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Benzene, 1-Bromo-3-Fluoro-2-Nitro-

Benzene, 1-Bromo-3-Fluoro-2-Nitro-

Hongda Chemical

Specifications

HS Code

836572

Chemical Formula C6H3BrFNO2
Molar Mass 236.00 g/mol
Appearance Solid (usually)
Solubility In Water Low (organic compound, relatively non - polar)
Solubility In Organic Solvents Soluble in common organic solvents like dichloromethane, chloroform
Odor Typical aromatic odor (but may be modified by substituents)
Hazard Class Harmful (toxicity and flammability may vary based on handling and quantity)

As an accredited Benzene, 1-Bromo-3-Fluoro-2-Nitro- factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

Packing & Storage
Packing 100g of 1 - bromo - 3 - fluoro - 2 - nitro - benzene in a sealed, chemical - resistant bottle.
Storage Store "1 - bromo - 3 - fluoro - 2 - nitrobenzene" in a cool, dry, well - ventilated area away from heat sources and ignition sources. Keep it in a tightly - sealed container, preferably made of corrosion - resistant materials. Separate it from oxidizing agents, reducing agents, and reactive chemicals to prevent potential reactions. Label the storage clearly for easy identification and safety.
Shipping 1 - bromo - 3 - fluoro - 2 - nitro - benzene, a hazardous chemical, is shipped in specialized, tightly - sealed containers. These are safeguarded in compliance with regulations, ensuring secure transport to prevent spills and environmental or safety risks.
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Benzene, 1-Bromo-3-Fluoro-2-Nitro- Benzene, 1-Bromo-3-Fluoro-2-Nitro-
General Information
Historical Development
The Chinese name of "Benzene, 1 - Bromo - 3 - Fluoro - 2 - Nitro -" is 1 - Bromo - 3 - Fluoro - 2 - Nitrobenzene. The following is presented in classical Chinese:
The first rise of chemistry in the past, the secrets of the substances studied by the sages. 1 - Bromo - 3 - Fluoro - 2 - Nitrobenzene is gradually entering the eyes of researchers. At the beginning, it was limited to the technique, and it was difficult to obtain this product. Researchers think hard and test.
After years, the technique has improved slightly. The public has thought a lot about the conditions of the reaction and the allocation of raw materials. Either adjust the temperature, or change the reagent, hoping to increase its yield and improve its purity. Therefore, the production of this product has gradually followed.
Years have passed, and science and technology have changed. The refinement of the instrument and the goodness of the theory, the research assistants have deepened the research of 1-bromo-3-fluoro-2-nitrobenzene. Today, it is also available in the fields of medicine and materials. The difficulties of the past have been turned into the benefits of the present, which can be said to be one of the evidence of chemical development.
Product Overview
The name of 1-bromo-3-fluoro-2-nitrobenzene is 1-bromo-3-fluoro-2-nitrobenzene. It is special, and the benzene group, bromine, fluorine, and nitro groups each occupy a specific position. Benzene is an important parent nucleus in chemical chemistry, which is fixed and has special properties. The bromine atom gives the properties of this substance, which can be reacted like nuclear substitution. The fluorine atom is reactive because of its reactive properties and the reactive properties of molecules. The nitro group absorbs the reactive group, which changes the density of the benzene sub-cloud, and the left and right reactive.
This substance has a value in the field of synthesis. It can be used in the synthesis, and it can be used to modify the molecules. Through ingenious and inverse methods, using the activity of each group, it can be synthesized for many compounds. Its physical properties are also worth noting. The characteristics of melting and boiling are important for molecular interaction, and operations such as separation and improvement are of great importance. Studying this substance is of great significance in deepening the knowledge of chemistry and expanding the synthesis method.
Physical & Chemical Properties
1-Bromo-3-fluoro-2-nitrobenzene, the physical and chemical properties of this compound are related to the research of our chemical researchers. Its properties are either solid or liquid, colorless or slightly halo. Melting point and boiling point are its key physical properties. The melting point is related to the temperature of its physical state transition; the boiling point is related to the difficulty of its gasification.
The solubility is also not negligible. The dissolution in water and organic solvents affects its mass transfer and reaction between different media. Its chemical activity, due to the substitution of bromine, fluorine and nitro, causes the electron cloud density of the benzene ring to change, and the electrophilic substitution reaction activity may change. The presence of nitro groups may endow them with oxidation-related properties, and halogen atoms will also affect many of their reaction pathways. This is the main point for exploring the physicochemical properties of 1-bromo-3-fluoro-2-nitrobenzene.
Technical Specifications & Labeling
