exploration of predecessors, and study its aliases and trade names in detail, in order to facilitate academic dissemination and industrial application, and to lay the foundation for future chemical research and industrial development, so that future generations can better understand the principles of chemistry and make good use of them.
    Safety & Operational Standards
    "1 - (chloromethyl) - 4 - fluoro - 2 - (trifluoromethyl) benzene" product safety and operating instructions
    "1 - (chloromethyl) - 4 - fluoro - 2 - (trifluoromethyl) benzene" is an important substance in chemical research. During its research and operation, safety regulations must not be ignored.
    Anyone who comes into contact with this object should be given the first protection. The operator should wear special protective clothing, which must be able to prevent its penetration and prevent the skin from coming into contact with it. The hand must wear chemically resistant gloves, which are tough to prevent accidental splashing. The surface should also be covered with a protective mask. It is essential to protect the eyes from volatile gas or droplets.
    As for the operation site, it must be well ventilated. Set up a strong ventilation device to keep the indoor air fresh and avoid the accumulation of its volatiles. If you operate in a closed space, the risk will increase sharply, so the ventilation should not be slack. And the operation table should be flat and clean, easy to clean, if there is a splash, it can be removed quickly.
    Furthermore, when storing, there are also regulations. It should be placed in a cool, dry and ventilated place, away from fire and heat sources. It must be placed separately from oxidizers, alkalis and other substances. Because of its active chemical properties, mixing may cause violent reactions, leading to safety risks. The reservoir must be well sealed to prevent it from leaking.
    When taking it, the action should be stable and accurate. Use special utensils, according to the method of accurate measurement, do not take more or use less. After measuring, the utensils will be clean, free from residual contamination. If accidentally splashed on the skin, rinse quickly with a lot of water, and then seek medical treatment. If sprinkled on the countertop or ground, immediately collect it with a suitable adsorbent, dispose of it properly, and do not let it flow.
    In short, in the research operation of "1 - (chloromethyl) - 4 - fluoro - 2 - (trifluoromethyl) benzene", following this safety and operation specification can ensure the smooth research, personnel safety, and safety from unexpected changes.
    Application Area
    Today, there is a chemical called "Benzene, 1- (Chloromethyl) -4-Fluoro-2- (Trifluoromethyl) -", the application field of this chemical is quite important. In various applications, one is in the field of pharmaceutical creation. With its unique structure, it can be used as a key intermediate for the synthesis of specific drugs. Through delicate chemical synthesis steps, it can be integrated into the molecular structure of drugs, which may endow drugs with novel pharmacological activities to deal with specific diseases. Second, in the field of materials science, it can participate in the preparation of special materials. Through chemical reactions, its properties can be introduced into materials, which may improve the stability and weather resistance of materials, so that materials can also play a good role in special environments. All of these demonstrate the value of this compound in the application field.
    Research & Development
    Recently, in my research, I focused on the compound "Benzene, 1- (Chloromethyl) -4-Fluoro-2- (Trifluoromethyl) -". After repeated research, the molecular structure of the compound was observed in detail, and it seemed that the subtleties were explored, and the mystery of its characteristics gradually became clear.
    Looking at its structure, the position of fluorine and trifluoromethyl affects the distribution of its electron cloud, making it have unique chemical activity. The existence of chloromethyl adds variables to the reaction. I tried various experimental methods to explore its reaction path.
    The process of experiment is difficult. The control of reaction conditions, such as temperature and solvent selection, all need to be fine. A little carelessness, the result is wrong. However, through unremitting trial and error, there have been gains. This compound can react smoothly with nucleophiles in specific bases and solvents to form new derivatives.
    Looking to the future, I hope to expand research based on this achievement. Or develop efficient synthesis methods to reduce its preparation costs; or research its application in new drug creation and materials science, hoping to make breakthroughs, adding bricks and mortar to the field of chemistry, promoting the transformation of this compound from research to use, and blooming.
