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What is the chemical structure of 7- (3-aminopyrrolidine-1-yl) -1- (2,4-difluorophenyl) -6-fluoro-4-oxo-1,4-dihydro-1,8-naphthidine-3-carboxylic acid 4-methylbenzene sulfonate (1:1)?
I think this is a question about the structure of organic compounds. The chemical structure of 7- (3-amino-1-yl) -1- (2,4-dichlorophenyl) -6-chloro-4-oxo-1,4-dihydro-1,8-naphthidine-3-carboxylic acid + 4-methylbenzenesulfonic anhydride (1:1), and let me explain in detail.
First of all, this compound has a complex structure and is composed of multiple parts. The naphthalidine ring is the core part, and its 1,4-dihydro-1,8-naphthalidine-3-carboxylic acid is connected with an amino-containing substituent at the 3rd position, and the amino group is connected to a specific group, which partially affects the electron cloud distribution and activity of the compound. At the 6th position, there is a chlorine atom substituted, and the chlorine atom has strong electronegativity, which plays an important role in molecular polarity and reactivity. At the 4th position, the oxo group changes the electron cloud density of the naphthalidine ring, which affects the stability and reactivity of the whole system.
Furthermore, 2,4-dichlorophenyl is attached to the first position, and the chlorine atom replaces the phenyl group, which further increases the molecular steric barrier and electronic effect, which affects the physicochemical properties and biological activities of the compound.
And the 7-position is connected to a specific group, which affects the entire molecular shape and charge distribution.
As for 4-methylbenzenesulfonic anhydride (1:1), it binds to the main body part, which may affect the stability and function of the compound through specific interactions, such as hydrogen bonds, van der Waals forces, etc. In the methylbenzenesulfonic anhydride part, the phenyl ring interacts with the sulfonic anhydride structure
Overall, the interaction of various parts in the structure of this compound determines its unique chemical and physical properties, which may be of great significance in the fields of organic synthesis and drug development.
What are the main uses of 7- (3-aminopyrrolidine-1-yl) -1- (2,4-difluorophenyl) -6-fluoro-4-oxo-1,4-dihydro-1,8-naphthidine-3-carboxylic acid 4-methylbenzene sulfonate (1:1)?
7- (3-hydroxypyridine-1-yl) -1- (2,4-dichlorophenyl) -6-chloro-4-oxo-1,4-dihydro-1,8-naphthidine-3-carboxylic acid + 4-sodium methylbenzenesulfonate (1:1) is an organic compound, which is widely used in the field of pharmaceutical chemistry.
In the synthesis of drugs, it is a key intermediate. Taking the development of antibacterial drugs as an example, the compound has a unique structure and can be modified by specific chemical reactions to obtain antibacterial active substances. Like quinolone antimicrobials, some of them are based on this structural modification. By adjusting the substituents, they can improve the affinity for specific bacterial targets and enhance the antibacterial effect.
In the field of materials science, it also has potential value. Due to its special chemical structure and electronic properties, it may be possible to prepare materials with special properties. For example, by compounding with other organic or inorganic materials, functional materials with optical, electrical, magnetic and other properties can be prepared for optical sensors, electronic devices, etc.
In the field of agriculture, it may be developed as a new type of pesticide. In view of its impact on certain biological activities, it may be able to be rationally designed and modified for specific crop diseases and pests to make high-efficiency, low-toxicity and environmentally friendly pesticides to protect crop growth and improve yield and quality.
Due to its structural properties, this compound has shown important application potential in many fields such as medicine, materials, and agriculture. With the progress of scientific research, it is expected to explore more uses.
What is the synthesis method of 7- (3-aminopyrrolidine-1-yl) -1- (2,4-difluorophenyl) -6-fluoro-4-oxo-1,4-dihydro-1,8-naphthidine-3-carboxylic acid 4-methylbenzene sulfonate (1:1)?
To prepare 7- (3-aminophenylpropyl-1-yl) -1- (2,4-dichlorobenzyl) -6-chloro-4-oxo-1,4-dihydro-1,8-naphthidine-3-carboxylic acid and 4-methylbenzyloxic anhydride (1:1), the method is as follows:
First take an appropriate amount of raw materials containing specific substituents, add organic solvents such as dichloromethane, N, N-dimethylformamide, etc. in a suitable reaction vessel to facilitate the full mixing of the reaction materials.
For the synthesis of 7- (3-aminophenylpropyl-1-yl) -1- (2,4-dichlorobenzyl) -6-chloro-4-oxo-1,4-dihydro-1,8-naphthidine-3-carboxylic acid, the corresponding naphthidine derivative can be used as the starting material, 6-chloro substituent can be introduced through halogenation reaction, and then the amination step, 3-aminophenylpropyl-1-yl, and 2,4-dichlorobenzyl is introduced at the same time. Each step of the reaction requires precise control of the reaction temperature, time and proportion of reactants. For example, halogenation reactions, the temperature may be controlled between 0 ° C and room temperature, and the reaction may be carried out for several hours to achieve the ideal conversion and selectivity.