Benzene, 1 - Bromo - 3 - Fluoro - 2 - Nitro - This compound, in order to clarify its technical specifications and identification (product parameters), it is necessary to investigate in detail. Its structure is unique, and bromine, fluorine, and nitro are all specific to the benzene ring. The technical specifications are related to the synthesis method, and must follow precise steps to control the reaction conditions, such as temperature, pressure, catalyst, etc., to obtain pure products. In terms of identification, product parameters need to be specified, such as purity geometry, impurity content, physical and chemical properties, melting point, boiling point, solubility, etc. The technical specifications and labeling of this compound are the foundation for its application in the chemical industry, and it is crucial to the success or failure of experiments and the production of good defects. Therefore, it must be treated with rigor to ensure accuracy and meet the needs of scientific research and production.
Preparation Method
To prepare 1-bromo-3-fluoro-2-nitrobenzene, first take an appropriate amount of benzene as raw material. Using iron bromide as a catalyst, benzene and bromine undergoes a substitution reaction under heating conditions to generate bromobenzene. The method is: put benzene and liquid bromine in a flask, add a little iron bromide, and it is slightly hot, with reddish-brown gas escaping. This is the image of the reaction.
Next, concentrated sulfuric acid and concentrated nitric acid are co-heated to obtain a mixed acid. At a specific temperature, bromobenzene and mixed acid are nitrified to obtain o-nitrobromobenzene. During operation, precise temperature control is required to prevent side reactions from occurring. After
, potassium fluoride is used as the fluorine source. In a suitable solvent and under the action of a catalyst, o-nitrobromobenzene reacts with potassium fluoride. After multi-step conversion, 1-bromo-3-fluoro-2-nitrobenzene is finally obtained. Each step of the reaction needs to pay attention to the reaction conditions, including temperature, pressure, catalyst dosage, etc., and fine operation can obtain the ideal yield.
Chemical Reactions & Modifications
Nowadays, there are chemical substances, named 1-bromo-3-fluoro-2-nitrobenzene. In the study of chemical modification of benzene, it is meaningful.
This compound, bromine, fluorine, and nitro are attached to benzene. Its chemical reaction may be due to the properties of the substituent. The prime properties of bromine can lead to nuclear substitution; the nitro group has absorptive properties, which affect the benzene sub-cloud separation, so that the anti-activity of fluorine and the anti-position can be changed. The special properties of fluorine also shape the molecular anti-activity.
In terms of modification, its properties can be improved by means of chemical modification. Or the substituent can be modified, or the benzene can be modified to achieve new functions. Exploring the chemical and reverse modification of this compound is beneficial to the fields of chemical materials and chemical research, and can lead to the development of new materials and the improvement of properties.
Synonyms & Product Names
1-Bromo-3-fluoro-2-nitrobenzene, in the field of chemistry, has many other names, that is, synonymous names and commercial names. In the industry, it is said to be a variant of special halogenated nitrobenzene, due to the substitution of bromine, fluorine and nitro at specific positions in the benzene ring, resulting in its unique physical and chemical properties.
Looking at the structure of this compound, on the benzene ring, bromine, fluorine and nitro are in their respective positions and interact with each other, making the reactivity very different from ordinary benzene derivatives. Its synonymous name is either derived from the naming from different angles of structure analysis, or to follow specific chemical rules and habits. The trade name is often chosen by merchants based on factors such as marketing and application scenarios, in order to highlight its use or characteristics in specific fields.
This compound is used in the field of organic synthesis or as a key intermediate. With its unique structure, it can introduce various functional groups to build complex organic molecules, and then provide assistance for cutting-edge fields such as drug development and materials science.
Safety & Operational Standards
1-Bromo-3-fluoro-2-nitrobenzene safety and operating specifications
Fu 1-bromo-3-fluoro-2-nitrobenzene is an important material in chemical research. In its experimental operation and research process, safety and operating standards are of paramount importance.
In terms of safety, this compound is dangerous to a certain extent. The bromine element is active, and the bromine atom is attached to the benzene ring, making it irritating. The strong electronegativity of the fluorine atom, coupled with the presence of nitro groups, makes the compound active, or potentially toxic and corrosive. Therefore, when coming into contact with this object, complete protective equipment, such as protective clothing, gloves and goggles, must be worn to prevent it from coming into contact with the skin and eyes. If it is inadvertently contacted, rinse with plenty of water as soon as possible and seek medical attention according to the specific situation.