    Toxicity Research
    Today, there is a substance called "Benzene, 1- (Chloromethyl) -4-Fluoro-2- (Trifluoromethyl) -". For us chemical researchers, the study of its toxicity is crucial. In the past, the nature of many poisons, when not carefully observed, caused frequent disasters. This substance should not be underestimated.
    View its structure, the genera of chloromethyl, fluorine and trifluoromethyl, or affect its toxicity. To understand its toxicity, we should use scientific methods and rigorous states. Or take animals and apply this substance to observe its physiological changes; or study its response to cells to explore the root cause of toxicity.
    The study of toxicity is not achieved overnight, and it must be done cautiously over time. Only in this way can we know its poison, avoid harm for the world, and protect the well-being of all beings. This is the important task of our chemical researchers.
    Future Prospects
    I have dedicated myself to studying chemistry and recently focused on a compound called "Benzene, 1- (Chloromethyl) -4-Fluoro-2- (Trifluoromethyl) -". This substance has unique properties and holds broad future development prospects.
    Looking at its structure, the ingenious combination of chloromethyl, fluorine and trifluoromethyl gives it a different chemical activity. In the chemical industry, it may be used as an efficient catalyst to significantly increase the reaction rate, reduce costs and increase efficiency. In materials science, it is expected to use its characteristics to improve material properties and develop new materials with more tolerance and stability, which can be used in key fields such as aerospace and electronic equipment.
    Although the current research on it is still in its infancy, I firmly believe that with time and in-depth exploration, this compound will be able to shine, contribute to future scientific and technological progress and social development, and achieve a gorgeous turn from laboratory to practical application, opening up a new world.
    Where to Buy Benzene, 1-(Chloromethyl)-4-Fluoro-2-(Trifluoromethyl)- in China?
    As a trusted Benzene, 1-(Chloromethyl)-4-Fluoro-2-(Trifluoromethyl)- manufacturer, we deliver: Factory-Direct Value: Competitive pricing with no middleman markups, tailored for bulk orders and project-scale requirements. Technical Excellence: Precision-engineered solutions backed by R&D expertise, from formulation to end-to-end delivery. Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
    Frequently Asked Questions

    As a leading Benzene, 1-(Chloromethyl)-4-Fluoro-2-(Trifluoromethyl)- supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

    What is the main use of this product 1- (chloromethyl) -4-fluoro-2- (trifluoromethyl) benzene?
    The main user of this medicine (1- (methoxy) -4-ene-2- (trimethylsilyl) benzene) lies in the field of organic synthesis, and its work is quite significant. It is often used as a key reagent or intermediate in various chemical reactions.
    In the vast world of organic synthesis, this medicine has a unique structure, which allows it to participate in a variety of reaction pathways. The existence of methoxy and trimethylsilyl groups endows the molecule with specific electron cloud distribution and steric resistance characteristics. The methoxy group has the effect of an electron conductor, which can increase the density of the electron cloud of the benzene ring. In the electrophilic substitution reaction, it can guide the selection of the check point of the reaction and make the reaction more selective. Trimethylsilyl group, on the other hand, can form protection for specific functional groups in the reaction due to its large steric resistance, or affect the stereochemical process of the reaction.
    In the reaction of carbon-carbon bond construction, this drug can be combined with other halogenated compounds or alkenyl compounds through coupling reactions and other paths, so as to realize the extension of the carbon chain and the construction of the molecular skeleton. For example, in palladium-catalyzed cross-coupling reactions, it can be used as a nucleophilic reagent to react with suitable electrophilic reagents to generate complex aromatic compounds, which is of great significance in the fields of drug synthesis and materials science.
    In some reactions involving functional group conversion, this drug can first remove or convert the silicon group through the reactivity of the silicon group, and then realize the precise modification of other parts of the molecule. Or in some redox reaction systems, due to its unique electronic structure, it can participate in the electron transfer process and promote the reaction, providing the possibility for the synthesis of novel organic compounds. In conclusion, this (1- (methoxy) -4-ene-2- (trimethylsilyl) benzene) in the field of organic synthesis, with its unique structure and reactivity, provides an important means and way for the creation of various complex organic molecules.
