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What are the chemical properties of Benzene-1,3-Diylbis [ (4-Fluorophenyl) Methanone]?
Benzene-1,3-diyl bis [ (4-fluorophenyl) methanone] is one of the organic compounds. Its chemical properties are unique and worthy of detailed investigation.
In this compound, the benzene ring is its core structure, and the 1 and 3 positions above it are respectively connected with the structure of bis [ (4-fluorophenyl) methanone]. The benzene ring has aromatic properties and is relatively stable, which can endow the compound with certain conjugate stability.
In terms of its physical properties, the substance is in a solid state under normal conditions, and the melting boiling point varies depending on the intermolecular forces. The intermolecular force includes van der Waals force, and the introduction of fluorine atoms may enhance the intermolecular force, which in turn affects its melting boiling point.
Chemically, the carbonyl group (the structural part of the ketone) is the active check point. The carbonyl group is polar, and in the carbon-oxygen double bond, the oxygen atom is highly electronegative, resulting in the carbon atom being partially positively charged and vulnerable to attack by nucleophilic reagents. For example, in the case of nucleophilic reagents, such as alcohols, amines, etc., the carbonyl carbon atom may undergo nucleophilic addition reaction.
Furthermore, although the benzene ring is stable, substitution reactions can also occur under specific conditions. Because the fluorine atom is an electron-withdrawing group, the electron cloud density of the benzene ring will decrease, and the electrophilic substitution reaction activity will decrease slightly, and the substitution position may be affected by the joint localization effect of the fluorine atom and the carbonyl group.
And because of its fluorine atom, the special properties of the fluorine atom make the compound have unique biological activities and optical properties. In terms of biological activity, or in the field of medicine, it shows potential value; in terms of optical properties, or due to the existence of the conjugate system of molecular structure, it presents specific fluorescence properties.
What are the main uses of Benzene-1,3-Diylbis [ (4-Fluorophenyl) Methanone]?
Benzene-1,3-diyl bis [ (4-fluorophenyl) methyl ketone], this substance has a wide range of uses. In the field of medicinal chemistry, it is often a key intermediate for the creation of new drugs. Due to its structure containing specific functional groups and aromatic rings, it can precisely interact with targets in organisms, or has the potential to regulate biological activities. It can be used as a starting material for the development of anti-cancer, anti-inflammatory and other drugs. Other groups can be added by organic synthesis to create ideal pharmacological properties.
In the context of materials science, it also has unique functions. Due to its stable molecular structure and fluorine atoms, it can be used to prepare high-performance polymer materials. Introducing it into the main chain or side chain of the polymer can improve the thermal stability, chemical stability and mechanical properties of the material. The prepared materials may be used in high-end fields such as aerospace, electronics and electrical appliances, such as aerospace components, electronic packaging materials, etc., and meet strict requirements with excellent properties.
Furthermore, in the field of organic synthetic chemistry, it is an important building block for building complex organic molecules. Using various organic reactions, such as nucleophilic substitution, addition reactions, etc., to build multivariate structural compounds on it, providing a cornerstone for organic synthetic chemists to explore new reaction paths and create novel compounds, and helping to expand and innovate frontier research in organic chemistry.
What is the synthesis method of Benzene-1,3-Diylbis [ (4-Fluorophenyl) Methanone]
To prepare Benzene-1,3-Diylbis [ (4-Fluorophenyl) Methanone], the following ancient method can be used.
First take an appropriate amount of benzene-1,3-diborate pinacol ester and 4-fluorobenzoyl chloride as starting materials. In a clean reactor, first add an appropriate amount of organic solvent, such as anhydrous dichloromethane, to create a suitable reaction environment. Place the reactor in a low-temperature cooling device and let the temperature drop slowly to about 0 ° C. Slowly pour in 4-fluorobenzoyl chloride and stir well. This is to make the materials initially mixed and make the reaction easy to start.
Next, dissolve benzene-1,3-diborate pinacol ester in an appropriate amount of organic solvent in another container, and then add it dropwise to the reactor. At the same time, add an appropriate amount of palladium catalyst, such as tetra (triphenylphosphine) palladium (0), and an appropriate amount of base, such as potassium carbonate aqueous solution. In this case, the palladium catalyst can promote the reaction, and the base can adjust the pH of the reaction system and assist the reaction to advance smoothly.
Add it up, slowly raise it to room temperature, and continue to stir the reaction. During this period, the reaction process must be closely monitored, which can be monitored by means of thin layer chromatography (TLC). After the reaction is completed, pour the reaction mixture into an appropriate amount of water and extract it with dichloromethane several times. The organic phases are combined, washed with saturated saline water, and dried with anhydrous sodium sulfate.
Finally, the dried organic phase is distilled in a vacuum distillation unit to remove the solvent, followed by column chromatography to purify the obtained crude product. Appropriate eluents are selected, such as the mixture of petroleum ether and ethyl acetate. After this step, pure Benzene-1,3-Diylbis [ (4-Fluorophenyl) Methanone] can be obtained. During the whole process, attention should be paid to the precise dosage of materials and strict control of reaction conditions, so that the ideal product can be obtained.
What is the price range of Benzene-1,3-Diylbis [ (4-Fluorophenyl) Methanone] in the market?
I don't know if "Benzene - 1,3 - Diylbis [ (4 - Fluorophenyl) Methanone]" is in the market price range. This is a more professional chemical substance, and its price is determined by many factors.
First, purity is the key factor. If the purity is extremely high, it is close to scientific research grade, and can be used in high-end experiments or special industrial processes, the price must be high; if the purity is slightly lower, it is suitable for general industrial use, and the price may be slightly lower.
Second, market supply and demand also have an impact. If there are many people who want it, but there are few products, the price will rise; if the supply exceeds the demand, the price may fall.
Third, manufacturers and brands are different, and prices are also different. Well-known large factories, due to their sophisticated production processes and strict quality control, their product prices may be higher; while some small factory products may be relatively close to the people.
Fourth, the amount of purchase is also related to the price. If you buy in bulk, you may get a discount, and the unit price will be reduced; if you only buy in small quantities, the price may be higher.
To know the exact price range, you need to consult chemical product suppliers, distributors, or professional chemical product trading platforms in detail to get accurate prices.
What are the safety and precautions of Benzene-1,3-Diylbis [ (4-Fluorophenyl) Methanone]
The safety and precautions of benzene-1,3-diyl bis [ (4-fluorophenyl) methyl ketone] are related to the safety and operation of the user. This substance needs to be treated with caution in terms of safety. In terms of its chemical properties, the chemically active part of its structure may react with other substances, so when stored, it should be avoided in the same place as easily reactive substances. And its stability varies under different environmental conditions. High temperature, high humidity or strong light may cause its properties to change, so it should be stored in a cool, dry and dark place.
In terms of precautions, the first protection. Those who handle this object should wear suitable protective equipment, such as gloves and goggles, to avoid contact with the skin and eyes. If you accidentally touch it, rinse it with plenty of water as soon as possible and seek medical attention according to the situation. Furthermore, the operation place must be well ventilated to prevent its volatile gas from accumulating in the air and causing potential harm.
In addition, during the experiment or use process, when strictly following the operating procedures, accurately weigh and mix carefully, do not change the established process at will. The disposal of waste should not be ignored, and it must be properly disposed of in accordance with relevant laws and regulations to avoid polluting the environment and endangering all living beings. In this way, the safety of this object must be guaranteed to avoid disasters.