In terms of operating specifications, the experimental environment should be well ventilated to disperse volatile gaseous substances and avoid danger from accumulation in the air. When taking 1-bromo-3-fluoro-2-nitrobenzene, use an accurate measuring tool and carefully measure the amount required for the experiment. Do not overdo it to avoid waste and danger. And the operation process should be smooth on the table to prevent the container from dumping and causing it to leak. If a leak occurs, deal with it immediately according to the emergency plan, such as collecting with suitable adsorption materials, and then dispose of it properly.
Furthermore, store 1-bromo-3-fluoro-2-nitrobenzene in a cool, dry and ventilated place, away from fire sources and oxidants. Store it in a sealed container to prevent it from volatilizing and reacting with external substances.
In summary, in the research and use of 1-bromo-3-fluoro-2-nitrobenzene, strict safety and operating practices can ensure the safety of experimental personnel and allow the research to proceed smoothly.
Application Area
In the genus of benzene, there is a thing called 1-bromo-3-fluoro-2-nitrobenzene, which is quite wonderful in various application fields. In the field of medicine, it can be used as the basis for synthesizing good medicines. Because of its unique structure, it can be in harmony with many biomolecules, helping to form new drugs with significant drug effects, treating diseases and relieving people's suffering.
In the place where materials are made, this substance also does something. It can participate in the synthesis of special materials and increase the characteristics of materials, such as toughness and stability, so that the materials can be used in various working conditions, or used in equipment, or used in buildings, all have good effects.
On the road of scientific research and exploration, 1-bromo-3-fluoro-2-nitrobenzene is an important test drug. Scientists use it to study the reaction mechanism, develop new knowledge of chemistry, and contribute to the advancement of academia and science and technology.
Research & Development
In recent years, I have continued to explore chemical substances. Today's focus is on "Benzene, 1 - Bromo - 3 - Fluoro - 2 - Nitro -" this compound. Its unique structure, bromine, fluorine, nitro and benzene ring are connected, and the bonding between atoms is wonderful, which affects its physical and chemical properties.
The preparation method or multi-step reaction requires precise design of the organic synthesis path. The choice of raw materials, the control of reaction conditions, such as temperature and catalyst, are all related to the yield and purity of the product. At the time of experiment, subtle differences may lead to very different results.
Looking forward to its development, it may have potential in the fields of medicine and materials. It can be used as an intermediate to derive new drugs and find new ways to treat diseases; it can be used in materials or endow materials with specific properties. We should continue to study it to understand more mysteries, promote its wide application, and contribute to the progress of chemistry and the prosperity of society.
Toxicity Research
The nature of taste and smell is related to human feelings, and the study of poisons cannot be ignored. Today there is Benzene, 1 - Bromo - 3 - Fluoro - 2 - Nitro - this substance, and the study of its toxicity is particularly important.
Fu Benzene, 1 - Bromo - 3 - Fluoro - 2 - Nitro -, chemical substances are also. Its molecular structure is unique, and bromine, fluorine, and nitro are connected to the benzene ring, which makes it special. After various experiments, it can be known that its toxicity exists. If it enters the body, it may damage the viscera, disrupt the circulation of qi and blood, and harm the nervous system. In the environment, it can also sewage the soil, dye the air, and harm the living.
As a doctor, you should know the harm of this thing, and in case of poisoning, you can quickly apply rescue and treatment methods. As a researcher, it is advisable to study its nature in detail, explore ways to detoxify it, and prevent it from harming you. Everyone should also be careful, avoid touching this thing, and protect themselves and the environment. This is the essence of toxicity research.
Future Prospects
In today's world, science and technology are changing day by day, and the field of chemistry is also a new machine. I focus on the research of 1-bromo-3-fluoro-2-nitrobenzene. This compound, seemingly ordinary, actually contains infinite future prospects.
Looking at its structure, the combination of bromine, fluorine, nitro and benzene rings is unique. With today's technology, although the synthesis method has made progress, there are still improvements. I hope that in the future, the synthesis process can be simpler, more efficient, with sharp reduction in energy consumption and cost, so that it can be mass-produced and widely used in various fields.
In the field of medicine, it may become a key intermediate for new drugs, helping to overcome difficult diseases; in the field of materials, it is expected to give birth to new materials with unique properties, such as those with excellent photoelectric properties, which will contribute to the electronics industry. I firmly believe that with time and in-depth research, 1-bromo-3-fluoro-2-nitrobenzene will shine, making extraordinary contributions to human well-being and leading us to a brighter future.
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Frequently Asked Questions

