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Benzene, 1-(Chloromethyl)-3-(Trifluoromethoxy)-

Benzene, 1-(Chloromethyl)-3-(Trifluoromethoxy)-

Hongda Chemical

    Specifications

    HS Code

    107683

    Chemical Formula C8H6ClF3O
    Molar Mass 210.58 g/mol
    Appearance likely a colorless liquid
    Boiling Point data may vary, needs experimental determination
    Melting Point data may vary, needs experimental determination
    Density data may vary, needs experimental determination
    Solubility In Water low solubility, as it is an organic compound with non - polar groups
    Solubility In Organic Solvents soluble in common organic solvents like ethanol, dichloromethane
    Vapor Pressure data may vary, needs experimental determination
    Flash Point data may vary, needs experimental determination
    Stability stable under normal conditions, but may react with strong oxidizing agents

    As an accredited Benzene, 1-(Chloromethyl)-3-(Trifluoromethoxy)- factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing 500g of 1-(chloromethyl)-3-(trifluoromethoxy) benzene in sealed chemical - grade bottles.
    Storage Store “Benzene, 1-(chloromethyl)-3-(trifluoromethoxy)-” in a cool, well - ventilated area away from heat, sparks, and open flames. Keep it in a tightly closed container, preferably made of a material compatible with its chemical properties, such as glass or certain plastics. Avoid storing near oxidizing agents to prevent potential chemical reactions.
    Shipping Shipment of "Benzene, 1-(chloromethyl)-3-(trifluoromethoxy)-" must follow strict chemical shipping regulations. It should be properly packaged in corrosion - resistant containers, labeled clearly, and transported by carriers licensed for hazardous chemicals.
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    Benzene, 1-(Chloromethyl)-3-(Trifluoromethoxy)- Benzene, 1-(Chloromethyl)-3-(Trifluoromethoxy)-
    General Information
    Historical Development
    The historical evolution of 1- (chloromethyl) -3- (trifluoromethoxy) benzene
    Guanfu 1- (chloromethyl) -3- (trifluoromethoxy) benzene, its development in the field of chemistry is a drop in the long river of scientific evolution. In the past, chemical scholars explored the way of organic synthesis and worked tirelessly.
    At the beginning, the theory of organic chemistry was still simple, and the means of synthesis were limited. However, chemists were eager to learn, and they kept trying new paths. After countless experiments, the understanding of benzene ring derivatives gradually deepened.
    In modern times, science and technology have flourished, analytical instruments have been refined, and synthesis technology has been revolutionized. Researchers can more accurately analyze molecular structures and optimize reaction conditions. For the synthesis of 1- (chloromethyl) -3- (trifluoromethoxy) benzene, it has been repeatedly reviewed and improved, from raw material screening to reaction path, all of which are in good condition.
    This compound has gradually emerged from obscurity in the world, emerging in the fields of medicine, materials, etc. Its historical evolution is a vivid portrayal of the development of chemistry, and it also paves the way for future scientific research.
    Product Overview
    Today there is a substance called 1- (chloromethyl) -3- (trifluoromethoxy) benzene. Its shape is also, with the cyclic structure of benzene, with chloromethyl on one side, and trifluoromethoxy on the opposite side. This is a key intermediate in organic synthesis and plays a pivotal role in the field of medicine and pesticide creation. It is active, because chloromethyl can cause nucleophilic substitution, and trifluoromethoxy adds electronic effects to change its reactivity and physicochemical properties. The synthesis method is often based on specific halogenated benzene, which is obtained by halomethylation, etherification, etc. During operation, conditions must be strictly controlled to ensure yield and purity. This product has broad prospects and unlimited potential for the development of new special drugs and high-efficiency pesticides. It is a hotspot in chemical research and urgently needs our generation to study it in depth and explore its more functions to benefit the world.
    Physical & Chemical Properties
    Recently, a substance was studied, named "Benzene, 1- (Chloromethyl) -3- (Trifluoromethoxy) -". The physical and chemical properties of this substance are particularly important and are related to many research directions. Its physical properties, looking at its form, are either solid or liquid, and its color, luster and odor also need to be carefully observed, which is related to its external characterization. The chemical properties, its reactivity with others, and changes under different conditions are all key. The structure of its chloromethyl and trifluoromethoxy gives it unique properties. It may react with nucleophiles, or exhibit different chemical behaviors at specific temperatures and pressures. A detailed study of the physical and chemical properties of this substance can lay the foundation for subsequent research and applications to clarify its potential and value in various fields.
    Technical Specifications & Labeling
    Today there is a thing called "1- (chloromethyl) -3- (trifluoromethoxy) benzene". To clarify its technical specifications and identification (commodity parameters), it is necessary to study it in detail.
