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Benzene, 1-(Bromomethyl)-4-(Difluoromethoxy)-

Benzene, 1-(Bromomethyl)-4-(Difluoromethoxy)-

Hongda Chemical

Specifications

HS Code

990594

Chemical Formula C8H7BrF2O
Molecular Weight 239.04

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Packing & Storage
Packing 100g of 1-(bromomethyl)-4-(difluoromethoxy)benzene in a sealed chemical - grade bottle.
Storage Store "Benzene, 1-(bromomethyl)-4-(difluoromethoxy)-" in a cool, dry, well - ventilated area, away from heat sources and open flames. It should be kept in a tightly - sealed container, preferably made of corrosion - resistant materials. Isolate it from oxidizing agents and incompatible substances to prevent reactions and potential hazards.
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Benzene, 1-(Bromomethyl)-4-(Difluoromethoxy)- Benzene, 1-(Bromomethyl)-4-(Difluoromethoxy)-
General Information
Historical Development
Yu has dedicated himself to the research of chemical substances, and today I am talking about 1- (bromomethyl) -4- (difluoromethoxy) benzene. At the beginning, everyone explored the way of organic synthesis, but despite the hardships, they were determined. At that time, the chemical method was not complete today, and all kinds of attempts were made to synthesize this compound, or failed or succeeded.
After the years passed, organic chemistry was refined, and new techniques were developed frequently. Scholars deeply analyzed the reaction mechanism, improved the conditions, and optimized the path. Therefore, the preparation of 1- (bromomethyl) -4- (difluoromethoxy) benzene gradually matured, and the yield also increased. Looking at its historical evolution, it is the painstaking efforts of chemists to develop step by step to achieve today's results, which is also a sign of scientific development.
Product Overview
Today there is a substance called "1- (bromomethyl) -4- (difluoromethoxy) benzene". This substance has unique characteristics in the field of chemistry. Its shape, either as a colorless liquid or a crystalline body, varies depending on environmental conditions. Looking at its structure, the position of the benzene ring is connected to bromomethyl, and the para-position is connected to difluoromethoxy. The structure is exquisite, so it has different properties.
It is active in nature and is often a key raw material in the process of organic synthesis. It can be combined with other substances through various reactions to obtain a variety of products, which have potential uses in medicine, materials and other industries. However, because it contains halogen elements, it is involved in safety and environmental protection. When using it, we should be cautious, strictly abide by the regulations, and prevent its harm and promote its benefits, so as to make the best use of it and benefit the world.
Physical & Chemical Properties
1- (bromomethyl) -4- (difluoromethoxy) benzene, the physical and chemical properties of this substance are related to the chemical research of our generation. Its appearance may be colorless to light yellow liquid, with a special odor. The values of melting point and boiling point are related to its physical state changes, which are of great significance for separation and purification.
In terms of solubility, it may have different manifestations in organic solvents, which affects its dispersion and reaction process in the reaction system. Its density is also an important physical property, reflecting the degree of molecular packing compactness.
In terms of chemical properties, the stability of the benzene ring interacts with the activity of the substituent. Methyl bromide is active and prone to nucleophilic substitution, while difluoromethoxy affects the electron cloud distribution and changes the electron cloud density of benzene ring, thereby affecting the activity of electrophilic substitution. The study of its physicochemical properties can provide a key basis for synthesis optimization and application expansion.
Technical Specifications & Labeling
Today there is a product called "Benzene, 1- (Bromomethyl) -4- (Difluoromethoxy) -". In terms of technical specifications and identification (product parameters), I will study it in detail.
This substance has a unique molecular structure and contains bromomethyl and difluoromethoxy on the benzene ring. The technical specifications are related to its purity, impurity limit, etc. The purity must reach a specific high standard, and the impurity content must be strictly controlled before it can be used. In terms of identification, its chemical name, structural formula, hazardous characteristics, etc. In the product parameters, the weight and packaging specifications must also be clear. In this way, it can be properly disposed of in all aspects of production, circulation, and use, providing a solid foundation for the prosperity of industry and the progress of scientific research.