As a leading Benzene, 1-Bromo-3-Fluoro-2-Nitro- supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

What is the main use of this compound 1-bromo-3-fluoro-2-nitrobenzene?
This compound, called 1-bromo-3-ene-2-carbonyl indole, has a wide range of main uses. In the field of pharmaceutical research and development, this compound is often used as a key intermediate due to its unique structure. Medical craftsmen use it to make a variety of specific drugs, such as anti-cancer drugs for specific diseases. Its structural properties can precisely act on specific targets of cancer cells, inhibit their proliferation, or induce their apoptosis, adding a powerful weapon to overcome cancer diseases.
In the field of organic synthesis, 1-bromo-3-ene-2-carbonyl indole is also an indispensable raw material. Organic synthesizers rely on their rich reactivity and ingenious reaction paths to construct complex and diverse organic molecular structures. Through various chemical reactions, such as nucleophilic substitution, addition reactions, etc., they can be converted into derivatives with different functions, greatly expanding the variety of organic compounds and paving the way for the research and development of new materials.
In the field of materials science, this compound has also emerged. Because of its special electronic properties and structure, it can be used to prepare materials with special optoelectronic properties. With appropriate modification and processing, materials that can respond uniquely to light and electrical stimulation may have extraordinary applications in optoelectronic devices, such as Light Emitting Diodes, sensors, etc., injecting vitality into the innovation and development of materials science.
What are the physical properties of 1-bromo-3-fluoro-2-nitrobenzene
Mercury, bromine, gallium, and cesium each have specific physical properties.
Mercury, at room temperature, is a liquid metal, shining with silver. Its density is quite high, about thirteen times that of water. The fluidity is very good, if the pearl jade rolls off, it will spread out in all directions. Thermal conductivity is also good. However, the melting point of mercury is extremely low, only -38.87 ° C, and it is easy to solidify in case of cold. Its boiling point is 356.6 ° C, and it is easy to vaporize into mercury vapor when heated. This vapor is highly toxic and should be careful.
Bromine is the only non-metal that is liquid at room temperature and pressure. Its color is red-brown, and it has a strong pungent smell, which is unbearable. Bromine has a higher density than water, can dissolve in water, form bromine water, and is also easily soluble in organic solvents. Its volatility is very strong, and in the air, reddish-brown bromine vapor can often be seen rising on the liquid surface of bromine.
Gallium has a very low melting point, only 29.78 ° C. When placed in the palm of your hand, body temperature can melt it into a liquid state, like magic. However, its boiling point is extremely high, up to 2403 ° C. Gallium is soft and can be easily cut. Although its conductivity is not as good as that of common metals such as copper and silver, it also has its own unique electrical properties and is widely used in the field of electronics.
Cesium is also a metal with a very low melting point, only 28.44 ° C. Soft as wax, the color is silver white and slightly golden. The chemical properties of cesium are extremely active, and it reacts violently when exposed to water. It explodes instantly and shines brightly, generating cesium hydroxide and hydrogen. This reaction releases a lot of heat and is powerful. It has important applications in optoelectronic devices, atomic clocks, etc., and has made great contributions to the development of science and technology.
What are the chemical properties of 1-bromo-3-fluoro-2-nitrobenzene
Mercury, bromine, gallium, and thallium are all special chemical substances, each with its own unique characteristics.
Mercury, commonly known as mercury, is a liquid metal at room temperature, with a silver-white color and a metallic luster. Its density is quite high, its fluidity is very good, and it has a certain toxicity. In the past, it was often seen in thermometers, sphygmomanometers and other appliances, but its use has been gradually restricted due to its toxicity. Mercury's chemical properties are relatively stable, and it is not easy to react with most substances. However, it can also undergo chemical changes when it encounters strong oxidants.
Bromine, a liquid non-metallic element, is dark reddish-brown in color, has a strong irritating odor, and is highly corrosive. Bromine is widely used in organic synthesis and other fields, and is often used as a brominating agent to participate in many chemical reactions. Its volatility is strong, and it needs to be stored with caution to prevent it from escaping and hurting people.
Gallium, with a very low melting point, slightly higher than room temperature, can be melted into a liquid state in the palm of your hand. Its appearance is like aluminum, and it is soft. Gallium is chemically active and can combine with a variety of non-metallic elements. It has important applications in semiconductor materials and other fields, and is an indispensable material in the modern electronics industry.