    In terms of technical specifications, it is necessary to check the method of synthesis. The raw materials are selected and processed, and the ratio must be accurate. The temperature, pressure and time of the reaction are all fixed. The operation is in sequence and must not be disordered.
    In terms of identification (commodity parameters), the appearance color, purity geometry, and impurity content must be clear. This is related to its quality and is crucial to the user.
    Therefore, if you want to make and use this product, you must study the technical specifications and labels (commodity parameters) carefully, so that you can get the best product and make the best use of it.
    Preparation Method
    To prepare 1 - (chloromethyl) - 3 - (trifluoromethoxy) benzene, there are three methods, and the raw materials and process are the main ones.
    First, find a suitable starting material, through subtle chemical changes. Select the compound containing the corresponding group, according to the organic reaction law, under the appropriate conditions, the chemical bond is broken and recombined. For example, starting with an aromatic hydrocarbon, chloromethyl and trifluoromethoxy are gradually introduced through a series of steps such as halogenation and etherification.
    Second, the reaction steps must be planned in detail. Chloromethyl is introduced by halogenation, and the reaction temperature, time and reagent ratio are controlled to make the reaction proceed in the desired direction; then trifluoromethoxy is introduced with suitable reagents and conditions, and the purity and yield of the product must be ensured in each step.
    Third, the key to the catalytic mechanism. Select a high-efficiency catalyst, such as a specific metal catalyst or an acid-base catalyst, to accelerate the reaction process, reduce the activation energy of the reaction, and at the same time improve the reaction selectivity, so that the side reactions are minimized, so that 1- (chloromethyl) -3- (trifluoromethoxy) benzene can be efficiently prepared.
    Chemical Reactions & Modifications
    The name of the chemical substance in this study is "Benzene, 1- (Chloromethyl) -3- (Trifluoromethoxy) -". Its chemical reaction and modification are quite heavy.
    Looking at past experiments, there are many things to be investigated about this compound. The corresponding conditions, such as temperature, pressure, catalysis, etc., are all related to the rate of reaction and the purity of the product. Or new catalytic methods can be found to make the reaction easier and the rate is higher.
    As for modification, different groups can be added. With its structure, it can either increase its stability, or change its solubility, or change its chemistry, so that it is suitable for more needs. If it can be improved in chemical processing and modification, this compound may have a wider range of uses and can be used in various fields.
    Synonyms & Product Names
    Today there is a product called 1- (chloromethyl) -3- (trifluoromethoxy) benzene. The alias and trade name of this product are also investigated by us. Although their names are different, they actually refer to the same thing.
    1- (chloromethyl) -3- (trifluoromethoxy) benzene has unique chemical characteristics. It is used in various fields of chemical industry and has a wide range of uses. It can be used as a raw material to help synthesize other products; or it has different effects and is used in specific processes.
    Explore its aliases and trade names, and it is of great significance in the industry to communicate and trade. Only by clarifying different terms can we accurately connect needs and communicate smoothly. In the process of scientific research, it also helps scholars to gather information and deepen their understanding of the thing. Therefore, we should study the alias and trade name of this thing in detail to understand its full picture in the chemical world.
    Safety & Operational Standards
    About 1- (chloromethyl) -3- (trifluoromethoxy) benzene product safety and operating specifications
    Fu 1- (chloromethyl) -3- (trifluoromethoxy) benzene is an important substance in chemical research. Its experimental operation and research process, safety regulations, cannot be ignored.
    First words storage. This substance should be placed in a cool, dry and well ventilated place, away from fire and heat sources. Because of its hot topic, it may be at risk of decomposition, and the decomposition products may be toxic, endangering people and the environment. Therefore, it must be placed separately from oxidizing agents, strong bases and other substances to prevent violent chemical reactions and accidental changes.
    When operating, the experimenter must wear professional protective equipment, such as protective clothing, protective gloves and goggles. Cover this substance is irritating to the skin, eyes and respiratory tract, and if you are not careful, it will hurt the body. The operation room also needs to have good ventilation equipment, or a local exhaust device, so that the concentration of this substance in the air can be reduced to a safe range, so as not to inhale too much and damage health.
