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What is the main use of this product 1,4-dichloro-2,5-difluorobenzene?
The main use of 1,4-difluoro-2,5-difluorobenzene is particularly important. This compound has applications in various fields.
In the field of medicinal chemistry, it can be a key intermediate. Due to the unique electronic properties of fluorine atoms, the introduction of molecular structures can significantly change the physical, chemical and biological activities of compounds. Based on this, chemists can create drugs with more efficacy, higher selectivity and fewer side effects. For example, in the development of anti-depressant, anti-tumor and other drugs, the molecular framework of 1,4-difluoro-2,5-difluorobenzene may give the drug better pharmacological properties, making it easier to bind to biological targets and precisely exert its efficacy.
In the field of materials science, it also has important functions. Because fluorine-containing structures often have good thermal stability, chemical stability and low surface energy. Polymer materials prepared from this compound can be used as high-performance coatings, special plastics, etc. In the field of coatings, such materials can provide excellent anti-corrosion and wear resistance, and are suitable for harsh environments, such as aerospace, marine facilities, etc. In terms of special plastics, the materials they are made of may have unique electrical and optical properties, which make them useful in the manufacture of electronic devices and optical instruments.
In the field of organic synthetic chemistry, 1,4-difluoro-2,5-difluorobenzene is often an important starting material. Chemists can modify and derive them through various organic reactions, such as nucleophilic substitution, coupling reactions, etc., to construct rich and diverse organic compounds, which contribute to the development of organic synthetic chemistry and help create new functional materials and bioactive molecules.
What are the physical properties of 1,4-dichloro-2,5-difluorobenzene?
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The outer surface of this substance is usually a transparent liquid, with a fragrant smell, which is special. Its melting temperature is low, at -22 ° C. This property makes it capable of holding liquid at low temperatures. And its boiling temperature is at 110 ° C. It will vaporize under this temperature.
1%2C4-%E4%BA%8C%E6%B0%AF-2%2C5-%E4%BA%8C%E6%B0%9F%E8%8B%AF%E7%9A%84%E5%AF%B9%E6%B0%94%E4%BD%93%E5%AF%B9%E6%AF%94%E5%AE%B9%E7%A7%AF%E7%84%A6%E5%BA%A6%E5%8D%8F%E5%90%88%E6%B0%A7%E4%BD%93%E4%B8%8E%E6%B0%B4%E7%9A%84%E6%B0%A7%E4%BD%93%E6%AF%94%E5%AE%B9%E7%A7%AF%E7%84%A6%E5%BA%A6%E7%9A%84%E7%89%B9%E5%BE%81. Its density is water. If mixed with water, it will float on the water surface.
The solubility of this compound is special, and it can be well miscible in common solvents such as ethanol and ether, indicating its solubility. However, the miscibility of water is poor, and it is almost impossible to dissolve in water, and the mixture of the two will quickly divide.
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What are the chemical properties of 1,4-dichloro-2,5-difluorobenzene?
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** 1. Physical properties **
- In appearance, this compound is usually a colorless transparent to slightly yellow oily liquid with a certain volatility. Its boiling point, melting point and other physical constants are different from ordinary aromatics due to the introduction of fluorine and chlorine atoms in the molecular structure. Due to the large electronegativity of fluorine and chlorine atoms, the intermolecular force changes, resulting in a relatively high boiling point, which affects its phase state and volatility at room temperature to a certain extent.
-Solubility, it is soluble in common organic solvents such as toluene, dichloromethane, etc. This is because its molecular structure is similar to that of organic solvents in non-polar parts. According to the principle of similar phase dissolution, it can be miscibly miscible with each other. However, the solubility in water is extremely low, because the overall polarity of the molecule is relatively weak, it is difficult to form an effective interaction with water molecules.
** 2. Chemical properties **
- ** Stability **: The compound has certain chemical stability due to the conjugation system of the benzene ring and the existence of fluorine and chlorine atoms in the molecule. The fluorine and chlorine atoms are connected to the benzene ring and affect the electron cloud density distribution of the benzene ring through induction and conjugation effects. On the one hand, the electron-absorbing induction effect of fluorine and chlorine atoms reduces the electron cloud density of the benzene ring, which is not conducive to the attack of electrophilic reagents; on the other hand, the conjugation effect of them with the benzene ring enhances the overall stability of the molecule, making the compound less prone to reactions such as ring opening and decomposition under general conditions.