Thallium, a heavy metal element, has certain toxicity. Thallium is chemically active and can react with oxygen, water, etc. Thallium and its compounds have been used in rodenticides, etc. However, due to their toxicity, they are extremely harmful to humans and animals. Thallium also has specific uses in electronics, optics and other fields, but special attention should be paid to its toxicity prevention during use.
These four have different chemical properties and are of unique value in industry, scientific research and other fields. However, when using and disposing, it is necessary to be careful to prevent harm to the environment and personal safety.
What are the common methods for synthesizing 1-bromo-3-fluoro-2-nitrobenzene?
The common methods for synthesizing 1-bromo-3-ene-2-carbonyl indoles are as follows:
One is the combination of halogenation and alkenylation. First, the indole derivative is halogenated with a suitable halogenating agent, such as a brominating agent, and bromine atoms are introduced at a specific location. This step requires attention to the control of reaction conditions, such as temperature, solvent selection, etc. Due to improper conditions, excessive halogenation or halogenation position deviation is easily caused. Then, through the alkenylation reaction, a carbon-carbon double bond is formed at a suitable position to form an alkenyl structure. In the alkenylation reaction, the alkenylation reagents and catalysts used have a great influence on the selectivity and yield of the reaction.
The second method is to take the carbonylation reaction as the key step. Select the appropriate starting material, through the carbonylation reaction, cleverly introduce the carbonyl group to form the 2-carbonyl structure. The carbonylation reaction often requires a specific catalyst system, and the requirements for the reaction environment are more stringent, such as pressure, carbon monoxide input, etc. After the carbonylation is completed, subsequent reactions such as bromination and alkenylation are carried out in an orderly manner to achieve the synthesis of the target product.
The third is to use the series reaction of metal catalysis. With the unique activity and selectivity of metal catalysts, multiple reaction steps are carried out in series. In the same reaction system, the structure of 1-bromo-3-ene-2-carbonyl indole is directly constructed by reasonably designing the reaction sequence and conditions, so that the starting material undergoes bromination, alkenylation, carbonylation and other reactions in sequence. The advantage of this method is that it is relatively simple to operate, can reduce the separation and purification steps of intermediate products, and improve the atomic economy of the reaction. However, the performance of metal catalysts is extremely high, and the reaction conditions need to be precisely regulated to ensure the smooth progress of each step of the reaction.
What are the precautions for storing and transporting 1-bromo-3-fluoro-2-nitrobenzene?
The process of storage and transportation of heavy metals such as mercury, lead, and cadmium is related to the safety of people's livelihood and physical properties, and caution must be taken.
Mercury is active, liquid at room temperature, and volatile into mercury vapor, a highly toxic thing. When storing, a sealed container must be used to prevent the escape of mercury. If the container leaks, the mercury seeps into the ground, and it is difficult to remove the adsorption, and it will accumulate for a long time. During transportation, it is crucial to prevent earthquakes and bumps, so as to avoid the leakage of mercury due to the damage of the container. And the escort must be familiar with the danger of mercury and emergency measures. Once there is a leakage, cover it with sulfur powder immediately, and turn mercury into mercury sulfide to reduce its toxic dispersion.
Lead is heavy in weight. Although its chemical properties are relatively stable, it is also resistant to oxidation and corrosion during storage. It should be placed in a dry place to avoid co-storage with acids and alkalis, because it will react with acids and alkalis, cause lead to qualitative change, and or produce harmful substances. When transporting, pack it with a solid material to ensure that it is not damaged, and the label is clear, so that viewers know it is a heavy metal.
Cadmium is highly toxic. It should be carefully selected for storage to prevent leakage. It is difficult to degrade in the environment. If it leaks outside, it will accumulate in water and soil, causing harm to organisms. During transportation, strengthen the packaging to avoid violent vibration and collision, and the transportation route should be planned to avoid densely populated areas and water sources to prevent unexpected danger.
In short, mercury, lead, cadmium and other heavy metals should not be ignored in all aspects of storage and transportation. From container selection, environmental control to transportation protection and emergency preparedness, all must be carried out in accordance with regulations to ensure personnel safety, environmental cleanliness, and avoid the harm of heavy metals in the world.