    If a leak unfortunately occurs, take emergency measures immediately. Evacuate the surrounding personnel first, isolate the leakage area, and strictly prohibit unrelated people from approaching. Emergency responders need special protective equipment to avoid direct contact with the leak. Small leaks can be absorbed by inert materials such as sand and vermiculite, and put in an airtight container and disposed of according to regulations. If there is a large amount of leakage, it is necessary to build a dike or dig a pit to contain it, transfer it to a special collector with an explosion-proof pump, and then dispose of it properly.
    Furthermore, the experimental operation should follow the established procedures. Do not change the reaction conditions, material ratio, etc. without authorization. In the reaction process, closely observe the reaction phenomenon. If there is any abnormality, stop the operation quickly to find the cause to prevent the accident from expanding.
    In short, the research of 1- (chloromethyl) -3- (trifluoromethoxy) benzene is the first priority. Only by strictly observing the operating specifications can the experiment be smooth, the safety of personnel and the harm of the environment be protected.
    Application Area
    Today there is a product called 1- (chloromethyl) -3- (trifluoromethoxy) benzene. This compound has its uses in many fields.
    In the field of medicine, it can be used as a key intermediate to help create new drugs, or it has a unique effect on the treatment of specific diseases, adding a sharp tool for doctors to treat diseases.
    In the material industry, it can also develop its capabilities. It can be integrated into new materials through specific processes, giving materials such as better stability, unique chemical resistance and other characteristics, and improving material quality to meet diverse needs.
    In the field of fine chemicals, with its special structure, it participates in the synthesis of a variety of fine chemicals, adding luster to the chemical industry and promoting innovation and development in the chemical field. Its wide range of uses is an important object of chemical research.
    Research & Development
    In recent years, those who have studied chemical substances have paid much attention to "Benzene, 1- (Chloromethyl) -3- (Trifluoromethoxy) -". Its structure is specific and its properties are also interesting. We have tried our best to explore its synthesis method and strive to improve.
    At the beginning, the synthesis road was full of thorns, and the yield was quite low. However, we did not dare to slack off, and we repeatedly considered and improved the steps. After many attempts, we finally got the best method, and the yield gradually increased.
    This product is widely used in industry and scientific research. In industry, it can be used as a raw material to make many important products; in scientific research, it is the key to exploring the reaction mechanism. We will continue to study it, hoping to expand its application, promote the development of the field of chemistry, and benefit future generations.
    Toxicity Research
    One of the benzene under investigation today, named 1- (chloromethyl) -3- (trifluoromethoxy) benzene, needs to be investigated in detail because of its toxicity. The chemical substance has unpredictable toxicity, and this product may be involved in poison. During the experiment, we should carefully observe its properties and analyze the principle of its interaction with the biological body from the microscopic structure. Observe the state of its molecules, and guess the changes in the human viscera and meridians. Although technology is gradually advancing today, the detection of poisons still needs to be cautious. Observe its volatilization and dissolution, and explore the path of entry into the body, either by breathing or through the skin. Only by understanding its poisonous style can we prevent it from developing, protect the well-being of the public, and pave the way for safety for those who use this product in the future.
    Future Prospects
    I have tried to research the technology of chemical industry, and I have put a lot of effort into new compounds. Today, I am talking about 1- (chloromethyl) -3- (trifluoromethoxy) benzene. Looking at its structure, chloromethyl and trifluoromethoxy are cleverly connected to the benzene ring, which is really unique.
    This compound has an extraordinary future prospect. It is used in materials science, or can be used to make materials with special properties to increase its stability and weather resistance. In the field of medicine, it also has potential for great use, or is the key to creating new drugs to treat intractable diseases. Although the current research is not perfect, with time and careful study, we will be able to explore its endless potential, seek the well-being of the world, and shine brightly in the chemical industry, leading a new path for future development.
    Where to Buy Benzene, 1-(Chloromethyl)-3-(Trifluoromethoxy)- in China?
    As a trusted Benzene, 1-(Chloromethyl)-3-(Trifluoromethoxy)- manufacturer, we deliver: Factory-Direct Value: Competitive pricing with no middleman markups, tailored for bulk orders and project-scale requirements. Technical Excellence: Precision-engineered solutions backed by R&D expertise, from formulation to end-to-end delivery. Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
    Frequently Asked Questions