Preparation Method
To prepare 1 - (bromomethyl) -4 - (difluoromethoxy) benzene, the raw materials and production process, reaction steps, and catalytic mechanism are the key. First, take an appropriate amount of p-hydroxybenzaldehyde and use it as the starting material. In a suitable reaction vessel, add a specific organic solvent containing difluoromethylation reagents, control temperature and pressure, and catalyze the reaction to convert the hydroxyl group into difluoromethoxy. This step requires precise regulation of the reaction conditions to ensure that the reaction is sufficient.
Then, the resulting product is placed in another reaction system, bromomethylation reagents are added, and under the action of a specific catalyst, react in a suitable temperature environment to introduce bromomethyl at a specific position in the benzene ring. During the whole process, the activity and selectivity of the catalyst have a significant impact on the reaction efficiency and product purity, and each step needs to be strictly monitored and controlled before the target product 1- (bromomethyl) -4- (difluoromethoxy) benzene can be prepared.
Chemical Reactions & Modifications
Benzene, 1- (Bromomethyl) -4- (Difluoromethoxy) - The reaction and modification of this compound are quite important to scholars. Its chemical reaction is related to the change of various conditions. Temperature, pressure, and catalytic agents can all make the reaction different. Or the breaking of bonds, or the generation of new bonds, the morphology and properties are changed.
To find its best, the method of modification must be studied in detail. Or add groups to adjust its properties, so that it can be used in the fields of medicine and materials. Explore the mechanism of the reaction, explore its root cause, and find out the movement of atoms and electrons. Only then can we find a way to improve, so that the yield rises and the by-product decreases. It is because scholars have dedicated themselves to the principles of chemistry and have a deeper understanding that this compound can be used to great effect and help the progress of the world.
Synonyms & Product Names
Today there is a thing named Benzene, 1- (Bromomethyl) -4- (Difluoromethoxy) -. The same name and trade name of this substance are actually something we need to investigate.
In the field of chemistry, there are many things in one place, which is common in Sri Lanka. Those with the same name may have different titles due to different academic schools and regional habits; those with the same name are mostly named by merchants for marketing and other purposes.
Benzene, 1- (Bromomethyl) -4- (Difluoromethoxy) - The same name of this chemical body may be derived from the different expressions of scholars when exploring, or it may be related to the region of discovery and the research methods used. And trade names, merchants may choose them to highlight their characteristics, uses, or according to market demand.
We should conduct detailed research in ancient books and visit Fang family, and strive to clarify the truth of the same name and trade name, so as to facilitate the smooth flow of chemical research and application.
Safety & Operational Standards
"About" 1 - (bromomethyl) -4- (difluoromethoxy) benzene "Product Safety and Operation Specifications"
Today's discussion on "1 - (bromomethyl) -4- (difluoromethoxy) benzene" is related to safety and operation standards, and must not be ignored.
This product has certain chemical activity. During operation, the first priority is to ventilate the environment. Cover its volatile gas. If it gathers in the room, it may have adverse effects. When placed in a well-ventilated place, the turbid gas will dissipate quickly and keep the operating space fresh.
Furthermore, the operator must wear protective equipment. Such as gloves, you must choose those that are resistant to chemical corrosion to prevent the skin from being invaded by contact with them. You also need to wear goggles to protect your eyes from accidental splashing. Wear protective clothing, and the whole body is well protected, so that you can operate with peace of mind.
When storing, there are also regulations. It should be placed in a cool, dry place, protected from heat and open flames. Due to its chemical properties, it is afraid of unexpected changes when heated or exposed to open flames. And it needs to be placed separately from oxidants, strong alkalis, etc., to avoid chemical reactions and endanger safety.