    What are the physical properties of 1- (chloromethyl) -4-fluoro-2- (trifluoromethyl) benzene?
    1-% (cyanomethyl) -4-cyanomethyl-2- (tricyanomethyl) benzene is a kind of organic compound. Its physical properties are quite unique.
    Looking at its appearance, under room temperature and pressure, it is mostly in a solid state, with a crystalline texture and a certain regular geometric shape. This is due to the orderly arrangement of molecules.
    When it comes to color, it is often white or almost white, especially when the purity is quite high, just like the first snow in winter, it is white and flawless. This color characteristic may be related to the distribution and transition characteristics of electron clouds in its molecular structure.
    Smell, this substance usually has no significant odor. Due to the weak volatility of functional groups in the molecule, it cannot produce obvious odor molecules to stimulate the olfactory nerve.
    In terms of solubility, this compound has different solubility in common organic solvents. In polar organic solvents, such as dimethyl sulfoxide, N, N-dimethylformamide, it has a certain solubility. Due to the principle of polar similarity and miscibility, the polar cyanyl group in the molecule and the polar solvent can form intermolecular forces, such as hydrogen bonds, dipole-dipole interactions, etc., to promote its dissolution. However, in non-polar organic solvents, such as n-hexane and benzene, the solubility is very small, and the intermolecular force between the non-polar solvent and the polar compound is weak, making it difficult to overcome the intermolecular force of the solute to dissolve.
    Furthermore, its melting point and boiling point are also important physical properties. The melting point is relatively high, due to the strong interaction force between molecules, such as the dipole-dipole interaction between cyanide groups, the molecule needs higher energy to overcome this force to melt. Similarly, a higher boiling point means that more energy is required to break free from the constraints of the liquid surface and vaporize the molecule.
    In summary, the physical properties of 1-% (cyanomethyl) -4-cyano-2- (tricyanomethyl) benzene are determined by its molecular structure, and these properties play a key role in applications in organic synthesis, materials science, and other fields.
    What are the chemical properties of 1- (chloromethyl) -4-fluoro-2- (trifluoromethyl) benzene?
    1 - (cyanomethyl) - 4 - cyanomethyl - 2 - (tricyanomethyl) benzene is a highly toxic compound with extremely reactive chemical properties. In this compound, the presence of cyanyl (-CN) gives it unique chemical properties.
    In the cyanyl group, the carbon atom and the nitrogen atom are connected by a triple bond, which has strong electron-withdrawing properties. In the structure of 1 - (cyanomethyl) - 4 - cyano- 2 - (tricyanomethyl) benzene, multiple cyanyl groups interact with each other, causing significant changes in the electron cloud distribution of the molecule as a whole.
    From the perspective of reactivity, due to the strong electron-absorbing effect of cyanyl groups, the electron cloud density on the benzene ring decreases, making the benzene ring more susceptible to attack by electrophilic reagents. At the same time, the α-hydrogen in cyanomethyl and tricyanomethyl groups is affected by cyanyl groups and has a certain acidity. Under appropriate alkaline conditions, it is prone to deprotonation, which in turn triggers a series of nucleophilic substitution or addition reactions.
    Furthermore, the cyanyl group in this compound can participate in a variety of classic organic reactions, such as hydrolysis reactions to generate carboxylic acids or amides, and reduction reactions can be converted into amine groups. However, due to its severe toxicity, it is necessary to take extremely strict safety measures when conducting related reaction research and operations to prevent poisoning accidents. Although its active chemical properties offer potential applications for organic synthesis, they also place high demands on its treatment and use.
    What are the production methods of 1- (chloromethyl) -4-fluoro-2- (trifluoromethyl) benzene?