    As a leading Benzene, 1-(Chloromethyl)-3-(Trifluoromethoxy)- supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

    What is the main use of this product 1- (chloromethyl) -3- (trifluoromethoxy) benzene?
    The main use of this item (1- (methoxy) -3- (triethoxy) silicon is in many fields.
    In the construction field, it can be used as a waterproof agent. This is because it can react with the components of the surface of the building material to form a tight and hydrophobic protective film. In this way, it can greatly improve the waterproof performance of building materials, effectively block the intrusion of external moisture such as rainwater, thereby prolonging the service life of the building. For example, when applied to external walls, it can make it difficult for rainwater to adhere and penetrate, keeping the wall dry.
    In the paint industry, it is an excellent additive. After addition, it can significantly enhance the adhesion between the paint and the base material. The principle is that the special structure of the substance can form chemical bonds with the groups on the surface of the coating and the substrate, allowing the coating to adhere more firmly. In addition, it can also improve the weather resistance of the coating, so that it can maintain its original performance for a longer time under different climatic conditions, delay the aging rate, and keep the coating beautiful and protective for a long time.
    In the electronics industry, its use is also crucial. It can be used as a packaging material for electronic components. With its good chemical stability and insulating properties, it can provide reliable protection for electronic components, avoid the erosion of the components by the external environment, and ensure the stable operation of electronic equipment. In addition, in the semiconductor manufacturing process, it can also play a role in improving the performance and reliability of semiconductor devices.
    In the textile industry, it can perform functional finishing on fabrics. After being treated, the fabric can obtain various functions such as waterproof, oil-proof, anti-fouling, etc. This is because it can form a special microstructure on the fabric surface, changing the wettability of the fabric surface, thereby giving the fabric new characteristics and enhancing the quality and added value of the textile.
    What are the physical properties of 1- (chloromethyl) -3- (trifluoromethoxy) benzene?
    (1) The properties of this substance are related to its structure. (1- (methoxy) -3- (trifluoromethoxy) benzene is formed by connecting a phenyl group to a specific group. Phenyl has a stable planar structure, which imparts a certain rigidity to the molecule. The connection of methoxy and trifluoromethoxy to the benzene ring has a great impact on its physical properties.
    (2) The characteristic of its melting point. Due to the existence of methoxy and trifluoromethoxy groups, the intermolecular forces are different. The oxygen atom in the methoxy group has a lone pair of electrons, which can participate in the weak interaction between molecules; the electronegativity of the fluorine atom in the trifluoromethoxy group is extremely high, which enhances the polarity of the molecule and increases the attractive force between molecules. The synergy between the two causes the melting and boiling point of the substance to be different from that of simple benzene ring compounds. Compared with benzene, the melting and boiling point may appear to be elevated.
    (3) The state of solubility. The molecule of the substance has a certain polarity, and according to the principle of "similar miscibility", it may have good solubility in polar organic solvents, such as ethanol and acetone. However, the non-polar part of the benzene ring has poor solubility in water. Because water is a strong polar solvent, it interacts weakly with the non-polar part of the molecule.
    (4) Volatility. Polar molecules and relative molecular masses affect their volatility. Due to the large force between polarity and molecules, the volatility is lower than that of some simple non-polar benzene derivatives, and it is difficult to volatilize into a gaseous state at room temperature.
    (5) Stability. The benzene ring structure is inherently highly stable. Although the power supply or absorption effect of methoxy and trifluoromethoxy groups adjusts the distribution of benzene ring electron clouds, on the whole, the substance can still maintain considerable stability under general conditions and is not prone to spontaneous decomposition and other reactions.
    What are the chemical properties of 1- (chloromethyl) -3- (trifluoromethoxy) benzene?
    (1) The properties of this substance are related to chemical principles. 1- (cyanomethyl) -3- (trifluoromethoxy) benzene is an organic compound. Its chemical properties are deeply affected by the groups in the molecular structure.
    (di) In cyanomethyl, the cyanyl group has strong electron-absorbing properties. This property changes the distribution of the molecular electron cloud and affects the reactivity. Because cyanyl groups can reduce the density of the electron cloud connected to them through induction effects, the activity of the electrophilic substitution of the benzene ring is weakened. For example, in the common halogenation and nitration reactions, the reaction rate of this compound is slower than that of benzene, and the reaction conditions are more severe.
    (3) Trifluoromethoxy, also a strong electron-withdrawing group. The strong electronegativity of trifluoromethyl reduces the electron cloud density of the oxygen atoms connected to it, which in turn affects the electronic effect of the whole trifluoromethoxy group on the benzene ring. The double electron-withdrawing group acts on the benzene ring, further strengthening the degree of reduction in the electron cloud density of the benzene ring. However, in the nucleophilic substitution reaction, the electron cloud density of the benzene ring is reduced, which is conducive to the attack of nucleophilic reagents, which may promote the progress of such reactions.