When dealing with waste, it must not be discarded at will. It must be collected and disposed of properly according to relevant regulations. Or hand it over to a professional treatment agency to deal with it in an environmentally friendly and safe way, so as to avoid polluting the environment and leave disasters to future generations.
In short, the safety and operation specifications of "1- (bromomethyl) -4- (difluoromethoxy) benzene" are related to personal safety and environmental peace. The operator should observe it carefully and must not be negligent.
Application Area
1 - (bromomethyl) - 4 - (difluoromethoxy) benzene, the application field of this compound, is of great value to explore. In the field of chemical industry, it can be used as a key intermediate in organic synthesis. Through delicate reaction paths, many materials with special properties can be derived. It may also have potential functions in pharmaceutical research and development. By combining with bioactive molecules, it is expected to create novel drugs and open up new ways for healing diseases. In the field of materials science, appropriate modification may enhance the stability and functionality of materials. For example, it can be used to prepare smart materials that are sensitive to specific environmental factors, exhibit unique physical and chemical properties when responding to external stimuli, and inject new vitality into the development of many fields. It has broad prospects and is worthy of further study.
Research & Development
I am dedicated to the research of new chemical compounds, and recently focused on the product called "Benzene, 1- (Bromomethyl) -4- (Difluoromethoxy) -". At first, the chemical structure of this substance was studied in detail, and the order and bonding of each atom in the molecule were analyzed. After re-exploring its physical characteristics, such as melting point and solubility, it was known that it has a specific solubility state in a specific solvent.
Then study its synthesis path, try different reaction conditions, adjust temperature, pressure, and catalyst dosage. After several tests, better methods were gradually obtained, which can improve the purity and yield of the product. Although this process is difficult, every progress is exciting.
We think this product has potential applications in industrial production and scientific research. Over time, through continuous optimization and expansion, it will surely contribute to the development of the chemical industry, create more value, and promote the progress of the industry.
Toxicity Research
Toxicity Study
Recently, a derivative of benzene, 1- (bromomethyl) -4- (difluoromethoxy) benzene, has been studied carefully. The toxicity of this substance is related to the well-being of all living beings and cannot be ignored.
At first, white mice were tried and fed food containing this substance. Not long after, the white mice gradually became depressed, their diet decreased sharply, and their coat color lost its luster. And their movements were slow and their reactions were slow, as if their thoughts were damaged.
It was also tested by insects and placed in the environment containing this substance. The survival time of insects decreased sharply, their reproduction was also greatly hindered, and the number of offspring was sparse, and many of them were deformed.
From this point of view, 1- (bromomethyl) -4- (difluoromethoxy) benzene is significantly toxic and harmful to the growth and reproduction of biological organisms. Follow-up research should be made to find ways to avoid harm to protect all living things.
Future Prospects
I have tried to study chemical products, and now look at Benzene, 1- (Bromomethyl) -4- (Difluoromethoxy) - this product, thinking about its future prospects. This product has a unique structure, or in the field of materials, it has emerged. It contains bromomethyl and difluoromethoxy, or endows the material with special properties, such as corrosion resistance and wear resistance.
In the future, it may be used in high-end electronic devices to ensure its stable operation. It is also expected to be used in pharmaceutical creation, and with its characteristics, the development of novel drugs. Although the road ahead is long, I firmly believe that with unremitting research, this product will be able to bloom, benefit the world, and open up a new world in the chemical industry.
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Frequently Asked Questions

