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What are the main uses of 5- (trifluoromethyl) benzene-1,3-diamine?
(Triethylamino) quinone-1,3-dione, that is, 5- (triethylamino) quinone-1,3-dione, its main uses are as follows:
This compound has shown unique effects in many fields. In the field of pharmaceutical chemistry, due to its specific chemical structure and biological activity, it may serve as a lead compound, laying the foundation for the development of new drugs. Through structural modification and optimization, it is expected to create innovative drugs with high efficiency, low toxicity and specific disease targets. For example, in the development of anti-tumor drugs, it may be able to precisely act on specific signaling pathways of tumor cells and inhibit the proliferation and metastasis of tumor cells.
In the field of organic synthesis, it is a key class of intermediates. With its active chemical properties, it can participate in a variety of chemical reactions, such as nucleophilic substitution, cyclization reactions, etc., to help build more complex organic molecular structures. It can be used to synthesize a series of organic compounds with special structures and functions, providing the possibility for the development of new organic functional materials in the field of materials science. For example, in photoelectric materials, or substances with unique optical and electrical properties can be synthesized, which can be used in organic Light Emitting Diodes (OLEDs), solar cells and other devices to improve their performance.
And because of the presence of specific functional groups in its structure, it may also play a role in the field of catalysis. Or it can be used as a ligand to complex with metal ions to form a metal complex catalyst with unique catalytic activity, exhibiting high catalytic efficiency and selectivity in organic synthesis reactions, promoting the development of green chemistry and sustainable chemistry.
What are the physical properties of 5- (trifluoromethyl) benzene-1,3-diamine?
(Trihydroxymethyl) propane-1,3-diol is an organic compound. Its physical properties are as follows:
Looking at its morphology, under room temperature and pressure, (trihydroxymethyl) propane-1,3-diol is often a white crystalline powder or a lump solid, with a pure appearance and a white color.
Smell its smell, this thing basically has no special smell, is quite pure, has no pungent and unpleasant smell, and does not cause discomfort due to the smell in the use environment.
Measure its melting point, about 56 ° C - 59 ° C, the melting point is relatively low, in case of moderate temperature, it can be gradually changed from solid to liquid, this characteristic provides specific convenience in many chemical operations and material processing processes.
Measure its boiling point, the boiling point is quite high, up to 295 ° C under normal pressure. A higher boiling point means that it can still maintain a liquid or solid state in a relatively high temperature environment, with good stability, can withstand a certain amount of heat and is not volatile, which is essential for application scenarios that require high temperature treatment or long-term exposure to high temperature environments.
In terms of its solubility, (trimethylolpropane) 1,3-diol is easily soluble in water, and can form a uniform and stable mixing system with water. At the same time, it can also be dissolved in a variety of polar organic solvents, such as methanol, ethanol, acetone, etc. Good solubility makes it easier to disperse and mix in different chemical systems and formulations, which greatly expands its application range in chemical industry, materials and other fields.
Its density is about 1.185g/cm ³. This density characteristic determines its relative volume and weight relationship when mixed with other substances. It provides an important basis for accurate control of the proportion of each component in actual production and formula design.
What are the chemical properties of 5- (trifluoromethyl) benzene-1,3-diamine?
5- (trimethyl) heptyl-1,3-diene is an organic compound with interesting chemical properties. This compound has a carbon-carbon double bond, which gives it a unique reactivity.
In terms of addition reactions, it can be added with many electrophilic reagents. In the case of hydrogen halides, such as hydrogen chloride (HCl), positively charged hydrogen atoms in hydrogen chloride will attack the carbon-carbon double bond first, forming a carbon-positive intermediate, which is then quickly combined with negatively charged chlorine atoms to form halogenated hydrocarbons. This is the embodiment of Markovnikov's rule, that is, hydrogen atoms tend to be added to carbon atoms with more hydrogen-containing double bonds.
In addition, the compound can also participate in the Diels-Alder reaction. As a diene, under heating or light conditions, it can undergo [4 + 2] cycloaddition reaction with suitable diene-friendly bodies, such as ethylene derivatives, to construct a new carbon ring structure. This reaction is extremely important in the field of organic synthesis to construct hexamembered cyclic compounds.
Furthermore, because it contains multiple carbon-carbon double bonds, it has a certain oxidation sensitivity. Under the action of strong oxidants, the carbon-carbon double bonds may be oxidized and broken to form corresponding alters, ketones or carboxylic acids.
At the same time, due to the influence of substituents in the molecule, the electron cloud density of its double bonds changes, which in turn affects the reaction activity. Alkyl and other donating groups will increase the electron cloud density of the double bond, which will increase the reactivity and make it more prone to reactions such as electrophilic addition. In short, 5- (trimethyl) heptyl-1,3-diene exhibits various chemical properties due to the existence of carbon-carbon double bonds and molecular structure characteristics, and is widely used in organic synthesis and chemistry research.
What are the synthesis methods of 5- (trifluoromethyl) benzene-1,3-diamine?
To prepare 5- (trifluoromethyl) quinine-1,3-diol, the following methods can be tried:
First, the aryl halide containing trifluoromethyl is used as the starting material, and the suitable quinoline-containing precursor is connected by a palladium-catalyzed coupling reaction. Subsequent selective oxidation and hydroxylation steps are carried out to introduce the desired 1,3-diol structure. This process requires fine regulation of the reaction conditions. The selection of palladium catalysts, the screening of ligands, and the type and dosage of bases all have a great impact on the selectivity and yield of the reaction.
Second, the quinoline parent nucleus can be constructed first, and then trifluoromethyl can be introduced at a suitable stage. For example, using quinoline as a substrate, using an electrophilic trifluoromethylation reagent, trifluoromethyl is introduced at a specific position. Subsequently, hydroxyl groups are introduced at the 1,3-position through an oxidation reaction. In this path, the activity and selectivity of the electrophilic trifluoromethylation reagent need to be carefully considered, and the oxidation step needs to avoid excessive oxidation to ensure the purity and yield of the product.
Third, design a bionic synthesis route. Simulate the biosynthesis mechanism of natural products, using simple and easy-to-obtain small molecules as the starting material, and gradually construct the target molecule through multi-step enzyme-catalyzed or enzyme-like-catalyzed reactions. Although this strategy is challenging, if successful, it may be able to achieve a more green and efficient synthesis. However, it is necessary to study the biosynthetic pathway in depth, screen suitable enzymes or catalysts, and optimize the reaction system to adapt to the abiotic environment.
All synthesis methods have their own advantages and disadvantages. In actual operation, it is necessary to weigh the choice according to the availability of raw materials, cost-effectiveness, reaction conditions and purity of target products to find the optimal synthesis strategy.
What is the price range of 5- (trifluoromethyl) benzene-1,3-diamine in the market?
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Changes in prices are related to supply and demand, the price of materials, the cost of labor, the simplicity of craftsmanship, or the nature of market competition and government regulations. If this thing is a rare treasure, there are few to get, and many to ask for, the price will be high; if the supply exceeds the demand, it will be easy to make and the cost will be minimal, and the price will be low.
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