    (4) In addition, the compound exhibits unique properties in some reactions due to the presence of special groups. For example, under specific catalytic conditions, the cyano group can undergo hydrolysis reaction and be converted into a carboxyl group to form a carbox The trifluoromethoxy group is relatively stable, but under extreme conditions such as high temperature and strong reducing agent, it may also change, participate in chemical reactions, and derive products with more complex structures.
    The chemical properties of (5) 1- (cyanomethyl) -3- (trifluoromethoxy) benzene are determined by the interaction of groups such as cyanomethyl and trifluoromethoxy in molecules, and under different reaction conditions, it presents a variety of reactivity and reaction pathways.
    What are the processes for producing 1- (chloromethyl) -3- (trifluoromethoxy) benzene?
    The process of preparing 1- (chloromethyl) -3- (trifluoromethoxy) benzene involves many delicate steps.
    The first is the selection and pretreatment of starting materials. Benzene derivatives with specific functional groups are often started, and they are purified and refined to remove impurities to achieve the required purity of the reaction. For example, fractionation, recrystallization and other methods are used to make the raw materials pure and lay a good foundation for subsequent reactions.
    Halogenation reaction is crucial. In a suitable reaction vessel, add the starting benzene derivative, and under the action of catalysts such as iron or aluminum catalysts, add an appropriate amount of halogenating agent, such as chloromethane, to control the reaction temperature and pressure, so that the halogenation reaction precisely occurs at a specific position of the benzene ring to form an intermediate containing chloromethyl. This step requires precise control of the reaction conditions to obtain a higher yield and selectivity. The methoxylation step is also indispensable. Transfer the halogenated intermediate to the new reaction system, add methoxylation reagents such as trifluoromethanols, and in an organic solvent, under the catalysis of bases, promote the substitution reaction of halogen atoms and methoxy groups to form a 3- (trifluoromethoxy) structure. At this time, the polarity of the solvent, the strength and dosage of the base all have a profound impact on the reaction process and need to be carefully regulated.
    During the reaction process, monitoring methods are quite important. With analytical techniques such as thin-layer chromatography and gas chromatography, the reaction progress can be tracked in real time to determine whether the reaction is completed or whether the intermediate is formed, so as to adjust the reaction parameters in time.
    After the reaction is completed, the separation and purification of the product is the key link. First, the reagents and by-products remaining in the reaction system are removed by preliminary treatment such as extraction and washing, and then the products are further purified by column chromatography and vacuum distillation to obtain high-purity 1- (chloromethyl) -3- (trifluoromethoxy) benzene.
    These various process steps are interconnected, and each step requires the attention and precise control of the craftsman, so that the product can be presented with the ideal yield and purity.
    What are the precautions for using 1- (chloromethyl) -3- (trifluoromethoxy) benzene?
    1 - (cyanomethyl) -3 - (trifluoromethoxy) benzene should be paid attention to the following numbers during use:
    First, this product has certain toxicity. Cyanomethyl contains cyanide groups and is highly toxic. It can be life-threatening if it touches the human body or is accidentally inhaled or ingested. When using, be sure to strictly follow safety procedures, wear complete protective equipment, such as gas masks, protective gloves, protective clothing, etc., and operate in a well-ventilated place, preferably in an environment with a fume hood to prevent the accumulation of toxic gases.
    Second, pay attention to its chemical properties. Trifluoromethoxy is an electron-withdrawing group, which will affect the distribution of electron clouds in the benzene ring, causing its chemical activity to be different from that of ordinary benzene derivatives. When participating in chemical reactions, it is necessary to precisely control the reaction conditions, such as temperature, pH, reaction time, etc. Due to differences in activity, the reaction rate and product selectivity may be different from expectations. It is necessary to carry out small tests in advance to explore suitable conditions to avoid the situation that the reaction is out of control or the product is impure.
    Third, pay attention to storage requirements. It should be stored in a cool, dry and ventilated place, away from fire and heat sources. Because it contains special groups, or is sensitive to environmental conditions, it may decompose or deteriorate in case of moisture, high temperature, etc. And it needs to be stored separately from oxidants, acids, bases, etc., to avoid dangerous reactions caused by mixed storage.
    Fourth, the operating specifications should not be ignored. The process of taking and handling should be handled with care to prevent leakage due to damaged packaging. In the event of a leak, an emergency plan should be activated immediately, evacuate personnel, seal the scene, and strictly prohibit irrelevant personnel from approaching. In the case of a small amount of leakage, it can be absorbed by inert materials such as sand and vermiculite; in the case of a large amount of leakage, it is necessary to build a dike or dig a pit for containment, transfer it to a special container with an explosion-proof pump, and then properly dispose of it.
    When using 1- (cyanomethyl) -3- (trifluoromethoxy) benzene, safety must be given top priority, a comprehensive understanding of its characteristics, and strict operation should be strictly standardized to ensure the safety of the use process.