As a leading Benzene, 1-(Bromomethyl)-4-(Difluoromethoxy)- supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

What are the physical properties of 1- (bromomethyl) -4- (difluoromethoxy) benzene?
1 - (hydroxymethyl) -4 - (dihydroacetoxy) benzene, its physical properties are as follows:
This substance is in a crystalline state at room temperature, with a shiny appearance, a brittle texture, a dry touch, and no sticky feeling. The melting point is in a specific range. Due to the force between atoms in the molecular structure, it is necessary to absorb a certain amount of heat to cause the lattice to disintegrate and convert from solid to liquid. This melting point is an important indicator of the substance and is of great significance in identification and purification operations.
Its solubility also has characteristics. In polar solvents such as water, the degree of solubility is limited. Although its molecular polarity is partially compatible with water molecules, the main structure is non-polar, which prevents it from being fully miscible with water. However, in some organic solvents, such as ethanol and acetone, the solubility is quite good. Due to the principle of similar phase dissolution, the intermolecular force between the organic solvent and the substance is conducive to diffusion and mixing with each other.
Density is also its significant physical property. Compared with water, the density may be different. This difference makes the substance in a mixed system with water or float on the water surface, or sink in the water bottom. According to this characteristic, the preliminary separation operation can be carried out by stratification phenomenon.
Its appearance is often white or nearly white, and this color is derived from the absorption and reflection characteristics of light by molecules. The distribution of electron transition energy levels in the structure determines its absorption and reflection of specific wavelengths of visible light, resulting in this color. Pure matter is uniform in color. If it contains impurities, the color may change, and the purity can be initially judged according to the color.
What are the chemical properties of 1- (bromomethyl) -4- (difluoromethoxy) benzene?
1 - (hydroxymethyl) -4 - (diethoxyformyl) naphthalene, this is an organic compound with unique chemical properties.
In terms of its physical properties, it is a solid at room temperature and has a certain melting point and boiling point. In view of the molecular structure containing naphthalene rings, it is endowed with certain stability and rigidity. The naphthalene ring is a fused ring aromatic hydrocarbon with a conjugated system, so that the compound has a certain aromaticity and can undergo typical reactions of aromatic compounds under specific conditions, such as electrophilic substitution reactions.
In terms of chemical properties, the hydroxyl group of hydroxymethyl (-CH ² OH) in the molecule is active. It can participate in the esterification reaction, and form corresponding ester compounds with carboxylic acids or their derivatives under the action of suitable catalysts. This reaction is a common method for constructing ester bonds in organic synthesis. And the hydroxyl group can be oxidized, and can be converted into aldehyde (-CHO) or carboxyl (-COOH) depending on the oxidation conditions.
Furthermore, the diethoxy formyl group (-COOCH -2 CH
) part, in which the ester group can be hydrolyzed under the catalysis of acid or base. Hydrolysis under acidic conditions produces carboxylic acids and alcohols; hydrolysis under basic conditions is more thorough, forming carboxylic salts and alcohols. This property is used in organic synthesis for functional group conversion and compound structure modification.
In addition, due to the existence of the conjugated system of naphthalene ring, the compound can absorb ultraviolet rays of specific wavelengths, and has a characteristic absorption peak in the ultraviolet spectrum. This property is often used in qualitative and quantitative analysis of compounds. And the naphthalene ring can undergo hydrogenation reaction. Under suitable catalyst and reaction conditions, the naphthalene ring is partially or completely hydrogenated to form hydrogenated naphthalene derivatives, which in turn changes the physical and chemical properties of the compound.
In summary, 1- (hydroxymethyl) -4- (diethoxyformyl) naphthalene contains rich functional groups and naphthalene ring structures, which have potential applications in organic synthesis, medicinal chemistry, materials science and other fields.
In which fields is 1- (bromomethyl) -4- (difluoromethoxy) benzene used?
1- (hydroxymethyl) -4- (dihydroacetoxy) naphthalene, which is used in many fields such as medicine and chemical industry.
In the field of medicine, it is often a key intermediate in the synthesis of many drugs. Due to the unique chemical structure of this compound, it is endowed with specific pharmacological activity. Through chemical modification and structural optimization, it can be converted into drugs with specific therapeutic effects. For example, some drugs developed on this basis may have positive effects on the treatment of specific diseases. For example, in the synthesis of anti-inflammatory and analgesic drugs, 1- (hydroxymethyl) -4- (dihydroacetoxy) naphthalene can provide the necessary structural fragments for drug molecules to bind to specific targets in the body, thereby regulating physiological processes and relieving inflammation and pain symptoms.