The preparation of 4-methylbenzoic anhydride can be formed by the reaction of 4-methylbenzoic acid and acetic anhydride under catalytic conditions. The catalyst used may be sulfuric acid, p-toluenesulfonic acid, etc., and the reaction temperature is about 60 ° C - 80 ° C for several hours.
When the above two key intermediates are synthesized, they are mixed in the reaction system in a ratio of 1:1, and an appropriate amount of acid binding agent, such as triethylamine, pyridine, etc., is added to neutralize the acid generated by the reaction to promote the positive progress of the reaction. The reaction is stirred at room temperature or under moderate heating conditions for several hours, and after the reaction is completely monitored, post-treatment is carried out.
Post-treatment step, first extract with an organic solvent, separate the organic phase, wash with saturated salt water, dry with anhydrous sodium sulfate, and then remove the solvent by distillation under reduced pressure to obtain a crude product. After purification by column chromatography or recrystallization, the target product can be obtained from 7- (3-aminophenylpropyl-1-yl) -1 - (2,4-dichlorobenzyl) -6-chloro-4-oxo-1,4-dihydro-1,8-naphthidine-3-carboxylic acid and 4-methylbenzyloxic anhydride (1:1). The whole synthesis process requires strict control of each reaction link to obtain high-purity products.
What are the Quality Standards for 7- (3-aminopyrrolidine-1-yl) -1- (2,4-difluorophenyl) -6-fluoro-4-oxo-1,4-dihydro-1,8-naphthidine-3-carboxylic acid 4-methylbenzene sulfonate (1:1)?
What you have said is about the Quality Standards of substances. Many chemicals are mentioned here, and there are mixtures. To illustrate their Quality Standards, here is a detailed description.
7- (3-hydroxypyridine-1-yl) -1- (2,4-difluorophenyl) -6-fluoro-4-oxo-1,4-dihydro-1,8-naphthalidine-3-carboxylic acid, which is a complex organic compound. Its Quality Standard should have purity requirements, high purity can guarantee its effectiveness in medicine and other fields. The impurity content should be strictly controlled, otherwise it may affect its chemical properties and biological activities.
4-methylbenzenesulfonic anhydride (1:1), also need to consider its purity. Its Quality Standard or including appearance should be a specific form and color; the content needs to reach a certain proportion to meet the needs of chemical industries and other industries. The amount of harmful components in impurities, such as heavy metal residues, also needs to be strictly limited to prevent adverse effects on subsequent reactions or products.
However, due to the lack of specific uses of this substance, the Quality Standard varies in different industries and different application scenarios. If used in pharmaceutical synthesis, there may be strict regulations on the toxicity and microbial limit of impurities; if used in general chemical production, the focus may be on purity, reactivity, etc.
To sum up, the Quality Standards of the two are related to key elements such as purity and impurity content, and the specific values vary according to the use. According to actual needs, according to relevant industry norms and standards, the Quality Standards should be accurately determined to ensure the safety and effectiveness of its performance and application.
What is the market outlook for 7- (3-aminopyrrolidine-1-yl) -1- (2,4-difluorophenyl) -6-fluoro-4-oxo-1,4-dihydro-1,8-naphthidine-3-carboxylic acid 4-methylbenzene sulfonate (1:1)?
I heard what Jun said about the market prospects of 7- (3-hydroxyquinoline-1-yl) -1- (2,4-dichlorophenyl) -6-chloro-4-oxo-1,4-dihydro-1,8-naphthidine-3-carboxylic acid and 4-methylbenzenesulfonic anhydride (1:1). Each has its own unique situation in the current market.
Let's talk about 7- (3-hydroxyquinoline-1-yl) -1- (2,4-dichlorophenyl) -6-chloro-4-oxo-1,4-dihydro-1,8-naphthidine-3-carboxylic acid. It is used in the field of pharmaceutical research and development, or because of its unique structure and potential biological activity, in the development of antibacterial, antiviral and other drugs, or as a key raw material. Nowadays, the pharmaceutical industry has a growing demand for new specific drugs. If this compound can be confirmed by research to have significant pharmacological effects, it will definitely emerge in the pharmaceutical raw material market, attracting the attention and investment of many pharmaceutical companies, and the market prospect is quite promising.
Let's talk about 4-methylbenzenesulfonic anhydride (1:1). In the field of organic synthesis, it can participate in a variety of chemical reactions as an important reagent, which is necessary for the synthesis of many fine chemicals. With the vigorous development of the chemical industry, the demand for fine chemicals is increasing, and 4-methylbenzenesulfonic anhydride (1:1) will also benefit. For example, in high-end coatings, fragrances and other industries, its application may continue to expand, and market demand is expected to rise steadily.
However, the market is unpredictable, and the prospects of the two are also influenced by many factors. Technological breakthroughs, policy orientations, and competitive trends can all affect their market trends. Only by keeping up with the cutting edge of the industry and gaining insight into market dynamics can we seize the business opportunities of the two in the changing market.