    To prepare 1 - (methoxy) - 4 - bromo - 2 - (trifluoromethoxy) benzene, the following methods can be used:
    One is the nucleophilic substitution method of halogenated aromatics. Select suitable halogenated aromatics, such as benzene derivatives containing suitable halogen atoms (such as chlorine, bromine, etc.), and the location of the halogen atoms must meet the structural requirements of the target. Using bases as acid binding agents, such as potassium carbonate, sodium carbonate, etc., in polar aprotic solvents, such as N, N - dimethylformamide (DMF), dimethylsulfoxide (DMSO), react with methoxylating agents (such as sodium methoxide, potassium methanol) to introduce methoxy groups. After that, it is brominated in a suitable solvent (such as dichloromethane) by a suitable brominating reagent, such as liquid bromine under the action of a catalyst (such as iron powder, iron tribromide), and bromine atoms are introduced at a specific position. Finally, it is reacted with a trifluoromethoxylation reagent (such as potassium trifluoromethanol, etc.) in the presence of a similar polar aprotic solvent and an acid binding agent to introduce a trifluoromethoxy group to obtain the target product.
    The second is the diazosalt method. First, an amino-containing benzene derivative is prepared. After the diazotization reaction, it reacts with sodium nitrite to form a diazosalt at a low temperature and in a strong acid (such as hydrochloric acid, sulfuric acid) environment. The diazosalt is active and reacts with a methoxylating reagent to After that, bromine atoms and trifluoromethoxy groups are gradually introduced to obtain 1- (methoxy) -4-bromo-2- (trifluoromethoxy) benzene as described above in the bromination and trifluoromethoxylation steps of the halogenated aromatic hydrocarbon nucleophilic substitution method.
    The third is the Grignard reagent method. A suitable halogenated benzene derivative is prepared to prepare Grignard reagent. In anhydrous ether or tetrahydrofuran and other solvents, Grignard reagent is reacted with magnesium to obtain Grignard reagent. The Grignard reagent reacts with the methoxylation reagent to introduce methoxy groups. Subsequent by a similar method, bromine atoms and trifluoromethoxy groups are
    All methods have their own advantages and disadvantages. The raw materials for the nucleophilic substitution method of halogenated aromatics are common and easy to obtain, but some reaction conditions are harsh, requiring an anhydrous environment and high temperature; the diazonium salt method has many steps, and the stability of the diazonium salt is not good, so the operation needs to be cautious; the Grignard reagent method has high requirements on the reaction conditions and needs to be strictly anhydrous and anoxic, so that the carbon-heterogeneous bond can be effectively constructed. In actual preparation, the best method should be selected according to the comprehensive consideration of raw material availability, cost, reaction conditions and yield.
    What are the precautions for using 1- (chloromethyl) -4-fluoro-2- (trifluoromethyl) benzene?
    During the use of 1-% (cyanomethyl) -4-cyano-2- (tricyanomethyl) benzene, the following things should be paid attention to:
    First, this material has high chemical activity. When storing and using it, it must be kept dry and protected from moisture. Because it is easy to react with water, or cause deterioration, which will affect the use effect, or even cause danger. Do not expose the material to humid air, and the humidity of the storage environment should be strictly controlled within a specific range.
    Second, its toxicity should not be underestimated. When operating, you must strictly wear professional protective equipment, such as gas masks, protective gloves, protective glasses, etc., to prevent skin contact and inhalation. In case of inadvertent contact, it should be immediately rinsed with a large amount of water and quickly seek medical treatment. Operate in a well-ventilated environment, it is best to equip a fume hood to discharge volatile gases in time and reduce the concentration of harmful substances in the air.
    Third, in view of its special chemical properties, it is necessary to know the compatibility of the two accurately before mixing or reacting with other chemicals. Mix or cause uncontrollable chemical reactions at will, such as violent exothermic, toxic gases, etc. Before use, the relevant chemical data and reaction mechanism should be carefully checked, and the reaction process and conditions should be carefully planned.
    Fourth, the process of taking and transferring should be extra careful to prevent material leakage. In the event of leakage, emergency measures should be initiated quickly, isolate the leakage area, and evacuate unrelated personnel. According to the amount of leakage and site conditions, select suitable adsorption materials for collection and treatment to avoid pollution to the environment.
    Fifth, after use, properly store the remaining materials. Follow the specified storage conditions, seal and store in a specific container, and clearly mark the name, date and other key information for subsequent management and traceability.