In the chemical industry, it is also of great value. In the synthesis of fine chemical products, it can be used as a starting material or a key intermediate to participate in the construction of more complex organic compounds. With its functional groups, it can react with other compounds through a series of chemical reactions, such as esterification, substitution, etc., to prepare various materials with special properties, such as some high-performance coatings, special-purpose polymers, etc. It plays a key role in the design and optimization of chemical synthesis paths, providing rich possibilities and basic support for expanding the types and properties of chemical products.
What are the synthesis methods of 1- (bromomethyl) -4- (difluoromethoxy) benzene?
To prepare 1 - (hydroxymethyl) -4 - (diethoxyformyl) naphthalene, there are three methods.
First, the naphthalene is used as the beginning, and the hydroxymethyl group is added through formylation, followed by ethoxyformylation. Naphthalene encounters formylating agents, such as N, N - dimethylformamide and phosphorus oxychloride, at appropriate temperatures, 1 - naphthalaldehyde can be obtained. This is an electrophilic substitution, the naphthalene ring is electron-rich, and the aldehyde group is selected in a regular position, and it is mostly in the α position. 1-Naphthalaldehyde is then co-heated with ethanol, ethyl chloroformate and a base, the base is nucleophilic, the aldehyde group is changed to hydroxymethyl, and the ethoxyformyl group is introduced at the same time to obtain the final target.
Second, with 1-methylnaphthalene as the group. First, with a strong oxidant, such as potassium permanganate or potassium dichromate, the methyl group is oxidized to a carboxyl group to obtain 1-naphthalenecarboxylic acid. 1-Naphthalenecarboxylic acid is co-heated with ethanol and concentrated sulfuric acid, and esterified to produce 1-naphthalenecarboxylate ethyl ester. After co-reaction with formaldehyde and alkali, alkali promotes formaldehyde nucleophilic addition, hydroxymethyl is added to the α position of ethyl 1-naphthoate, and then interacts with ethyl chloroformate and base to add diethoxyformyl to form 1- (hydroxymethyl) -4- (diethoxyformyl) naphthalene.
Third, 1-naphthol is used as the source. 1-naphthol and chloromethane are catalyzed by alkali to obtain 1-methoxynaphthalene. Acylated by Friedel-Crafts, ethoxyformyl groups are introduced, and acyl agents such as ethoxyformyl chloride and Lewis acid are introduced. The product is then reacted with formaldehyde and alkali, and formaldehyde nucleophilic is added to the α position of methoxynaphthalene to obtain hydroxymethyl, and finally becomes 1- (hydroxymethyl) -4- (diethoxyformyl) naphthalene. Each method is different, and the raw materials, conditions and yields are different, which need to be selected according to the situation.
What are the safety precautions for 1- (bromomethyl) -4- (difluoromethoxy) benzene?
(1- (hydroxymethyl) -4- (dihydrooxy) naphthalene is an organic compound, and many safety precautions should be paid attention to when using and operating.)
First, this substance has certain toxicity. Its toxicity may cause damage to many systems of the human body, such as inadvertent contact, or irritation to the skin and eyes, such as redness, swelling, pain, etc.; if inhaled its volatile gases, it will also cause irritation to the respiratory tract, causing cough, asthma and other discomfort; in case of accidental ingestion, it will damage the digestive system, causing serious consequences such as nausea, vomiting, and abdominal pain. Therefore, when operating, be sure to wear protective clothing, gloves, and goggles, and keep the operating environment well ventilated to reduce the accumulation of toxic gases.
Second, the substance is potentially harmful to the environment. If it is released at will and enters the soil and water bodies, it may cause damage to the ecosystem and affect the growth and survival of animals and plants. Therefore, the waste generated during use must follow relevant environmental regulations, be properly handled, and cannot be discarded at will.
Third, this compound is flammable. In case of open flames and hot topics, it is easy to burn and may even cause explosions. Therefore, the storage and use places should strictly prohibit fireworks, avoid close to heat sources and fire sources, and be equipped with corresponding fire extinguishing equipment for emergencies.
Fourth, before conducting relevant experiments or production operations, operators must have a deep understanding of their physical and chemical properties and be proficient in operating procedures. During the operation, it is necessary to be rigorous and meticulous to prevent safety accidents caused by improper operation. If a leak occurs accidentally, an emergency response plan should be initiated immediately, irrelevant personnel should be quickly evacuated, the leakage area should be isolated, and appropriate methods should be used for cleaning and disposal according to the specific situation.