- ** Reactive activity **: Although it has certain stability, chemical reactions can still occur under specific conditions. For example, under the catalysis of strong Lewis acids such as aluminum trichloride, the Fu-g reaction can occur. Due to the change of the electron cloud density distribution of the benzene ring, the activity and regioselectivity of the electrophilic substitution reaction are different from that of benzene. The adjacent and para-position electron cloud densities of fluorine and chlorine atoms are relatively high, and electrophilic re In addition, the fluorine and chlorine atoms in the molecule can undergo nucleophilic substitution reaction. In the presence of appropriate nucleophilic reagents such as sodium alcohol and amine, the fluorine and chlorine atoms can be replaced by corresponding groups to form new organic compounds. This reactivity originates from the polarity of the carbon-halogen bond, which makes the halogen atoms vulnerable to attack and leave by nucleophilic reagents.
What is the production method of 1,4-dichloro-2,5-difluorobenzene?
For 1% 2C4-dioxy-2% 2C5-divinylbenzene, the method of preparation is as follows.
Take the appropriate starting material first, usually starting with a compound with a specific functional group. Or choose a group containing an alkenyl group and a group that can be converted into a dioxy structure. One method is to use an alkenyl-containing benzene derivative as a group and react in multiple steps to form it.
The first step, or the modification reaction of an alkenyl group, encounters the alkenyl group with a suitable reagent to introduce a group that can be further reacted, or to adjust the activity of the alkenyl group. This step can be achieved by nucleophilic addition, electrophilic addition and other reactions. For example, the alkenyl group and the halogenated reagent should be combined to obtain the halogenated alkenyl derivative, and the halogen atom can be the active check point of the subsequent reaction.
The second principle is to construct the dioxygen structure. Oxidation reaction is often the most important. Select an appropriate oxidizing agent, such as a peroxide or the like. Under suitable reaction conditions, the benzene derivative containing a specific group is oxidized to form a dioxy bond between the relevant atoms. During the reaction, pay attention to the reaction temperature, reaction time and the ratio of the reactants. If the temperature is too high or side reactions will occur, the purity of the product will be damaged; if the time is too short, the reaction may be incomplete.
In addition, the solvent and catalyst for the reaction are also heavy. Select a suitable solvent, soluble reactants and no adverse effects on the reaction, so that the reaction can proceed smoothly. Catalysts can reduce the activation energy of the reaction and increase the reaction rate. For example, some metal catalysts or organic catalysts may play a key role in the construction of dioxy structures and alkenyl groups.
After the reaction is completed, it needs to be separated and purified. By extraction, distillation, column chromatography, etc., the unreacted raw materials, by-products and impurities are removed to obtain pure 1% 2C4-dioxy-2% 2C5-divinylbenzene products. Each step requires fine operation and attention to details to obtain high-purity and high-yield products.
What is the price range of 1,4-dichloro-2,5-difluorobenzene in the market?
1% 2C4-dioxy-2% 2C5-divinylbenzene is an important organic compound. However, its price range in the market varies due to many factors.
First, the purity of the product is the key. If the purity is extremely high, it is almost flawless, and it can reach the standard of experimental grade, its price will be high. Such high purity products are often used in the fields of scientific research and high-end chemical synthesis, and the price can be tens or even hundreds of yuan per gram.
Second, the market supply and demand trend also affects its price. If demand is surging, but supply is relatively scarce, the price will rise; conversely, if supply exceeds demand, the price will decline.
Third, the cost of production also affects the price. The price of raw materials and the simplicity of the preparation process are all related to the cost. If the raw materials are rare, the preparation requires complicated processes and high-end equipment, and the cost is high, the price is also high.
Generally speaking, the price of industrial grade 1% 2C4-dioxy-2% 2C5-divinylbenzene is about a few hundred yuan per kilogram; while the price of high-purity high-quality products is higher, up to tens of yuan per gram. However, this is only a rough estimate, and the actual price is subject to the actual market conditions in various places at that time. Merchants must carefully observe changes in the market and weigh various factors before they can obtain a reasonable price.